Timely topics in medicine. Cardiovascular diseases最新文献_第5页

Highlights from the 2006 Scientific Sessions of the American Heart Association. 2006年美国心脏协会科学会议的亮点。

Timely topics in medicine. Cardiovascular diseases Pub Date : 2006-12-12

K Zareba

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A report from the 31st European Society of Medical Oncology congress. 来自第31届欧洲肿瘤医学学会大会的一份报告。

Timely topics in medicine. Cardiovascular diseases Pub Date : 2006-11-28

Xavier Rabasseda

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Noninjectable methods of insulin administration. 胰岛素非注射给药方法。

Timely topics in medicine. Cardiovascular diseases Pub Date : 2006-11-01

Simona Cernea, Itamar Raz

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Bleeding in acute coronary syndromes. 急性冠状动脉综合征出血。

Timely topics in medicine. Cardiovascular diseases Pub Date : 2006-11-01

Christopher B Granger

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Evolving therapies for diabetes: a report from the 42nd annual meeting of the European Association for the Study of Diabetes. 不断发展的糖尿病治疗:来自第42届欧洲糖尿病研究协会年会上的一份报告。

Timely topics in medicine. Cardiovascular diseases Pub Date : 2006-10-12

X Rabasseda

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Cardiovascular health: highlights from the 15th World Congress of Cardiology. 心血管健康:第15届世界心脏病学大会的亮点。

Timely topics in medicine. Cardiovascular diseases Pub Date : 2006-10-12

X Rabasseda

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Aspirin for the primary prevention of cardiovascular events. 阿司匹林用于心血管事件的一级预防。

Timely topics in medicine. Cardiovascular diseases Pub Date : 2006-10-01

John A Colwell

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Links between Alzheimer's disease and diabetes. 阿尔茨海默病和糖尿病之间的联系。

Timely topics in medicine. Cardiovascular diseases Pub Date : 2006-10-01

Miao-Kun Sun, Daniel L Alkon

{"title":"Links between Alzheimer's disease and diabetes.","authors":"Miao-Kun Sun, Daniel L Alkon","doi":"","DOIUrl":"","url":null,"abstract":"The existence of links between Alzheimer's disease and diabetes is an important topic currently under active debate. Establishing such links if they exist and defining their common pathogenesis and pathophysiological mechanisms may lead to new concepts and research directions for the pharmacological treatment of Alzheimer's disease and diabetes. Alzheimer's disease is associated with peripheral and central insulin abnormalities. Cognitive capacities are often impaired in patients with diabetes. There are many mechanisms by which insulin-signaling abnormalities may affect clinical and pathological outcome of Alzheimer's disease. Insulin resistance and dysregulation of the degradation of neurotoxic amyloid and insulin appear at the core of the links between Alzheimer's disease and diabetes. Functions and expression of insulysin, an enzyme involved in the degradation of neurotoxic amyloid peptides and insulin, are usually impaired or reduced in Alzheimer's disease and diabetes. The increased occurrence of insulin resistance in Alzheimer's disease suggests that improving insulin effectiveness and insulysin activity may have therapeutic value in Alzheimer's disease patients and therefore is worth intensive investigation.","PeriodicalId":87159,"journal":{"name":"Timely topics in medicine. Cardiovascular diseases","volume":"10 ","pages":"E24"},"PeriodicalIF":0.0,"publicationDate":"2006-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26331132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Cardiovascular disease and diabetes mellitus: highlights from the Annual Professional Conference of Diabetes UK. 心血管疾病和糖尿病:英国糖尿病年度专业会议的亮点。

Timely topics in medicine. Cardiovascular diseases Pub Date : 2006-10-01

Prabirkumar Bandyopadhyay

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ADP receptors: inhibitory strategies for antiplatelet therapy. ADP受体:抗血小板治疗的抑制策略。

Timely topics in medicine. Cardiovascular diseases Pub Date : 2006-09-01

Marco Cattaneo

{"title":"ADP receptors: inhibitory strategies for antiplatelet therapy.","authors":"Marco Cattaneo","doi":"","DOIUrl":"","url":null,"abstract":"The interaction of adenosine-5'-diphosphate (ADP) with its platelet receptors (P2Y1 and P2Y12) plays a very important role in thrombogenesis. The thienopyridine ticlopidine was the first specific antagonist of the platelet P2Y12 ADP receptor to be tested in randomized clinical trials for the prevention of arterial thrombotic events. Although ticlopidine reduces the incidence of vascular events in patients at risk, it also unfortunately has some significant drawbacks: a relatively high incidence of toxic effects, which may be fatal in some cases; delayed onset of action; and a high interindividual variability in response. A second thienopyridine, clopidogrel, has superseded ticlopidine, because it is also an efficacious antithrombotic drug and is less toxic than ticlopidine. However, clopidogrel is not completely free from faults: severe toxic effects, albeit occurring much less frequently than with ticlopidine, may still complicate its administration to patients; the onset of pharmacologic action can be accelerated by the use of large loading doses, but may still not be optimal; the high interpatient variability in response remains an important issue. These concerns justify the continued search for agents that can further improve the clinical outcome of patients with atherosclerosis through greater efficacy and/or safety. A new thienopyridyl compound, prasugrel, which is characterized by higher potency and faster onset of action compared with clopidogrel, is currently under clinical evaluation. Two direct and reversible P2Y12 antagonists, cangrelor and AZD6140, feature very rapid onset and reversal of platelet inhibition, which make them attractive alternatives to thienopyridines, especially when rapid inhibition of platelet aggregation or its quick reversal are required. Along with new the P2Y12 antagonists, inhibitors of the other platelet receptor for ADP, the antagonists P2Y1, are under development and may prove to be effective antithrombotic agents.","PeriodicalId":87159,"journal":{"name":"Timely topics in medicine. Cardiovascular diseases","volume":"10 ","pages":"E22"},"PeriodicalIF":0.0,"publicationDate":"2006-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26331137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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