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Timely topics in medicine. Cardiovascular diseases最新文献

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Acute total occlusion of the left main coronary artery with emphasis on electrocardiographic manifestations. 急性冠状动脉左主干全闭塞的心电图表现。
Timely topics in medicine. Cardiovascular diseases Pub Date : 2007-08-01
Kjell C Nikus
{"title":"Acute total occlusion of the left main coronary artery with emphasis on electrocardiographic manifestations.","authors":"Kjell C Nikus","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Survival from sudden total occlusion of the left main coronary artery is rare. The majority of these patients suffer major myocardial necrosis accompanied by cardiogenic shock. Case reports and small series of acute left main occlusion present descriptions of electrocardiographic (ECG) changes during the acute phase. Severe ischemia may be manifested in the ECG by life-threatening tachyarrhythmias, conduction disturbances and ST-segment deviation. Because of the potential for life-saving therapeutic options by emergency bypass grafting or immediate stenting, the ECG markers of the serious condition should be recognized by the medical profession. Acute left main occlusion should be suspected in severely ill patients with wide-spread ST-segment depressions, especially in the lateral precordial leads with inverted T waves or ST elevation involving the anterior precordial leads and the lateral extremity leads I and aVL. Also, lead aVR ST elevation accompanied by either anterior ST elevation or widespread ST-segment depression, may indicate left main occlusion. However, as other ECG manifestations have been reported, the absence of these changes should not exclude immediate invasive evaluation of hemodynamically compromised patients. The exact electrophysiological and pathophysiological background for different ECG manifestations of left main occlusion need to be better defined.</p>","PeriodicalId":87159,"journal":{"name":"Timely topics in medicine. Cardiovascular diseases","volume":"11 ","pages":"E22"},"PeriodicalIF":0.0,"publicationDate":"2007-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27284071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New research and new guidelines for the treatment of hypertension: a report from the 17th European Meeting on Hypertension. 高血压治疗的新研究和新指南:来自第17届欧洲高血压会议的报告
Timely topics in medicine. Cardiovascular diseases Pub Date : 2007-07-17
X Rabasseda
{"title":"New research and new guidelines for the treatment of hypertension: a report from the 17th European Meeting on Hypertension.","authors":"X Rabasseda","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87159,"journal":{"name":"Timely topics in medicine. Cardiovascular diseases","volume":"11 ","pages":"E19"},"PeriodicalIF":0.0,"publicationDate":"2007-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27284065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New joint European Society of Hypertension/European Society of Cardiology guidelines for the management of arterial hypertension. 新的联合欧洲高血压学会/欧洲心脏病学会动脉高血压管理指南。
Timely topics in medicine. Cardiovascular diseases Pub Date : 2007-07-16
X Rabasseda
{"title":"New joint European Society of Hypertension/European Society of Cardiology guidelines for the management of arterial hypertension.","authors":"X Rabasseda","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87159,"journal":{"name":"Timely topics in medicine. Cardiovascular diseases","volume":"11 ","pages":"E18"},"PeriodicalIF":0.0,"publicationDate":"2007-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27284064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapies for heart failure: a report from the Heart Failure Congress 2007. 心力衰竭的治疗:2007年心力衰竭大会的一份报告。
Timely topics in medicine. Cardiovascular diseases Pub Date : 2007-07-13
X Rabasseda
{"title":"Therapies for heart failure: a report from the Heart Failure Congress 2007.","authors":"X Rabasseda","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87159,"journal":{"name":"Timely topics in medicine. Cardiovascular diseases","volume":"11 ","pages":"E16"},"PeriodicalIF":0.0,"publicationDate":"2007-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27284062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modern antihypertensive therapy: a report from the 22nd annual meeting of the American Society of Hypertension. 现代降压疗法:美国高血压学会第22届年会上的一份报告。
Timely topics in medicine. Cardiovascular diseases Pub Date : 2007-07-13
X Rabasseda
{"title":"Modern antihypertensive therapy: a report from the 22nd annual meeting of the American Society of Hypertension.","authors":"X Rabasseda","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87159,"journal":{"name":"Timely topics in medicine. Cardiovascular diseases","volume":"11 ","pages":"E17"},"PeriodicalIF":0.0,"publicationDate":"2007-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27284063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multivessel coronary artery disease: how do we treat it? 多支冠状动脉疾病:我们如何治疗?
Timely topics in medicine. Cardiovascular diseases Pub Date : 2007-07-09
Satyavan Sharma
{"title":"Multivessel coronary artery disease: how do we treat it?","authors":"Satyavan Sharma","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87159,"journal":{"name":"Timely topics in medicine. Cardiovascular diseases","volume":"11 ","pages":"E15"},"PeriodicalIF":0.0,"publicationDate":"2007-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27284061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stem cells: therapeutic present and future. 干细胞:治疗的现在和未来。
Timely topics in medicine. Cardiovascular diseases Pub Date : 2007-05-10
V K Khurdayan
{"title":"Stem cells: therapeutic present and future.","authors":"V K Khurdayan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ever since the first embryonic stem cells were isolated in the 1990s scientists and clinicians as well as the general public have followed the development of the field with great attention. As unspecialized cells capable of dividing, renewing and differentiating into specialized cells, stem cells hold great promise as a therapeutic strategy for many diseases, especially those of degenerative nature. In 2006, stem cells were actively investigated in preclinical and clinical settings to manage heart failure, amyotrophic lateral sclerosis, spinal cord injury, stroke, hematologic disorders, renal cell carcinoma, solid tumor cancer, Crohn's disease and cirrhosis, among other disorders. Likewise, biotech and pharmaceutical industry highlighted stem cells and associated products and technologies as useful tools for drug discovery that provide relevant clinical models and ensure efficacious transition of investigational compounds into preclinical testing.</p>","PeriodicalId":87159,"journal":{"name":"Timely topics in medicine. Cardiovascular diseases","volume":"11 ","pages":"E14"},"PeriodicalIF":0.0,"publicationDate":"2007-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27284060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Focus on neurologic diseases: a report from the 59th American Academy of Neurology annual meeting. 关注神经系统疾病:来自第59届美国神经病学学会年会的报告。
Timely topics in medicine. Cardiovascular diseases Pub Date : 2007-05-09
Xavier Rabasseda
{"title":"Focus on neurologic diseases: a report from the 59th American Academy of Neurology annual meeting.","authors":"Xavier Rabasseda","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87159,"journal":{"name":"Timely topics in medicine. Cardiovascular diseases","volume":"11 ","pages":"E13"},"PeriodicalIF":0.0,"publicationDate":"2007-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27284059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pleiotropic effects of statins and related pharmacological experimental approaches. 他汀类药物的多效效应及相关药理实验方法。
Timely topics in medicine. Cardiovascular diseases Pub Date : 2007-04-18
M Alegret, J S Silvestre
{"title":"Pleiotropic effects of statins and related pharmacological experimental approaches.","authors":"M Alegret,&nbsp;J S Silvestre","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Statins, the most widely prescribed cholesterol-lowering drugs, are considered to be first-line therapeutics for the prevention of coronary heart disease and atherosclerosis. Statins act by inhibiting the enzyme 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, the rate-limiting enzyme in endogenous cholesterol biosynthesis, which catalyzes the reduction of HMG-CoA to mevalonic acid. Inhibition of this enzyme has proven to be effective for lowering plasma total cholesterol, low-density lipoprotein-cholesterol, and triglyceride levels in humans and can therefore be useful to treat atherosclerotic and dyslipidemic disorders. However, the clinical benefits of statins appear to extend beyond their lipid-lowering effects. Besides reducing cholesterol biosynthesis, inhibition of mevalonate by statins also leads to a reduction in the synthesis of important intermediates, such as the isoprenoids farnesyl pyrophosphate and geranylgeranyl pyrophosphate. These intermediates are involved in the posttranslational prenylation of several proteins (e.g., Ras, Rho, Rac) that modulate a variety of cellular processes including cellular signaling, differentiation, and proliferation. Given the central role of these isoprenylated proteins in endothelial function, atherosclerotic plaque stability, platelet activity, coagulation, oxidation, and inflammatory and immunologic responses, it could be anticipated that these compounds may exert multiple beneficial effects in a broad spectrum of disorders including cardiovascular disease, osteoporosis, Alzheimer's disease and related vascular dementia, viral and bacterial infection, etc. This article summarizes these cholesterol-lowering-independent effects of statins, termed \"pleiotropic effects,\" and the underlying mechanisms, as well as the preclinical experimental approaches that would be useful to evaluate the effects of statins.</p>","PeriodicalId":87159,"journal":{"name":"Timely topics in medicine. Cardiovascular diseases","volume":"11 ","pages":"E10"},"PeriodicalIF":0.0,"publicationDate":"2007-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26699278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highlights of the 56th annual scientific session of the American College of Cardiology. 美国心脏病学会第56届年度科学会议的亮点。
Timely topics in medicine. Cardiovascular diseases Pub Date : 2007-04-13
X Rabasseda
{"title":"Highlights of the 56th annual scientific session of the American College of Cardiology.","authors":"X Rabasseda","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87159,"journal":{"name":"Timely topics in medicine. Cardiovascular diseases","volume":"11 ","pages":"E12"},"PeriodicalIF":0.0,"publicationDate":"2007-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27284068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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