Japanese medical journal最新文献

{"title":"A CASE OF RABIES WITH A PROLONGED INCUBATION PERIOD AND AN UNUSUAL VARIATION PHENOMENON OF THE VIRUS ISOLATED THEREFROM","authors":"D. Ushiba, K. Abe, J. Tanaka, K. Horie","doi":"10.7883/YOKEN1948.2.177","DOIUrl":"https://doi.org/10.7883/YOKEN1948.2.177","url":null,"abstract":"BY DAIZO USHIBA, KAZUO ABE , JUTARO TANAKA and KIICHI HORDE The Department of Bacteriology , Keio Gijuku University School of Medicine , Tokyo We have isolated a virus strain from the brain of a patient who di ed of rabies in January 1948 following a very long incubation period . We are now continuing immunological studies with this strain . In the course of experiments with mice a curious variation phenomenon was noted , which seems to us to be a sufficient inter est to merit description and discussion .","PeriodicalId":86969,"journal":{"name":"Japanese medical journal","volume":"51 1","pages":"177-184"},"PeriodicalIF":0.0,"publicationDate":"1949-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71312871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STUDIES ON AN ANTIBIOTIC SUBSTANCE OF S. GRISEUS, GRISEIN","authors":"H. Umezawa, S. Hayano, Y. Ogata","doi":"10.7883/YOKEN1948.2.79","DOIUrl":"https://doi.org/10.7883/YOKEN1948.2.79","url":null,"abstract":"","PeriodicalId":86969,"journal":{"name":"Japanese medical journal","volume":"2 1","pages":"79-84"},"PeriodicalIF":0.0,"publicationDate":"1949-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71313379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STUDIES ON THE STREPTOTHRICIN-GROUP-SUBSTANCES ON STREPTOTHRICIN A AND STREPTOTHRICIN B","authors":"H. Umezawa, T. Takeuchi, Eiji Kurosu","doi":"10.7883/YOKEN1948.2.9","DOIUrl":"https://doi.org/10.7883/YOKEN1948.2.9","url":null,"abstract":"Streptothricin is a well-known antibiotic found by Waksman and his collaborators (1). However, there are more than two kinds of antibiotic substances which are very similar to streptothricin. Lavendulin and actinorubin reported by Kelner and Morton (2) are very resembling to Streptothricin. E. coli whose resistance to streptothricin has been forcedly raised becomes simultaneously more resistant to lavendul in and actinorub in than the normal culture. Umezawa and his collaborators (3,4) found that antibiotic substances resembling to streptothricin were produced by various kinds of streptomyces, and called them streptothricin-group-substances. Streptothricin-group-substances have the following characters. (1) They are produced by strains belonging to streptomyces. (2) They are adsorbed by activated carbon from their neutral solution and eluted into acid methanol. (3) A streptothricinfast E. coli is more resistant to them than the normal culture. A streptomycinfast E. coli is almost as susceptible to them as the normal culture. In this character streptothricin-group substances can be easily differentiated from streptomycin. Ten strains of S. lavendulae, two strains of S. albus , one strain of S. ruber, one strain resembling to S. antibioticus, and five strains of S. fradiae , which all had been isolated by Umezawa and his collaborators (5,6) were found to produce streptothricin-group-substances. Moveover, during testing the resistances of B. subtilis (N. R. R. L. B-558) and B. anthracis, it was found that antibiotic substances of all strains except the strains of S. fradiae showed a longer inhibition length against B. subtilis than against B. anthracis, but the antibiotic substance of S. fradiae showed a longer inhibition length against B. anthracis than B. subtilis. The antibiotic substance of S. fradiae seemed to be different from other streptothricin-group-substances. In further studies the antibiotic substance of S. fradiae was found to be different from other streptothricin-group-substances in the antibacterial spectrum and the toxicity. The later appearing toxicity which was specific . for streptothricin was not found in the case of the antibotic of S. fradiae. And we decided to call the antibiotic of S. fradiae Streptothricin B, and the others streptothricin A, for among the streptothricin-group-substances streptothricin, the antibiotic of S. lavendulae, was first discovered. Now the streptothricin A indicates the streptothricin-group-substances produced by various kinds of streptomyces other than S. fradiae. Whether the streptothricin. A is only one kind of substance or there are more than two kinds of streptothricin","PeriodicalId":86969,"journal":{"name":"Japanese medical journal","volume":"2 1","pages":"9-15"},"PeriodicalIF":0.0,"publicationDate":"1949-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71313467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE CONDUCTION VELOCITY IN RELATION TO THE STIMULATION INTENSITY AND TO THE SIZE OF THE ACTIVATED AREA (OBSERVATIONS ON LILLIE'S NERVE MODEL)","authors":"K. Yamagiwa","doi":"10.7883/YOKEN1948.2.217","DOIUrl":"https://doi.org/10.7883/YOKEN1948.2.217","url":null,"abstract":"The relation between the conduction velocity and the stimulation intensity has often been a subject of investigation because of its fundamental importance in nerve physiology. After a period of indetermination, the general opinion seemed to have once settled that the velocity is invariable, not depending on the stimulation intensity (Engelmann (1), Nicolai (2)). Recently, however, we have again a few reports, which contradict to the above conclusion. According to Iiizumi (3), the conduction velocity of the leaf-stalk of Mimosa pudica varies greatly with the intensity of the stimulation. Shibaoka (4) showed on the same material a clear increment and decrement of the velocity in the vicinity of the stimulated point. Gelfan (5) found on, verve that the distance travelled and also the conduction velocity get larger with larger stimulation intensity or with larger diameter of the stimulating electrode. On the other hand, the increment and decrement, also the increase and decrease, of the velocity, are all possible theoretically, if only the size of the area primarily excited can be made large or small properly (Yamagiwa (6, 7)). We should notice here that in usual methods of stimulation, the variation of the intensity brings forth necessarily that of the area stimulated. So, to answer the question whether the velocity varies with the stimulation intensity or not, we have first to invent a method in which we can control the intensity or the area only, and then to ex amine carefully whether the velocity varies or not 1) with the intensity when a certain definite area is stimulated, 2) with the size of the stimulated area and 3) with distance from the stimulating electrode. It has long been one of the author's desires to perform these examinations on the nerve itself, but owing to the methodi cal difficulty they have not been realized yet. That is why he took up Li11ie's model in the present work. It turned out after the experiments, however, that an exact method cannot be established even in the model, and, consequently, we cannot get any definite answer for the question. Still it was not without results, about which we should like to describe here briefly. As to the methodical details, the reader is . referred to the previous paper (Yamagiwa (7)). Here, just a few particular points will be described.","PeriodicalId":86969,"journal":{"name":"Japanese medical journal","volume":"2 1","pages":"217-229"},"PeriodicalIF":0.0,"publicationDate":"1949-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71312577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A SPECIAL CASE OF INTERACTION (FURTHER OBSERVATIONS ON LILLIE'S NERVE MODEL)","authors":"K. Yamagiwa","doi":"10.7883/YOKEN1948.2.93","DOIUrl":"https://doi.org/10.7883/YOKEN1948.2.93","url":null,"abstract":"In a pevious paper (Yamagiwa(1)), some studies on the interaction between two or more Lillie's nerve models with regard to the conduction velocity , were described. The present paper deals with a fact belonging to the same category. It . offers nothing of new principle but it demonstrates most clearly the effect of interaction and , moreover, it seems to be suggesting something essential as to the mode of conduction of the activation wave , which will be worth while to be mentioned here.","PeriodicalId":86969,"journal":{"name":"Japanese medical journal","volume":"7 1","pages":"93-98"},"PeriodicalIF":0.0,"publicationDate":"1949-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71313074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ON A NEW SPECIES OF ANAEROBIC COCCUS ISOLATED FROM TROPICAL ULCER","authors":"M. Magara, Kachu Go, Kimpa So, T. Akima","doi":"10.7883/YOKEN1948.1.289","DOIUrl":"https://doi.org/10.7883/YOKEN1948.1.289","url":null,"abstract":"isolated from 10 materials. Also from two cases of experimental ulcer, produced by the inoculation of the secretion of the ulcer into other persons, the same coccus was isolated . The frequency of isolation was greater in the early stage of illness . In our subsequent experiments, we have succeeded in isolating this coccus from almost all cases by repeated and careful cultivation. The nature of this coccus is as follows: Morphology: The coccus is spheric, and in diplococcus form in most cases , is found in single in some cases, and seldom forms a very short chain or a small mass . The diameter is approximately 1.5-1.8ƒÊ. It is unmobile, has neither. spore.nor capsule. Coloration: Gram +","PeriodicalId":86969,"journal":{"name":"Japanese medical journal","volume":"1 1","pages":"289-291"},"PeriodicalIF":0.0,"publicationDate":"1948-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71312086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STUDIES ON THE BITING-LICE (MALLOPHAGA) OF JAPAN AND ADJACENT TERRITORIES (SUBORDER ISCHNOCERA Pt. I)","authors":"Seinosuke Uchida","doi":"10.7883/YOKEN1948.1.303","DOIUrl":"https://doi.org/10.7883/YOKEN1948.1.303","url":null,"abstract":"","PeriodicalId":86969,"journal":{"name":"Japanese medical journal","volume":"26 1","pages":"303-326"},"PeriodicalIF":0.0,"publicationDate":"1948-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71312140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STUDIES ON THE EXTRACTION OF PENICILLIN","authors":"H. Umezawa, T. Takeuchi","doi":"10.7883/YOKEN1948.1.327","DOIUrl":"https://doi.org/10.7883/YOKEN1948.1.327","url":null,"abstract":"","PeriodicalId":86969,"journal":{"name":"Japanese medical journal","volume":"1 1","pages":"327-338"},"PeriodicalIF":0.0,"publicationDate":"1948-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71312151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ON THE DIFFERENTIATION OF STREPTOMYCIN AND ALLIED SUBSTANCES (STREPTOTHRICIN GROUP) AND RAPID ISOLATION OF STREPTOMYCIN-PRODUCING STRAIN","authors":"H. Umezawa, S. Hayano, Y. Ogata","doi":"10.7883/YOKEN1948.1.339","DOIUrl":"https://doi.org/10.7883/YOKEN1948.1.339","url":null,"abstract":"Since we undertook the studies on streptomycin, various kinds of actinomyces producing substances resembling streptomycin were isolated (1, 2), and we were thrown into confusion, as to which one of them was streptomycin. The difficulties of the isolation of streptomycin-producing strain seem to be ascribable to the existence of many kinds of actinomyces producing other substances resembling streptomycin. which, in the broth, inhibit B. coli and other gram negative bacteria rather more strongly than streptomycin. Streptomycin, streptothricin (3) and allied substances are usually differentiated on the basis of their antibacterial spectra, but this differentiation method can only be utilized in laboratories, where streptomycin, streptothricin and other related substances are already isolated, since even among the same species the resistance of bacteria may be different in different individual strains. Recently Waksman, Reilly, ahd Jonstone (4) reported that streptomycin-producing strain was much more resistant against streptomycin and the incorporation of streptomycin in the isolating medium in concentration sufficient to inhibit the growth of the usual actinomyces facilitated the isolation of streptomycin strain. Among 120 antibiotic strains of various kinds of actinomyces isolated by us, 21 strains grew on the nutrient agar plus 50 pug of streptomycin hydrochloride (Merck's sample, about 600 ƒÊ/mg) and from one of them streptomycin was extracted and purified as its reineckate crystal. This and other strains producing related substances and the antibiotic substances extracted from them were comparatively studied, and it was concluded that among these substances streptomycin was particular in respect of the tolerance of streptomycin-fast bacteria and the colour of its Sakaguchi's reaction, though they were all similar in extractability and solubility, and inhibited both gram positive and negative bacteria. Now we should like to devide the antibiotic substances resembling, streptomycin and streptothricin into streptomycin and streptothricin-group substances, among the latter streptothricin having been first isolated by Waksman and others (3). Lavendulin and actinorubin found by Kelner and Morton (5) and basic antibiotic substances resembling a streptomycin and streptothricin reported by us (1, 2) are to be included in streptothricingroup substances, for the streptothricin-fast B. coil is nearly as susceptible to these substances as the normal culture. Streptin found by Foster and others (6) also seems to belong to the streptothricin-group substances, for it is extracted in the same way as streptomycin from the broth of A, reticulus-ruber, which was found by us to produce a streptothricin group: substances and a streptomycin-producing strain is not yet found in","PeriodicalId":86969,"journal":{"name":"Japanese medical journal","volume":"1 1","pages":"339-346"},"PeriodicalIF":0.0,"publicationDate":"1948-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71312175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OBSERVATIONS ON THE LARGE SCALE PRODUCTION OF VACCINE LYMPH: OUTCOME DURING 3 MONTHS PERIOD FROM JANUARY 26th TO APRIL 30th, 1946","authors":"H. Yaoi, S. Arakawa, I. Tagaya","doi":"10.7883/YOKEN1948.1.347","DOIUrl":"https://doi.org/10.7883/YOKEN1948.1.347","url":null,"abstract":"To meet the urgent need during the recent epidemic of smallpox the greatest effort has been made by workers in the Lymph-Department of Government Institute for Infectious Diseases, to prepare smallpox vaccine. Since, at the time, almost all the Lymph-Laboratories were deprived of their own working places and equipments owing to the sudden termination of the War, there was no other way than to do our duty to the best of our ability. The present paper describes the procedures, with which we produced the smallpoxvaccine for 30,000,000 personnels within a 3 months period.","PeriodicalId":86969,"journal":{"name":"Japanese medical journal","volume":"1 1","pages":"347-350"},"PeriodicalIF":0.0,"publicationDate":"1948-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71312217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}