Avicenna Journal of Clinical Microbiology and Infection最新文献_第4页

Investigating the Inhibitory Effect of Probiotic Lactobacillus Species Isolated From Dairy Products 乳制品中分离的益生菌乳酸菌的抑菌作用研究

Avicenna Journal of Clinical Microbiology and Infection Pub Date : 2022-09-29 DOI: 10.34172/ajcmi.2022.3337

A. Rahi, M. Marhamatizadeh

{"title":"Investigating the Inhibitory Effect of Probiotic Lactobacillus Species Isolated From Dairy Products","authors":"A. Rahi, M. Marhamatizadeh","doi":"10.34172/ajcmi.2022.3337","DOIUrl":"https://doi.org/10.34172/ajcmi.2022.3337","url":null,"abstract":"Background: Lactobacilli are among the most important known probiotic species, and efforts are underway to isolate them from various sources. The beneficial effect of probiotics on health is the main reason for their wide use in dairy products, including yogurt. This research was conducted to isolate and identify Lactobacillus species present in traditional Iranian yogurt. Methods: Thirty samples of traditional yogurt were collected from different regions of the Gachsaran district south of Iran. Bacterial isolations were performed according to the standard international protocols. Following successive culturing on selective media, obtaining typical colonies, and conducting microscopic examinations, five isolates were selected and analyzed for anti-microbial activities against three bacteria and two pathogenic fungi. To confirm biochemical results, three bacterial isolates were selected for molecular analysis and identified by 16S rRNA sequencing. Results: Lactobacillus paracasei JCM1171 with 1384 nucleotides and Lactobacillus plantarum subsp. Plantarum.A1 with 1380 nucleotides were isolated based on investigations. The most anti-microbial activities were related to strain A, and the least effects belonged to strain X3. Moreover, among the applied pathogenic microorganisms, Staphylococcus aureus and the fungus, Aspergillus niger had the highest sensitivity. Conclusion: Probiotic bacteria have highly beneficial effects on the host, and their mechanism of action is through functions such as the production of bioactive compounds. In addition to dairy products, this bacterium has the potential to be isolated from non-dairy products and even plant products, and this issue can be an idea to isolate this bacterium from other sources and even identify new species with probiotic potential.","PeriodicalId":8689,"journal":{"name":"Avicenna Journal of Clinical Microbiology and Infection","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83784837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Royal Jelly Feeding as a Main Inducer of Bcl-2-associated X Protein in the Peripheral Blood Immune Cells of Patients With Chronic Hepatitis B 饲喂蜂王浆作为慢性乙型肝炎患者外周血免疫细胞bcl -2相关X蛋白的主要诱导剂

Avicenna Journal of Clinical Microbiology and Infection Pub Date : 2022-09-29 DOI: 10.34172/ajcmi.2022.3399

Morteza Bahaaldin-Beygi, A. Kariminik, M. Arababadi

{"title":"Royal Jelly Feeding as a Main Inducer of Bcl-2-associated X Protein in the Peripheral Blood Immune Cells of Patients With Chronic Hepatitis B","authors":"Morteza Bahaaldin-Beygi, A. Kariminik, M. Arababadi","doi":"10.34172/ajcmi.2022.3399","DOIUrl":"https://doi.org/10.34172/ajcmi.2022.3399","url":null,"abstract":"Aim: Chemokines, cytokines, and their related molecules play crucial roles in the fight against the hepatitis B virus (HBV) and its related complications. Royal jelly (RJ) is considered an immunomodulatory factor for humans. This clinical trial study aimed to explore the RJ effects on the relative expression of CCL2, CCL3, CCL8, IFN-β, NANOG, OCT4, BAX, and MAVS in chronic hepatitis B (CHB) patients. Methods: The CHB patients were under one month of RJ treatment, 1 g/d. The relative expressions of CCL2, CCL3, CCL8, IFN-β, NANOG, OCT4, BAX, and MAVS were evaluated using the real-time polymerase chain reaction (PCR) technique. Results: RJ feeding significantly increased the expression of BAX in the peripheral blood immune cells of CHB patients. However, relative expressions of CCL2, CCL3, CCL8, IFN-β, NANOG, OCT4, and MAVS were not altered following RJ feeding. Conclusion: RJ can modulate immune responses via induction of homeostasis in the peripheral blood immune cells of CHB patients. Reduced inflammation following RJ feeding may be a result of homeostasis in the peripheral blood immune cells.","PeriodicalId":8689,"journal":{"name":"Avicenna Journal of Clinical Microbiology and Infection","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79336969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viral Gastroenteritis Prevalence in Iranian Pediatric Population: A Systematic Review 伊朗儿童病毒性肠胃炎患病率:系统综述

Avicenna Journal of Clinical Microbiology and Infection Pub Date : 2022-09-29 DOI: 10.34172/ajcmi.2022.3389

Nooshin Mojahed, Mohammad Ali Mohammadkhani, M. Pourasgari, Golnosh Gol-Jah Rad, A. Mohamadkhani

{"title":"Viral Gastroenteritis Prevalence in Iranian Pediatric Population: A Systematic Review","authors":"Nooshin Mojahed, Mohammad Ali Mohammadkhani, M. Pourasgari, Golnosh Gol-Jah Rad, A. Mohamadkhani","doi":"10.34172/ajcmi.2022.3389","DOIUrl":"https://doi.org/10.34172/ajcmi.2022.3389","url":null,"abstract":"Background: Viral gastroenteritis infection, a prevalent condition in adolescents and children, is still a rigid and serious problem among humans. This disease is responsible for up to three million fatalities nationwide. noroviruses, rotaviruses, astroviruses, adenoviruses, and sapoviruses are the most common and well-known pathogens associated with viral gastroenteritis agents. In this systematic review, we extracted all original articles and data on viral gastroenteritis that were performed on the Iranian pediatric population. Methods: To investigate the viral agent pathogens of gastroenteritis in Iran, 48 articles on the identification of viral gastroenteritis were gathered from the existing data. Viral gastroenteritis was detected in fourteen provinces, including the southern and northern parts of Iran. The seasonal distribution in Iran was analyzed as well. Finally, all the data from 1978-2021, along with their detailed information, were summarized, including the number of patients, the number of positive cases, applied technics, and the region of the studied cases in Iran. Results: Based on the results, most of the viral detection was associated with Rotavirus, the major pathogen responsible for gastroenteritis disease, followed by Adenovirus, Norovirus, Parechovirus, Bocavirus, Astrovirus, Aichivirus, Sapovirus, and three case reports of SARS-CoV-2 that were associated with viral gastroenteritis. Conclusion: Different studies conducted over Iran, including the northern, southern, and central regions, were obtained based on the data. Most studies had been merely dedicated to rotavirus, which had the highest prevalence of all other viral gastroenteritis. Our review clearly demonstrated that Rotavirus genotype G1P [8] is the dominating sereotype among the other studied gastroenteritis viral agents in Iran in which the most frequency rate was during the winter (44.26%), while the least frequency rate was observed during summer (8.96%).","PeriodicalId":8689,"journal":{"name":"Avicenna Journal of Clinical Microbiology and Infection","volume":"206 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87877656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Inhibitory Activity of Oliveria decumbens Essential Oil on Staphylococcus aureus Biofilm and Planktonic Cells 卧枕橄榄精油对金黄色葡萄球菌生物膜和浮游细胞的抑制作用

Avicenna Journal of Clinical Microbiology and Infection Pub Date : 2022-09-29 DOI: 10.34172/ajcmi.2022.3397

Mahshad Javid Moghadam, S. Maktabi, M. Zarei, Pezhman Mahmoodi Koohi

{"title":"Inhibitory Activity of Oliveria decumbens Essential Oil on Staphylococcus aureus Biofilm and Planktonic Cells","authors":"Mahshad Javid Moghadam, S. Maktabi, M. Zarei, Pezhman Mahmoodi Koohi","doi":"10.34172/ajcmi.2022.3397","DOIUrl":"https://doi.org/10.34172/ajcmi.2022.3397","url":null,"abstract":"Background: Staphylococcus aureus is a pathogenic bacterium that forms biofilms on biotic and abiotic surfaces. Biofilm formation is important for researchers because it increases the risk of food contamination in the food industry, increases the pathogenicity of bacteria, and damages the equipment. The main purpose of this study was to find out the antimicrobial and antibiofilm properties of Oliveria decumbens essential oil (Od-EO) against Staphylococcus aureus. Methods: In this study, the antibacterial and anti-biofilm properties of Od-EO were tested against four strong biofilm producers. S. aureus isolates were obtained from food and humans. The antibacterial properties of Od-EO on planktonic S. aureus were investigated using the disk diffusion method; further, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined. The microtiter plate (MTP) method and slime production evaluation were used to assess the inhibitory effect of Od-EO on S. aureus biofilm formation. Results: Od-EO indicated strong antimicrobial activity against planktonic S. aureus. After performing tests related to the anti-biofilm activity of Od-EO, it was found that Od-EO significantly reduced slime production and thus inhibited biofilm formation. Conclusions: Od-EO and its components can be used as a new anti-biofilm agent in medical, dental, and food industry equipment.","PeriodicalId":8689,"journal":{"name":"Avicenna Journal of Clinical Microbiology and Infection","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83870417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MicroRNA155 May Be an Important Part of Human Papilloma Virus-Related Cancers MicroRNA155可能是人类乳头瘤病毒相关癌症的重要组成部分

Avicenna Journal of Clinical Microbiology and Infection Pub Date : 2022-06-29 DOI: 10.34172/ajcmi.2022.12

Banafsheh Douzandeh-Mobarrez, A. Kariminik, B. Kheirkhah

引用次数: 0

Elevated Levels of Anti-SARS-Cov2 IgG Antibody in Health Care Workers in Hospitals From Hamadan Province, Iran: A Prospective Study 伊朗哈马丹省医院医护人员抗sars - cov2 IgG抗体水平升高的前瞻性研究

Avicenna Journal of Clinical Microbiology and Infection Pub Date : 2022-06-29 DOI: 10.34172/ajcmi.2022.13

E. Jalili, S. Bashirian, M. Faryabi, Mina Noroozbeygi, Ebrahim Daneshyar, S. Ghelichkhani, S. Khazaei, G. Solgi

{"title":"Elevated Levels of Anti-SARS-Cov2 IgG Antibody in Health Care Workers in Hospitals From Hamadan Province, Iran: A Prospective Study","authors":"E. Jalili, S. Bashirian, M. Faryabi, Mina Noroozbeygi, Ebrahim Daneshyar, S. Ghelichkhani, S. Khazaei, G. Solgi","doi":"10.34172/ajcmi.2022.13","DOIUrl":"https://doi.org/10.34172/ajcmi.2022.13","url":null,"abstract":"Aim: Seroprevalence among health care workers (HCWs) has been estimated in different studies in various regions and countries. This study aimed to screen the immunoglobulin M (IgM) and IgG seroprevalences and to assess the durability of IgG seropositivity, as well as the incidence of subsequent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a group of Iranian HCWs. Methods: This voluntary serological screening was prospectively performed on 800 HCWs (492 females and 308 males) in Hamadan between November 2020 and February 2021. Anti-SARS-CoV-2 IgG and IgM antibodies were assessed by the enzyme-linked immunosorbent assay method at two-time intervals. Results: Overall, 243 out of 800 (30.38%) and 66 (8.25%) cases were IgG and IgM seropositive at their first antibody assessment, respectively. The male staff had a higher seroprevalence than females (31.49% vs. 29.67% for IgG, P=0.59 and 10.39% vs. 6.91% for IgM, P=0.08). Higher prevalences for both antibodies were found in the age group of 30-39.9 years (P=0.12 and P=0.05, respectively). In the second antibody screening, 81 (56.6%) cases were IgG seropositive. The mean titer of the first IgG antibody assessment in seropositive cases was lower than that of the second titer (2.95±2.07 vs. 5.08±4.01 cut-off index (COI) , P=1.4×10-5 ). Moreover, the comparison of the first and second IgG titers among 81 seropositive cases demonstrated a significantly increased level of anti-SARS-CoV-2 antibody (5.08±4.01 vs. 3.49±2.41 COI, P=0.002). Conclusions: Our findings revealed that the mean level of the anti-SARS-CoV-2 IgG antibody was significantly increased in the seropositive individuals after 2 months of follow-up.","PeriodicalId":8689,"journal":{"name":"Avicenna Journal of Clinical Microbiology and Infection","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85090922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of Helicobacter Pylori Infection Prevalence by Non-invasive Methods 无创法测定幽门螺杆菌感染率

Avicenna Journal of Clinical Microbiology and Infection Pub Date : 2022-06-29 DOI: 10.34172/ajcmi.2022.09

M. Gharavi, J. Zarei, Parisa Roshani Asl, Zahra Yazdanyar, Masoud Sharif, Niloufar Rashidi

{"title":"Determination of Helicobacter Pylori Infection Prevalence by Non-invasive Methods","authors":"M. Gharavi, J. Zarei, Parisa Roshani Asl, Zahra Yazdanyar, Masoud Sharif, Niloufar Rashidi","doi":"10.34172/ajcmi.2022.09","DOIUrl":"https://doi.org/10.34172/ajcmi.2022.09","url":null,"abstract":"Background: Helicobacter pylori (H. pylori) is identified as the most frequent agent of bacterial infections in humans which can cause various gastrointestinal diseases. This pathogen has infected approximately half of the world’s population, and its outbreak has varied across different regions. The purpose of this study was to estimate the H. pylori infection prevalence amongst patients in Fardis county, Alborz province, Iran, using noninvasive methods. Methods: A total of 5677 patients were analyzed from September 2020 to October 2021 to detect H. pylori by the use of enzyme-linked immunosorbent assay (ELISA) IgG, IgA, and IgM tests, stool antigen test (SAT), and urea breath test (UBT). Results: Of 5677 patients, 3486 (61.4%) were female and 2191 (38.6%) were male with the mean age of 38.82 ± 18.289 years old. The overall rate of H. pylori infection positive was 31.46%, and the serological tests were the most prescribed types of tests. The IgG test and then SAT detected the most positive cases. Further, the infection rate was significantly associated with age. Except for the case of IgM, which was higher in females compared to males, no significant difference was found between gender and bacteria outbreak. Conclusions: This study indicated a decline in H. pylori infection prevalence compared with the prior survey conducted at this center. However, its rate amongst the patients referring to Fardis laboratory is still high.","PeriodicalId":8689,"journal":{"name":"Avicenna Journal of Clinical Microbiology and Infection","volume":"218 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79733411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Short Review of Forensic Microbiology 法医微生物学综述

Avicenna Journal of Clinical Microbiology and Infection Pub Date : 2022-06-29 DOI: 10.34172/ajcmi.2022.14

Fatemeh Yousefsaber, Z. Naseri, Amir Hossein Hasani

{"title":"A Short Review of Forensic Microbiology","authors":"Fatemeh Yousefsaber, Z. Naseri, Amir Hossein Hasani","doi":"10.34172/ajcmi.2022.14","DOIUrl":"https://doi.org/10.34172/ajcmi.2022.14","url":null,"abstract":"Background: Microbial forensics is a multidisciplinary area, which has been recently considered an effective tool in forensic investigations. This growing field of forensics covers a wide spectrum of different branches of science, including biology, chemistry, physics, geology, mathematics, and computer sciences, leading to a practical approach that can be applied in several areas such as bioterrorist actions, environmental issues, emerging and reemerging diseases, as well as reliable trace evidence at a crime scene. Methods: The information has been gathered via Google Scholar using several keywords, including forensic microbiology, bioterrorism, forensic investigation, and trace evidence. The data were from reliable articles and books published over 50 years. This paper is a short review of forensic microbiology with a bioinformatics perspective to use in different fields such as the court. Results: It is known that using either microorganisms or their toxins is a low-cost potential tool with serious morbidity and mortality rates that can spread all around the world by food or water supplies or even through the air, making them a perfect candidate bioweapon with minimum traceability. Studies have indicated that environmental conditions plus biological and abiotic factors would affect the following analysis and the final validation, which is an essential step in the forensic investigation due to its highly effective role in the court vote. To face different challenges, law enforcement has the infrastructure for attribution and deterrence (e.g., following the exact microbial forensics program) so that it can be used in court. Developing more reproducible, sensitive, and accurate methods, preparing a wide reliable database, and devoting the right amount of budget will help improve the whole forensic procedure in the legal system. Conclusions: The current paper is a short review of how forensic scientists can use microbial features on a crime scene to clarify and enhance the procedure to solve different criminal cases.","PeriodicalId":8689,"journal":{"name":"Avicenna Journal of Clinical Microbiology and Infection","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82285624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Relationship Between Positive Cultures With Multidrug-Resistant Microorganisms and Mortality in a General Intensive Care Unit 多药耐药微生物阳性培养与普通重症监护病房死亡率的关系

Avicenna Journal of Clinical Microbiology and Infection Pub Date : 2022-06-29 DOI: 10.34172/ajcmi.2022.11

Bahareh Marghoob, Malihe Khosravi-Khezri

{"title":"The Relationship Between Positive Cultures With Multidrug-Resistant Microorganisms and Mortality in a General Intensive Care Unit","authors":"Bahareh Marghoob, Malihe Khosravi-Khezri","doi":"10.34172/ajcmi.2022.11","DOIUrl":"https://doi.org/10.34172/ajcmi.2022.11","url":null,"abstract":"Aim: The patients in the intensive care unit (ICU) are more susceptible to healthcare-associated infections (HAI). Higher rates of nosocomial infections in ICU patients are associated with higher morbidity, mortality, and costs. The primary outcome of our study was to investigate the relationship between antibiotic resistance and mortality in ICU patients, and the secondary outcome was to evaluate the relationship between antibiotic resistance and the length of ICU or hospital stay. Methods: A 5-year observational retrospective study was conducted on patients in the ICU of Hasheminejad Kidney Center affiliated with Iran University of Medical Sciences, Tehran, Iran from January 1, 2015, to January 1, 2020. The data related to age, gender, admission type, comorbidities, length of ICU stay, length of hospital stay, infection source, microorganism type, and resistance pattern of all isolates and outcomes were collected based on the study purpose. Results: During the 5-year study, 2899 patients were admitted to the ICU, but only 747 patients were enrolled in the study, including 426 males (57%). The median age was 65 years (19-97 years). The mean length of ICU stay was greater in culture-positive patients (8.42 vs. 3.5 days, P>0.001). Culture-positive patients had significantly higher mortality compared to culture-negative patients (63.8% vs. 36.2%, P>0.001). In our study, it was found that resistant microorganisms have increased mortality by 2.6 times in the ICU in the crude model (OR: 2.6, P>0.001). Conclusion: The findings of our study suggest that multidrug-resistant pathogens increase ICU stay and mortality.","PeriodicalId":8689,"journal":{"name":"Avicenna Journal of Clinical Microbiology and Infection","volume":"126 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80443398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Prevalence of Nosocomial Infections and Related Microbial Agents Based on the NNIS System in Sabzevar During 2011-2015 基于NNIS系统的2011-2015年Sabzevar地区医院感染流行及相关微生物因子分析

Avicenna Journal of Clinical Microbiology and Infection Pub Date : 2022-06-29 DOI: 10.34172/ajcmi.2022.10

Zahra Souizi, M. Nematshahi, M. Sahebkar, Zahra Jafarabadi, Masoud Hiteh, R. Akrami

{"title":"The Prevalence of Nosocomial Infections and Related Microbial Agents Based on the NNIS System in Sabzevar During 2011-2015","authors":"Zahra Souizi, M. Nematshahi, M. Sahebkar, Zahra Jafarabadi, Masoud Hiteh, R. Akrami","doi":"10.34172/ajcmi.2022.10","DOIUrl":"https://doi.org/10.34172/ajcmi.2022.10","url":null,"abstract":"Background: Nosocomial infection is an infection that hospitalized patients get while receiving health care. This study aimed to determine the prevalence and factors involved in the incidence of nosocomial infections, related microbial agents, and antibiotic resistance profiles. Methods: This cross-sectional study was conducted on 390 patients with nosocomial infection admitted to Shahid Beheshti Hospital in Sabzevar from 2011 to 2015. The acquired data were assessed by the standard checklist of the National Nosocomial Infections Surveillance (NNIS) system of the Ministry of Health. The collected data were analyzed using the Stata 12 software. Results: Of the 41979 admitted patients during the mentioned period, 390 patients with an average age of 48.08 years suffered from a hospital-acquired infection. The prevalence of nosocomial infections was 1% with the highest rate related to the respiratory tract in men and surgical sites in women. Intravenous catheters, surgical wounds, urinary catheters, suction, ventilator, tracheotomy, and tracheostomy were the most commonly encountered factors (invasive measures) of nosocomial infection, respectively. The most prevalent causes of nosocomial infections were Klebsiella, Staphylococcus aureus, and Acinetobacter. Conclusions: Based on our findings, several factors play a pivotal role in preventing hospital-associated infections, including proper follow-up and timely reporting of nosocomial infection cases. The other influential factors were accurate identification of microorganisms involved, allocation of sufficient funds to provide appropriate facilities for infection prevention, the appropriate and timely medical interventions, and the rational use of antibiotics.","PeriodicalId":8689,"journal":{"name":"Avicenna Journal of Clinical Microbiology and Infection","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74479909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0