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Autoimmune and Infectious Diseases: Open Access最新文献

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Comparison of the Efficacy of 3 Anti-Viral Regimens Containing Kaletra, Ribavirin and Sofosbuvir in COVID 19 Disease 卡雷特拉、利巴韦林和索非布韦3种抗病毒方案治疗COVID - 19的疗效比较
Autoimmune and Infectious Diseases: Open Access Pub Date : 2020-01-01 DOI: 10.16966/2470-1025.129
Davoudi A, Najafi N, Sphandyari E, Kasgari Ha, Tayebi A, Akbari A, Tabarestani M, Beyzaee Am
{"title":"Comparison of the Efficacy of 3 Anti-Viral Regimens Containing Kaletra, Ribavirin and Sofosbuvir in COVID 19 Disease","authors":"Davoudi A, Najafi N, Sphandyari E, Kasgari Ha, Tayebi A, Akbari A, Tabarestani M, Beyzaee Am","doi":"10.16966/2470-1025.129","DOIUrl":"https://doi.org/10.16966/2470-1025.129","url":null,"abstract":"Background: New therapeutic options are urgently needed to handle the ongoing pandemic of coronavirus disease 2019 (COVID-19). As some antiviral therapeutic regimens are assumed to be helpful, we decided to compare the efficacy of kaletra, kaletra plus ribavirin, and kaletra plus ribavirin plus sofosbuvir, as three different therapeutic regimens in covid 19 patients.","PeriodicalId":8657,"journal":{"name":"Autoimmune and Infectious Diseases: Open Access","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86268544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High Prevalence of Altered Immunological Biomarkers in a Transgender Population 变性人群免疫生物标志物改变的高发率
Autoimmune and Infectious Diseases: Open Access Pub Date : 2020-01-01 DOI: 10.16966/2470-1025.125
Ramos Sg, Ingenito F, Mormandi Ea, Nagelberg Aj, Otero Pm, Lessa Cf, Carballo Og
{"title":"High Prevalence of Altered Immunological Biomarkers in a Transgender Population","authors":"Ramos Sg, Ingenito F, Mormandi Ea, Nagelberg Aj, Otero Pm, Lessa Cf, Carballo Og","doi":"10.16966/2470-1025.125","DOIUrl":"https://doi.org/10.16966/2470-1025.125","url":null,"abstract":"Prevalence of in a Transgender","PeriodicalId":8657,"journal":{"name":"Autoimmune and Infectious Diseases: Open Access","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88822738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Mycobacterium tuberculosis/Cryptococcus neoformans Co-Infection in an Immunocompetent Non-HIV Patient 免疫功能正常的非hiv患者结核分枝杆菌/新型隐球菌合并感染
Autoimmune and Infectious Diseases: Open Access Pub Date : 2020-01-01 DOI: 10.16966/2470-1025.127
Albahrani S, Al Hassan D, Vapra Y, Alsubaiae S, Shilash A
{"title":"Mycobacterium tuberculosis/Cryptococcus neoformans Co-Infection in an Immunocompetent Non-HIV Patient","authors":"Albahrani S, Al Hassan D, Vapra Y, Alsubaiae S, Shilash A","doi":"10.16966/2470-1025.127","DOIUrl":"https://doi.org/10.16966/2470-1025.127","url":null,"abstract":"Background: Tuberculosis and cryptococcosis co-infection usually occurs in immunocompromised patients with impaired cell-mediated immunity. Here, we report a case of disseminated tuberculosis with co-existing pulmonary cryptococcosis in a non-HIV patient. However, there is a history of preceding exposure to anti-tumor necrosis agents.","PeriodicalId":8657,"journal":{"name":"Autoimmune and Infectious Diseases: Open Access","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90158980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Polymorphisms of TLR4 and MICA are Associated with Severity of Trachoma Disease in Tanzania. TLR4和MICA基因多态性与坦桑尼亚沙眼病的严重程度相关
Autoimmune and Infectious Diseases: Open Access Pub Date : 2016-06-01 Epub Date: 2016-06-03 DOI: 10.16966/2470-1025.116
Muneer Abbas, Noureddine Berka, Mozna Khraiwesh, Ali Ramadan, Victor Apprey, Paulette Furbert-Harris, Thomas Quinn, Hassan Brim, Georgia Dunston
{"title":"Genetic Polymorphisms of TLR4 and MICA are Associated with Severity of Trachoma Disease in Tanzania.","authors":"Muneer Abbas,&nbsp;Noureddine Berka,&nbsp;Mozna Khraiwesh,&nbsp;Ali Ramadan,&nbsp;Victor Apprey,&nbsp;Paulette Furbert-Harris,&nbsp;Thomas Quinn,&nbsp;Hassan Brim,&nbsp;Georgia Dunston","doi":"10.16966/2470-1025.116","DOIUrl":"https://doi.org/10.16966/2470-1025.116","url":null,"abstract":"<p><strong>Aim: </strong>To examine the association of TLR4 Asp299Gly and MICA exon 5 microsatellites polymorphisms with severity of trachoma in a sub-Saharan East Africa population of Tanzanian villagers.</p><p><strong>Methods: </strong>The samples were genotyped for MICA exon 5 microsatellites and the TLR4 299 A/G polymorphism by Restriction Fragment Length Polymorphism (RFLP), and GeneScan<sup>®</sup>, respectively. The association of TLR4 Asp299Gly and MICA exon 5 microsatellites with inflammatory trachoma (TI) and trichiasis (TI) were examined.</p><p><strong>Results: </strong>The results showed an association between TLR4 and MICA polymorphisms and trachoma disease severity, as well as with protection. TLR4 an allele was significantly associated with inflammatory trachoma (p=0.0410), while the G allele (p=0.0410) was associated with protection.</p><p><strong>Conclusion: </strong>TLR4 and MICA may modulate the risk of severity to trachoma disease by modulating the immune response to <i>Ct.</i> In addition; the increased frequency of MICA-A9 heterozygote in controls may suggest a positive selection of these alleles in adaptation to environments where <i>Ct</i> is endemic.</p>","PeriodicalId":8657,"journal":{"name":"Autoimmune and Infectious Diseases: Open Access","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34692692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Stem Cell-Derived Regulatory T Cells for Therapeutic Use in Arthritis 干细胞衍生调节性T细胞用于关节炎的治疗
Autoimmune and Infectious Diseases: Open Access Pub Date : 2016-06-01 DOI: 10.16966/2470-1025.119
Jianxun Song
{"title":"Stem Cell-Derived Regulatory T Cells for Therapeutic Use in Arthritis","authors":"Jianxun Song","doi":"10.16966/2470-1025.119","DOIUrl":"https://doi.org/10.16966/2470-1025.119","url":null,"abstract":"Pluripotent stem cells (PSCs) can be utilized to obtain a renewable source of healthy regulatory T cells (Tregs) to treat autoimmune arthritis as they have the ability to produce almost all cell types in the body, including Tregs. However, the right conditions for the development of antigen (Ag)-specific Tregs from PSCs (i.e., PSC-Tregs) remain unknown. An ongoing project will determine the mechanisms underlying the Ag-specific PSC-Treg treatments that aim to modulate tolerance in autoimmune arthritis. The knowledge gained from these studies will provide new insights into cell-based therapies in autoimmune arthritis, and advance the understanding of fundamental mechanisms underlying Treg differentiation.","PeriodicalId":8657,"journal":{"name":"Autoimmune and Infectious Diseases: Open Access","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81950336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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