Auto-Immunity Highlights最新文献

{"title":"Infections as a cause of autoimmune rheumatic diseases","authors":"L. Sakkas, D. Bogdanos","doi":"10.1007/s13317-016-0086-x","DOIUrl":"https://doi.org/10.1007/s13317-016-0086-x","url":null,"abstract":"","PeriodicalId":8655,"journal":{"name":"Auto-Immunity Highlights","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86985332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relative merits of therapies being developed to tackle inappropriate (‘self’-directed) complement activation","authors":"S. Antwi-Baffour, R. Kyeremeh, J. Adjei, Claudia Aryeh, G. Kpentey","doi":"10.1007/s13317-016-0078-x","DOIUrl":"https://doi.org/10.1007/s13317-016-0078-x","url":null,"abstract":"","PeriodicalId":8655,"journal":{"name":"Auto-Immunity Highlights","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90088809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nailfold videocapillaroscopy and serum VEGF levels in scleroderma are associated with internal organ involvement","authors":"M. De Santis, A. Ceribelli, F. Cavaciocchi, C. Crotti, M. Massarotti, L. Belloli, B. Marasini, N. Isailovic, E. Generali, C. Selmi","doi":"10.1007/s13317-016-0077-y","DOIUrl":"https://doi.org/10.1007/s13317-016-0077-y","url":null,"abstract":"","PeriodicalId":8655,"journal":{"name":"Auto-Immunity Highlights","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86705952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behçet’s disease physiopathology: a contemporary review","authors":"Mohamad J. Zeidan, D. Saadoun, M. Garrido, D. Klatzmann, A. Six, P. Cacoub","doi":"10.1007/s13317-016-0074-1","DOIUrl":"https://doi.org/10.1007/s13317-016-0074-1","url":null,"abstract":"","PeriodicalId":8655,"journal":{"name":"Auto-Immunity Highlights","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13317-016-0074-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53176885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease prevalence in a rural Andean population of central Peru: a focus on autoimmune and allergic diseases","authors":"G. Caturegli, P. Caturegli","doi":"10.1007/s13317-016-0076-z","DOIUrl":"https://doi.org/10.1007/s13317-016-0076-z","url":null,"abstract":"","PeriodicalId":8655,"journal":{"name":"Auto-Immunity Highlights","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13317-016-0076-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53177000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International consensus on ANA patterns (ICAP): the bumpy road towards a consensus on reporting ANA results","authors":"J. Damoiseaux, C. V. von Mühlen, I. García-De La Torre, O. G. Carballo, W. de Melo Cruvinel, Paulo Luiz Carvalho Francescantônio, M. Fritzler, Manfred Herold, T. Mimori, M. Satoh, L. Andrade, E. Chan, K. Conrad","doi":"10.1007/s13317-016-0075-0","DOIUrl":"https://doi.org/10.1007/s13317-016-0075-0","url":null,"abstract":"","PeriodicalId":8655,"journal":{"name":"Auto-Immunity Highlights","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13317-016-0075-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53176935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous detection of celiac disease-specific IgA antibodies and total IgA","authors":"K. Grossmann, N. Röber, R. Hiemann, S. Rödiger, P. Schierack, D. Reinhold, M. Laaß, K. Conrad, D. Roggenbuck","doi":"10.1007/s13317-016-0073-2","DOIUrl":"https://doi.org/10.1007/s13317-016-0073-2","url":null,"abstract":"","PeriodicalId":8655,"journal":{"name":"Auto-Immunity Highlights","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13317-016-0073-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53176831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of the upper reference limit for thyroid peroxidase autoantibodies according to the guidelines proposed by the National Academy of Clinical Biochemistry: comparison of five different automated methods.","authors":"Federica D'Aurizio,&nbsp;Paolo Metus,&nbsp;Annalisa Polizzi Anselmo,&nbsp;Danilo Villalta,&nbsp;Anna Ferrari,&nbsp;Roberto Castello,&nbsp;Graziella Giani,&nbsp;Elio Tonutti,&nbsp;Nicola Bizzaro,&nbsp;Renato Tozzoli","doi":"10.1007/s13317-015-0070-x","DOIUrl":"https://doi.org/10.1007/s13317-015-0070-x","url":null,"abstract":"<p><strong>Aim of the study: </strong>The estimation of the upper reference limit (URL) for autoantibodies against thyroid peroxidase (TPOAbs) is a controversial issue, because of an uncertainty associated with the criteria used to correctly define the reference population. In addition, the URL of TPOAbs is method-dependent and often arbitrarily established in current laboratory practice. The aim of this study was to determine the reference limits of TPOAbs in a male sample according to the National Academy of Clinical Biochemistry (NACB) guidelines, and to compare them with those obtained in a female group, for five third-generation commercial-automated immunoassay (IMA) platforms.</p><p><strong>Methods: </strong>120 healthy males and 120 healthy females with NACB-required characteristics (younger than 30 years, TSH between 0.5 and 2.0 mIU/L, normal thyroid ultrasound, absence of thyroid disease and absence of other autoimmune diseases) were studied. Sera were analyzed for TPOAbs concentration using five IMA methods applied in automated analyzers: Immulite 2000 XPi (IMM); Maglumi 2000 Plus (MAG); Kryptor Compact Plus (KRY); Phadia 250 (PHA) and Liaison XL (LIA).</p><p><strong>Results: </strong>A statistically significant difference (p < 0.05) between medians in male and female groups was observed for PHA (2.6 and 3.1 IU/mL, respectively) but not for the other four methods. Scatter plots of TPOAbs values revealed a wide dispersion with very different coefficients of variation between the five methods, varying from 48.6 % for KRY in females to 126.3 % for MAG in females. The URLs differed in males and females according to the method: 28.7 and 29.0 IU/mL for IMM, 24.6 and 25.4 IU/mL for MAG, 6.4 and 6.9 IU/mL for KRY, 8.3 and 10.0 IU/mL for PHA and 14.2 and 17.9 IU/mL for LIA, respectively. Such URLs were lower than those stated by the manufacturers except for LIA in females. The difference between URLs ranged from a minimum of 11.3 % (LIA in males) to a maximum of 66.8 % (PHA in males).</p><p><strong>Conclusions: </strong>Differences in URLs could result from the different coating preparations of the TPO antigen (purified native or recombinant) on solid phase, which affect the proper exposure of the immunodominant epitopes recognized by the polyclonal antibodies present in serum of patients with autoimmune thyroid disease (AITD). Based on these findings, we suggest to overcome the proposal of the NACB guidelines which recommend to involve a single group of young male subjects, and propose, instead, to utilize two distinct groups: one of males and one of females. This new proposal removes the apparent contrast of an all-male reference group for a disease (such as AITD) that affects mainly females. However, in spite of the harmonization among methods provided by the use of an international standard preparation, the wide dispersion of quantitative results still observed in this study suggests the need for further efforts to better understand the caus","PeriodicalId":8655,"journal":{"name":"Auto-Immunity Highlights","volume":"6 3","pages":"31-7"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13317-015-0070-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34093200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Typical evanescent and atypical persistent polymorphic cutaneous rash in an adult Brazilian with Still's disease: a case report and review of the literature.","authors":"Despina Michailidou, Junghee Shin, Inga Forde, Kavitha Gopalratnam, Paul Cohen, Angela DeGirolamo","doi":"10.1007/s13317-015-0071-9","DOIUrl":"10.1007/s13317-015-0071-9","url":null,"abstract":"<p><p>Adult onset Still's disease (AOSD) is a systemic auto-inflammatory condition of unknown etiology, characterized by high fever, an evanescent, salmon-pink maculopapular skin rash, arthralgia or arthritis and leukocytosis. AOSD can also present with atypical cutaneous manifestations, such as persistent pruritic coalescent papules or plaques and linear lesions that have highly distinctive pathological features and are usually associated with severe disease. Herein, we present a 31-year-old Brazilian man with both typical Still's rash and atypical persistent polymorphic cutaneous manifestations associated with severe systemic inflammatory response syndrome. Eosinophils that are consistently lacking in the AOSD-associated skin lesions were evident in the skin biopsy of the persistent atypical cutaneous manifestations and were either drug-related or AOSD-associated. </p>","PeriodicalId":8655,"journal":{"name":"Auto-Immunity Highlights","volume":"6 3","pages":"39-46"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34118504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-zinc transporter protein 8 autoantibodies significantly improve the diagnostic approach to type 1 diabetes: an Italian multicentre study on paediatric patients.","authors":"Martina Fabris,&nbsp;Silvia Zago,&nbsp;Marco Liguori,&nbsp;Maria Teresa Trevisan,&nbsp;Manuela Zanatta,&nbsp;Alberto Comici,&nbsp;Giorgio Zanette,&nbsp;Eva Carlin,&nbsp;Francesco Curcio,&nbsp;Elio Tonutti","doi":"10.1007/s13317-015-0068-4","DOIUrl":"https://doi.org/10.1007/s13317-015-0068-4","url":null,"abstract":"<p><strong>Background and aim: </strong>Anti-ZnT8 antibodies (ZnT8A) were recently proposed as a new independent serological marker in Type 1 diabetes (T1D), leading to a significant improvement of the positive predictive value of autoantibody measurement in this setting. The aim of this retrospective multicentre study was to investigate ZnT8A as a complement to the current T1D autoantibody assays in a large cohort of paediatric Italian patients.</p><p><strong>Methods: </strong>ZnT8A were assessed by ELISA in 213 T1DM paediatric patients referred to six different centres in North-East Italy. Fifty-four were analysed at disease onset, 79 within 4 years from diagnosis and 80 after 5 or more years from diagnosis. Retrospective data about islet cell autoantibodies (ICA), anti-insulin (IAA), anti-glutamate decarboxylase (GADA) and anti-protein tyrosine phosphatase IA-2 (IA-2A) antibodies were collected and compared.</p><p><strong>Results: </strong>Overall, ZnT8A showed positive results in 106/213 (49.8 %) T1D patients and were found in 10 (4.7 %) subjects previously classified as autoantibody negative based on the existing markers (GADA, IA-2A, IAA and ICA), increasing the overall diagnostic sensitivity from 85.9 to 90.6 %. ZnT8A disclosed the same sensitivity (61.1 %) at disease onset as GADA (61.1 %) and higher than IA-2A (53.7 %), with only GADA showing much persistence in the long-term follow-up. Focusing on patients at disease onset, all the ICA positive were associated with at least one positive autoantibody among GADA, IA-2A and ZnT8A, 16.7 % of whom presenting only anti-ZnT8-positive antibodies.</p><p><strong>Conclusion: </strong>This study confirms ZnT8A as an important additional and independent diagnostic marker of T1D and supports its introduction in the routine diagnostic process to replace less sensitive methods and improve the overall autoantibody sensitivity.</p>","PeriodicalId":8655,"journal":{"name":"Auto-Immunity Highlights","volume":"6 1-2","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13317-015-0068-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34024447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}