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All-fiber real-time ultrafast ranging Lidar for motion management of patients during stereotactic radiotherapy 全光纤实时超快测距激光雷达用于立体定向放射治疗患者的运动管理
Bios Pub Date : 2023-03-17 DOI: 10.1117/12.2650276
B. Boroomandisorkhabi, M. Esmaeelpour
{"title":"All-fiber real-time ultrafast ranging Lidar for motion management of patients during stereotactic radiotherapy","authors":"B. Boroomandisorkhabi, M. Esmaeelpour","doi":"10.1117/12.2650276","DOIUrl":"https://doi.org/10.1117/12.2650276","url":null,"abstract":"We report a fiber-optic-based ultrafast time-stretch laser detection and ranging (Lidar) sensor with 10 MHz speed and 10 μm accuracy with 30 mm dynamic range for head motion detection under the thermoplastic mask during image-guided radiotherapy procedures. The sensor (1) is miniaturized and fits under the mask, (2) is small enough not to cause attenuation in radiation beams, (3) has a spatial resolution of a tenth of a millimeter, (4) is real-time, and (5) is immune to electromagnetic radiation.","PeriodicalId":86381,"journal":{"name":"Bios","volume":"12393 1","pages":"1239304 - 1239304-8"},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48775726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensing the penetration of nanodiamond along different skin layers according to their optical properties 根据纳米金刚石的光学特性，检测其在不同皮肤层上的穿透性
Bios Pub Date : 2023-03-17 DOI: 10.1117/12.2649927
Channa Shapira, Ariel Foraiter, Israel Messenberg, H. Duadi, D. Fixler
{"title":"Sensing the penetration of nanodiamond along different skin layers according to their optical properties","authors":"Channa Shapira, Ariel Foraiter, Israel Messenberg, H. Duadi, D. Fixler","doi":"10.1117/12.2649927","DOIUrl":"https://doi.org/10.1117/12.2649927","url":null,"abstract":"Imaging in opaque media is limited in spatial resolution. Therefore, detection of nanoelements that are behind the imaging resolution limit is challenging. In this work, we used the iterative multiplane optical properties extraction (IMOPE) technique to detect nanoparticles (NP) within the different skin layers. The IMOPE technique was originally designed for detecting NPs in turbid environment based on their scattering property. However, the scattering depends on the size of the particle, therefore detecting extremely small particles, with negligible scattering, was still a challenge for the IMOPE technique. In our work, we adapted the IMOPE technique to detect nanodiamonds (ND) as such, with negligible scattering but nonnegligible absorption, inside the different layers of the skin. In the following manuscript we present an extension of the automated technique, that is more robust and applicable to non-symmetrical samples.","PeriodicalId":86381,"journal":{"name":"Bios","volume":"12394 1","pages":"1239404 - 1239404-6"},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44083109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimising cross-reactive plasmonic arrays for biosensing applications 优化交叉反应等离子体阵列用于生物传感应用
Bios Pub Date : 2023-03-17 DOI: 10.1117/12.2649244
I. Christie, W. Peveler, A. Clark
{"title":"Optimising cross-reactive plasmonic arrays for biosensing applications","authors":"I. Christie, W. Peveler, A. Clark","doi":"10.1117/12.2649244","DOIUrl":"https://doi.org/10.1117/12.2649244","url":null,"abstract":"Extraordinary optical transmission (EOT) in nanohole arrays has proven to be a useful tool for biosensing applications. The enhanced light transmission observed in these structures is due to interactions between propagating surface waves and localised resonances. In this paper we present methods to both optimise the resonance peaks of nanohole array sensors and to tune their resonance wavelength. Sensor performance is enhanced by annealing. Annealing significantly increases the grain size of the gold thin-film, reducing losses and narrowing the resonance width. In addition, we show that by changing the size and arrangement of nanoholes we can control the position of their resonance peak. In doing so, we seek to improve the performance of EOT sensors for cross-reactive sensing applications.","PeriodicalId":86381,"journal":{"name":"Bios","volume":"12396 1","pages":"1239608 - 1239608-6"},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49510313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surface plasmon enhanced upconversion luminescence for biosensing applications 用于生物传感应用的表面等离子体增强上转换发光
Bios Pub Date : 2023-03-17 DOI: 10.1117/12.2647339
Duc H. Le, Marjut Kreivi, S. Aikio, Jarno Petäjä, S. Uusitalo, Tianlong Guo, M. Roussey, J. Hiltunen
{"title":"Surface plasmon enhanced upconversion luminescence for biosensing applications","authors":"Duc H. Le, Marjut Kreivi, S. Aikio, Jarno Petäjä, S. Uusitalo, Tianlong Guo, M. Roussey, J. Hiltunen","doi":"10.1117/12.2647339","DOIUrl":"https://doi.org/10.1117/12.2647339","url":null,"abstract":"Upconversion (UC) luminescence sensing is a technique to improve the detection limit of conventional fluorescence in biosensing that is commonly limited by the autofluorescence-generated background signal. The main limitation of UC materials is their low wavelength conversion efficiency. Many studies have been made to enhance the efficiency of UC materials by optimizing light absorption and energy transfer processes. However, rather low efficiency remains an issue limiting the practical usage of UC materials in biosensors. Plasmon enhancement is a way to improve UC photoluminescence by enhancing the excitation and emission rates. In this study, we modeled and fabricated gold gratings for exciting surface plasmon polaritons (SPPs) at 976-nm wavelength. We aim at increasing the local optical intensity at the locations of UC nanoparticles on a nano-structured plasmonic surface. The UC nanoparticles were adsorbed on the gratings via biomolecule conjugation. UC photoluminescence on the gratings was compared with flat gold surfaces. Experimentally, we achieved UC enhancement up to 70, which is relatively high in comparison with other plasmon-enhanced UC techniques presented in the literature. The results of our work can be applied in various biosensing applications in which low excitation intensity is preferred.","PeriodicalId":86381,"journal":{"name":"Bios","volume":"12396 1","pages":"1239604 - 1239604-7"},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45053810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wavelengths encoded illumination for resolution enhancement and imaging beyond scattering medium 用于分辨率增强和超越散射介质成像的波长编码照明
Bios Pub Date : 2023-03-17 DOI: 10.1117/12.2649518
Omer Wagner, Asaf Shahmoon, Z. Zalevsky
{"title":"Wavelengths encoded illumination for resolution enhancement and imaging beyond scattering medium","authors":"Omer Wagner, Asaf Shahmoon, Z. Zalevsky","doi":"10.1117/12.2649518","DOIUrl":"https://doi.org/10.1117/12.2649518","url":null,"abstract":"In this paper a wavelength-multiplexing based super-resolving concept is presented to allow high resolution imaging through blood. We use temporally pulsed and spectrally wide-band laser while at its output we have special grating and a spatial 2-D transmission mask allowing to project wavelengths’ dependent high-resolution spatial orthogonal encoding patterns (different spatial patterns for each wavelength). The ballistic photons of the short temporal pulses allow the high-resolution encoding pattern to reach the inspected object through the scattering blood medium without being spatially blurred. The light is intentionally collected via low resolution optics. The high-resolution reconstruction can be obtained digitally by post processing or optically by passing the collected low-resolution data through a similar grating and 2-D mask which do an all-optical decoding. After summing all the images together, the super-resolved reconstruction through the highly scattering blood medium is formed.","PeriodicalId":86381,"journal":{"name":"Bios","volume":"208 1","pages":"1239402 - 1239402-9"},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74587938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The bright future of fluorescence lifetime analysis 荧光寿命分析的光明前景
Bios Pub Date : 2023-03-17 DOI: 10.1117/12.2655694
A. Rossetta
{"title":"The bright future of fluorescence lifetime analysis","authors":"A. Rossetta","doi":"10.1117/12.2655694","DOIUrl":"https://doi.org/10.1117/12.2655694","url":null,"abstract":"Fluorescence lifetime-based technology has experienced a rapid growth during the last decade, becoming a unique tool for performing real-time, non-invasive analysis in a large variety of scientific fields, from life-sciences to medical surgery and agrifood. Its potential has aroused the interest of industry and a technological shift in the detection and estimation of fluorescence lifetime is around the corner. Nevertheless, devices capable of implementing state-of-the-art fluorescence lifetime analysis that are compact, customizable and affordable, are still incredibly hard to find on the market. We aim at supporting this existing technological shift by developing instruments that are portable and extremely easy to use, either for beginners or experienced users. Our mission is rooted in the intention of democratizing the use of fluorescence lifetime in both scientific and industrial environments, by creating cutting-edge, AI-driven instruments, with a focus on simplicity and modularity. The idea is to be part of a new, emerging scientific force that has as its leading concept the widespread use of fluorescence lifetime analysis, either as a standing-alone technique or combined with pre-existing setups and instruments. Our instruments will provide a larger number of researchers with access to a technology that is reliable and simple to implement.","PeriodicalId":86381,"journal":{"name":"Bios","volume":"12398 1","pages":"1239805 - 1239805-4"},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44518305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Bioimaging, pH sensing, and fluorescence lifetime imaging microscopy using polyethyleneimine coated carbon dots and gold nanoparticles 使用聚乙烯亚胺涂层碳点和金纳米颗粒的生物成像、pH传感和荧光寿命成像显微镜
Bios Pub Date : 2023-03-17 DOI: 10.1117/12.2648414
Shweta Pawar, H. Duadi, D. Fixler
{"title":"Bioimaging, pH sensing, and fluorescence lifetime imaging microscopy using polyethyleneimine coated carbon dots and gold nanoparticles","authors":"Shweta Pawar, H. Duadi, D. Fixler","doi":"10.1117/12.2648414","DOIUrl":"https://doi.org/10.1117/12.2648414","url":null,"abstract":"The unique fluorescent nanomaterials known as carbon dots (CDs) are highly resistant to photobleaching, have low toxicity, and are well soluble in water. Polyethyleneimine (PEI) coated CDs are a novel fluorophore with good biocompatibility and pH sensing ability. Here, p-phenylenediamine (p-PD) is used as a carbon source and hyperbranched PEI is used as a surface passivation agent in a simple, one-step hydrothermal synthesis process. The CDs optical characteristics are pH-responsive due to the presence of different amine groups on PEI, which is functional polycationic polymer. The limits of techniques based on fluorescence intensity can be overcome by fluorescent lifetime imaging microscopy (FLIM), a very sensitive method for detecting a microenvironment. In this study, FLIM was used to measure pH with pH-sensitive CDs. These molecules are nontoxic to the cells, and the positively charged CDs have the potential for nuclear targeting, allowing for electrostatic contact with DNA in the nucleus. Higher wavelengths have a larger penetration depth of electromagnetic radiation and low tissue autofluorescence, hence CDs emitting at these wavelengths are used for biolabeling applications. However, the quantum yield of these synthesized red-emissive CDs is lower. In order to enhance it, they are conjugated with gold nanoparticles(AuNPs) for metal enhanced fluorescence (MEF). Through a potent covalent bond between them, the AuNPs are linked to CDs surfaces. These gold-CDs nanoconjugate can be used in the future for targeted imaging applications.","PeriodicalId":86381,"journal":{"name":"Bios","volume":"12394 1","pages":"1239408 - 1239408-6"},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49424911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pilot investigations on solids, liquids and gases using a portable shifted excitation Raman difference spectroscopy sensor system 使用便携式位移激发拉曼差分光谱传感器系统对固体、液体和气体进行试验研究
Bios Pub Date : 2023-03-17 DOI: 10.1117/12.2649696
M. Maiwald, K. Sowoidnich, B. Sumpf
{"title":"Pilot investigations on solids, liquids and gases using a portable shifted excitation Raman difference spectroscopy sensor system","authors":"M. Maiwald, K. Sowoidnich, B. Sumpf","doi":"10.1117/12.2649696","DOIUrl":"https://doi.org/10.1117/12.2649696","url":null,"abstract":"Raman investigations are carried out to evaluate potential real-world application fields using an in-house developed portable shifted excitation Raman difference spectroscopy (SERDS) system at 785 nm. Pilot Raman measurements are performed in the presence of background light, laser-induced fluorescence, within optically turbid media and of weak Raman scatterers i.e., ambient air gases. In the presence of background light and laser-induce fluorescence, SERDS separates Raman signals of soil substances with a 15-fold improvement of the signal-to-background noise. Ingredients of bovine milk as the optically turbid test sample are clearly detected and identified. Ambient air gases are investigated even under daylight conditions. The results show the potential of the portable SERDS sensor systems for real-world applications,","PeriodicalId":86381,"journal":{"name":"Bios","volume":"12396 1","pages":"1239602 - 1239602-8"},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43200505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A simple, pipette-free, and power-free device for virus nucleic acid detection 一种简单、无移液管、无电源的病毒核酸检测装置
Bios Pub Date : 2023-03-17 DOI: 10.1117/12.2653148
Mengdi Bao, Shuhuan Zhang, Chad ten Pas, S. Dollery, Ruth V. Bushnell, .. Yuqing, Rui Liu, Guoyu Lu, G. Tobin, K. Du
{"title":"A simple, pipette-free, and power-free device for virus nucleic acid detection","authors":"Mengdi Bao, Shuhuan Zhang, Chad ten Pas, S. Dollery, Ruth V. Bushnell, .. Yuqing, Rui Liu, Guoyu Lu, G. Tobin, K. Du","doi":"10.1117/12.2653148","DOIUrl":"https://doi.org/10.1117/12.2653148","url":null,"abstract":"A portable, inexpensive, and easy-to-manufacture microfluidic device is developed for the detection of SARS-CoV-2 dsDNA fragments. In this device, four reaction chambers separated by carbon fiber rods are pre-loaded with isothermal amplification and CRISPR-Cas12a reagents. The reaction is carried out by simply pulling the rods, without the need for manual pipetting. To facilitate power-free pathogen detection, the entire detection is designed to be heated with a disposable hand warmer. After the CRISPR reaction, the fluorescence signal generated by positive samples is identified by naked eye, using an inexpensive flashlight. This simple and sensitive device will serve as a new model for the next-generation viral diagnostics in either hospital or resource-limited settings.","PeriodicalId":86381,"journal":{"name":"Bios","volume":"12397 1","pages":"1239705 - 1239705-3"},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49054559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A proposal of spectral magneto-thermo-acoustics imaging of magnetic nanoparticles by using a static bias magnetic field on top of a continuous-wave alternating magnetic field 在连续波交变磁场的基础上，利用静态偏置磁场对磁性纳米颗粒进行磁热声光谱成像
Bios Pub Date : 2023-03-17 DOI: 10.1117/12.2651562
D. Piao
{"title":"A proposal of spectral magneto-thermo-acoustics imaging of magnetic nanoparticles by using a static bias magnetic field on top of a continuous-wave alternating magnetic field","authors":"D. Piao","doi":"10.1117/12.2651562","DOIUrl":"https://doi.org/10.1117/12.2651562","url":null,"abstract":"In 2013 we proposed the magneto-thermo-acoustic effect [Piao et al, Med. Phys. 2013], which refers to acoustic emission from magnetic nanoparticles (MNPs) when thermally mediated under an alternating magnetic field (AMF) applied in a pulsed or frequency-chirped mode. Several independent experimental studies have since validated magneto-thermo-acoustic effect in association with various modes of AMF application including pulsing and chirping of the intensity modulation [Feng et al, Appl Phys. Lett., 2013]. Later Kellnberger et al demonstrated that [Phys Rev Lett. 2016] a continuous-wave (CW) AMF applying to MNPs activated acoustic emission at ONLY the second-harmonic frequency of AMF. We predict that applying a static bias magnetic field to MNPs in the presence of a CW AMF produces acoustic emission at the fundamental frequency of AMF, in addition to the known second harmonic frequency of AMF. The mechanism of this dual-frequency acoustic emission is projected as the partial magnetization of MNPS by the bias field affecting the AMF mediation of MNPs. The coupling between the two magnetic fields in modulating the magnetic susceptibility of MNPs causes acoustic emission at both the fundamental and second harmonic frequencies of AMF. Interestingly, the intensity ratio of the acoustic emission at the two frequencies is determined uniquely by the intensity ratio of the two magnetic fields. This spectral intensity characteristic of the dual-frequency acoustic emission from MNPs can thus be made spatially unique by controlling the bias field over AMF. This potentiates spatial encoding or magnetically scanned imaging of MNPs towards theragnostic applications.","PeriodicalId":86381,"journal":{"name":"Bios","volume":"12394 1","pages":"1239406 - 1239406-7"},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43961083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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