Austin journal of medical oncology最新文献

{"title":"Reduction of Chemotherapy–Induced Side Effects by Complementary Medicine in Breast Cancer Patients","authors":"J. Beuth, R. Böwe","doi":"10.26420/austinjmedoncol.2021.1063","DOIUrl":"https://doi.org/10.26420/austinjmedoncol.2021.1063","url":null,"abstract":"This clinical investigation was performed to evaluate the benefit of Complementary Medicine (CM) in breast cancer patients undergoing adjuvant Chemotherapy (ChT). Patients and Methods: The patients (n=668) were treated according to international guidelines with adjuvant ChT. As to reduce the side effects, the patients were complementarily treated with a combination of sodium selenite, proteolytic plant enzymes (bromelaine and papain) and Lens culinaris lectin. On Case Report Formulas (CRFs) assessment of side effects of ChT was documented at defined times during adjuvant ChT and additional complementary treatment. Validation was carried out by scoring from 1 (no side-effects/optimal tolerability) to 6 (extreme side-effects/extremely bad tolerability), however, only patients suffering from severe side effects (symptom scores 4 and higher) were enrolled into this investigation. Results: The severity of side-effects of ChT was significantly reduced by complementary treatment. Mean scores of symptoms declined for sleep disorder, fatigue, lack of drive (p<0.05) and for arthralgia, hot flushes, mucosal dryness, nausea, vomiting, diarrhea, loss of appetite, pain of tumour (p<0.001). Conclusion: This investigation confirms benefits of indication-based complementary treatment with the combination of sodium selenite, proteolytic enzymes and Lens culinaris lectin in breast cancer patients, e.g. reduction of side-effects of adjuvant ChT.","PeriodicalId":8626,"journal":{"name":"Austin journal of medical oncology","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85494370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ATPase Effects on Pro-Nutrients-mTOR Release Long Fatty Acids Chains which Under Mitochondrial Phospholipase, Synthase, & Synthetase Effects form Three ROR-Alpha, Beta, Gamma Isoforms","authors":"E. Am","doi":"10.26420/austinjmedoncol.2021.1062","DOIUrl":"https://doi.org/10.26420/austinjmedoncol.2021.1062","url":null,"abstract":"RORs isoforms are a metabolic strong regulators have their own functions in the lipid metabolism and in genes, subunits, and hormones reproductions, where during their necessary metabolic activities on lipid metabolism with the effects Mitochondrial enzymes on lipid molecules the acyl-CoA-synthase (RORbeta), acyl-CoA-phospholipase (ROR-alpha), and acyl-CoA-synthetase (RORgama) will be synthesised and released for running the lipid metabolic pathways. Where the RORs isoforms functions are strongly linked to FOX forkhead genes and strongly depending on mitochondrial anabolic active enzymes activities (phospholipase, synthase, synthetase), and are having a strong regulations by mitochondrial OPA1 membrane which act on long fatty acids molecules for releasing the three enzymatic acyl-CoA active molecules for the cholesterol productn, for TNF-a with TXA2 alpha subunits productions, for sestrin-Leu 1 synthesis, for prostaglandins synthesis which reflect the strengthen of ROR-beta with ROR-alpha activities, for S6K1 production, and for estrogen & insulin growth and their ratio biosynthesis. When lipid associated with absorbed nutrient molecules (pro-lipo-mTOR) will be firstly affect by ATPase and by Cox2 for releasing long fatty acids molecules and will be directed to FOX forkhead and to ROR genes, where first the ATPase and COX-2 will act on lipid molecules for releasing long fatty acids molecules then the mitochondrial anabolic enzymes effects will act fatty acids molecules for releasing the acyl-CoA-phospholipase (ROR alpha isoforms), acyl-CoAsynthase (ROR-beta), and acyl-CoA synthetase (ROR-gama isoforms), where all RORs isoforms are having the same molecular structure but differ only in their terminals. The decreasing in mitochondrial synthetase enzyme will reflect inhibition or decreasing in acyl-CoA-synthetase enzymatic molecules (ROR-gama) synthesis which adopted for carbohydrate metabolic cycles and the ratio of pyrimidine in biological molecules, that can reflect decreasing in the pyrimidine synthesis from purines which will lead to decreasing in hormone biosynthesis, and sestrin biosynthesis, and decreasing in RORs isoforms stabilities and activities, which can reflect decreasing in FOX genes stabilities, and decreasing in Thymine kinases molecules activities which consequently lead to inhibition or decreasing in cholesterol biosynthesis, and in estrogen or insulin hormones biosynthesis pathways. Long-fatty acyl-CoAs are produced due to the effects of mitochondrial anabolic enzymes on the long fatty acids molecules which produced from the effects of ATPase and mitochondrial COX-2 on the lipid molecules, which considered as necessary anabolic regulatory and intermediates molecules in lipid metabolic pathways and in the active kinases molecules resynthesis during the binding of Pro-nutrients-mTOR molecules. Following the long fatty acids formation by the effects of ribosomal ATPase is the effect of mitochondrial OPA1 membrane activities for pro","PeriodicalId":8626,"journal":{"name":"Austin journal of medical oncology","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89862307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Program against Cancer in Sri Lanka","authors":"Mbaye Ehs","doi":"10.26420/AUSTINJMEDONCOL.2021.1060","DOIUrl":"https://doi.org/10.26420/AUSTINJMEDONCOL.2021.1060","url":null,"abstract":"Worldwide, one in eight deaths is due to cancer. Projections based on the GLOBOCAN 2012 estimates predict a substantive increase new cancer cases per year by 2035 in developing countries if preventive measures are not widely applied. According to the World Health Organization (WHO), millions of lives could be saved each year if countries made use of existing knowledge and the best cost-effective methods to prevent and treat cancer. Therefore, the aim of this study is to estimate a provisional budget against cancer in low and middle incomes countries, according the GNI-PPP, the cancer incidence and the number of population. Economically country classification is determining with the Gross National Income (GNI), per capita, Purchasing Power Parity (PPP), according the administrations of the International Monetary Fund (IMF), the World Bank (WB) and the Central Intelligence Agency (CIA). Cancer incidence data presented are based on the most recent data available at IARC. However, population compares estimates from the US Bureau of the Census. The provisional budget is establishing among the guidelines developed by WHO for regional and national cancer control programs according to national economic development. Provisional budget against cancer is estimated to 664,650.944 (thousands of U.S $) for a population of 22,409,381 persons in Sri Lanka.","PeriodicalId":8626,"journal":{"name":"Austin journal of medical oncology","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85780830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Seed Localisation for Non-Palpable Breast Lesions: A Comparison with Hooked-Wire","authors":"A. Dehaene, A. Smeets, H. Vos, C. Vanongeval, P. Neven, A. Laenen, L. Schops, R. Prevos, T. Thywissen, M. Keupers, I. Nevelsteen","doi":"10.26420/AUSTINJMEDONCOL.2021.1059","DOIUrl":"https://doi.org/10.26420/AUSTINJMEDONCOL.2021.1059","url":null,"abstract":"Introduction: Screening programs and improved imaging result in higher frequency of non-palpable breast lesions, requiring preoperative localisation. Several localisation methods have been developed, with Magseed® among the more recent techniques. This observational study registered safety, effectiveness and surgeon satisfaction of Magseed® localisation. Data were compared with hooked-wire procedure. Methods: Data regarding safety, effectiveness and surgeon satisfaction of 100 patients who underwent Magseed® localisation were prospectively collected between September 2018 and April 2019, and compared with retrospectively collected data of 91 patients who underwent hooked-wire localisation between March 2018 and September 2018. Results: In total, 103 seeds and 102 wires were included. All magnetic seeds were placed under ultrasound guidance, with a median of two days preoperative. Complication rate did not significantly differ between Magseed® and hooked-wire (2.97% vs. 2.13%; p = 1.000). 94.06% of the seeds were detected with Sentimag®, with a retrieval rate of 100%. Positive margin rate was lower for Magseed®, although not significant (4.76% vs. 10.39%; p = 0.233). Due to positive margins, 1 additional mastectomy was performed, in contrast with 3 mastectomies and 1 additional re-excision in the hooked-wire group. Surgeons scored 81% of the Magseed® procedures as ’easier than hookedwire’. Conclusion: Rate of positive margins and re-excision/mastectomy showed a tendency to be lower with Magseed® localisation compared to hooked-wire localisation. Complication rate was equal. Moreover, high surgeon satisfaction and logistical advantages designate Magseed® as preferable over hooked-wire.","PeriodicalId":8626,"journal":{"name":"Austin journal of medical oncology","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76342403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary EBV-positive Diffuse Large B-cell Lymphoma of Skeletal Muscle from EBV-positive Primary Diffuse Large B-cell Lymphoma of Thyroid Gland: Case Report and Literature Review","authors":"L. C, S. M., J. X","doi":"10.26420/austinjmedoncol.2021.1057","DOIUrl":"https://doi.org/10.26420/austinjmedoncol.2021.1057","url":null,"abstract":"Diffuse Large B-Cell Lymphoma (DLBCL) is the most common lymphoid malignancy in adults, which often takes a nonlymph nodes organ as the primary focus. Primary lymphoid malignancy of thyroid gland is not common in clinic, EBV-positive primary diffuse large B-cell lymphoma of thyroid gland is rare in clinic, and its pathogenesis, treatment and prognosis are rarely studied. We reported an 85-year-old female patient with EBV-positive primary diffuse large B-cell lymphoma of thyroid gland, and the disease eventually relapsed in skeletal muscle of the patient. The pathological type after relapse was consistent with that of the primary focus. As far as we know secondary EBV-positive DLBCL of skeletal muscle from EBV-positive primary DLBCL of thyroid gland. For elderly patients with multiple adverse prognostic factors, individualized treatment on the premise of ensuring their quality of life may be more important.","PeriodicalId":8626,"journal":{"name":"Austin journal of medical oncology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81921997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of a Capacitor-Based Respiratory Position Sensing Device: Implications for Radiation Therapy.","authors":"Weng Y,&nbsp;Westover Mb,&nbsp;Speier C,&nbsp;Sharp G,&nbsp;Bianchi Mt,&nbsp;Westover Kd","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Respiratory motion may significantly affect the outcome in a number of medical imaging techniques and some radiation therapy applications. 4-dimensional computed tomography (4DCT) and respiratory gating technology, which account for the dynamics of respiration, are expensive and often unavailable in smaller radiation treatment centers. Here we evaluate the ability of an inexpensive, technology comprised of two capacitors placed next to the skin to provide real-time respiratory phase information. Three subjects were simultaneously monitored by the new capacitor-based device (CBD) and a commercially available Real time Position Management (RPM) system by Varian. All respiratory phases detected by the RPM system were also detected by the CBD. Automatically detected peaks were not significantly different in timing when comparing RPM and CBD-derived respiratory amplitudes. The anatomic locations of the CBD were varied to evaluate the change in signal quality across the abdomen and thorax. CBD signals were reliable on the abdomen and lower thorax but degraded when recorded from the upper thorax. We also used computed tomography (CT) to assess the imaging characteristics of CBD and found that there were minimal artifacts. We therefore conclude that CBD respiratory amplitude measurements may be useful for tracking respiratory movements as part of a number of advanced radiation therapy technologies including 4DCT image resorting, adaptive radiation therapy and gated radiation therapy.</p>","PeriodicalId":8626,"journal":{"name":"Austin journal of medical oncology","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956860/pdf/nihms-1053779.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37540032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}