Audiology and Neurotology最新文献_第10页

Audiology and Neurotology Pub Date : 2016-11-01 DOI: 10.1159/000448353

Á. Ramos-Macías, J. C. Falcón González, Silvia A Borkoski-Barreiro, Á. Ramos de Miguel, David S. Batista, D. Pérez Plasencia

引用次数: 19

The Epidemiology of Cognitive Impairment in the Aging Population: Implications for Hearing Loss 老龄化人群中认知障碍的流行病学:听力损失的影响

Audiology and Neurotology Pub Date : 2016-11-01 DOI: 10.1159/000448346

A. Peracino, S. Pecorelli

{"title":"The Epidemiology of Cognitive Impairment in the Aging Population: Implications for Hearing Loss","authors":"A. Peracino, S. Pecorelli","doi":"10.1159/000448346","DOIUrl":"https://doi.org/10.1159/000448346","url":null,"abstract":"Cognitive impairment and dementia are characterized by a progressive and devastating reduction in most cognitive abilities, functional independence, and social relationships. Dementia represents a substantial financial burden on society, one that is comparable to the financial burden of heart disease and cancer. Due to its insidious onset, cognitive impairment can be clinically silent for several years; therefore, diagnosis occurs late in the disease process, and treatment becomes almost useless. The identification of predictors of dementia may help identify the pathophysiological mechanisms underlying the disease and lead to the development of a more effective medical diagnosis and therapy, and thus an early treatment. Review of the literature suggests that in those individuals with less cognitive impairment (normal/predementia group), hearing loss has an association with language comprehension, and when cognitive impairment increases (moderate or severe dementia group), the contributing effect of hearing loss as a cognitive ability-impairing factor also increases. Greater understanding of the links between hearing impairment and cognition may have important implications for the screening and diagnosis of cognitive decline in older people with hearing impairment.","PeriodicalId":8624,"journal":{"name":"Audiology and Neurotology","volume":"14 1","pages":"3 - 9"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78449840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Author and Subject Index Vol. 21, Suppl. 1, 2016 作者和主题索引第21卷，增刊1,2016年

Audiology and Neurotology Pub Date : 2016-11-01 DOI: 10.1159/000448829

引用次数: 0

Contributing Determinants to Hearing Loss in Elderly Men and Women: Results from the Population-Based Rotterdam Study 老年男性和女性听力损失的决定因素:基于人群的鹿特丹研究结果

Audiology and Neurotology Pub Date : 2016-11-01 DOI: 10.1159/000448348

Stephanie C. Rigters, M. Metselaar, M. Wieringa, R. J. Baatenburg de Jong, A. Hofman, A. Goedegebure

引用次数: 31

Surgical Strategy and Facial Nerve Outcomes in Petrous Bone Cholesteatoma 岩质骨胆脂瘤的手术策略和面神经预后

Audiology and Neurotology Pub Date : 2016-10-07 DOI: 10.1159/000448584

S. Prasad, G. Piras, E. Piccirillo, A. Taibah, A. Russo, Jingchun He, M. Sanna

{"title":"Surgical Strategy and Facial Nerve Outcomes in Petrous Bone Cholesteatoma","authors":"S. Prasad, G. Piras, E. Piccirillo, A. Taibah, A. Russo, Jingchun He, M. Sanna","doi":"10.1159/000448584","DOIUrl":"https://doi.org/10.1159/000448584","url":null,"abstract":"Objective: To review the classification and management of petrous bone cholesteatomas (PBCs) at our center and the outcomes of facial nerve (FN) management in these lesions. Methods: This was a retrospective study. The setting was a quaternary referral center for skull base pathology in Italy. A total of 200 patients with 201 PBCs were included in the study. All patients diagnosed radiologically with PBCs were classified according to the Sanna classification. All patients were surgically treated and followed up with radiology. The main outcome measures - classification of PBCs, the surgical approach used, disease control, and FN outcomes - were analyzed. Results: Supralabyrinthine PBCs were the most common type with 92 cases (45.8%) followed by the massive PBCs with 72 cases (35.8%). Preservation of preoperative FN function was highest in the infralabyrinthine (72.2%) and infralabyrinthine-apical (73.3%) types. The transotic approach was used in 66 cases (32.8%) in this series. The modified transcochlear approach type A was applied in 55 cases (27.3%). Active management of the nerve (rerouting, anastomosis, or grafting) was required in 53 cases (26.4%). Postoperatively, of the 116 cases with FN House-Brackmann grade I and II, 107 cases (92.2%) retained the same grade or improved. Recurrence was seen in 7 cases (3.5%). The mean duration of follow-up was 6.3 years. Conclusions: Radical disease clearance must take precedence over hearing and FN preservation in PBCs. Active FN management, including rerouting, end-to-end anastomosis, and cable nerve grafting, routinely come to play in the surgical management of PBCs, and the postoperative FN results after such interventions can be satisfactory in most cases.","PeriodicalId":8624,"journal":{"name":"Audiology and Neurotology","volume":"11 1","pages":"275 - 285"},"PeriodicalIF":0.0,"publicationDate":"2016-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75818048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Functional Expression of an Osmosensitive Cation Channel, Transient Receptor Potential Vanilloid 4, in Rat Vestibular Ganglia 渗透敏感阳离子通道瞬时受体电位香草蛋白4在大鼠前庭神经节中的功能表达

Audiology and Neurotology Pub Date : 2016-10-01 DOI: 10.1159/000449238

Takefumi Kamakura, M. Kondo, Y. Koyama, Yukiko Hanada, Y. Ishida, Yukiko Nakamura, Takahiro Yamada, Y. Takimoto, T. Kitahara, Y. Ozono, A. Horii, T. Imai, H. Inohara, S. Shimada

{"title":"Functional Expression of an Osmosensitive Cation Channel, Transient Receptor Potential Vanilloid 4, in Rat Vestibular Ganglia","authors":"Takefumi Kamakura, M. Kondo, Y. Koyama, Yukiko Hanada, Y. Ishida, Yukiko Nakamura, Takahiro Yamada, Y. Takimoto, T. Kitahara, Y. Ozono, A. Horii, T. Imai, H. Inohara, S. Shimada","doi":"10.1159/000449238","DOIUrl":"https://doi.org/10.1159/000449238","url":null,"abstract":"Transient receptor potential vanilloid (TRPV) 4 is a nonselective cation channel expressed in sensory neurons such as those in the dorsal root and trigeminal ganglia, kidney, and inner ear. TRPV4 is activated by mechanical stress, heat, low osmotic pressure, low pH, and phorbol derivatives such as 4α-phorbol 12,13-didecanoate (4α-PDD). We investigated the expression of TRPV4 in rat vestibular ganglion (VG) neurons. The TRPV4 gene was successfully amplified from VG neuron mRNA using reverse-transcription polymerase chain reaction. Furthermore, immunoblotting showed positive expression of TRPV4 protein in VG neurons. Immunohistochemistry indicated that TRPV4 was localized predominantly on the plasma membrane of VG neurons. Calcium (Ca2+) imaging of VG neurons showed that 4α-PDD and/or hypotonic stimuli caused an increase in intracellular Ca2+ concentration ([Ca2+]i) that was almost completely inhibited by ruthenium red, a selective antagonist of TRPV channels. Interestingly, a [Ca2+]i increase was evoked by both hypotonic stimuli and 4α-PDD in approximately 38% of VG neurons. These data indicate that TRPV4 is functionally expressed in VG neurons as an ion channel and that TRPV4 likely participates in VG neurons for vestibular neurotransmission as an osmoreceptor and/or mechanoreceptor.","PeriodicalId":8624,"journal":{"name":"Audiology and Neurotology","volume":"4 1","pages":"268 - 274"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73170842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Front & Back Matter 正面和背面

Audiology and Neurotology Pub Date : 2016-10-01 DOI: 10.1159/000452811

引用次数: 0

Five-Year Hearing Outcomes in Bilateral Simultaneously Cochlear-Implanted Adult Patients 双侧同时人工耳蜗植入成人患者5年听力结果

Audiology and Neurotology Pub Date : 2016-09-22 DOI: 10.1159/000448582

D. De Seta, Y. Nguyen, A. Vanier, E. Ferrary, J. Bébéar, B. Godey, A. Robier, M. Mondain, O. Déguine, O. Sterkers, I. Mosnier

{"title":"Five-Year Hearing Outcomes in Bilateral Simultaneously Cochlear-Implanted Adult Patients","authors":"D. De Seta, Y. Nguyen, A. Vanier, E. Ferrary, J. Bébéar, B. Godey, A. Robier, M. Mondain, O. Déguine, O. Sterkers, I. Mosnier","doi":"10.1159/000448582","DOIUrl":"https://doi.org/10.1159/000448582","url":null,"abstract":"Objective: To report the speech performance and sound localization in adult patients 5 years after bilateral simultaneous cochlear implantation and to evaluate the change in speech scores between 1 and 5 years. Design: In this prospective multicenter study, 26 patients were evaluated 5 years after implantation using long straight electrode arrays (MED-EL Combi 40+, standard electrode array, 31 mm). Speech perception was measured using disyllabic words in quiet and noise, with the speech coming from the front and a cocktail party background noise coming from 5 loudspeakers. Speech localization measurements were performed in noise under the same test conditions. These results were compared to those obtained at 1 year reported in a previous study. Results: Five years after implantation, an improvement in speech performance scores compared to 1 year after implantation was found for the poorer ear both in quiet and in noise (+12.1 ± 2.6%, p < 0.001). The lower the speech score of the poorer ear at 1 year, the greater the improvement at 5 years, both in quiet (r = -0.62) and at a signal-to-noise ratio of +15 dB (r = -0.58). The sound localization on the horizontal plane in noise provided by bilateral implantation was better than the unilateral one and remained stable after the results observed at 1 year. Conclusion: In adult patients simultaneously and bilaterally implanted, the poorest speech scores improved between 1 and 5 years after implantation. These findings are an additional element to recommend bilateral implantation in adult patients. The use of both cochlear implants and speech training sessions for patients with poor performance should continue in the period after 1 year following implantation, since the speech scores will improve over time.","PeriodicalId":8624,"journal":{"name":"Audiology and Neurotology","volume":"130 1","pages":"261 - 267"},"PeriodicalIF":0.0,"publicationDate":"2016-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87319281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Front & Back Matter 正面和背面

Audiology and Neurotology Pub Date : 2016-07-01 DOI: 10.1159/000448441

引用次数: 0

Front & Back Matter 正面和背面

Audiology and Neurotology Pub Date : 2016-04-01 DOI: 10.1159/000446461

引用次数: 0