Medical worldPub Date : 2019-05-01DOI: 10.1093/med/9780198701101.003.0034
P. Wade
{"title":"Skin cancer.","authors":"P. Wade","doi":"10.1093/med/9780198701101.003.0034","DOIUrl":"https://doi.org/10.1093/med/9780198701101.003.0034","url":null,"abstract":"This chapter focuses on the management of skin cancer, exploring both malignant melanoma and non-melanoma skin cancer. The epidemiology of melanoma is covered, and risk factors are described. Management looks at both early-stage and widespread disease, including surgery, adjuvant drug therapy, and radiotherapy. There is further emphasis on recent developments in biological and immunotherapy treatments such as ipilimumab and nivolumab. Non-melanoma skin cancer is discussed, covering risk factors and presentation of these diseases and a summary of their management.","PeriodicalId":86129,"journal":{"name":"Medical world","volume":"1 1","pages":"21-9"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74698163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical worldPub Date : 2019-02-08DOI: 10.1002/9781119557456.ch10
Andrew Dalby, P. Panayi, Gin Lesley Jacobs Solmonson, M. Millón
{"title":"Cheese.","authors":"Andrew Dalby, P. Panayi, Gin Lesley Jacobs Solmonson, M. Millón","doi":"10.1002/9781119557456.ch10","DOIUrl":"https://doi.org/10.1002/9781119557456.ch10","url":null,"abstract":"Conventional web interfaces respond to and consider only mouse clicks when defining a user model. We have extended this and take into account all mouse movements on a page as an additional layer of information for inferring user interest. We have developed a straightforward way to record all mouse movements on a page, and conducted a user study to analyze and investigate mouse behavior trends. We found certain mouse behaviors, common across many users, which are useful for content providers in increasing the effectiveness of their interface design.","PeriodicalId":86129,"journal":{"name":"Medical world","volume":"38 1","pages":"632-40"},"PeriodicalIF":0.0,"publicationDate":"2019-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83586753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical worldPub Date : 2018-08-12DOI: 10.1145/3230744.3230758
Yuka Takahashi, Tsukasa Fukusato
{"title":"STITCH.","authors":"Yuka Takahashi, Tsukasa Fukusato","doi":"10.1145/3230744.3230758","DOIUrl":"https://doi.org/10.1145/3230744.3230758","url":null,"abstract":"This international multi-center, patient-randomized, parallel-group trial compared early surgery (hematoma evacuation within 12 h of randomization) with initial conservative treatment (subsequent evacuation allowed if deemed necessary). Patients were randomized using an independent randomization service within 48 h of TBI. Patients were eligible if they had no more than two intraparenchymal hemorrhages of 10 mL or more and did not have an extradural or subdural hematoma that required surgery. The primary outcome measure was the traditional dichotomous split of the Glasgow Outcome Scale obtained by postal questionnaires sent directly to patients at 6 months. The trial was halted early by the UK funding agency (NIHR HTA) for failure to recruit sufficient patients from the UK (trial registration: ISRCTN19321911). A total of 170 patients were randomized from 31 of 59 registered centers worldwide. Of 82 patients randomized to early surgery with complete follow-up, 30 (37%) had an unfavorable outcome. Of 85 patients randomized to initial conservative treatment with complete follow-up, 40 (47%) had an unfavorable outcome (odds ratio, 0.65; 95% confidence interval, CI 0.35, 1.21; p=0.17), with an absolute benefit of 10.5% (CI, -4.4-25.3%). There were significantly more deaths in the first 6 months in the initial conservative treatment group (33% vs. 15%; p=0.006). The 10.5% absolute benefit with early surgery was consistent with the initial power calculation. However, with the low sample size resulting from the premature termination, we cannot exclude the possibility that this could be a chance finding. A further trial is required urgently to assess whether this encouraging signal can be confirmed .","PeriodicalId":86129,"journal":{"name":"Medical world","volume":"39 1","pages":"222-4"},"PeriodicalIF":0.0,"publicationDate":"2018-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84374357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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