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[Ultrastructure of chronic liver diseases; Kupffer cells of the hepatic sinusoids]. 慢性肝病的超微结构;[肝窦库普弗细胞]。
Taehan Kan Hakhoe chi = The Korean journal of hepatology Pub Date : 2002-12-01
Kyu Won Chung
{"title":"[Ultrastructure of chronic liver diseases; Kupffer cells of the hepatic sinusoids].","authors":"Kyu Won Chung","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":85610,"journal":{"name":"Taehan Kan Hakhoe chi = The Korean journal of hepatology","volume":"8 4","pages":"505-14"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22176785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A case of intraluminal gallbladder hematoma after percutaneous liver biopsy]. [经皮肝活检后胆囊腔内血肿1例]。
Taehan Kan Hakhoe chi = The Korean journal of hepatology Pub Date : 2002-12-01
Taek Kun Kwon, Sang Hoon Jeon, Hae Won Park, Woo Jin Jung, Jun Young Hwang, Kyung Sik Park, Kwang Bum Cho, Jae Seok Hwang, Sung Hoon Ahn, Soong Kook Park
{"title":"[A case of intraluminal gallbladder hematoma after percutaneous liver biopsy].","authors":"Taek Kun Kwon,&nbsp;Sang Hoon Jeon,&nbsp;Hae Won Park,&nbsp;Woo Jin Jung,&nbsp;Jun Young Hwang,&nbsp;Kyung Sik Park,&nbsp;Kwang Bum Cho,&nbsp;Jae Seok Hwang,&nbsp;Sung Hoon Ahn,&nbsp;Soong Kook Park","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Percutaneous liver biopsy is valued in the diagnosis of diffuse or localized liver disease. Serious complications after ultrasonography-guided liver biopsy are rare. We report a case of a 69-year-old man who underwent a percutaneous liver biopsy for the evaluation of his underlying liver disease with subsequent late complication of intraluminal gallbladder hematoma.</p>","PeriodicalId":85610,"journal":{"name":"Taehan Kan Hakhoe chi = The Korean journal of hepatology","volume":"8 4","pages":"486-9"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22175771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Clinical and virologic characteristics of lamivudine resistance in HBV-associated chronic liver disease]. 乙肝相关慢性肝病拉米夫定耐药的临床和病毒学特征
Taehan Kan Hakhoe chi = The Korean journal of hepatology Pub Date : 2002-12-01
Sun Suk Kim, Moon Gi Chung, Ki Tak Ju, Dong Kyun Park, Oh Sang Kwon, Yang Suh Koo, Yu Kyung Kim, Duck Ju Choi, Yu Jin Hwang, Ju Hyun Kim
{"title":"[Clinical and virologic characteristics of lamivudine resistance in HBV-associated chronic liver disease].","authors":"Sun Suk Kim,&nbsp;Moon Gi Chung,&nbsp;Ki Tak Ju,&nbsp;Dong Kyun Park,&nbsp;Oh Sang Kwon,&nbsp;Yang Suh Koo,&nbsp;Yu Kyung Kim,&nbsp;Duck Ju Choi,&nbsp;Yu Jin Hwang,&nbsp;Ju Hyun Kim","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background/aims: </strong>Lamivudine therapy in chronic hepatitis B has been shown to be effective in inhibiting HBV replication. However, lamivudine resistance has been developed with prolonged use. We studied to determine the prevalence, predictive factors, and clinical outcomes of lamivudine resistance. Mutations in YMDD motif of HBV polymerase, which have been associated with lamivudine resistance, were also assessed.</p><p><strong>Methods: </strong>170 patients with HBV-associated chronic liver disease who have received lamivudine for at least one year, were studied. The clinical, biochemical, and virologic characteristics were analyzed and compared according to presence (resistance group) or absence (non-resistance group) of DNA breakthrough. Their clinical outcomes were regularly followed. Stored sera before treatment and after DNA breakthrough were examined for detection of HBV polymerase mutation by direct sequencing and/or RFLP.</p><p><strong>Results: </strong>Cumulative rates of lamivudine resistance after one and two years of treatment were 11% and 34%, respectively. In the resistance group, as compared to the non-resistance group, age, the presence of HBeAg before treatment, and disappearance of HBeAg during treatment, were significantly different. The predictive factors associated with lamivudine resistance were not found. ALT and HBV-DNA level after lamivudine resistance was variable, but jaundice or hepatic failure was absent. Mutation in YMDD motif was detected in 73% and other variable mutations were detected before treatment and after DNA breakthrough.</p><p><strong>Conclusions: </strong>Lamivudine resistance increases the longer the duration of treatment and clinical outcomes are variable. The mutation in YMDD motif was found in about 2/3 of cases. Other causes for lamivudine resistance may be considered.</p>","PeriodicalId":85610,"journal":{"name":"Taehan Kan Hakhoe chi = The Korean journal of hepatology","volume":"8 4","pages":"405-17"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22175847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Therapeutic efficacy of transjugular intrahepatic portosystemic shunt on bleeding gastric varices]. [经颈静脉肝内门静脉分流术治疗胃底静脉曲张出血的疗效]。
Taehan Kan Hakhoe chi = The Korean journal of hepatology Pub Date : 2002-12-01
Hee Gon Song, Han Chu Lee, Young Hwan Park, Saera Jung, Young-Hwa Chung, Yung Sang Lee, Hyun Ki Yoon, Kyu Bo Sung, Dong Jin Suh
{"title":"[Therapeutic efficacy of transjugular intrahepatic portosystemic shunt on bleeding gastric varices].","authors":"Hee Gon Song,&nbsp;Han Chu Lee,&nbsp;Young Hwan Park,&nbsp;Saera Jung,&nbsp;Young-Hwa Chung,&nbsp;Yung Sang Lee,&nbsp;Hyun Ki Yoon,&nbsp;Kyu Bo Sung,&nbsp;Dong Jin Suh","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background/aims: </strong>Gastric variceal bleeding is a severe complication of liver cirrhosis with a high mortality. The purpose of this study was to determine the efficacy of transjugular intrahepatic portosystemic shunt (TIPS) in patients with gastric variceal bleedings and predictive factors for survival.</p><p><strong>Methods: </strong>We retrospectively analyzed the medical records of 30 consecutive patients with gastric variceal bleedings from January 1998 to March 2001. The causes of cirrhosis were viral hepatitis in 17, alcohol in 12, and biliary cirrhosis in 1. Eighteen patients were in Child-Pugh class B and 9 in class C at the time of TIPS. The median follow-up period was 403 days (3-1,215 days).</p><p><strong>Results: </strong>TIPS insertion was successful in all 30 patients. The portal pressure gradient (PPG) was significantly reduced from 23+/-8 mmHg to 11+/-5 mmHg (p<0.05). Hepatic encephalopathy, which developed in 3 patients and was aggravated in 1, was improved with medical therapy. Patients with non-alcoholic etiology experienced deterioration of liver function after TIPS. Those with alcoholic etiology did not. The 6-month and 1-year rebleeding rates were 22% and 41%, respectively. 56% of bleeding episodes were associated with stent dysfunction. The degree of PPG reduction and the development of stent dysfunction were independent predictive factors for rebleeding. The 6-month and 1-year survival rates were 83% and 79%. The causes of death were hepatic failure in 3 (37.5%), recurrent variceal bleeding in 3, and others in 2. Child-Pugh class C was the only prognostic factor for survival.</p><p><strong>Conclusions: </strong>TIPS was effective in acute hemostasis and the prevention of rebleeding in patients with gastric variceal bleeding. Especially, it can be safely applied to patients with alcoholic etiology and in Child-Pugh class A or B.</p>","PeriodicalId":85610,"journal":{"name":"Taehan Kan Hakhoe chi = The Korean journal of hepatology","volume":"8 4","pages":"448-57"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22175766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Spontaneous intrahepatic portosystemic shunt]. 自发性肝内门静脉系统分流。
Taehan Kan Hakhoe chi = The Korean journal of hepatology Pub Date : 2002-09-01
Joon Koo Han, Se Hyung Kim
{"title":"[Spontaneous intrahepatic portosystemic shunt].","authors":"Joon Koo Han,&nbsp;Se Hyung Kim","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":85610,"journal":{"name":"Taehan Kan Hakhoe chi = The Korean journal of hepatology","volume":"8 3","pages":"340-2"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22169750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Isolation and culture of pig hepatocyte in large scale for the application of bioartificial liver system]. [用于生物人工肝系统应用的猪肝细胞的大规模分离培养]。
Taehan Kan Hakhoe chi = The Korean journal of hepatology Pub Date : 2002-09-01
Yu Jeong Chung, Hyuk Joon Lee, Young Taeg Koh, Sang Beom Kim, Seong Hoon Kim, Seok Ho Choi, Nam Joon Yi, Seong Hwan Chang, Eun Lan Yang, Kyung Suk Suh, Yoon Shin Lee, Kuhn Uk Lee
{"title":"[Isolation and culture of pig hepatocyte in large scale for the application of bioartificial liver system].","authors":"Yu Jeong Chung,&nbsp;Hyuk Joon Lee,&nbsp;Young Taeg Koh,&nbsp;Sang Beom Kim,&nbsp;Seong Hoon Kim,&nbsp;Seok Ho Choi,&nbsp;Nam Joon Yi,&nbsp;Seong Hwan Chang,&nbsp;Eun Lan Yang,&nbsp;Kyung Suk Suh,&nbsp;Yoon Shin Lee,&nbsp;Kuhn Uk Lee","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background/aims: </strong>Acute hepatic failure is a serious problem. Its mortality reaches up to 80%. Only liver transplantation has been accepted as a definite treatment for patients with hepatic failure but shortage of donor organs is the main obstacle of this approach. A possible solution to this problem is a bioartificial liver system, perfusion of patients blood to isolated hepatocyte. In this study, we performed the isolation and culture of pig hepatocyte in large scale for the application of bioartificial liver system.</p><p><strong>Methods: </strong>Hepatocyte isolation was performed by two-step collagenase method via portal vein perfusion in 10 kg female pigs. After that, we compared the functional differences of the spheroid culture to the monolayer culture of hepatocyte. The viability and the function of hepatocyte were assessed using trypan-blue exclusion test and the measurement of the rate of ureagenesis and ammonia removal.</p><p><strong>Results: </strong>The average viability and yield of hepatocyte were 86.8 +/- 8.0 % and 7.8 +/- 5.4 X 10(9), respectively. The spheroid culture was superior to the monolayer culture in functional aspect of hepatocyte, and their differences, especially for ammonia removal, were more apparent in parallel with culture time.</p><p><strong>Conclusions: </strong>For hepatocyte isolation, we obtained sufficient viability and yield of hepatocyte for clinical usage of bioartificial liver system. The function of hepatocyte seems to be better in the spheroid culture than in the monolayer culture. Further studies are needed for application of bioartificial liver system in clinical setting.</p>","PeriodicalId":85610,"journal":{"name":"Taehan Kan Hakhoe chi = The Korean journal of hepatology","volume":"8 3","pages":"249-55"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22171169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Radiation therapy for bone metastasis from hepatocellular carcinoma]. [肝癌骨转移的放射治疗]。
Taehan Kan Hakhoe chi = The Korean journal of hepatology Pub Date : 2002-09-01
Woong Sub Koom, Jin Sil Seong, Min Jeong Lee, Hee Cheul Park, Kwang Hyub Han, Jae Yoon Chon, Young Myoung Moon, Chang Ok Suh
{"title":"[Radiation therapy for bone metastasis from hepatocellular carcinoma].","authors":"Woong Sub Koom,&nbsp;Jin Sil Seong,&nbsp;Min Jeong Lee,&nbsp;Hee Cheul Park,&nbsp;Kwang Hyub Han,&nbsp;Jae Yoon Chon,&nbsp;Young Myoung Moon,&nbsp;Chang Ok Suh","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background/aims: </strong>Recent advances in both diagnosis and treatment have markedly improved the prognosis in patients with hepatocellular carcinoma (HCC). Bone metastasis has become a clinical problem in the treatment of HCC patients. The purpose of this study was to evaluate the palliative effect of radiotherapy for painful bone metastasis from HCC.</p><p><strong>Methods: </strong>From January 1991 to June 2000, 51 patients (77 sites) with painful bone metastasis from HCC were retrospectively analyzed. Ages ranged from 21 to 80 years (median 55 years). The male:female ratio was 7.5:1. Synchronous or metachronous bone metastasis was seen in 20 (39%) and 31 patients (61%), respectively. The most common symptom of bone metastasis was pain (45 patients, 88%). Twenty-one patients (41%) had a solitary bone metastasis while 30 (59%) had multiple ones. The sites of bone metastasis, in order of frequency, were the vertebra (38), rib (20), and pelvis (19). The total radiation dose ranged from 12.5 to 50 Gy (median 30 Gy). The Wisconsin Brief Pain Questionnaire was used to evaluate pain response.</p><p><strong>Results: </strong>The overall 1 and 2 year survival rates from the time of bone metastasis were 15% and 4%, respectively. The median survival time was 5 months. Intrahepatic stage(p=0.014), and metastasis to other organs(p=0.019) were significant prognostic factor for survival by univariate analysis. There was, however, no independent prognostic factor on multivariate analysis. Pain relief after radiotherapy was achieved for 56 sites (73%).</p><p><strong>Conclusion: </strong>The expected life span (median 5 months) in this group of patients suggests a strong necessity for effective treatment for symptomatic palliation. Radiation therapy was effective in pain palliation for bone metastasis from HCC, and this could improve patients' quality of life.</p>","PeriodicalId":85610,"journal":{"name":"Taehan Kan Hakhoe chi = The Korean journal of hepatology","volume":"8 3","pages":"304-11"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22169840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A case of idiopathic hypereosinophilic syndrome with hepatic involvement in a 5-year-old boy]. [特发性嗜酸性粒细胞增多综合征伴肝脏累及1例5岁男孩]。
Taehan Kan Hakhoe chi = The Korean journal of hepatology Pub Date : 2002-09-01
Young Mi Kim, Yoon Jin Lee, Jae Hong Park, Jun Woo Lee, Chang Hun Lee
{"title":"[A case of idiopathic hypereosinophilic syndrome with hepatic involvement in a 5-year-old boy].","authors":"Young Mi Kim,&nbsp;Yoon Jin Lee,&nbsp;Jae Hong Park,&nbsp;Jun Woo Lee,&nbsp;Chang Hun Lee","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Idiopathic hypereosinophilic syndrome is defined as the presence of prolonged eosinophilia without an identifiable underlying cause and with evidence of end-organ dysfunction. The organs involved are the heart, bone marrow, nervous system, lungs, liver, skin, and gastrointestinal tract. Hepatic involvement is found in about 30% of patients of idiopathic hypereosinophilic syndrome. It occurs rarely in infants and children. In this report, we experienced one case of idiopathic hypereosinophilic syndrome with hepatic involvement in a 5-year-old boy who complained of intermittent fever and right upper quadrant abdominal pain. An abdominal ultrasound examination revealed an ill-defined low-echoic lesion in the liver. Pathologic findings of a biopsy specimen clearly showed the infiltration of eosinophils in the liver. Laboratory data disclosed absolute eosinophilia. There was no evidence of allergic disease or parasitic infestation.</p>","PeriodicalId":85610,"journal":{"name":"Taehan Kan Hakhoe chi = The Korean journal of hepatology","volume":"8 3","pages":"321-6"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22169843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Biliary papillomatosis]. [胆道乳头状瘤病]。
Taehan Kan Hakhoe chi = The Korean journal of hepatology Pub Date : 2002-09-01
Hyun Lyoung Koo, Eun Sil Yu
{"title":"[Biliary papillomatosis].","authors":"Hyun Lyoung Koo,&nbsp;Eun Sil Yu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":85610,"journal":{"name":"Taehan Kan Hakhoe chi = The Korean journal of hepatology","volume":"8 3","pages":"336-9"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22169749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A case of acute hepatitis E]. [一例急性戊型肝炎]。
Taehan Kan Hakhoe chi = The Korean journal of hepatology Pub Date : 2002-09-01
Nam Jin Kim, June Sung Lee, Kyung Ah Kim, Hye Ran Lee, Jang Weon Oh, Yi Dae Cho, Woo Jin Lee, Hyun Wook Baik, Young Bin Jeon, Chung Yong Kim
{"title":"[A case of acute hepatitis E].","authors":"Nam Jin Kim,&nbsp;June Sung Lee,&nbsp;Kyung Ah Kim,&nbsp;Hye Ran Lee,&nbsp;Jang Weon Oh,&nbsp;Yi Dae Cho,&nbsp;Woo Jin Lee,&nbsp;Hyun Wook Baik,&nbsp;Young Bin Jeon,&nbsp;Chung Yong Kim","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hepatitis E is an infectious viral disease with clinical and morphologic features of acute hepatitis. Although HEV infection is endemic in the Indian subcontinent, Southeast and Central Asia, a large outbreak of hepatitis E was identified in China. Smaller outbreaks have been observed in the Middle East, northern and western parts of Africa, and Mexico. Sporadic hepatitis E also has been observed in several countries. In nonendemic regions, the sporadic cases of hepatitis E are almost always associated with travel to HEV-endemic regions. In Korea, there has been no report on hepatitis E. Recently, we experienced a case of acute icteric hepatitis in which serologic study showed seroconversion of IgM anti-HEV. The patient did not have any travel history to an HEV-endemic area. We report this as an initial case of acute hepatitis E in Korea.</p>","PeriodicalId":85610,"journal":{"name":"Taehan Kan Hakhoe chi = The Korean journal of hepatology","volume":"8 3","pages":"312-6"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22169841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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