Malaria weekly最新文献

Malaria: Deadly parasites, exciting research and no vaccination 疟疾:致命的寄生虫，令人兴奋的研究和没有疫苗接种

Malaria weekly Pub Date : 2023-01-01 DOI: 10.1007/978-3-658-38407-4

F. Frischknecht

引用次数: 0

Plasmodium falciparumProtein Exported in Erythrocyte and Mechanism Resistance to Malaria 红细胞输出恶性疟原虫蛋白及其抗疟机制

Malaria weekly Pub Date : 2019-12-11 DOI: 10.5772/intechopen.83700

Neyder Contreras-Puentes

引用次数: 0

Malarial Pathophysiology and Phytochemical Interventions: A Current Discourse on Oxidative Stress Anti-Disease Phytotherapeutics 疟疾病理生理和植物化学干预:氧化应激抗疾病植物治疗的当前论述

Malaria weekly Pub Date : 2019-12-11 DOI: 10.5772/intechopen.83529

G. A. Mavondo, B. N. Mkhwanazi, Joy Mavondo, Wisdom Peresuh, O. Moyo

{"title":"Malarial Pathophysiology and Phytochemical Interventions: A Current Discourse on Oxidative Stress Anti-Disease Phytotherapeutics","authors":"G. A. Mavondo, B. N. Mkhwanazi, Joy Mavondo, Wisdom Peresuh, O. Moyo","doi":"10.5772/intechopen.83529","DOIUrl":"https://doi.org/10.5772/intechopen.83529","url":null,"abstract":"Malarial systemic pathophysiology refers to physiological changes or abnor-malities that are experienced by individuals infected with the Plasmodium parasite not be presenting in the absence of active, chronic or previous infection. The pathologies are derived, in part, from OS induced insults whose mediators are readily available in malaria. The malaria disease is equivalent to the pathophysiology as shown by the abnormal syndromic expressions ranging from ailments that affect homeostatic mechanisms and processes to tissues and organ specific damages and derangements. Phytotherapeutic remedies refer to the natural phytochemicals or plant medicinal compounds and their derivatives with known antiparasitic and antimalarial disease effects in both experimental and clinical situations. The chapter explores how Plasmodium infection generates or cause to be generated oxidative stress, how oxidative stress drives systemic disease process and how phytotherapeutics treatment (artemisinins) and administration (asiatic acid) in malaria resolves the various pathologies as a current situational analysis.","PeriodicalId":85112,"journal":{"name":"Malaria weekly","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80227473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aedes aegypti: The Main Enemy of Public Health in Brazil - Challenges and Perspective for Public Health 埃及伊蚊:巴西公共卫生的主要敌人-公共卫生的挑战和前景

Malaria weekly Pub Date : 2019-11-27 DOI: 10.5772/intechopen.79780

É. D. Carvalho, S. Valverde, J. A. Muñoz

引用次数: 1

Commercial Mosquito Repellents and Their Safety Concerns 商业驱蚊剂及其安全问题

Malaria weekly Pub Date : 2019-08-08 DOI: 10.5772/INTECHOPEN.87436

H. Khater, Abdelfattah M. Selim, Galal A. Abouelella, Nour A. Abouelella, K. Murugan, Nelissa P. Vaz, M. Govindarajan

{"title":"Commercial Mosquito Repellents and Their Safety Concerns","authors":"H. Khater, Abdelfattah M. Selim, Galal A. Abouelella, Nour A. Abouelella, K. Murugan, Nelissa P. Vaz, M. Govindarajan","doi":"10.5772/INTECHOPEN.87436","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.87436","url":null,"abstract":"Mosquitoes are serious vectors of diseases threading millions of humans and animals worldwide, as malaria, filariasis, and important arboviruses like dengue, yellow fever, chikungunya, West Nile virus, and Zika viruses. The swift spread of arboviruses, parasites, and bacteria in conjunction with the development of resistance in the pathogens, parasites, and vectors represents a great challenge in modern parasitology and tropical medicine. Unfortunately, synthetic insecticides had led to some serious health and risk concerns. There are no vaccines or other specific treatments for arboviruses transmitted by mosquitoes. Accordingly, avoidance of mosquito bites remains the first line of defense. Insect repellents usually work by providing a vapor barrier deterring mosquitoes from coming into contact with the skin surface, and this chapter focused on assets and liabilities, mechanism of action, improving efficacy, safety, and future perspective of synthetic and natural repellents that could potentially prevent mosquito-host interactions, thereby playing an important role in reducing mosquito-borne diseases when used correctly and consistently.","PeriodicalId":85112,"journal":{"name":"Malaria weekly","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81896100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Origin of Two Most Virulent Agents of Human Malaria: Plasmodium falciparum and Plasmodium vivax 两种最致命的人类疟疾病原体:恶性疟原虫和间日疟原虫的起源

Malaria weekly Pub Date : 2019-03-07 DOI: 10.5772/INTECHOPEN.84481

Boundenga Larson

引用次数: 13

Pharmacokinetic and Pharmacodynamic Profiles of Rapid- and Slow-Acting Antimalarial Drugs 快速和慢效抗疟药的药动学和药效学特征

Malaria weekly Pub Date : 2019-02-06 DOI: 10.5772/INTECHOPEN.83505

Qigui Li, B. Pybus

{"title":"Pharmacokinetic and Pharmacodynamic Profiles of Rapid- and Slow-Acting Antimalarial Drugs","authors":"Qigui Li, B. Pybus","doi":"10.5772/INTECHOPEN.83505","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.83505","url":null,"abstract":"Artemisinin and its derivatives are highly effective antimalarial drugs. These compounds combine potent and rapid antimalarial activity with a wide therapeutic index. An initiation of artemisinin resistance, described by a delayed parasite clearance time, is unlikely to cause high-level resistance. Artemisinins as a class demonstrate poor efficacy as monotherapy. This shortcoming can be overcome using oral artemisinin-based combination therapies (ACT) and intravenous-artesunate (IV-AS) in combination with slow-acting partner drugs. Pharmacokinetic and pharmacodynamic (PK/PD) evaluation demonstrates that the rapid efficacy of artemisinins is largely due to drug peak concentrations. Critical evaluation also demonstrates that AS is superior in PK/PD either following oral or intravenous administration when compared to the other rapid-acting artemisinins. This rapid efficacy and decreased mortality demonstrates that currently available artemisinins have a great advantage when combined with slow-acting antimalarial drugs for uncomplicated malaria or in sequential therapy with AS injection initially for severe and complicated malaria. Compared to other ACTs, dihydroartemisininpiperaquine (DP) demonstrates a superior in PK/PD profile, most likely due to the long half-life of piperaquine. These findings will help us better understand the PK/ PD profiles of rapid-acting (artemisinins) and slow-acting (piperaquine) drugs, and suggest how to best use ACTs in the future.","PeriodicalId":85112,"journal":{"name":"Malaria weekly","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88643746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Nipping the Malaria Vectors in the Bud: Focus on Nigeria 将疟疾病媒消灭在萌芽状态:重点关注尼日利亚

Malaria weekly Pub Date : 2019-01-28 DOI: 10.5772/INTECHOPEN.83554

O. Okwa

{"title":"Nipping the Malaria Vectors in the Bud: Focus on Nigeria","authors":"O. Okwa","doi":"10.5772/INTECHOPEN.83554","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.83554","url":null,"abstract":"Vector control is an important component of malaria control. Human malaria is a mosquito-borne parasitic disease which causes up to a million deaths a year and is estimated to infect over 212 million people worldwide. It is present in 97 countries covering half of the world’s population. Around 90% of deaths occur in sub-Saharan Africa, especially Nigeria and the Democratic Republic of the Congo (DRC). Malaria is the most widespread mosquito-borne disease in Nigeria where it has a holoendemic status. Of the four malaria parasites in Africa, Plasmodium falciparum is the most common malaria species, while Anopheles gambiae sensu stricto is the predominant vector in Nigeria. This review discusses the challenges to control malaria in Nigeria which gives a larger picture of sub-Saharan Africa. These challenges include the adaptability of the anopheles mosquito to the environment, their diversity, and their different vectorial capacities. Despite all the efforts to control malaria, it is still a public health challenge in Nigeria and in sub-Saharan Africa. However, one of the basic challenges is the source which are the diverse breeding sites. This problem is enhanced by malariogenic activities of humans. Salient recommendations for vector control by nipping the malaria vector in the bud were identified and advocated. ,","PeriodicalId":85112,"journal":{"name":"Malaria weekly","volume":"525 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80164615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Public Health und die Hybris moderner Wissenschaft 公共卫生以及现代科学的傲慢

Malaria weekly Pub Date : 2019-01-01 DOI: 10.1007/978-3-658-25300-4_5

Friedrich Frischknecht

引用次数: 0

Gentechnik und Impfstoffe 基因和疫苗

Malaria weekly Pub Date : 2019-01-01 DOI: 10.1007/978-3-658-25300-4_4

Friedrich Frischknecht

引用次数: 0