JK practitioner : a journal of current clinical medicine & surgery最新文献

{"title":"Cytological Analysis of Body Fluids in A Tertiary Care Hospital of Jammu Region: A One-year Retrospective Observational Study","authors":"Syed Aanif, Deepti Gupta","doi":"10.61081/9jkp/30v1i106","DOIUrl":"https://doi.org/10.61081/9jkp/30v1i106","url":null,"abstract":"Introduction: Exfoliative cytology of body fluids involves the analysis of cells present in fluids such as cerebrospinal fluid, pleural fluid, peritoneal fluid, pericardial fluid and synovial fluid. The cytological interpretation of individual cells exfoliated into these fluids provides an insight into the diagnosis, prognosis and therapeutic aspects of various pathological conditions. It also helps in staging of malignancies. Objective: To evaluate the significance of fluid cytology for various pathological conditions, including malignancies. Materials and Methods: This observational retrospective study was carried out for a period of one year from 31st May 2023 to 1st June 2024. A total of 392 cases of peritoneal, pleural, cerebrospinal, synovial, and pericardial fluids received during the study period in the cytology section of Department of Pathology, Government Medical College and Hospital, Jammu, J&K, India were included in this study. Gross and clinical findings were noted from the requisition forms. The fluids were centrifuged at 2000 rpm for 5 minutes and the sediment was used to prepare smears that were stained by May-Grunwald-Giemsa (MGG) stain and Papanicolaou (Pap) stain. Results: A total of 392 cases of serous effusions were studied. The most common fluid was peritoneal fluid, 230 (58.67%) cases, followed by pleural fluid, 145 (36.99%) cases, CSF, 15 (3.83%) and least common were pericardial fluid and synovial fluid, 1 (0.26%) case each. The age ranged from 4 years to 98 years. Most cases, 85 (21.68%) belonged to 51-60 years age group. Female preponderance was observed with M: F ratio of 1:1.23. 43 (10.97%) of the total effusions were malignant, out of which 23 were malignant peritoneal effusions. 23 (5.87%) cases were suspicious of malignancy of which 13 (56.52%) cases were peritoneal fluids. Carcinoma ovary was the most common primary site causing malignant peritoneal effusion. Conclusions: Exfoliative cytology is a valuable tool in evaluation of body cavity fluids. It is relatively painless, simple, cost effective, rapid technique that yields quick and reliable results. Some cases may present major interpretative challenges to the pathologist like presence of reactive mesothelial cells which at times poses difficulty in diagnosis, being close mimicker of malignancy. It is especially helpful in evaluation and staging of malignancy.","PeriodicalId":84965,"journal":{"name":"JK practitioner : a journal of current clinical medicine & surgery","volume":"30 1","pages":"29-35"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://9vom.in/journals/index.php/jkp/article/download/818/666","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147882157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CyBorD vs. VRD as Induction Therapy in Multiple Myeloma: A Retrospective Study on Kashmiri Patients","authors":"Rahul Roshan, Aakash Chozkade, Imran Nazir, Santosh Govind Rathod, Sumyra Khurshid Qadri, Javid Rasool","doi":"10.61081/9jkp/30v1i103","DOIUrl":"https://doi.org/10.61081/9jkp/30v1i103","url":null,"abstract":"Background: Multiple Myeloma (MM) is a clonal plasma cell malignancy that commonly presents with anemia, bone pain, renal dysfunction, and hypercalcemia. While combination regimens like VRD (bortezomib, lenalidomide, dexamethasone) are globally preferred as first-line induction therapy for transplant-eligible patients, real-world data comparing VRD with CyBorD (cyclophosphamide, bortezomib, dexamethasone) remain limited in specific ethnic and resource-constrained settings, including the Kashmiri population.Objective: To compare the clinical profile, treatment response, and survival outcomes of CyBorD versus VRD as induction regimens in newly diagnosed multiple myeloma patients from Kashmir.Methods: This retrospective observational study included 101 MM patients treated between January 2015 and June 2022 at a tertiary care center in Kashmir. Patients received either CyBorD (n = 81) or VRD (n = 20). Baseline characteristics, biochemical parameters, response rates, and survival outcomes were analyzed. Kaplan-Meier analysis was used for progression-free survival (PFS) and overall survival (OS).Results: The median age was 60-years in both groups, with a male predominance. A higher proportion of CyBorD patients presented with ISS Stage III disease (65.4% vs. 40%) and renal dysfunction, reflected by elevated creatinine levels. Lenalidomide, a key component of VRD, was either contraindicated in renal impairment or not freely available during the early study period, influencing treatment selection. The overall response rate (ORR) was comparable between the two regimens (64.3% for CyBorD vs. 68.7% for VRD). The three-year PFS was 67.2% for CyBorD and 60% for VRD. Despite the unequal group sizes, CyBorD showed efficacy even in patients with poor-risk features such as renal impairment.Conclusion: CyBorD is an effective, accessible, and well-tolerated alternative to VRD in the real-world management of multiple myeloma, especially in patients with renal dysfunction or in settings with limited access to lenalidomide. This study provides valuable regional data and supports the use of CyBorD in resource-constrained environment while highlighting the need for prospective studies with balanced group sizes.","PeriodicalId":84965,"journal":{"name":"JK practitioner : a journal of current clinical medicine & surgery","volume":"30 1","pages":"9-16"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://9vom.in/journals/index.php/jkp/article/download/814/663","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147904325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal cholestasis in Kashmiri children.","authors":"M Ahmad,&nbsp;M Jan,&nbsp;W Ali,&nbsp;Shabir-ud-din,&nbsp;C Bashir,&nbsp;Q Iqbal,&nbsp;Masood-ul-hassan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Neonatal cholestasis is prolonged elevation of conjugated serum bilirubin (more than 20% of total bilirubin) beyond first 14 days of life. After extensive evaluation a diagnosis of either biliary atresia or neonatal hepatitis is made in 70-80% of cases. Neonatal hepatitis and biliary atresia form a pathophysiologic process directed at various levels of the hepatobiliary tract. Inflammation in the bile duct epithelium may result in the sclerosis and obliteration of the bile ducts and manifest as biliary atresia. Primary hepatocellular inflammation is more likely to result in neonatal hepatitis. Half of the cases of neonatal hepatitis resolve without sequelae, while most of the biliary atresia cases require surgical intervention for repair or, ultimately, liver transplant.</p>","PeriodicalId":84965,"journal":{"name":"JK practitioner : a journal of current clinical medicine & surgery","volume":"7 2","pages":"125-6"},"PeriodicalIF":0.0,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22040466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood tuberculosis (part-II) (diagnosis and management).","authors":"M Mubarik, B Nahi, G M Ladakhi, A S Sethi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":84965,"journal":{"name":"JK practitioner : a journal of current clinical medicine & surgery","volume":"7 2","pages":"93-9"},"PeriodicalIF":0.0,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22040469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status of passive tuberculosis detection in a rural district of J & K.","authors":"B Gaash,&nbsp;G A Khan,&nbsp;M Ahmad","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":84965,"journal":{"name":"JK practitioner : a journal of current clinical medicine & surgery","volume":"7 2","pages":"153-5"},"PeriodicalIF":0.0,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22040467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood tuberculosis (Part-I). Epidemiology, pathogenesis, clinical profile.","authors":"M Mubarik, B Nabi, G M Ladakhi, A S Sethi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":84965,"journal":{"name":"JK practitioner : a journal of current clinical medicine & surgery","volume":"7 1","pages":"12-5"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22020437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural tube defect and folic acid.","authors":"M A Wani","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":84965,"journal":{"name":"JK practitioner : a journal of current clinical medicine & surgery","volume":"7 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22020434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of perinatal mortality: a hospital baed study.","authors":"F Fazili,&nbsp;G M Mattoo","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":84965,"journal":{"name":"JK practitioner : a journal of current clinical medicine & surgery","volume":"6 1","pages":"41-5"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22020358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1998 management recommendations for sexually transmitted diseases.","authors":"B A Malik,&nbsp;G Singh,&nbsp;T Mir","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":84965,"journal":{"name":"JK practitioner : a journal of current clinical medicine & surgery","volume":"6 1","pages":"84-91"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22020361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculous meningitis.","authors":"S K Gupta,&nbsp;S Gupta,&nbsp;A Parinar","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":84965,"journal":{"name":"JK practitioner : a journal of current clinical medicine & surgery","volume":"6 1","pages":"6-10"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22020360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}