Asian Journal of Pharmaceutics最新文献_第5页

Accidental Formation of Eutectics during Crystal Engineering of Lamotrigine with Solubility Advantage and Drug Release Efficiency 拉莫三嗪晶体工程过程中偶然形成的共晶具有溶解度优势和药物释放效率

IF 0.4

Asian Journal of Pharmaceutics Pub Date : 2021-04-05 DOI: 10.22377/AJP.V15I1.3960

Deepak Kulkarni

{"title":"Accidental Formation of Eutectics during Crystal Engineering of Lamotrigine with Solubility Advantage and Drug Release Efficiency","authors":"Deepak Kulkarni","doi":"10.22377/AJP.V15I1.3960","DOIUrl":"https://doi.org/10.22377/AJP.V15I1.3960","url":null,"abstract":"Objective: Lamotrigine (LMG) is the Biopharmaceutical Classification System Class-II drug with hurdle in drug release and dissolution efficiency due to poor water solubility. The present investigation was aimed to improve the solubility and dissolution of LMG by crystal engineering by formation of cocrystals but which accidently turn toward eutectics formation. Methods: LMG was subjected to neat grinding with different Cocrystal Formers (CCF) to develop multicomponent crystalline system. The prepared multicomponent system was analyzed by Differential Scanning Calorimetry, Raman spectroscopy, and Powder X-ray Diffraction reveals the formation of multicomponent system. Improved dissolution was interpreted by comparative drug release study of tablet formulation of unprocessed drug and eutectics. Results: There was unplanned formation of eutectics of LMGAscorbic acid (LMG-AA) that was observed with improved drug solubility. LMG-AA eutectics showed enhanced solubility (651.61 ± 1.02 μg/ml) in comparison with pure drug (161.46 ± 0.86 μg/ml) and all remaining multicomponent systems formed with other CCF’s. The LMG-AA eutectics showed comparatively better drug release than pure LMG tablet. LMG eutectics also showed significant improvement in flow properties and compressibility as compared to pure drug. Conclusion: Multicomponent LMG-AA eutectics although formed in unplanned way they effectively enhances the solubility of LMG serving the main purpose of the research work. It can be utilized efficiently for drug delivery due to its improved dissolution and better drug release.","PeriodicalId":8489,"journal":{"name":"Asian Journal of Pharmaceutics","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41484422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Formulation and Evaluation of Self-Emulsifying Drug Delivery Systems of Rosuvastatin Calcium 瑞舒伐他汀钙自乳化给药系统的研制与评价

IF 0.4

Asian Journal of Pharmaceutics Pub Date : 2021-03-17 DOI: 10.22377/AJP.V15I1.3939

Madhuri Desavathu

{"title":"Formulation and Evaluation of Self-Emulsifying Drug Delivery Systems of Rosuvastatin Calcium","authors":"Madhuri Desavathu","doi":"10.22377/AJP.V15I1.3939","DOIUrl":"https://doi.org/10.22377/AJP.V15I1.3939","url":null,"abstract":"Aim: The objective of this study was to develop a novel self-nanoemulsifying drug delivery system (SNEDDS) which produced very small and uniform emulsion droplets, resulting in enhanced solubility, dissolution, and oral bioavailability of poorly water-soluble rosuvastatin (RST) calcium. Materials and Methods: The effects of oil, surfactant, and cosurfactant on the drug solubility were assessed, and pseudoternary phase diagrams were plotted. Among the liquid SNEDDS formulations tested, the liquid SNEDDS composed of cinnamon oil (oil), Cremophor EL (surfactant), and transcutol P (cosurfactant) at a ratio of 2:1 (Smix) and 1:5 (oil:Smix) ratio, produced the smallest emulsion droplet size. The RST-loaded liquid SNEDDS formulation was assessed for the emulsion droplet size, solubility, and dissolution of the emulsified SNEDDS and compared to the pure drug. Different SNEDDS formulations of RST calcium were prepared by aqueous phase titration method. Selected formulations were characterized in terms of self-emulsification time, cloud point temperature, drug content, and particle size. Finally, selected SNEDDS (F1–F8) was subjected to in vitro dissolution/drug release studies. Results and Discussion: Droplet size of formulation F5 was found to be lowest as compared to other formulations. In vitro drug release studies showed 98.3% release of drug from optimized formulation, which was found to be much faster than marketed RST calcium. Conclusion: Thus, this novel SNEDDS developed represents a potentially powerful oral delivery system for RST calcium to enhance solubility and thereby bioavailability.","PeriodicalId":8489,"journal":{"name":"Asian Journal of Pharmaceutics","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68329116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chloroquine and Hydroxychloroquine in Coronavirus Disease-19: The Real Savior or a False-positive Testament 氯喹和羟氯喹在冠状病毒疾病-19:真正的救世主或假阳性的遗嘱

IF 0.4

Asian Journal of Pharmaceutics Pub Date : 2021-03-17 DOI: 10.22377/AJP.V15I1.3936

M. Iqbal

引用次数: 36

Current Practice of Using Technology in Health-care Delivery in Saudi Arabia: Challenges and Solutions 沙特阿拉伯在医疗保健服务中使用技术的现状：挑战和解决方案

IF 0.4

Asian Journal of Pharmaceutics Pub Date : 2021-03-17 DOI: 10.22377/AJP.V15I1.3935

N. Ahmed

{"title":"Current Practice of Using Technology in Health-care Delivery in Saudi Arabia: Challenges and Solutions","authors":"N. Ahmed","doi":"10.22377/AJP.V15I1.3935","DOIUrl":"https://doi.org/10.22377/AJP.V15I1.3935","url":null,"abstract":"The use of technology in delivering health-care services in Saudi Arabia is a significant step to take. Several application systems were implemented now in Saudi Arabia and provide medical services. This paper explores the current practice of using technology in health-care delivery in Saudi Arabia and brought to light the impact of technologies in health-care delivery on patients and their reported barriers. This is a narrative review which was conducted of published articles as well as gray literature on the application of technology in delivering medical care. Studies that met the following criteria were included: Addressed a relevant aspect of technology in health-care delivery; written in English; published between 1994 and June 2020; qualitative and quantitative study designs, systematic reviews, and primary and secondary research. The findings reveal evidence that utilizing technologies in delivering health services in Saudi Arabia are growing; however, it remains low. It has been found that inadequate infrastructure, lack of awareness of the importance of these technologies, shortage of professionals, lack of an information management plan, lacking a national plan for medical data exchange, and lacking a national regulator were among the main barriers. To achieve greater acceptance and use of technologies to deliver health-care services in our region, health workers should ensure that the services provided reflect as closely as possible local services and that social and religious culture is taken into account in the community. The findings of this study are also valuable for governments, organizations, and health policymakers to develop plans and policies to enhance the use of technology in delivering health-care services in Saudi Arabia.","PeriodicalId":8489,"journal":{"name":"Asian Journal of Pharmaceutics","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45886207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Evaluation of the Cytotoxic Effects of Thorn Extracts from Medicinal Plants on the sf21 Cell Line 药用植物荆棘提取物对sf21细胞系细胞毒性作用的评价

IF 0.4

Asian Journal of Pharmaceutics Pub Date : 2021-03-17 DOI: 10.22377/AJP.V15I1.3938

H. Malathi

{"title":"Evaluation of the Cytotoxic Effects of Thorn Extracts from Medicinal Plants on the sf21 Cell Line","authors":"H. Malathi","doi":"10.22377/AJP.V15I1.3938","DOIUrl":"https://doi.org/10.22377/AJP.V15I1.3938","url":null,"abstract":"Objective: The present study was aimed to screen the cytotoxic effect of thorn extracts of seven different plants. Methodology: The methanol extract of thorn of seven different plants were investigated for cytotoxic activity on Sf21 cell line using MTT (3-(4, 5-dimetylthiazol-2-yl)-2 and 5-diphenyltetrazolium bromide) assay. After exposure of the cell line at different concentrations to the plant extract (1.56–500 μg/mL), it was found that percentage of cell viability decreased in dose dependent manner. Results: The extract of Acacia ferruginea showed potential cytotoxic activity with IC50 value of 92.15 μg/mL against Sf21 cell line. Among the studied plants Limonia aciddisima (L), Gymnosporia senegalensis (L), Acacia nilotica and Acacia catechu (L) extracts were exhibited lesser cytotoxic activity, whereas Acacia senegal, Aegel marmelos and Acacia ferruginea were exhibited maximum cytotoxic activity on the Sf21 cell line and these 3 plant extracts has shown potent IC50 value of 188.5 μg/mL, 307.6 μg/mL, 92.15 μg/mL respectively on Sf21 cell lines when compared to control Benzonitrile drug. It is clear from the study that Acacia ferruginea is more cytotoxic to Sf21 cell lines compared to other plant extracts. The GC–MS study of Acacia feruginea showed that it has 37 bioactive components, of which some of the bioactive compounds are methyl mannose (57.14), phenol (8.07), cyclopropane carboxylic acid, benzene-di-carboxylic acid (0.31), hydroxy gamma butyrolactone (0.38), gamma sitosterol (3.52), Hexacosanol (3.83), and stigmasterol (4.65). Conclusion: The bioactive components found in Acacia ferruginia are cytotoxic and insecticidal to other pest. It shows that thorn not only defends themselves against the herbivores, but the specialized bioactive presence also plays a major defensive role. Hence, some of the bioactive can be isolated, characterized, and be used as a potential herbicides.","PeriodicalId":8489,"journal":{"name":"Asian Journal of Pharmaceutics","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43731025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Solid Lipid Nanoparticles: A Trending Slant for Drug Delivery System 固体脂质纳米颗粒:药物输送系统的趋势倾斜

IF 0.4

Asian Journal of Pharmaceutics Pub Date : 2021-03-17 DOI: 10.22377/AJP.V15I1.3937

Sachin R. Hangargekar

{"title":"Solid Lipid Nanoparticles: A Trending Slant for Drug Delivery System","authors":"Sachin R. Hangargekar","doi":"10.22377/AJP.V15I1.3937","DOIUrl":"https://doi.org/10.22377/AJP.V15I1.3937","url":null,"abstract":"Drug delivery systems have opened various doors to fulfill the requirements of chemotherapy. It improves therapeutic effects of already efficient molecules by delivering it to the targeted site. Research area achieved a high peak in the aspect of lipid-based nano-drug delivery system. Conventional oral therapy has various problems especially lower oral bioavailability of a drug. To overcome such problems, researcher found a way in the form of solid lipid nanoparticles (SLNs). Newest form of medication carrier system, that is, SLN concept firstly introduced in December 1991. It is a system of medication carrier over the traditional colloidal carriers. It mainly includes nanoparticles ranges of spherical stable lipid cells, scattered in fluid surfactant. It includes of nanometer ranges of spherical stable lipid cells, which are often scattered in fluid surfactant arrangement or in water. The main issues raised in previous type of carrier systems are poor water soluble and under development; absolutely having low bioavailability. In this type we have to prepare medicine with physiologically well tolerated lipids is the main advantage of this system to achieve good therapeutic outcomes. Lipid-based nanoparticles are SLNs which has size in between 10 and 1000 nm. This review will focuses on SLNs and their applications in various aspects. Applications comprise targeted therapy in brain tumors. Along with this treatment of metastatic breast cancer can also achieve using SLNs.","PeriodicalId":8489,"journal":{"name":"Asian Journal of Pharmaceutics","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43995969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chitosan-coated Liposomes of Centella asiatica Extract: An In vitro Formulation Design for Oral Delivery 积雪草提取物壳聚糖包被脂质体的体外口服配方设计

IF 0.4

Asian Journal of Pharmaceutics Pub Date : 2020-11-28 DOI: 10.22377/ajp.v14i4.3837

A. Dubey

{"title":"Chitosan-coated Liposomes of Centella asiatica Extract: An In vitro Formulation Design for Oral Delivery","authors":"A. Dubey","doi":"10.22377/ajp.v14i4.3837","DOIUrl":"https://doi.org/10.22377/ajp.v14i4.3837","url":null,"abstract":"Aim: A chitosan-coated liposomes of standardized Centella asiatica extract (CAE) was developed with the aim of improving the solubility of its phytoconstituents for the oral route with the intention to treat Alzheimer’s disease. Materials and Methods: The CAE was obtained by the soxhletion process. The formulation was optimized using design-expert software, solvent evaporation, and ionotropic gelation method was adopted to prepare CAE liposome (CAEL) and chitosan-coated CAE liposomes (CCAEL), respectively. The prepared CCAEL was characterized for its vesicle size, entrapment efficiency, polydispersity index, drug content analysis, Fourier transform infrared (FTIR), differential scanning calorimetry (DSC), transmission electron microscopy (TEM), atomic force microscopy (AFM), in vitro drug release, in vitro antioxidant study, ex vivo permeation study, and stability study. Results and Discussion: The proper amalgamation of drug and chitosan-phospholipid mixture was confirmed by FTIR and DSC. The surface morphology of the prepared formulation was examined by TEM and AFM. The in vitro rate of drug release pattern was analyzed where CAE showed less rate of release of 35.34 ± 0.30% in about 10 h due to poor solubility, while approximately 58.6 ± 0.42% release was observed from optimized CCAEL. In vitro antioxidant study demonstrated that free radical scavenging activity of CAE was retained even after intricate it with the phospholipid, that is, % inhibition of 2,2-diphenyl-1-picrylhydrazyl at 50 μg/ml was found 73.84% whereas 74.4% CAE. In vitro intestinal study proved that the permeation rate increases due to the encapsulation of chitosan-phospholipid complex. Stability study showed that chitosan coated liposomes were stable due to compact chitosan coating layer. Conclusion: The outcome of the current study is quite encouraging, shows better solubility and permeability. Further detailed preclinical studies are required to be conducted to ensure better product development.","PeriodicalId":8489,"journal":{"name":"Asian Journal of Pharmaceutics","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2020-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45796387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Awareness Level and Attitudes regarding Breast Self-Examination and Breast Cancer among Women in Saudi Arabia 沙特阿拉伯妇女对乳房自我检查和乳腺癌的认识水平和态度

IF 0.4

Asian Journal of Pharmaceutics Pub Date : 2020-11-28 DOI: 10.22377/ajp.v14i4.3828

N. Ahmed

{"title":"Awareness Level and Attitudes regarding Breast Self-Examination and Breast Cancer among Women in Saudi Arabia","authors":"N. Ahmed","doi":"10.22377/ajp.v14i4.3828","DOIUrl":"https://doi.org/10.22377/ajp.v14i4.3828","url":null,"abstract":"Aim: This study aimed to evaluate the attitudes and the level of awareness of women in Saudi Arabia regarding breast self-examination and breast cancer. Females must conduct breast self-examination regularly to observe any changes in their breast. Materials and Methods: This is a retrospective research that was conducted using a survey that was adapted from previously published studies conducted in Jordan and Northeast Nigeria. The questionnaire was validated by content validation and by face validation, and after that, the survey was prepared online using online electronic forms. Results: Approximately 95% of the respondents said that they are aware of breast cancer, mainly by social media (53.62%). The main risk factor of breast cancer, as reported by females, was family history (50.98%) followed by radiation exposure (35.04%). Change in the shape or size of the breast is the most common symptoms of breast cancer (66.93%). Moreover, 62.2 % of females stated that they heard about the self-examination but did not practice it. Conclusion: Although the females reported that their knowledge about breast cancer and self-examination was good, the majority did not practice breast self-examination. It is recommended to increase females’ awareness of breast cancer and self-examination by workshops, community services activities, and lectures.","PeriodicalId":8489,"journal":{"name":"Asian Journal of Pharmaceutics","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2020-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42365797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Impact of Concurrent Use of Diuretics, RAAS Inhibitors with Non-steroidal Anti-inflammatory Drugs “Triple Whammy” on Renal Function 同时使用利尿剂、RAAS抑制剂和非甾体抗炎药“三重打击”对肾功能的影响

IF 0.4

Asian Journal of Pharmaceutics Pub Date : 2020-11-28 DOI: 10.22377/ajp.v14i4.3824

M. Iqbal

{"title":"The Impact of Concurrent Use of Diuretics, RAAS Inhibitors with Non-steroidal Anti-inflammatory Drugs “Triple Whammy” on Renal Function","authors":"M. Iqbal","doi":"10.22377/ajp.v14i4.3824","DOIUrl":"https://doi.org/10.22377/ajp.v14i4.3824","url":null,"abstract":"Objective: This study aimed to evaluate the concomitant use of diuretics, angiotensin-converting-enzyme inhibitors/ angiotensin receptor blocker (ACEIs/ARBs) and non-steroidal anti-inflammatory drugs, frequently termed as “Triple Whammy,” prescribed among out-patients. It also aimed to determine the impact of this combination on patients’ renal function. Methodology: A retrospective and observational study was conducted in a hospital located in the state of Selangor, Malaysia. Patients who were receiving two or more of triple whammy agents were reviewed and analyzed. The associations between the prescriptions and patients’ demographics and comorbidities were tested using the Chi-square test. On the other hand, a paired sample t-test was used to determine the impact of prescriptions on renal function with a consideration of statistical significance when P < 0.05. Results: Out of 412 prescriptions (60.2% male) were included in this study, 407 prescriptions were containing two of the mentioned medication with only 5 prescriptions for triple whammy. The majority of prescriptions had (64.1%) ACEIs/ARBs and diuretics, and it was mainly prescribed to hypertensive patients (98.5%) aged less than 65 years old (38.3%). Furthermore, males were more likely to receive this combination of ACEIs/ARB and diuretics than females (P < 0.001) due to the fact that the male gender is considered as a risk factor for cardiovascular conditions that require ACEIs/ARBs + diuretics. In addition, there was a statistically significant decrease in CrCl after these risky combinations were initiated. Conclusion: The prescribing trend of triple whammy during the period of data collection was low compared to prescriptions of two risky combinations. This is indeed a good predictor of safe prescribing of drugs among physicians, as concomitant use of these three medications may impair renal functions.","PeriodicalId":8489,"journal":{"name":"Asian Journal of Pharmaceutics","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2020-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46504243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polysaccharides Based Novel and Controlled Released Multiparticulate Systems for Colon-specific Delivery: Contemporary Scenario and Future Prospects 基于多糖的新型可控释放多颗粒系统用于结肠特异性递送:当代情景和未来展望

IF 0.4

Asian Journal of Pharmaceutics Pub Date : 2020-11-28 DOI: 10.22377/ajp.v14i4.3815

S. Lanjhiyana

引用次数: 2