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The European Society of Cardiology (ESC) Annual Meeting 2005. 2005年欧洲心脏病学会年会。
Heart failure monitor Pub Date : 2005-01-01
Stephan von Haehling
{"title":"The European Society of Cardiology (ESC) Annual Meeting 2005.","authors":"Stephan von Haehling","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":84857,"journal":{"name":"Heart failure monitor","volume":"4 4","pages":"150-2"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25645958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aging and heart failure--similar syndromes of exercise intolerance? Implications for exercise-based interventions. 衰老和心力衰竭——运动不耐受的类似症状?运动干预的意义。
Heart failure monitor Pub Date : 2005-01-01
Stephan Gielen, Volker Adams, Josef Niebauer, Gerhard Schuler, Rainer Hambrecht
{"title":"Aging and heart failure--similar syndromes of exercise intolerance? Implications for exercise-based interventions.","authors":"Stephan Gielen,&nbsp;Volker Adams,&nbsp;Josef Niebauer,&nbsp;Gerhard Schuler,&nbsp;Rainer Hambrecht","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A classic hallmark of chronic heart failure (CHF) is exercise intolerance; however, the extent of exercise limitation is not correlated with the degree of left ventricular dysfunction. Over the past 2 decades it has become more and more evident that peripheral factors, such as skeletal muscle dysfunction, ventilatory abnormalities, and endothelial dysfunction, contribute the greater part to the limitation of exercise capacity. The molecular and pathophysiological changes observed in these organ systems are not always specific to the underlying CHF but rather represent a common pathway that is activated in several chronic disease processes, including severe chronic obstructive pulmonary disease, cancer, and in the normal aging process. A major contributing factor for skeletal muscle catabolism (i.e. elevated cytokine expression in the skeletal muscle) can be found in both normal healthy aging and in heart failure patients. It is reasonable to assume that the overlap of aging and CHF-associated changes in the skeletal muscle partially explains the disabling consequences of the CHF syndrome among elderly patients (nearly 80% of all patients hospitalized for CHF are >65 years old). Peripheral alterations in CHF are often not adequately treated in routine clinical care since standard pharmacological therapy is still focused on the cardiac function and neurohormonal alteration. Exercise training is a guideline-oriented adjuvant therapy with well-documented beneficial effects on exercise tolerance, skeletal muscle function, endothelial function, and respiration. In this review, the effects of exercise in aging and in CHF are compared and the parallel mechanisms are explored.</p>","PeriodicalId":84857,"journal":{"name":"Heart failure monitor","volume":"4 4","pages":"130-6"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25645957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BNP in the diagnosis and risk stratification of heart failure. BNP在心衰诊断和危险分层中的作用。
Heart failure monitor Pub Date : 2005-01-01
Gordon W Moe
{"title":"BNP in the diagnosis and risk stratification of heart failure.","authors":"Gordon W Moe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Heart failure (HF) is a common disorder that is associated with significant mortality and morbidity. However, the diagnosis of HF may at times be difficult when using conventional tools. The cardiac natriuretic peptides, particularly brain (B-type) natriuretic peptide (BNP), have evolved to be useful biomarkers of cardiac function and prognosis in HF and other cardiovascular disorders. Multiple observational studies have established the close association between plasma BNP as well as the N-terminal fragment of the BNP prohormone (NT-proBNP) with the diagnosis of HF and an independent prediction of mortality and HF events. Although there are confounding variables to consider, when used in the correct clinical settings, BNP or NT-proBNP testing can be extremely useful. Furthermore, preliminary data from randomized controlled trials suggest that knowledge of BNP and/or NT-proBNP level may optimize the management of patients with HF. Large-scale randomized controlled trials that evaluate BNP/NT-proBNP-guided therapy are ongoing.</p>","PeriodicalId":84857,"journal":{"name":"Heart failure monitor","volume":"4 4","pages":"116-22"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25645955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic heart failure and multiple micronutrient supplementation: realistic hope or idealistic conjecture? 慢性心力衰竭和多种微量营养素补充:现实的希望还是理想主义的猜想?
Heart failure monitor Pub Date : 2005-01-01
Klaus K A Witte, Andrew L Clark
{"title":"Chronic heart failure and multiple micronutrient supplementation: realistic hope or idealistic conjecture?","authors":"Klaus K A Witte,&nbsp;Andrew L Clark","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recent studies have demonstrated the inefficacy of nutritional supplements containing various combinations of vitamins and minerals for otherwise healthy elderly people and patients with ischemic heart disease. However, patients with chronic heart failure (CHF) have, up until recently, been excluded from such studies. CHF has a high mortality and morbidity and patients are often elderly with poor general nutrition and high levels of micronutrient deficiency. It is in this population that nutritional supplementation has the most potential benefit. Evidence is accumulating that a strategy of long-term highdose multiple micronutrient supplementation might improve symptoms and cardiac function in elderly patients with CHF. In this article, we review the effects of individual micronutrients and how they might impact on CHF, and present recent data that dietary supplementation might offer an addition to standard therapy for CHF.</p>","PeriodicalId":84857,"journal":{"name":"Heart failure monitor","volume":"4 4","pages":"123-9"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25645956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular and clinical aspects of heart failure therapy. 心力衰竭治疗的分子和临床方面。
Heart failure monitor Pub Date : 2005-01-01
Josef Niebauer
{"title":"Molecular and clinical aspects of heart failure therapy.","authors":"Josef Niebauer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":84857,"journal":{"name":"Heart failure monitor","volume":"4 4","pages":"114-5"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25647599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing the clinical exercise test: a commentary on the exercise protocol. 优化临床运动试验:对运动方案的评论。
Heart failure monitor Pub Date : 2004-01-01
Jonathan Myers
{"title":"Optimizing the clinical exercise test: a commentary on the exercise protocol.","authors":"Jonathan Myers","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The exercise test has a high yield of diagnostic, prognostic, and functional information and continues to have an integral place in cardiovascular medicine. Its two most common clinical uses are to estimate the probability of a patient having coronary disease and to estimate the likelihood of future coronary events. Although recent guidelines for exercise testing have recommended that the exercise protocol should be adjusted for each patient, this is often overlooked. This review examines the use of the exercise test and discusses which protocols are most appropriate for which patients. Appropriate attention given to exercise testing methodology, including the choice of the exercise protocol, can help to assure the maximum functional, diagnostic, and prognostic yield of information.</p>","PeriodicalId":84857,"journal":{"name":"Heart failure monitor","volume":"4 3","pages":"82-9"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25009804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multisite thrombosis: a late presentation of myocardial infarction. 多部位血栓形成:心肌梗死的晚期表现。
Heart failure monitor Pub Date : 2004-01-01
Ruth MacPherson, Youssif Abousleiman, Andrew Jamieson
{"title":"Multisite thrombosis: a late presentation of myocardial infarction.","authors":"Ruth MacPherson,&nbsp;Youssif Abousleiman,&nbsp;Andrew Jamieson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Systemic thromboembolism is well recognized in patients with left ventricular (LV) impairment. We report a case of cardiac failure presenting with systemic coagulopathy and an unusual pattern of thrombotic manifestations as a consequence of LV impairment.</p>","PeriodicalId":84857,"journal":{"name":"Heart failure monitor","volume":"4 3","pages":"98-9"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25009806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Statins: a treatment option for chronic heart failure? 他汀类药物:慢性心力衰竭的治疗选择?
Heart failure monitor Pub Date : 2004-01-01
Stephan von Haehling, Darlington O Okonko, Stefan D Anker
{"title":"Statins: a treatment option for chronic heart failure?","authors":"Stephan von Haehling,&nbsp;Darlington O Okonko,&nbsp;Stefan D Anker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Statins, also known as 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, consistently reduce cardiovascular risk. It has recently emerged that cholesterol reduction is not their only mode of action, with current research largely focused on the pleiotropic effects of statins. These include the improvement of endothelial dysfunction, their anti-inflammatory properties, and the mobilization of bone marrow-derived endothelial progenitor cells. All these effects are potentially beneficial in chronic heart failure (CHF), although prospective trials are needed to confirm this. However, cholesterol reduction by statins per se may prove detrimental in patients with CHF, as cholesterol seems to be able to inactivate endotoxin as a stimulus for proinflammatory cytokine production. It is therefore tempting to speculate that low doses of statins still confer pleiotropic effects without lowering plasma cholesterol levels.</p>","PeriodicalId":84857,"journal":{"name":"Heart failure monitor","volume":"4 3","pages":"90-7"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25009805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Back to the future? 回到未来?
Heart failure monitor Pub Date : 2003-01-01
Andrew L Clark
{"title":"Back to the future?","authors":"Andrew L Clark","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":84857,"journal":{"name":"Heart failure monitor","volume":"3 4","pages":"151-6"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22464831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognosis of patients with heart failure compared with common types of cancer. 心衰患者与普通类型癌症的预后比较。
Heart failure monitor Pub Date : 2003-01-01
Simon Stewart
{"title":"Prognosis of patients with heart failure compared with common types of cancer.","authors":"Simon Stewart","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Heart failure (HF) is a growing epidemic that not only exerts an enormous burden on the healthcare system but also imparts extremely poor quality of life in the increasing number of patients dying from this fatal syndrome. For the majority of these patients, end-of-life care is clearly suboptimal. It is within this context that this article reviews the case for comparing the prognosis of HF with that of the most common types of cancer. It also summarizes the numerous difficulties in trying to make such comparisons and highlights key comparative data--the majority of which indicate that the prognosis of HF is comparable with that of cancer. Finally, it discusses how these comparisons can highlight the need to extend the type of public health response to HF usually reserved for high profile disease states, such as cancer.</p>","PeriodicalId":84857,"journal":{"name":"Heart failure monitor","volume":"3 3","pages":"87-94"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22288723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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