Asian Journal of Andrology最新文献

{"title":"Vasectomy reversal in China during the recent decade: insights from a multicenter retrospective investigation.","authors":"Li-Juan Ren,&nbsp;Rui-Zhi Xue,&nbsp;Zi-Qiang Wu,&nbsp;Er-Lei Zhi,&nbsp;Wei Li,&nbsp;Liang Huang,&nbsp;Xu-Yu Xiang,&nbsp;Dao-Yuan Li,&nbsp;Xue-Ming Lin","doi":"10.4103/aja202244","DOIUrl":"https://doi.org/10.4103/aja202244","url":null,"abstract":"<p><p>To date, there is little information about the demography of vasectomy reversal (VR) patients or the factors currently influencing VR effectiveness in China, especially after the universal two-child policy was released in 2015. In this research, demographic data and perioperative medical records of VR patients were extracted from seven major hospitals in different provinces or municipalities of China. Meanwhile, a telephone survey of the patients was conducted to collect follow-up information. Eventually, 448 VR cases from the past 13 years were included. The results were analyzed by stratified comparison to investigate factors that can influence postoperative vas deferens patency and pregnancy rate. Appropriately statistical methods were used, and all of the protocols were approved by the Ethics Committees of the institutes in this research. The results showed that the annual operation volume of VR quadrupled after the two-child policy was implemented. Nonmicrosurgery and a long duration of vasectomy were significantly associated with a lower patency rate. A follow-up survey showed that the general postoperative pregnancy rate was 27.2%. For female partners over the age of 35 years, the postoperative pregnancy rate showed a more severe decline, but only 35.5% of them had been given a fertility examination before their husbands' VR surgery. Our work revealed that more patients in China have been demanding VR in recent years. High-quality microsurgery and a short duration of vasectomy are crucial for restoring patency by VR. Clinical andrologists should perform a preoperative fertility evaluation of the patients' female partners.</p>","PeriodicalId":8483,"journal":{"name":"Asian Journal of Andrology","volume":"25 3","pages":"416-420"},"PeriodicalIF":2.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/21/64/AJA-25-416.PMC10226496.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9543101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of androgen receptor-dependent alternative splicing has identified a unique subtype of lethal prostate cancer.","authors":"Sean Seltzer,&nbsp;Paresa N Giannopoulos,&nbsp;Tarek A Bismar,&nbsp;Mark Trifiro,&nbsp;Miltiadis Paliouras","doi":"10.4103/aja202263","DOIUrl":"https://doi.org/10.4103/aja202263","url":null,"abstract":"<p><p>A complete proteomics study characterizing active androgen receptor (AR) complexes in prostate cancer (PCa) cells identified a diversity of protein interactors with tumorigenic annotations, including known RNA splicing factors. Thus, we chose to further investigate the functional role of AR-mediated alternative RNA splicing in PCa disease progression. We selected two AR-interacting RNA splicing factors, Src associated in mitosis of 68 kDa (SAM68) and DEAD (Asp-Glu-Ala-Asp) box helicase 5 (DDX5) to examine their associative roles in AR-dependent alternative RNA splicing. To assess the true physiological role of AR in alternative RNA splicing, we assessed splicing profiles of LNCaP PCa cells using exon microarrays and correlated the results to PCa clinical datasets. As a result, we were able to highlight alternative splicing events of clinical significance. Initial use of exon-mini gene cassettes illustrated hormone-dependent AR-mediated exon-inclusion splicing events with SAM68 or exon-exclusion splicing events with DDX5 overexpression. The physiological significance in PCa was investigated through the application of clinical exon array analysis, where we identified exon-gene sets that were able to delineate aggressive disease progression profiles and predict patient disease-free outcomes independently of pathological clinical criteria. Using a clinical dataset with patients categorized as prostate cancer-specific death (PCSD), these exon gene sets further identified a select group of patients with extremely poor disease-free outcomes. Overall, these results strongly suggest a nonclassical role of AR in mediating robust alternative RNA splicing in PCa. Moreover, AR-mediated alternative spicing contributes to aggressive PCa progression, where we identified a new subtype of lethal PCa defined by AR-dependent alternative splicing.</p>","PeriodicalId":8483,"journal":{"name":"Asian Journal of Andrology","volume":"25 3","pages":"296-308"},"PeriodicalIF":2.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7a/b4/AJA-25-296.PMC10226513.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9896403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The protective effects and underlying mechanisms of dapagliflozin on diabetes-induced testicular dysfunction.","authors":"Zhi-Chao Luo,&nbsp;Zi-Run Jin,&nbsp;Ya-Fei Jiang,&nbsp;Tian-Jiao Wei,&nbsp;Ya-Lei Cao,&nbsp;Zhe Zhang,&nbsp;Rui Wei,&nbsp;Hui Jiang","doi":"10.4103/aja202242","DOIUrl":"https://doi.org/10.4103/aja202242","url":null,"abstract":"<p><p>Male diabetic individuals present a marked impairment in fertility; however, knowledge regarding the pathogenic mechanisms and therapeutic strategies is unsatisfactory. The new hypoglycemic drug dapagliflozin has shown certain benefits, such as decreasing the risk of cardiovascular and renal events in patients with diabetes. Even so, until now, the effects and underlying mechanisms of dapagliflozin on diabetic male infertility have awaited clarification. Here, we found that dapagliflozin lowered blood glucose levels, alleviated seminiferous tubule destruction, and increased sperm concentrations and motility in leptin receptor-deficient diabetic db/db mice. Moreover, the glucagon-like peptide-1 receptor (GLP-1R) antagonist exendin (9-39) had no effect on glucose levels but reversed the protective effects of dapagliflozin on testicular structure and sperm quality in db/db mice. We also found that dapagliflozin inhibited the testicular apoptotic process by upregulating the expression of the antiapoptotic protein B-cell lymphoma 2 (BCL2) and X-linked inhibitor of apoptosis protein (XIAP) and inhibiting oxidative stress by enhancing the antioxidant status, including total antioxidant capacity, total superoxide dismutase (SOD) activity, and glutathione peroxidase (GPx) activity, as well as decreasing the level of 4-hydroxynonenal (4-HNE). Exendin (9-39) administration partially reversed these effects. Furthermore, dapagliflozin upregulated the glucagon-like peptide-1 (GLP-1) level in plasma and GLP-1R expression by promoting AKT8 virus oncogene cellular homolog (Akt) phosphorylation in testicular tissue. Exendin (9-39) partially inhibited Akt phosphorylation. These results suggest that dapagliflozin protects against diabetes-induced spermatogenic dysfunction via activation of the GLP-1R/phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. Our results indicate the potential effects of dapagliflozin against diabetes-induced spermatogenic dysfunction.</p>","PeriodicalId":8483,"journal":{"name":"Asian Journal of Andrology","volume":"25 3","pages":"331-338"},"PeriodicalIF":2.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f9/eb/AJA-25-331.PMC10226494.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9912846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel homozygous loss-of-function mutation in <i>RAD51AP2</i> induces male infertility with nonobstructive azoospermia.","authors":"Liu Liu,&nbsp;Shu-Yan Tang,&nbsp;Feng Zhang,&nbsp;Feng Jiang","doi":"10.4103/aja202272","DOIUrl":"https://doi.org/10.4103/aja202272","url":null,"abstract":"similar phenotype in the proband’s brother, who had a 9-year history of male infertility. The proband did not have a medical history of infectious disease, chronic disease, or cancer or a history of smoking or consuming alcohol. He had normal sexual activity with ejaculation. The physical examination showed normal development of the penis, prostate, epididymis, and vas deferens. No varicocele was observed, but bilateral testicular size (10 ml) was slightly smaller than reference value (>12.5 ml) 2 . Further laboratory examinations showed a normal karyotype and normal serum levels of hormones such as follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T). There was no microdeletion in the Y chromosome. However, semen samples from the proband and his brother lacked sperm before and after centrifugation. Their testicular biopsies showed many spermatocytes but no spermatids or","PeriodicalId":8483,"journal":{"name":"Asian Journal of Andrology","volume":"25 3","pages":"435-437"},"PeriodicalIF":2.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5f/a3/AJA-25-435.PMC10226490.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9542420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of m⁶A methylation in prostate cancer.","authors":"Shou-Yi Zhang,&nbsp;Yu Zeng","doi":"10.4103/aja202265","DOIUrl":"https://doi.org/10.4103/aja202265","url":null,"abstract":"<p><p>N⁶-methyladenosine (m⁶A) is a ubiquitous RNA modification in mammals. This modification is \"written\" by methyltransferases and then \"read\" by m⁶A-binding proteins, followed by a series of regulation, such as alternative splicing, translation, RNA stability, and RNA translocation. At last, the modification is \"erased\" by demethylases. m⁶A modification is essential for normal physiological processes in mammals and is also a very important epigenetic modification in the development of cancer. In recent years, cancer-related m⁶A regulation has been widely studied, and various mechanisms of m⁶A regulation in cancer have also been recognized. In this review, we summarize the changes of m⁶A modification in prostate cancer and discuss the effect of m⁶A regulation on prostate cancer progression, aiming to profile the potential relevance between m⁶A regulation and prostate cancer development. Intensive studies on m⁶A regulation in prostate cancer may uncover the potential role of m⁶A methylation in the cancer diagnosis and cancer therapy.</p>","PeriodicalId":8483,"journal":{"name":"Asian Journal of Andrology","volume":"25 2","pages":"166-170"},"PeriodicalIF":2.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e9/48/AJA-25-166.PMC10069701.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9298609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scaffold protein MAPK8IP2 expression is a robust prognostic factor in prostate cancer associated with AR signaling activity.","authors":"Jian Huang,&nbsp;Wang Liu,&nbsp;Bi-Yun Lin,&nbsp;Jean C Li,&nbsp;Jane Lu,&nbsp;Ben-Yi Li","doi":"10.4103/aja202240","DOIUrl":"https://doi.org/10.4103/aja202240","url":null,"abstract":"<p><p>Mitogen-activated protein kinase-8-interacting protein 2 (MAPK8IP2) is a scaffold protein that modulates MAPK signal cascades. Although MAPK pathways were heavily implicated in prostate cancer progression, the regulation of MAPK8IP2 expression in prostate cancer is not yet reported. We assessed MAPK8IP2 gene expression in prostate cancer related to disease progression and patient survival outcomes. MAPK8IP2 expression was analyzed using multiple genome-wide gene expression datasets derived from The Cancer Genome Atlas (TCGA) RNA-sequence project and complementary DNA (cDNA) microarrays. Multivariable Cox regressions and log-rank tests were used to analyze the overall survival outcome and progression-free interval. MAPK8IP2 protein expression was evaluated using the immunohistochemistry approach. The quantitative PCR and Western blot methods analyzed androgen-stimulated MAPK8IP2 expression in LNCaP cells. In primary prostate cancer tissues, MAPK8IP2 mRNA expression levels were significantly higher than those in the case-matched benign prostatic tissues. Increased MAPK8IP2 expression was strongly correlated with late tumor stages, lymph node invasion, residual tumors after surgery, higher Gleason scores, and preoperational serum prostate-specific antigen (PSA) levels. MAPK8IP2 upregulation was significantly associated with worse overall survival outcomes and progression-free intervals. In castration-resistant prostate cancers, MAPK8IP2 expression strongly correlated with androgen receptor (AR) signaling activity. In cell culture-based experiments, MAPK8IP2 expression was stimulated by androgens in AR-positive prostate cancer cells. However, MAPK8IP2 expression was blocked by AR antagonists only in androgen-sensitive LNCaP but not castration-resistant C4-2B and 22RV1 cells. These results indicate that MAPK8IP2 is a robust prognostic factor and therapeutic biomarker for prostate cancer. The potential role of MAPK8IP2 in the castration-resistant progression is under further investigation.</p>","PeriodicalId":8483,"journal":{"name":"Asian Journal of Andrology","volume":"25 2","pages":"198-207"},"PeriodicalIF":2.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/23/e4/AJA-25-198.PMC10069696.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9243541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the predictive value of anthropometric indicators for the risk of benign prostatic hyperplasia in southern China.","authors":"Meng-Jun Huang,&nbsp;Yan-Yi Yang,&nbsp;Can Chen,&nbsp;Rui-Xiang Luo,&nbsp;Chu-Qi Wen,&nbsp;Yang Li,&nbsp;Ling-Peng Zeng,&nbsp;Xiang-Yang Li,&nbsp;Zhuo Yin","doi":"10.4103/aja202249","DOIUrl":"https://doi.org/10.4103/aja202249","url":null,"abstract":"<p><p>This study aimed to compare the predictive value of six selected anthropometric indicators for benign prostatic hyperplasia (BPH). Males over 50 years of age who underwent health examinations at the Health Management Center of the Second Xiangya Hospital, Central South University (Changsha, China) from June to December 2020 were enrolled in this study. The characteristic data were collected, including basic anthropometric indices, lipid parameters, six anthropometric indicators, prostate-specific antigen, and total prostate volume. The odds ratios (ORs) with 95% confidence intervals (95% CIs) for all anthropometric parameters and BPH were calculated using binary logistic regression. To assess the diagnostic capability of each indicator for BPH and identify the appropriate cutoff values, receiver operating characteristic (ROC) curves and the related areas under the curves (AUCs) were utilized. All six indicators had diagnostic value for BPH (all P ≤ 0.001). The visceral adiposity index (VAI; AUC: 0.797, 95% CI: 0.759-0.834) had the highest AUC and therefore the highest diagnostic value. This was followed by the cardiometabolic index (CMI; AUC: 0.792, 95% CI: 0.753-0.831), lipid accumulation product (LAP; AUC: 0.766, 95% CI: 0.723-0.809), waist-to-hip ratio (WHR; AUC: 0.660, 95% CI: 0.609-0.712), waist-to-height ratio (WHtR; AUC: 0.639, 95% CI: 0.587-0.691), and body mass index (BMI; AUC: 0.592, 95% CI: 0.540-0.643). The sensitivity of CMI was the highest (92.1%), and WHtR had the highest specificity of 94.1%. CMI consistently showed the highest OR in the binary logistic regression analysis. BMI, WHtR, WHR, VAI, CMI, and LAP all influence the occurrence of BPH in middle-aged and older men (all P ≤ 0.001), and CMI is the best predictor of BPH.</p>","PeriodicalId":8483,"journal":{"name":"Asian Journal of Andrology","volume":"25 2","pages":"265-270"},"PeriodicalIF":2.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/48/e7/AJA-25-265.PMC10069681.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9249975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Will male semen quality improve with environmental quality?","authors":"Xu-Chao Dai,&nbsp;Meng-Qi Zhang,&nbsp;Gang Chen,&nbsp;Kun Mei,&nbsp;Yan-Long Liu,&nbsp;Hong Huang,&nbsp;Zhi-Gang Wu","doi":"10.4103/aja202239","DOIUrl":"https://doi.org/10.4103/aja202239","url":null,"abstract":"<p><p>Wenzhou has improved its environmental quality because of comprehensive environmental remediation; nevertheless, the semen quality of infertile males remains unclear. This study determined whether better environmental quality improved semen quality in this region. We recorded semen quality data from 22 962 infertile males from January 2014 to November 2019 at the Center for Reproductive Health of The First Affiliated Hospital of Wenzhou Medical University (Wenzhou, China). Patients were predominantly 30-35 years old (33.1%) and workers (82.0%), with high school education or lower (77.6%); more than a half of the patients (52.6%) were Wenzhou household registration; and most patients (77.5%) had abnormal semen quality. Patients who were older than 40 years and workers, and those with Wenzhou household registration, had significantly worse semen quality (all P < 0.05). From 2014 to 2019, progressive sperm motility, total sperm motility, and semen volume showed increasing linear trends in all patients (P = 0.021, 0.030, and 0.005, respectively), yet normal sperm morphology showed a linearly decreasing trend (P = 0.046). Sensitivity analyses for subgroups yielded similar results. In conclusion, the improvement of environmental quality and better function of the accessory glands are associated with progressive sperm motility, total sperm motility, and semen volume. Normal sperm morphology is influenced by occupational exposures and personal lifestyle and does not improve with environmental quality.</p>","PeriodicalId":8483,"journal":{"name":"Asian Journal of Andrology","volume":"25 2","pages":"252-258"},"PeriodicalIF":2.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/74/c8/AJA-25-252.PMC10069693.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9249540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell fate determination and lineage plasticity in prostate cancer.","authors":"Dong Gao","doi":"10.4103/aja20231","DOIUrl":"https://doi.org/10.4103/aja20231","url":null,"abstract":"P cancer (PCa) initiation, progression, and therapy resistance involve genetic and epigenetic alterations that l e ad to ab err ant cel l l ine age specification and plasticity.1–3 The vast majority of primary prostate cancers are pathologically defined as luminal cancer with luminal cell expansion and absence of basal cells. The basal or neuroendocrine PCa is extremely rare in primary or untreated PCa. Adeno-to-neuroendocrine PCa lineage plasticity has been identified in advanced PCa following the targeted therapy of AR inhibition.2 However, the underlying mechanisms of PCa cell fate determination and lineage plasticity are still poorly understood. Therefore, systematically defining the genetic, epigenetic, and microenvironment factors in PCa cell lineage determination and plasticity may reveal the underlying molecular mechanisms and stimulate the development of novel therapeutic strategies to prevent or reverse the current therapy resistance of prostate cancers. This special issue, “Prostate Cell Fate and Diseases”, contains six original articles and five reviews to introduce some recent PCa research progress in the field of prostate cell fate determination and lineage plasticity. PCa is one of the most common cancers in men in the world. The normal prostate epithelium consists of luminal cells, basal cells, INVITED EDITORIAL","PeriodicalId":8483,"journal":{"name":"Asian Journal of Andrology","volume":"25 2","pages":"149-151"},"PeriodicalIF":2.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/99/90/AJA-25-149.PMC10069700.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9922527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Added value of shear-wave elastography in the prediction of extracapsular extension and seminal vesicle invasion before radical prostatectomy.","authors":"Yi-Kang Sun,&nbsp;Yang Yu,&nbsp;Guang Xu,&nbsp;Jian Wu,&nbsp;Yun-Yun Liu,&nbsp;Shuai Wang,&nbsp;Lin Dong,&nbsp;Li-Hua Xiang,&nbsp;Hui-Xiong Xu","doi":"10.4103/aja202256","DOIUrl":"https://doi.org/10.4103/aja202256","url":null,"abstract":"<p><p>The purpose of this study was to analyze the value of transrectal shear-wave elastography (SWE) in combination with multivariable tools for predicting adverse pathological features before radical prostatectomy (RP). Preoperative clinicopathological variables, multiparametric magnetic resonance imaging (mp-MRI) manifestations, and the maximum elastic value of the prostate (Emax) on SWE were retrospectively collected. The accuracy of SWE for predicting adverse pathological features was evaluated based on postoperative pathology, and parameters with statistical significance were selected. The diagnostic performance of various models, including preoperative clinicopathological variables (model 1), preoperative clinicopathological variables + mp-MRI (model 2), and preoperative clinicopathological variables + mp-MRI + SWE (model 3), was evaluated with area under the receiver operator characteristic curve (AUC) analysis. Emax was significantly higher in prostate cancer with extracapsular extension (ECE) or seminal vesicle invasion (SVI) with both P < 0.001. The optimal cutoff Emax values for ECE and SVI were 60.45 kPa and 81.55 kPa, respectively. Inclusion of mp-MRI and SWE improved discrimination by clinical models for ECE (model 2 vs model 1, P = 0.031; model 3 vs model 1, P = 0.002; model 3 vs model 2, P = 0.018) and SVI (model 2 vs model 1, P = 0.147; model 3 vs model 1, P = 0.037; model 3 vs model 2, P = 0.134). SWE is valuable for identifying patients at high risk of adverse pathology.</p>","PeriodicalId":8483,"journal":{"name":"Asian Journal of Andrology","volume":"25 2","pages":"259-264"},"PeriodicalIF":2.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e8/f3/AJA-25-259.PMC10069689.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9613225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}