Fibrinolysis最新文献_第10页

5 Characterization of the 5′-regulatory region in normal and abnormal plasminogen genes and their related genes 5正常和异常纤溶酶原基因中5 '调控区及其相关基因的表征

Fibrinolysis Pub Date : 1996-06-01 DOI: 10.1016/S0268-9499(96)80093-2

引用次数: 0

Isolation and storage of DNA for population studies 群体研究中DNA的分离和储存

Fibrinolysis Pub Date : 1996-06-01 DOI: 10.1016/S0268-9499(96)80041-5

S. Droog, N. Lakenberg, I. Meulenbelt, M.P.M. de Maat, L.G.M. Huisman, A.F.H. Jie, P.E. Slagboom

引用次数: 6

Activation of coagulation and fibrinolysis in HIV-infected patients hiv感染者凝血和纤溶的激活

Fibrinolysis Pub Date : 1996-06-01 DOI: 10.1016/S0268-9499(96)80051-8

P. Toulon , J.C. Gris , N. Candia , D. Salmon , D. Sereni , D. Sicard , J.F. Schved

{"title":"Activation of coagulation and fibrinolysis in HIV-infected patients","authors":"P. Toulon , J.C. Gris , N. Candia , D. Salmon , D. Sereni , D. Sicard , J.F. Schved","doi":"10.1016/S0268-9499(96)80051-8","DOIUrl":"https://doi.org/10.1016/S0268-9499(96)80051-8","url":null,"abstract":"<div><p>Various coagulation abnormalities were reported in HIV-infected patients, which were usually considered as risk factors for thrombosis in the general population or in other disease states. This study was undertaken to determine whether HIV-infection was associated with an on-going pre/prothrombotic state. For that purpose, 70 consecutive HIV-infected out-patients were evaluated at distance of any acute episode. (55 males and 15 females with a mean age of 34 years, range: 19–69). 29 patients (41%) with a CD4+ lymphocytes count below 200 × 10<sup>6</sup>/L were classified as having AIDS. The control group consisted of 33 age and sex-matched healthy individuals. The plasma levels of sensitive markers of thrombin generation (prothrombin fragment 1+2 and thrombin-antithrombin complex), plasmin generation (plasmin-plasmin inhibitor complex), and plasmin activity (fibrin degradation products) were measured using ELISAs. The plasma level of these markers were significantly higher in HIV-infected patients than in healthy HIV-negative controls. Moreover, the plasma levels of these markers were found to be highly significantly correlated (p<0.001) in the patients group, suggesting an increased activation of both coagulation and fibrinolysis. However, despite trends toward increasing levels with decreasing CD4+ lymphocyte count, the plasma levels of these markers were not significantly different in AIDS and in non AIDS patients (classified upon the CD4+ lymphocytes count below and above 200 × 10<sup>6</sup>/L). These results suggest that HIV-infection is associated with an activation of both the coagulation and fibrinolytic systems, which could lead to a prothrombotic state in some of the patients.</p></div>","PeriodicalId":84750,"journal":{"name":"Fibrinolysis","volume":"10 ","pages":"Pages 59-61"},"PeriodicalIF":0.0,"publicationDate":"1996-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0268-9499(96)80051-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71796863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Urokinase and tissue-type plasminogen activator stimulate human vascular smooth muscle cell migration 尿激酶和组织型纤溶酶原激活剂刺激人血管平滑肌细胞迁移

Fibrinolysis Pub Date : 1996-06-01 DOI: 10.1016/S0268-9499(96)80055-5

M.J. Wijnberg, N.M.E. Nieuwenbroek, J. Slomp, P.H.A. Quax, J.H. Verheijen

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引用次数: 7

83 Analysis of conformational changes of plasminogen induced by monoclonal antibody 83单克隆抗体诱导纤溶酶原构象变化分析

Fibrinolysis Pub Date : 1996-06-01 DOI: 10.1016/S0268-9499(96)80170-6

引用次数: 0

51 Cyclic AMP-mediated signal transduction in urokinase-induced monocyte adhesion 循环amp介导的信号转导在尿激酶诱导单核细胞粘附中的作用

Fibrinolysis Pub Date : 1996-06-01 DOI: 10.1016/S0268-9499(96)80139-1

引用次数: 0

52 Role of pp60 Src in uPAR-dependent myelomonocytic adherence pp60 Src在upar依赖性骨髓单核细胞粘附中的作用

Fibrinolysis Pub Date : 1996-06-01 DOI: 10.1016/S0268-9499(96)80140-8

引用次数: 0

41 Plasminogen activator inhibitor type 2 forms intracellular polymers and has a cell-specific secretion pattern 2型纤溶酶原激活物抑制剂形成细胞内聚合物，具有细胞特异性分泌模式

Fibrinolysis Pub Date : 1996-06-01 DOI: 10.1016/S0268-9499(96)80129-9