Chungang uihak = The Korean central journal of medicine最新文献_第9页

Heterologous Vaccination for Preparing COVID-19 Pandemic 异源疫苗预防COVID-19大流行

Chungang uihak = The Korean central journal of medicine Pub Date : 2021-12-01 DOI: 10.3904/kjm.2021.96.6.450

Tae Hyong Kim

引用次数: 0

Molecular Risk Stratification using Next-generation Sequencing in Acute Myeloid Leukemia 新一代测序在急性髓系白血病中的分子风险分层

Chungang uihak = The Korean central journal of medicine Pub Date : 2021-12-01 DOI: 10.3904/kjm.2021.96.6.493

Jae-Sook Ahn

引用次数: 0

The Advantages and Disadvantages of Prokinetics 原动力学的优点和缺点

Chungang uihak = The Korean central journal of medicine Pub Date : 2021-12-01 DOI: 10.3904/kjm.2021.96.6.478

Jeongkuk Seo, K. Jung

引用次数: 0

Adverse Drug Reactions to First-line Anti-tubercular Drugs Based on Individual Case Safety Report in a Single Tertiary Hospital 一线抗结核药物不良反应——基于某三级医院个案安全报告的分析

Chungang uihak = The Korean central journal of medicine Pub Date : 2021-10-01 DOI: 10.3904/kjm.2021.96.5.421

Hyun Hwa Kim, M. Moon, Nigh Choi, D. Kang, K. Chae, Jungsil Lee, Jaesung Lim, Sang-Heon Cho, H. Kang

{"title":"Adverse Drug Reactions to First-line Anti-tubercular Drugs Based on Individual Case Safety Report in a Single Tertiary Hospital","authors":"Hyun Hwa Kim, M. Moon, Nigh Choi, D. Kang, K. Chae, Jungsil Lee, Jaesung Lim, Sang-Heon Cho, H. Kang","doi":"10.3904/kjm.2021.96.5.421","DOIUrl":"https://doi.org/10.3904/kjm.2021.96.5.421","url":null,"abstract":"Background/Aims: Tuberculosis has incidence and mortality rates that are among the highest for all communicable diseases. Adverse drug reactions (ADRs) to anti-tubercular drugs are common, and have a major impact on treatment maintenance and prognosis. It is important to understand the characteristics of ADRs and establish a suitable management plan. Methods: We retrospectively reviewed patients with ADRs during treatment with first-line antitubercular drugs such as isoniazid, rifampicin, ethambutol, and pyrazinamide from 2009 to 2018. Age, sex, and total treatment period, and the onset, severity, seriousness, and system organ class of ADRs, were analyzed to understand the characteristics of first-line anti-tubercular drug-related ADRs. Results: A total of 1,606 of 5,482 patients (29.3%) experienced ADRs after administration of first-line anti-tubercular drugs. The incidence of ADRs related to isoniazid, rifampicin, ethambutol, and pyrazinamide was 22.2%, 21.3%, 24.5%, and 29.6%, respectively. A total of 2,098 ADR reports were made (mean of 1.3 ± 0.6 per patient). The rates of mild, moderate, and severe ADRs were 32.4%, 61.1%, and 6.5%, respectively. There were 127 reports (6.1%) of serious ADRs. Skin and appendage disorders were most frequently reported (27.5%), followed by gastrointestinal disorders (17.5%), and liver and biliary system disorders (13.1%). The total treatment period was longer in patients who experienced ADRs (224.0 ± 3.1 days vs. 247.0 ± 4.7 days, p = 0.009). Conclusions: The incidence of ADRs to first-line anti-tuberculosis drugs was 29.3%, and 6.5% were severe ADRS. ADRs prolonged the overall treatment duration, indicating the importance of their detection and management.","PeriodicalId":84452,"journal":{"name":"Chungang uihak = The Korean central journal of medicine","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87606229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Rapid Tests for the Diagnosis of Viral Infections 诊断病毒感染的快速试验

Chungang uihak = The Korean central journal of medicine Pub Date : 2021-10-01 DOI: 10.3904/kjm.2021.96.5.415

Hyun Soo Kim

引用次数: 0

Screening Tests for Early Diagnosis of Multiple Myeloma and Related Plasma Cell Disorders 早期诊断多发性骨髓瘤及相关浆细胞疾病的筛选试验

Chungang uihak = The Korean central journal of medicine Pub Date : 2021-10-01 DOI: 10.3904/kjm.2021.96.5.371

Jin Seok Kim, Sung-Soo Yoon, C. Min, Je-Jung Lee, D. Yoon, Kihyun Kim

{"title":"Screening Tests for Early Diagnosis of Multiple Myeloma and Related Plasma Cell Disorders","authors":"Jin Seok Kim, Sung-Soo Yoon, C. Min, Je-Jung Lee, D. Yoon, Kihyun Kim","doi":"10.3904/kjm.2021.96.5.371","DOIUrl":"https://doi.org/10.3904/kjm.2021.96.5.371","url":null,"abstract":"Monoclonal gammopathy (MG) encompasses a diverse group of disorders characterized by the secretion of monoclonal immunoglobulins or their light-chain components. The incidence of multiple myeloma (MM) in South Korea is rapidly increasing, and it is important to be aware of its initial clinical presentations and the most efficient laboratory algorithms for early detection. Serum protein electrophoresis (SPE) and urine protein electrophoresis (UPE) are the primary screening tests for patients with clinically suspected MM or amyloid light-chain amyloidosis; these tests are reimbursed in South Korea. We reviewed clinical studies that applied national and international guidelines to evaluate test panels for early detection of MGs, including MM. The serum free light chain (sFLC) with SPE panel is recommended for the initial work up for diagnosis of MGs. In the case of a normal SPE, sFLC should be measured subsequently, so as not to miss the presence of M-protein. Use of this screening panel avoids medical expenses related to delayed diagnosis. Guidelines and recommendations suggest that no single method (SPE, serum immunofixation electrophoresis, sFLC, or UPE) should be used to exclude a diagnosis of MM. We believe that a screening test panel comprising SPE plus sFLC will increase the rate of early and accurate diagnosis of MM and related disorders.","PeriodicalId":84452,"journal":{"name":"Chungang uihak = The Korean central journal of medicine","volume":"318 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79703717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis and Treatment of Adult Growth Hormone Deficiency 成人生长激素缺乏的诊断与治疗

Chungang uihak = The Korean central journal of medicine Pub Date : 2021-10-01 DOI: 10.3904/kjm.2021.96.5.400

J. H. Kim

引用次数: 0

The 2021 Korean Heart Rhythm Society Guidelines for a New Approach and Integrated Management of Atrial Fibrillation 2021韩国心律学会心房颤动的新方法和综合管理指南

Chungang uihak = The Korean central journal of medicine Pub Date : 2021-10-01 DOI: 10.3904/kjm.2021.96.5.382

Junbeum Park, M. Cha, Y. Baek, M. Cho, B. Joung

{"title":"The 2021 Korean Heart Rhythm Society Guidelines for a New Approach and Integrated Management of Atrial Fibrillation","authors":"Junbeum Park, M. Cha, Y. Baek, M. Cho, B. Joung","doi":"10.3904/kjm.2021.96.5.382","DOIUrl":"https://doi.org/10.3904/kjm.2021.96.5.382","url":null,"abstract":"The prevalence of atrial fibrillation (AF) is gradually increasing with the aging of the population, and there is also increasing interest in AF with the development of various single-lead electrocardiography measurement methods for diagnosis. Further, the current diagnosis and treatment policies for AF do not reflect its progression and complexity. In addition, the various factors related to AF diagnosis and treatment are not simple due to the diversification of tools, advances in treatment methods, and complex mechanism of AF. Therefore, there are many challenges to developing a simple AF classification system. To overcome these, there have been a number of attempts to systematically characterize AF according to treatment and prognosis rather than using a uniform classification. Further, as mentioned in the previous AF guidelines, further research is being conducted on an integrated patient–physician approach to AF. Such an approach would be the basis for consistent treatment based on the guidelines, and would help to improve patient outcomes. Further, for the integrated management of AF patients, some changes should be made to the current approach to develop a multidisciplinary approach, including changes to the behavior of team members, patients, their family members, and physicians. The Korean Heart Rhythm will introduce an integrated approach to the classification and structure of AF management, and provide guidelines for its application in clinical practice.","PeriodicalId":84452,"journal":{"name":"Chungang uihak = The Korean central journal of medicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89666953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Fibromuscular Dysplasia with Postpartum Renal Artery Rupture in a Non-Hypertensive Woman 非高血压妇女产后肾动脉破裂合并纤维肌肉发育不良1例

Chungang uihak = The Korean central journal of medicine Pub Date : 2021-10-01 DOI: 10.3904/kjm.2021.96.5.438

Eunjoo Kim, Y. Won, Y. Kim, Inhye Shin, Young Ok Kim

引用次数: 0

Recent Advances in Drug Susceptible Pulmonary Tuberculosis Diagnosis and Treatment 药物敏感肺结核诊断与治疗的最新进展

Chungang uihak = The Korean central journal of medicine Pub Date : 2021-10-01 DOI: 10.3904/kjm.2021.96.5.390

Jiwon Lyu, T. Shim

{"title":"Recent Advances in Drug Susceptible Pulmonary Tuberculosis Diagnosis and Treatment","authors":"Jiwon Lyu, T. Shim","doi":"10.3904/kjm.2021.96.5.390","DOIUrl":"https://doi.org/10.3904/kjm.2021.96.5.390","url":null,"abstract":"The most important thing for the management of drug susceptible pulmonary tuberculosis is to diagnose active pulmonary tuberculosis as soon as possible and prevent the occurrence of new patients through appropriate treatment. Therefore, it should be a priority to quickly detect tuberculosis mycobacterium and quickly exclude drug-resistant tuberculosis before treatment begins. To this end, recent guidelines recommend the general use of Mycobacterium tuberculosis (MTB) polymerase chain reaction (PCR) tests, Xpert MTB/RIF tests, and rapid sensitivity tests through line probe assay (LPA). In addition, if the results of the test are positive, it is important to establish an in-hospital reporting system so that rapid reporting can be made. The treatment principle for drug susceptible pulmonary tuberculosis is 2 months of initial intensive phase (isoniazid, rifampin, ethambutol, pyrazinamide) followed by 4 months of maintenance phase (isoniazid, rifampin). Despite global efforts to shorten the duration of the treatment, the treatment of drug susceptible pulmonary tuberculosis has not changed for more than 35 years, and problems such as increased side effects and reduced drug adherence are serious obstacles to tuberculosis management. Therefore, efforts have been steadily made to shorten the treatment period through the combination of new drugs worldwide, and after many failures, they are finally paying off. A recently published Study 31/A5349 study found that 4 months short-term regimen using rifapentine (RPT) and moxifloxacin (MFX) demonstrated non-inferiority in existing standard regimen, as the result, a revision of World Health Organization guidelines is scheduled that 4 months short-term regimen using RPT and MFX may be an alternative. However, it is unlikely that RPT/MFX 4 months short-term regimen will be applied immediately in Korea because the use of RPT is currently limited in Korea due to the high frequency of side effects.","PeriodicalId":84452,"journal":{"name":"Chungang uihak = The Korean central journal of medicine","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75267624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0