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The Impact of Pulmonary Hypertension on the Clinical Outcomes of Acute Myocardial Infarction after Percutaneous Coronary Intervention 肺动脉高压对经皮冠状动脉介入治疗后急性心肌梗死临床结局的影响
Chungang uihak = The Korean central journal of medicine Pub Date : 2022-08-01 DOI: 10.3904/kjm.2022.97.4.257
E. Cho, M. Jeong, Hyung Yoon Kim, H. Park, H. Yoon, Kye-Hun Kim, Y. Ahn
{"title":"The Impact of Pulmonary Hypertension on the Clinical Outcomes of Acute Myocardial Infarction after Percutaneous Coronary Intervention","authors":"E. Cho, M. Jeong, Hyung Yoon Kim, H. Park, H. Yoon, Kye-Hun Kim, Y. Ahn","doi":"10.3904/kjm.2022.97.4.257","DOIUrl":"https://doi.org/10.3904/kjm.2022.97.4.257","url":null,"abstract":"Background/Aims: Pulmonary hypertension (PH) in patients with heart failure contributes to a poor prognosis. However, the role of PH in the long-term clinical outcome is unclear in those with acute myocardial infarction (AMI). The clinical significance of elevated right ventricular systolic pressure (RVSP) on routine echocardiography is underestimated.Methods: This study enrolled 2,526 AMI patients (65.1 ± 12.7 years; 1,757 males [69.6%]) from the Korean AMI registry who underwent successful percutaneous coronary intervention and pre-discharge transthoracic echocardiography (TTE). The patients were divided into four groups according to the RVSP on TTE: normal RVSP (RVSP < 35 mmHg, n = 1,695), mild PH (35 ≤ RVSP < 45 mmHg, n = 601), moderate PH (45 ≤ RVSP < 70 mmHg, n = 211), and severe PH (RVSP ≥ 70 mmHg, n = 19). Major adverse cardiac events (MACE) were compared among the four groups.Results: During the 3-year clinical follow-up period, MACE occurred in 562 patients (22.2%), including 321 (18.9%), 145 (24.1%), 83 (39.3%), and 13 patients (68.4%) in the normal RVSP and mild, moderate, and severe PH groups, respectively. On multivariate analysis, independent factors for MACE were moderate or severe PH, age ≥ 65 years, Killip class ≥ III, left ventricular ejection fraction < 40%, hypertension, and diabetes.Conclusions: Measuring RVSP is useful for stratifying the risk of patients with AMI; MACE occurred in patients with moderate or severe PH.","PeriodicalId":84452,"journal":{"name":"Chungang uihak = The Korean central journal of medicine","volume":"183 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74921534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chimeric Antigen Receptor-T Cell Therapy 嵌合抗原受体- t细胞疗法
Chungang uihak = The Korean central journal of medicine Pub Date : 2022-08-01 DOI: 10.3904/kjm.2022.97.4.229
J. Byun, Sung-Soo Yoon
{"title":"Chimeric Antigen Receptor-T Cell Therapy","authors":"J. Byun, Sung-Soo Yoon","doi":"10.3904/kjm.2022.97.4.229","DOIUrl":"https://doi.org/10.3904/kjm.2022.97.4.229","url":null,"abstract":"Chimeric antigen receptor (CAR) T-cell therapy constitutes a revolutionary advancement in personalized cancer treatment. During this treatment, a patient's own T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen. CAR-T cells are then expanded for clinical use and infused back into the patient's body to attack cancer. CAR-T cells have produced remarkable clinical responses with B-cell malignancies. However, CAR-T cells therapy is not without problems. Barriers to effective CAR-T cells therapy include severe life-threatening toxicities and modest anti-tumor activity. In this review, we introduce the concept of CAR-T cells therapy, currently available CAR-T cells therapy options, and how to deal with adverse events.","PeriodicalId":84452,"journal":{"name":"Chungang uihak = The Korean central journal of medicine","volume":"122 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74336322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis of Small Intestinal Bacterial Overgrowth 小肠细菌过度生长的诊断
Chungang uihak = The Korean central journal of medicine Pub Date : 2022-08-01 DOI: 10.3904/kjm.2022.97.4.253
Tae Hee Lee
{"title":"Diagnosis of Small Intestinal Bacterial Overgrowth","authors":"Tae Hee Lee","doi":"10.3904/kjm.2022.97.4.253","DOIUrl":"https://doi.org/10.3904/kjm.2022.97.4.253","url":null,"abstract":"Small intestinal bacterial overgrowth (SIBO) occurs when the small bowel is colonized by high numbers of abnormal microorganisms. There is no gold standard diagnostic test for SIBO. Both small bowel aspiration and breath testing have limitations as diagnostic tests. However, breath testing has the practical advantages of being readily available, inexpensive, and noninvasive.","PeriodicalId":84452,"journal":{"name":"Chungang uihak = The Korean central journal of medicine","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73839126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Consensus Document on Perioperative Antithrombotic Management: Part 2. Case Study 围手术期抗血栓管理共识文件:第2部分。案例研究
Chungang uihak = The Korean central journal of medicine Pub Date : 2022-08-01 DOI: 10.3904/kjm.2022.97.4.204
Yongwhi Park, A. Her, Hyun Kuk Kim, J. Moon, J. Park, K. Park, Kyung Hoon Lee, H. Joo, Ho-Yeon Won, S. Ahn, H. Park, Sung‐Jin Hong, B. Kim, S. Ban, J. Suh, Y. Song, J. Cho, Y. Jeong, Weon Kim, E. Shin
{"title":"Consensus Document on Perioperative Antithrombotic Management: Part 2. Case Study","authors":"Yongwhi Park, A. Her, Hyun Kuk Kim, J. Moon, J. Park, K. Park, Kyung Hoon Lee, H. Joo, Ho-Yeon Won, S. Ahn, H. Park, Sung‐Jin Hong, B. Kim, S. Ban, J. Suh, Y. Song, J. Cho, Y. Jeong, Weon Kim, E. Shin","doi":"10.3904/kjm.2022.97.4.204","DOIUrl":"https://doi.org/10.3904/kjm.2022.97.4.204","url":null,"abstract":"Given the progressive improvements in antithrombotic strategies, management of cardiovascular disease has become sophisticated/refined. However, the optimal perioperative management of antithrombotic therapy in patients with acute coronary syndrome or who are scheduled for percutaneous coronary intervention remains unclear. Assessments of the thrombotic and hemorrhagic risks are essential to reduce the rates of mortality and major cardiac events. However, the existing guidelines do not mention these topics. This case-based consensus document deals with common clinical scenarios and offers evidence-based guidelines for individualized perioperative management of antithrombotic therapy in the real world.","PeriodicalId":84452,"journal":{"name":"Chungang uihak = The Korean central journal of medicine","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74436271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient Safety and Quality Improvement in Hospital Medicine 医院医学中的患者安全与质量改进
Chungang uihak = The Korean central journal of medicine Pub Date : 2022-08-01 DOI: 10.3904/kjm.2022.97.4.238
Jisoo Jeong, J. Ohn
{"title":"Patient Safety and Quality Improvement in Hospital Medicine","authors":"Jisoo Jeong, J. Ohn","doi":"10.3904/kjm.2022.97.4.238","DOIUrl":"https://doi.org/10.3904/kjm.2022.97.4.238","url":null,"abstract":"Hospitalists are specialists in inpatient care who aim to improve patient safety and quality of care. Accordingly, hospitalist research focuses on patient safety and quality improvement (QI). Major hospital medicine journals publish studies on patient safety and QI. This review introduces the latest research related to patient safety and QI research in the field of hospital medicine.","PeriodicalId":84452,"journal":{"name":"Chungang uihak = The Korean central journal of medicine","volume":"112 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84159735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Diagnosis and Management of Comorbidities Associated with Bronchiectasis 支气管扩张相关合并症的诊断和治疗
Chungang uihak = The Korean central journal of medicine Pub Date : 2022-08-01 DOI: 10.3904/kjm.2022.97.4.244
Hayoung Choi, Hyun Lee
{"title":"Diagnosis and Management of Comorbidities Associated with Bronchiectasis","authors":"Hayoung Choi, Hyun Lee","doi":"10.3904/kjm.2022.97.4.244","DOIUrl":"https://doi.org/10.3904/kjm.2022.97.4.244","url":null,"abstract":"Patients with non-cystic fibrosis bronchiectasis (hereafter referred to as bronchiectasis) often present with comorbidities. These comorbidities significantly impact symptoms, acute exacerbation, hospitalization, disease progression, and mortality in patients with bronchiectasis. Thus, accurate diagnosis and management of comorbidities associated with bronchiectasis are essential to reduce the disease burden of bronchiectasis. This review provides a state-of-the-art summary of key pulmonary and extra-pulmonary comorbidities associated with bronchiectasis, outlines clinical tools to quantify the prognosis of bronchiectasis, and suggests a workflow to diagnose and manage comorbidities associated with bronchiectasis.","PeriodicalId":84452,"journal":{"name":"Chungang uihak = The Korean central journal of medicine","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84315009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What is the Fee for Infection Prevention and Control? Current Status and Prospect 预防和控制感染的费用是多少?现状与展望
Chungang uihak = The Korean central journal of medicine Pub Date : 2022-08-01 DOI: 10.3904/kjm.2022.97.4.199
J. Eom
{"title":"What is the Fee for Infection Prevention and Control? Current Status and Prospect","authors":"J. Eom","doi":"10.3904/kjm.2022.97.4.199","DOIUrl":"https://doi.org/10.3904/kjm.2022.97.4.199","url":null,"abstract":"Infection control is an essential factor for improving the quality of acute and long-term care facilities, including patient safety. Infection control should be implemented in all medical facility sectors, and participation of all healthcare workers is required. For efficient infection control, securing and maintaining professionals with sufficient experience and training to establish and implement infection control plans focusing the infection control unit is imperative. Moreover, there should be no shortage of infection control supplies, including consumables and disposables necessary for hand hygiene, personal protective equipment, and isolation. The fee for infection prevention and control should be resourced as necessary funding to establish such infection control infrastructure. Moreover, re-evaluating whether the standard for the fee for infection prevention and control is appropriate, improving the current payment mode, and monitoring whether the fee used is executed as infection control costs are necessary.","PeriodicalId":84452,"journal":{"name":"Chungang uihak = The Korean central journal of medicine","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85145097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Renal Infarction in Vascular Ehlers-Danlos Syndrome 血管性埃勒-丹洛斯综合征的肾梗死
Chungang uihak = The Korean central journal of medicine Pub Date : 2022-08-01 DOI: 10.3904/kjm.2022.97.4.271
Hea Ran Lee, Si Chan Kim, E. Yang, Susanne Jung, J. Chang, Eun Kyoung Lee
{"title":"Renal Infarction in Vascular Ehlers-Danlos Syndrome","authors":"Hea Ran Lee, Si Chan Kim, E. Yang, Susanne Jung, J. Chang, Eun Kyoung Lee","doi":"10.3904/kjm.2022.97.4.271","DOIUrl":"https://doi.org/10.3904/kjm.2022.97.4.271","url":null,"abstract":"Renal infarction is a condition caused by sudden disturbance of renal arterial blood flow, which occurs frequently in cardioembolic disease, renal artery injury (trauma, Marfan syndrome, rarely Ehlers-Danlos syndrome), and in association with a hypercoagulable state. Ehlers-Danlos syndrome is a rare hereditary connective tissue disease characterized by skin fragility, hyperelasticity, hypermobility of small joints, and easy bruising. Among the subtypes, vascular Ehlers-Danlos syndrome is a very rare genetic disease caused by a mutation in the COL3A1 gene. As blood vessels are fragile due dysfunctional collagen synthesis, complications of bleeding due to arterial dissection or rupture are common in patients with this disease. Here, we report a case of vascular Ehlers-Danlos syndrome diagnosed based on a renal infarction caused by thrombus and renal artery injury; we also present a review of the relevant literature.","PeriodicalId":84452,"journal":{"name":"Chungang uihak = The Korean central journal of medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89823723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraductal Radiofrequency Ablation as a Palliative Treatment for Advanced Malignant Hilar Biliary Obstruction 导管内射频消融作为晚期恶性肝门胆道梗阻的姑息性治疗
Chungang uihak = The Korean central journal of medicine Pub Date : 2022-06-01 DOI: 10.3904/kjm.2022.97.3.164
Huapyong Kang, E. Kim, Yeonsuk Kim
{"title":"Intraductal Radiofrequency Ablation as a Palliative Treatment for Advanced Malignant Hilar Biliary Obstruction","authors":"Huapyong Kang, E. Kim, Yeonsuk Kim","doi":"10.3904/kjm.2022.97.3.164","DOIUrl":"https://doi.org/10.3904/kjm.2022.97.3.164","url":null,"abstract":"Malignant hilar biliary obstruction (MHBO) frequently accompanies cholestasis and cholangitis, and requires biliary stent placement. To prevent stent occlusion and prolong survival, local ablation therapy can be considered adjunctive to stent placement. Intraductal radiofrequency ablation (ID-RFA) is a recently developed local therapy for malignant biliary obstruction that can be easily performed employing endoscopic retrograde cholangiography. The use of ID-RFA to treat MHBO (as distinct from distal biliary obstruction) was suggested to be associated with severe adverse events. However, recent comparative studies have shown that ID-RFA is feasible and safe, and acceptably efficacious, in patients with advanced MHBO; newer temperature-controlled ID-RFA devices may enhance safety further. Regularly repeated ID-RFA with stent exchange affords better survival than stenting alone. However, the optimal ID-RFA strategy for MHBO remains inconclusive given the lack of data. Further large-scale clinical trials are needed.","PeriodicalId":84452,"journal":{"name":"Chungang uihak = The Korean central journal of medicine","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91164618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crohn’s Disease Identified as Granulomatous Tubulointerstitial Nephritis 克罗恩病被鉴定为肉芽肿性小管间质性肾炎
Chungang uihak = The Korean central journal of medicine Pub Date : 2022-06-01 DOI: 10.3904/kjm.2022.97.3.186
Jung Suk Han, B. Choi, C. Park, Yeong-jin Choi, Chul-woo Yang, Hanbi Lee, T. Ban
{"title":"Crohn’s Disease Identified as Granulomatous Tubulointerstitial Nephritis","authors":"Jung Suk Han, B. Choi, C. Park, Yeong-jin Choi, Chul-woo Yang, Hanbi Lee, T. Ban","doi":"10.3904/kjm.2022.97.3.186","DOIUrl":"https://doi.org/10.3904/kjm.2022.97.3.186","url":null,"abstract":"Crohn’s disease is usually diagnosed according to intestinal symptoms, but extra-intestinal manifestations are important in approximately one-third of cases. Although several extra-intestinal symptoms associated with various organs have been reported, renal involvement is uncommon in patients with Crohn’s disease. Tubulointerstitial nephritis in a patient with Crohn’s disease is usually caused by infection, sarcoidosis, or medications. However, primary tubulointerstitial nephritis caused by Crohn’s disease alone is extremely rare. A 19-year-old male patient was referred to our hospital because of an increase in serum creatinine level. He underwent a kidney biopsy with renal insufficiency. Renal histological findings revealed granulomatous tubulointerstitial nephritis. Thereafter, a colonoscopy was performed with suspicion of Crohn’s disease. Ultimately, he was diagnosed with granulomatous tubulointerstitial nephritis based on Crohn’s disease. The patient had improved gastrointestinal symptoms after the last treatment. This case report presents a rare case of primary tubulointerstitial nephritis caused by Crohn’s disease.","PeriodicalId":84452,"journal":{"name":"Chungang uihak = The Korean central journal of medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87502768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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