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Arthritis and rheumatism最新文献

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Double-blind, Randomized, 8-week Placebo-controlled followed by a 16-week open label extension study, with the LPA1 receptor antagonist SAR100842 for Patients With Diffuse Cutaneous Systemic Sclerosis 双盲，随机，8周安慰剂对照，随后是16周的开放标签扩展研究，LPA1受体拮抗剂SAR100842用于弥漫性皮肤系统性硬化症患者
Arthritis and rheumatism Pub Date : 2018-05-06 DOI: 10.5167/UZH-151637
Y. Allanore, O. Distler, A. Jagerschmidt, S. Illiano, Laetitia Ledein, E. Boitier, I. Agueusop, C. Denton, D. Khanna
{"title":"Double-blind, Randomized, 8-week Placebo-controlled followed by a 16-week open label extension study, with the LPA1 receptor antagonist SAR100842 for Patients With Diffuse Cutaneous Systemic Sclerosis","authors":"Y. Allanore, O. Distler, A. Jagerschmidt, S. Illiano, Laetitia Ledein, E. Boitier, I. Agueusop, C. Denton, D. Khanna","doi":"10.5167/UZH-151637","DOIUrl":"https://doi.org/10.5167/UZH-151637","url":null,"abstract":"BACKGROUND Preclinical studies suggest a role for lysophosphatidic acid (LPA) in the pathogenesis of systemic sclerosis (SSc). OBJECTIVES SAR100842, a potent selective oral antagonist of LPA1 receptor, was assessed for safety, biomarkers and clinical efficacy in patients with diffuse cutaneous SSc (dcSSc). METHODS An 8-week double-blind, randomized, placebo-controlled study followed by a 16-week open label extension with SAR100842 was performed in patients with early dcSSc and a baseline Rodnan skin score (mRSS) of at least 15. The primary endpoint was safety during the double-blind phase of the trial. Exploratory endpoints included the identification of a LPA-induced gene signature in patients 'skin. RESULTS 17 of 32 subjects were randomized to placebo and 15 to SAR100842; 30 patients participated in the extension study. The most frequent adverse events reported for SAR100842 during the blinded phase were headache, diarrhea, nausea and fall and the safety profile was acceptable during the extension part. At Week 8, mean reduction in mRSS was numerically greater in the SAR100842 compared to placebo (mean change [SD]: -3.57 [4.18] versus -2.76 [4.85]; difference [95% CI]: -1.2 [-4.37 to 2.02], p=0.46). A greater reduction of LPA related genes was observed in skin of SAR100842 group at Week 8, indicating LPA target engagement. CONCLUSION SAR100842, a selective orally available LPA receptor antagonist, was well tolerated in patients with dcSSc. MRSS improved during the study although not reaching significance, and additional gene signature analysis suggested target engagement. These results need to be confirmed in a larger controlled trial. This article is protected by copyright. All rights reserved.","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":"70 1","pages":"1634-1643"},"PeriodicalIF":0.0,"publicationDate":"2018-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41424214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Secukinumab Achievement of Psoriatic Arthritis Disease Activity Score (PASDAS) Related Remission: 2-Year Results from a Phase 3 Study Secukinumab实现银屑病关节炎疾病活动评分(PASDAS)相关缓解:来自3期研究的2年结果
Arthritis and rheumatism Pub Date : 2018-02-23 DOI: 10.25251/SKIN.2.SUPP.17
L. Coates, D. Gladman, P. Nash, O. FitzGerald, A. Kavanaugh, L. Rasouliyan, L. Pricop, K. Ding, C. Gaillez
{"title":"Secukinumab Achievement of Psoriatic Arthritis Disease Activity Score (PASDAS) Related Remission: 2-Year Results from a Phase 3 Study","authors":"L. Coates, D. Gladman, P. Nash, O. FitzGerald, A. Kavanaugh, L. Rasouliyan, L. Pricop, K. Ding, C. Gaillez","doi":"10.25251/SKIN.2.SUPP.17","DOIUrl":"https://doi.org/10.25251/SKIN.2.SUPP.17","url":null,"abstract":"Abstract not available. Disclosures:  Study sponsored by Novartis. Copyright 2018 SKIN","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":"69 1","pages":"2657-2658"},"PeriodicalIF":0.0,"publicationDate":"2018-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43786896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of methods to quantitatively evaluate global synovitis activity with FDG-PET/CT FDG-PET/CT定量评价滑膜炎活动性的方法评价
Arthritis and rheumatism Pub Date : 2017-01-01 DOI: 10.1002/ART.4032
William Y. Raynor, V. Jonnakuti, Kaiyuan Zheng, P. Høilund-Carlsen, A. Alavi, J. Baker
{"title":"Assessment of methods to quantitatively evaluate global synovitis activity with FDG-PET/CT","authors":"William Y. Raynor, V. Jonnakuti, Kaiyuan Zheng, P. Høilund-Carlsen, A. Alavi, J. Baker","doi":"10.1002/ART.4032","DOIUrl":"https://doi.org/10.1002/ART.4032","url":null,"abstract":"","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":"69 1","pages":"2011"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51519159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibodies Against Domain 1 and Domain 4/5 of β2 Glycoprotein I : Clinical Relevance in Obstetric Anti-Phospholipid Syndrome 抗β2糖蛋白I结构域1和结构域4/5抗体:与产科抗磷脂综合征的临床相关性
Arthritis and rheumatism Pub Date : 2016-11-01 DOI: 10.1002/art.39977/full
C. Chighizola, L. Andreoli, M. Tonello, M. Raimondo, F. Pregnolato, C. Nalli, E. Mattia, L. Cesana, R. Kumar, C. Comerio, C. Grossi, F. Mombelli, M. Gerosa, M. Borghi, A. Ruffatti, A. Tincani, Marcus John Beasley
{"title":"Antibodies Against Domain 1 and Domain 4/5 of β2 Glycoprotein I : Clinical Relevance in Obstetric Anti-Phospholipid Syndrome","authors":"C. Chighizola, L. Andreoli, M. Tonello, M. Raimondo, F. Pregnolato, C. Nalli, E. Mattia, L. Cesana, R. Kumar, C. Comerio, C. Grossi, F. Mombelli, M. Gerosa, M. Borghi, A. Ruffatti, A. Tincani, Marcus John Beasley","doi":"10.1002/art.39977/full","DOIUrl":"https://doi.org/10.1002/art.39977/full","url":null,"abstract":"Ayten Yazici , OZAN UNLU , Cecilia B. Chighizola , Doruk Erkan , Michelle Petri and On Behalf of APS ACTION . , Hospital for Special Surgery, Cornell Weill Cornell Medicine, NEW YORK CITY, NY, Turkey, Rheumatology, Kocaeli University School of Medicine, Kocaeli, Turkey, Rheumatology Department, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, Department of Clinical Sciences and Community Health, University of Milan, IRCCS Istituto Auxologico Italiano, Milano, Italy, Rheumatology, Hospital for Special SurgeryWeill Cornell Medicine, New York, NY, Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD, ., New York, NY","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51519079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A Self-Determination Theory Based Intervention to Increase Levels of Cardiorespiratory Fitness, Self-Determined Motivation, Physical Activity and Improve Health Outcomes Among Patients Living with Rheumatoid Arthritis 基于自我决定理论的干预提高类风湿关节炎患者的心肺健康水平、自我决定动机、身体活动和改善健康结果
Arthritis and rheumatism Pub Date : 2016-10-01 DOI: 10.1002/ART.V68.S10
J. Duda, S. Fenton, J. V. Zanten, G. Metsios, P. Rouse, N. Ntoumanis, Chen-an Yu, Y. Koutedakis, G. Kitas
{"title":"A Self-Determination Theory Based Intervention to Increase Levels of Cardiorespiratory Fitness, Self-Determined Motivation, Physical Activity and Improve Health Outcomes Among Patients Living with Rheumatoid Arthritis","authors":"J. Duda, S. Fenton, J. V. Zanten, G. Metsios, P. Rouse, N. Ntoumanis, Chen-an Yu, Y. Koutedakis, G. Kitas","doi":"10.1002/ART.V68.S10","DOIUrl":"https://doi.org/10.1002/ART.V68.S10","url":null,"abstract":"","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":"68 1","pages":"524"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51519191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of a Spectrum of Therapeutic Targets of a New Treatment for Osteoarthritis Composed By Curcuminoids Extract, Hydrolyzed Collagen and Green Tea Extract 姜黄素提取物、水解胶原蛋白和绿茶提取物组成的治疗骨关节炎新靶点谱的鉴定
Arthritis and rheumatism Pub Date : 2016-04-01 DOI: 10.1016/J.JOCA.2016.01.634
F. Comblain, C. Lambert, Isabelle Lesponne, Christelle Sanchez, J. Dubuc, Y. Henrotin
{"title":"Identification of a Spectrum of Therapeutic Targets of a New Treatment for Osteoarthritis Composed By Curcuminoids Extract, Hydrolyzed Collagen and Green Tea Extract","authors":"F. Comblain, C. Lambert, Isabelle Lesponne, Christelle Sanchez, J. Dubuc, Y. Henrotin","doi":"10.1016/J.JOCA.2016.01.634","DOIUrl":"https://doi.org/10.1016/J.JOCA.2016.01.634","url":null,"abstract":"","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/J.JOCA.2016.01.634","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54658975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of Long-Term Physical Activity Trajectories in Individuals with Chronic Widespread Pain Who Received Exercise Treatment As Part of a Randomized Controlled Trial 作为一项随机对照试验的一部分，在接受运动治疗的慢性广泛性疼痛患者中识别长期体育活动轨迹
Arthritis and rheumatism Pub Date : 2015-10-01 DOI: 10.1002/art.39448_2
K. Martin, K. Druce, L. D’Ambruoso, G. Macfarlane
{"title":"Identification of Long-Term Physical Activity Trajectories in Individuals with Chronic Widespread Pain Who Received Exercise Treatment As Part of a Randomized Controlled Trial","authors":"K. Martin, K. Druce, L. D’Ambruoso, G. Macfarlane","doi":"10.1002/art.39448_2","DOIUrl":"https://doi.org/10.1002/art.39448_2","url":null,"abstract":"","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51519058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Baseline Fibulin3 Concentrations Are Associated with Incidence of Clinical Knee OA after 30 Months in Overweight and Obese Women 基线Fibulin3浓度与超重和肥胖女性30个月后临床膝关节OA发病率相关
Arthritis and rheumatism Pub Date : 2015-04-01 DOI: 10.1016/J.JOCA.2015.02.782
Runhaar, Christelle Sanchez, S. Taralla, Y. Henrotin, S. Bierma-Zeinstra
{"title":"Baseline Fibulin3 Concentrations Are Associated with Incidence of Clinical Knee OA after 30 Months in Overweight and Obese Women","authors":"Runhaar, Christelle Sanchez, S. Taralla, Y. Henrotin, S. Bierma-Zeinstra","doi":"10.1016/J.JOCA.2015.02.782","DOIUrl":"https://doi.org/10.1016/J.JOCA.2015.02.782","url":null,"abstract":"","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/J.JOCA.2015.02.782","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54650399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Replication of PTPRC As Genetic Biomarker of Response to TNF Inhibitors in Patients with Rheumatoid Arthritis. PTPRC作为类风湿关节炎患者对TNF抑制剂反应的遗传生物标志物的复制
Arthritis and rheumatism Pub Date : 2014-01-01 DOI: 10.1002/ART.38..
J. J. G. Carnota, Antonio González Martínez-Pedrayo, Aida Ferreiro Iglesias
{"title":"Replication of PTPRC As Genetic Biomarker of Response to TNF Inhibitors in Patients with Rheumatoid Arthritis.","authors":"J. J. G. Carnota, Antonio González Martínez-Pedrayo, Aida Ferreiro Iglesias","doi":"10.1002/ART.38..","DOIUrl":"https://doi.org/10.1002/ART.38..","url":null,"abstract":"","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51519012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salivary Expression of S100A7/Psoriasin and Oral Damage in Primary Sjögren's Syndrome and Overlapping Disorders. S100A7/银屑病蛋白在原发性Sjögren综合征和重叠性疾病中的唾液表达与口腔损伤
Arthritis and rheumatism Pub Date : 2014-01-01 DOI: 10.1002/ART.38914/PDF
F. Sernissi, C. Baldini, D. Martini, L. Lorenzini, L. Bazzichi, A. Sabbatini, G. D. Marchi, C. Giacomelli, M. Mosca, S. Bombardieri
{"title":"Salivary Expression of S100A7/Psoriasin and Oral Damage in Primary Sjögren's Syndrome and Overlapping Disorders.","authors":"F. Sernissi, C. Baldini, D. Martini, L. Lorenzini, L. Bazzichi, A. Sabbatini, G. D. Marchi, C. Giacomelli, M. Mosca, S. Bombardieri","doi":"10.1002/ART.38914/PDF","DOIUrl":"https://doi.org/10.1002/ART.38914/PDF","url":null,"abstract":"","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51519034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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