Arthritis Research最新文献

{"title":"Cardiovascular risk in rheumatoid arthritis versus osteoarthritis: acute phase response related decreased insulin sensitivity and high-density lipoprotein cholesterol as well as clustering of metabolic syndrome features in rheumatoid arthritis.","authors":"Patrick H Dessein,&nbsp;Anne E Stanwix,&nbsp;Barry I Joffe","doi":"10.1186/ar428","DOIUrl":"https://doi.org/10.1186/ar428","url":null,"abstract":"<p><p>Rheumatoid arthritis (RA) patients experience a markedly increased frequency of cardiovascular disease. We evaluated cardiovascular risk profiles in 79 RA patients and in 39 age-matched and sex-matched osteoarthritis (OA) patients. Laboratory tests comprised ultrasensitive C-reactive protein (CRP) and fasting lipids. Insulin sensitivity (IS) was determined by the Quantitative Insulin Sensitivity Check Index (QUICKI) in all OA patients and in 39 of the RA patients. Ten RA patients were on glucocorticoids. RA patients exercised more frequently than OA patients (chi2 = 3.9, P < 0.05). Nine RA patients and one OA patient had diabetes (chi2 = 4.5, P < 0.05). The median CRP, the mean QUICKI and the mean high-density lipoprotein (HDL) cholesterol were 9 mg/l (range, 0.5-395 mg/l), 0.344 (95% confidence interval [CI], 0.332-0.355) and 1.40 mmol/l (95% CI, 1.30-1.49 mmol/l) in RA patients, respectively, as compared with 2.7 mg/l (range, 0.3-15.9 mg/l), 0.369 (95% CI, 0.356-0.383) and 1.68 mmol/l (95% CI, 1.50-1.85 mmol/l) in OA patients. Each of these differences was significant (P < 0.05). After controlling for the CRP, the QUICKI was similar in RA and OA patients (P = 0.07), while the differences in HDL cholesterol were attenuated but still significant (P = 0.03). The CRP correlated with IS, while IS was associated with high HDL cholesterol and low triglycerides in RA patients and not in OA patients. A high CRP (>/= 8 mg/l) was associated with hypertension (chi2 = 7.4, P < 0.05) in RA patients. RA glucocorticoid and nonglucocorticoid users did not differ in IS and lipids (P > 0.05). Excess cardiovascular risk in RA patients as compared with OA patients includes the presence of decreased IS and HDL cholesterol in RA patients. The latter is only partially attributable to the acute phase response. The CRP, IS, HDL cholesterol, triglycerides and hypertension are inter-related in RA patients, whereas none of these relationships were found in OA patients.</p>","PeriodicalId":8403,"journal":{"name":"Arthritis Research","volume":"4 5","pages":"R5"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/ar428","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21984353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statins as modulators of bone formation.","authors":"Christopher J Edwards, Tim D Spector","doi":"10.1186/ar399","DOIUrl":"10.1186/ar399","url":null,"abstract":"<p><p>The use of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) to reduce serum cholesterol is well described. However, the recent finding that statins have direct effects on bone was unexpected. A number of epidemiological studies have recently been published that explore the effects of statins on bone mineral density and risk of fracture in humans. Statins may act by directly stimulating the expression of bone morphogenetic protein-2 and increasing osteoblast differentiation or, like nitrogen-containing bisphosphonates, may have effects on the mevalonate pathway that leads to inhibition of osteoclast activity and osteoblast apoptosis. In addition, the demonstration that statins can inhibit inflammation and encourage angiogenesis offers other possibilities for action.</p>","PeriodicalId":8403,"journal":{"name":"Arthritis Research","volume":"40 1","pages":"151-3"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC128924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79399074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular profile of synovial fibroblasts in rheumatoid arthritis depends on the stage of proliferation.","authors":"Kimio Masuda, Riako Masuda, Michel Neidhart, Beat R Simmen, Beat A Michel, Ulf Müller-Ladner, Renate E Gay, Steffen Gay","doi":"10.1186/ar427","DOIUrl":"10.1186/ar427","url":null,"abstract":"<p><p>The aim of this study was to explore the molecular profile of proliferating rheumatoid arthritis synovial fibroblasts (RA-SF). Total RNA was extracted from two cultures of RA-SF (low-density [LD] proliferating cells and high-density [HD] nonproliferating cells) and suppression subtractive hybridization was performed to compare differential gene expression of these two cultures. Subtracted cDNA was subcloned, and nucleotide sequences were analyzed to identify each clone. Differential expression of distinct clones was confirmed by semiquantitative RT-PCR. The expression of certain genes in synovial tissues was examined by in situ hybridization. In both LD and HD cells, 44 clones were upregulated. Of the 88 total clones, 46 were identical to sequences that have previously been characterized. Twenty-nine clones were identical to cDNAs that have been identified, but with unknown functions so far, and 13 clones did not show any significant homology to sequences in GenBank (NCBI). Differential expression of distinct clones was confirmed by RT-PCR. In situ hybridization showed that certain genes, such as S100A4, NFAT5, unr and Fbx3, were also expressed predominantly in synovial tissues from patients with RA but not from normal individuals. The expression of distinct genes in proliferating RA-SF could also be found in RA synovium, suggesting that these molecules are involved in synovial activation in RA. Most importantly, the data indicate that the expression of certain genes in RA-SF depends on the stage of proliferation; therefore, the stage needs to be considered in any analysis of differential gene expression in SF.</p>","PeriodicalId":8403,"journal":{"name":"Arthritis Research","volume":"4 5","pages":"R8"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC125298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21984283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors","authors":"M. Vincenti, C. Brinckerhoff","doi":"10.1186/ar401","DOIUrl":"https://doi.org/10.1186/ar401","url":null,"abstract":"","PeriodicalId":8403,"journal":{"name":"Arthritis Research","volume":"19 1","pages":"157 - 164"},"PeriodicalIF":0.0,"publicationDate":"2001-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78745908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"T-cell activation without proliferation in juvenile idiopathic arthritis","authors":"A. Black, Hansha Bhayani, C. Ryder, J. Gardner-Medwin, T. Southwood","doi":"10.1186/ar403","DOIUrl":"https://doi.org/10.1186/ar403","url":null,"abstract":"","PeriodicalId":8403,"journal":{"name":"Arthritis Research","volume":"15 1","pages":"177 - 183"},"PeriodicalIF":0.0,"publicationDate":"2001-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81780445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on \"Genetic linkage and transmission disequilibrium of marker haplotypes at chromosome 1q41 in human systemic lupus erythematosus\", by RR Graham et al.","authors":"A. Barton, Jane Worthington","doi":"10.1186/ar394","DOIUrl":"https://doi.org/10.1186/ar394","url":null,"abstract":"","PeriodicalId":8403,"journal":{"name":"Arthritis Research","volume":"106 ","pages":"84 - 86"},"PeriodicalIF":0.0,"publicationDate":"2001-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91552924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of interleukin-18 receptor in fibroblast-like synoviocytes","authors":"B. Möller, U. Kessler, S. Rehart, U. Kalina, O. Ottmann, Joachim Peter Kaltwasser, D. Hoelzer, N. Kukoc-Zivojnov","doi":"10.1186/AR390","DOIUrl":"https://doi.org/10.1186/AR390","url":null,"abstract":"","PeriodicalId":8403,"journal":{"name":"Arthritis Research","volume":"8 1","pages":"139 - 144"},"PeriodicalIF":0.0,"publicationDate":"2001-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80834596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoantibodies directed to novel components of the PM/Scl complex, the human exosome","authors":"R. Brouwer, W. V. Vree Egberts, G. Hengstman, Reinout Raijmakers, B. V. van Engelen, Hans Peter Seelig, M. Renz, R. Mierau, E. Genth, G. Pruijn, W. V. van Venrooij","doi":"10.1186/AR389","DOIUrl":"https://doi.org/10.1186/AR389","url":null,"abstract":"","PeriodicalId":8403,"journal":{"name":"Arthritis Research","volume":"17 1","pages":"134 - 138"},"PeriodicalIF":0.0,"publicationDate":"2001-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85277590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proinflammatory activity of TWEAK on human dermal fibroblasts and synoviocytes: blocking and enhancing effects of anti-TWEAK monoclonal antibodies","authors":"Y. Chicheportiche, R. Chicheportiche, I. Sizing, J.E. Thompson, Christopher B Benjamin, C. Ambrose, J. Dayer","doi":"10.1186/AR388","DOIUrl":"https://doi.org/10.1186/AR388","url":null,"abstract":"","PeriodicalId":8403,"journal":{"name":"Arthritis Research","volume":"8 1","pages":"126 - 133"},"PeriodicalIF":0.0,"publicationDate":"2001-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86451235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytokine mRNA and protein expression in primary-culture and repeated-passage synovial fibroblasts from patients with rheumatoid arthritis","authors":"A. Hirth, A. Skapenko, R. Kinne, F. Emmrich, H. Schulze-Koops, U. Sack","doi":"10.1186/AR391","DOIUrl":"https://doi.org/10.1186/AR391","url":null,"abstract":"","PeriodicalId":8403,"journal":{"name":"Arthritis Research","volume":"1 1","pages":"117 - 125"},"PeriodicalIF":0.0,"publicationDate":"2001-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79856059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}