Arthritis Research最新文献

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Combined antibiotic and free radical trap treatment is effective at combating Staphylococcus-aureus-induced septic arthritis 联合抗生素和自由基陷阱治疗是有效的对抗金黄色葡萄球菌引起的脓毒性关节炎
Arthritis Research Pub Date : 2002-01-15 DOI: 10.1186/ar406
E. Sakiniene, L Vincent Collins
{"title":"Combined antibiotic and free radical trap treatment is effective at combating Staphylococcus-aureus-induced septic arthritis","authors":"E. Sakiniene, L Vincent Collins","doi":"10.1186/ar406","DOIUrl":"https://doi.org/10.1186/ar406","url":null,"abstract":"","PeriodicalId":8403,"journal":{"name":"Arthritis Research","volume":"22 1","pages":"196 - 200"},"PeriodicalIF":0.0,"publicationDate":"2002-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82641802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Tissue factor as a proinflammatory agent 组织因子作为促炎剂
Arthritis Research Pub Date : 2002-01-10 DOI: 10.1186/ar405
M. Bokarewa, J. Morrissey, A. Tarkowski
{"title":"Tissue factor as a proinflammatory agent","authors":"M. Bokarewa, J. Morrissey, A. Tarkowski","doi":"10.1186/ar405","DOIUrl":"https://doi.org/10.1186/ar405","url":null,"abstract":"","PeriodicalId":8403,"journal":{"name":"Arthritis Research","volume":"53 1","pages":"190 - 195"},"PeriodicalIF":0.0,"publicationDate":"2002-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81393448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 63
Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on NF-κB binding activity and TNF-α secretion of T cells 抗cd4单克隆抗体治疗大鼠佐剂性关节炎的临床疗效差异与对T细胞NF-κB结合活性和TNF-α分泌的差异影响有关
Arthritis Research Pub Date : 2002-01-08 DOI: 10.1186/ar404
D. Pohlers, C. Schmidt‐Weber, À. Franch, J. Kuhlmann, R. Bräuer, F. Emmrich, R. Kinne
{"title":"Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on NF-κB binding activity and TNF-α secretion of T cells","authors":"D. Pohlers, C. Schmidt‐Weber, À. Franch, J. Kuhlmann, R. Bräuer, F. Emmrich, R. Kinne","doi":"10.1186/ar404","DOIUrl":"https://doi.org/10.1186/ar404","url":null,"abstract":"","PeriodicalId":8403,"journal":{"name":"Arthritis Research","volume":"11 1","pages":"184 - 189"},"PeriodicalIF":0.0,"publicationDate":"2002-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88635653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
The molecular mechanism of osteoclastogenesis in rheumatoid arthritis. 类风湿关节炎中破骨细胞发生的分子机制。
Arthritis Research Pub Date : 2002-01-01 Epub Date: 2002-04-12 DOI: 10.1186/ar431
Nobuyuki Udagawa, Shigeru Kotake, Naoyuki Kamatani, Naoyuki Takahashi, Tatsuo Suda
{"title":"The molecular mechanism of osteoclastogenesis in rheumatoid arthritis.","authors":"Nobuyuki Udagawa,&nbsp;Shigeru Kotake,&nbsp;Naoyuki Kamatani,&nbsp;Naoyuki Takahashi,&nbsp;Tatsuo Suda","doi":"10.1186/ar431","DOIUrl":"https://doi.org/10.1186/ar431","url":null,"abstract":"<p><p>Bone-resorbing osteoclasts are formed from hemopoietic cells of the monocyte-macrophage lineage under the control of bone-forming osteoblasts. We have cloned an osteoblast-derived factor essential for osteoclastogenesis, the receptor activator of NF-kappaB ligand (RANKL). Synovial fibroblasts and activated T lymphocytes from patients with rheumatoid arthritis also express RANKL, which appears to trigger bone destruction in rheumatoid arthritis as well. Recent studies have shown that T lymphocytes produce cytokines other than RANKL such as IL-17, granulocyte-macrophage colony-stimulating factor and IFN-gamma, which have powerful regulatory effects on osteoclastogenesis. The possible roles of RANKL and other cytokines produced by T lymphocytes in bone destruction are described.</p>","PeriodicalId":8403,"journal":{"name":"Arthritis Research","volume":"4 5","pages":"281-9"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/ar431","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21983396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 129
Autoantibody profiling for the study and treatment of autoimmune disease. 自身抗体谱分析用于自身免疫性疾病的研究和治疗。
Arthritis Research Pub Date : 2002-01-01 Epub Date: 2002-05-07 DOI: 10.1186/ar426
Wolfgang Hueber, Paul J Utz, Lawrence Steinman, William H Robinson
{"title":"Autoantibody profiling for the study and treatment of autoimmune disease.","authors":"Wolfgang Hueber,&nbsp;Paul J Utz,&nbsp;Lawrence Steinman,&nbsp;William H Robinson","doi":"10.1186/ar426","DOIUrl":"https://doi.org/10.1186/ar426","url":null,"abstract":"<p><p>Proteomics technologies enable profiling of autoantibody responses using biological fluids derived from patients with autoimmune disease. They provide a powerful tool to characterize autoreactive B-cell responses in diseases including rheumatoid arthritis, multiple sclerosis, autoimmune diabetes, and systemic lupus erythematosus. Autoantibody profiling may serve purposes including classification of individual patients and subsets of patients based on their 'autoantibody fingerprint', examination of epitope spreading and antibody isotype usage, discovery and characterization of candidate autoantigens, and tailoring antigen-specific therapy. In the coming decades, proteomics technologies will broaden our understanding of the underlying mechanisms of and will further our ability to diagnose, prognosticate and treat autoimmune disease.</p>","PeriodicalId":8403,"journal":{"name":"Arthritis Research","volume":"4 5","pages":"290-5"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/ar426","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21983397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Therapy of ankylosing spondylitis and other spondyloarthritides: established medical treatment, anti-TNF-alpha therapy and other novel approaches. 强直性脊柱炎和其他脊椎关节炎的治疗:已建立的药物治疗、抗tnf - α治疗和其他新方法。
Arthritis Research Pub Date : 2002-01-01 Epub Date: 2002-08-06 DOI: 10.1186/ar592
Juergen Braun, Joachim Sieper
{"title":"Therapy of ankylosing spondylitis and other spondyloarthritides: established medical treatment, anti-TNF-alpha therapy and other novel approaches.","authors":"Juergen Braun,&nbsp;Joachim Sieper","doi":"10.1186/ar592","DOIUrl":"10.1186/ar592","url":null,"abstract":"<p><p>Therapeutic options for patients with more severe forms of spondyloarthritis (SpA) have been rather limited in recent decades. There is accumulating evidence that anti-tumor-necrosis-factor (anti-TNF) therapy is highly effective in SpA, especially in ankylosing spondylitis and psoriatic arthritis. The major anti-TNF-alpha agents currently available, infliximab (Remicade(R)) and etanercept (Enbrel(R)), are approved for the treatment of rheumatoid arthritis (RA) in many countries. In ankylosing spondylitis there is an unmet medical need, since there are almost no disease-modifying antirheumatic drugs (DMARDs) available for severely affected patients, especially those with spinal manifestations. Judging from recent data from more than 300 patients with SpA, anti-TNF therapy seems to be even more effective in SpA than in rheumatoid arthritis. However, it remains to be shown whether patients benefit from long-term treatment, whether radiological progression and ankylosis can be stopped and whether long-term biologic therapy is safe.</p>","PeriodicalId":8403,"journal":{"name":"Arthritis Research","volume":"4 5","pages":"307-21"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/ar592","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21984352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 122
Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers. 系统性硬化症中的血管生成和血管抑制因子:血管内皮生长因子水平升高是疾病早期阶段的特征,并与没有指尖溃疡有关。
Arthritis Research Pub Date : 2002-01-01 Epub Date: 2002-08-30 DOI: 10.1186/ar596
Oliver Distler, Angela Del Rosso, Roberto Giacomelli, Paola Cipriani, Maria L Conforti, Serena Guiducci, Renate E Gay, Beat A Michel, Pius Brühlmann, Ulf Müller-Ladner, Steffen Gay, Marco Matucci-Cerinic
{"title":"Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers.","authors":"Oliver Distler,&nbsp;Angela Del Rosso,&nbsp;Roberto Giacomelli,&nbsp;Paola Cipriani,&nbsp;Maria L Conforti,&nbsp;Serena Guiducci,&nbsp;Renate E Gay,&nbsp;Beat A Michel,&nbsp;Pius Brühlmann,&nbsp;Ulf Müller-Ladner,&nbsp;Steffen Gay,&nbsp;Marco Matucci-Cerinic","doi":"10.1186/ar596","DOIUrl":"https://doi.org/10.1186/ar596","url":null,"abstract":"<p><p>To examine whether the lack of sufficient neoangiogenesis in systemic sclerosis (SSc) is caused by a decrease in angiogenic factors and/or an increase in angiostatic factors, the potent proangiogenic molecules vascular endothelial growth factor (VEGF) and basic fibroblast growth factor, and the angiostatic factor endostatin were determined in patients with SSc and in healthy controls. Forty-three patients with established SSc and nine patients with pre-SSc were included in the study. Serum levels of VEGF, basic fibroblast growth factor and endostatin were measured by ELISA. Age-matched and sex-matched healthy volunteers were used as controls. Highly significant differences were found in serum levels of VEGF between SSc patients and healthy controls, whereas no differences could be detected for endostatin and basic fibroblast growth factor. Significantly higher levels of VEGF were detected in patients with Scl-70 autoantibodies and in patients with diffuse SSc. Patients with pre-SSc and short disease duration showed significant higher levels of VEGF than healthy controls, indicating that elevated serum levels of VEGF are a feature of the earliest disease stages. Patients without fingertip ulcers were found to have higher levels of VEGF than patients with fingertip ulcers. Levels of endostatin were associated with the presence of giant capillaries in nailfold capillaroscopy, but not with any other clinical parameter. The results show that the concentration of VEGF is already increased in the serum of SSc patients at the earliest stages of the disease. VEGF appears to be protective against ischemic manifestations when concentrations of VEGF exceed a certain threshold level.</p>","PeriodicalId":8403,"journal":{"name":"Arthritis Research","volume":"4 6","pages":"R11"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/ar596","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22130357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 280
Genetic aspects of Sjögren's syndrome. Sjögren综合征的遗传方面。
Arthritis Research Pub Date : 2002-01-01 Epub Date: 2002-09-24 DOI: 10.1186/ar599
Anne I Bolstad, Roland Jonsson
{"title":"Genetic aspects of Sjögren's syndrome.","authors":"Anne I Bolstad,&nbsp;Roland Jonsson","doi":"10.1186/ar599","DOIUrl":"https://doi.org/10.1186/ar599","url":null,"abstract":"<p><p>Sjögren's syndrome is a multisystem inflammatory rheumatic disease that is classified into primary and secondary forms, with cardinal features in the eye (keratoconjunctivitis sicca) and mouth (xerostomia). The aetiology behind this autoimmune exocrinopathy is probably multifactorial and influenced by genetic as well as by environmental factors that are as yet unknown. A genetic predisposition to Sjögren's syndrome has been suggested on the basis of familial aggregation, animal models and candidate gene association studies. Recent advances in molecular and genetic methodologies should further our understanding of this complex disease. The present review synthesizes the current state of genetics in Sjögren's syndrome.</p>","PeriodicalId":8403,"journal":{"name":"Arthritis Research","volume":"4 6","pages":"353-9"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/ar599","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22130354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 114
Abnormalities of B cell phenotype, immunoglobulin gene expression and the emergence of autoimmunity in Sjögren's syndrome. Sjögren综合征B细胞表型、免疫球蛋白基因表达异常及自身免疫的出现。
Arthritis Research Pub Date : 2002-01-01 Epub Date: 2002-09-25 DOI: 10.1186/ar603
Thomas Dörner, Peter E Lipsky
{"title":"Abnormalities of B cell phenotype, immunoglobulin gene expression and the emergence of autoimmunity in Sjögren's syndrome.","authors":"Thomas Dörner,&nbsp;Peter E Lipsky","doi":"10.1186/ar603","DOIUrl":"https://doi.org/10.1186/ar603","url":null,"abstract":"<p><p>Primary Sjögren's syndrome (pSS) is an autoimmune disorder characterized by specific pathologic features and the production of typical autoantibodies. In addition, characteristic changes in the distribution of peripheral B cell subsets and differences in use of immunoglobulin variable-region genes are also features of pSS. Comparison of B cells from the blood and parotid gland of patients with pSS with those of normal donors suggests that there is a depletion of memory B cells from the peripheral blood and an accumulation or retention of these antigen-experienced B cells in the parotids. Because disordered selection leads to considerable differences in the B cell repertoire in these patients, the delineation of its nature should provide important further clues to the pathogenesis of this autoimmune inflammatory disorder.</p>","PeriodicalId":8403,"journal":{"name":"Arthritis Research","volume":"4 6","pages":"360-71"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/ar603","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22130355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 48
Cartilage-specific autoimmunity in animal models and clinical aspects in patients - focus on relapsing polychondritis. 软骨特异性自身免疫在动物模型和患者的临床方面-重点关注复发性多软骨炎。
Arthritis Research Pub Date : 2002-01-01 Epub Date: 2002-07-17 DOI: 10.1186/ar425
Ann-Sofie Hansson, Rikard Holmdahl
{"title":"Cartilage-specific autoimmunity in animal models and clinical aspects in patients - focus on relapsing polychondritis.","authors":"Ann-Sofie Hansson,&nbsp;Rikard Holmdahl","doi":"10.1186/ar425","DOIUrl":"https://doi.org/10.1186/ar425","url":null,"abstract":"<p><p>Relapsing polychondritis is an autoimmune disease in which an inappropriate immune response destroys cartilage. Cartilage of the ears, larynx and nose rather than spine and joint cartilage is affected by a chronic relapsing and erosive inflammation. Several animal models for relapsing polychondritis have been published in which immunization with various cartilage proteins induces a variety of chondritis symptoms that mimic those seen in patients. In this review we describe the collagens, matrilin-1 and cartilage oligomeric matrix protein as potential autoantigens able to trigger the tissue-specific immune response seen both in patients and in animal models for relapsing polychondritis and related autoimmune diseases.</p>","PeriodicalId":8403,"journal":{"name":"Arthritis Research","volume":"4 5","pages":"296-301"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/ar425","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21984348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
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