AROC in Natural Products Research最新文献_第2页

Combretum dolichopentalum extract normalized biochemical and haematological parameters in carbon tetrachloride (CCL4) intoxicated rats 四氯化碳(CCL4)中毒大鼠的标准化生化和血液学指标

AROC in Natural Products Research Pub Date : 2021-09-09 DOI: 10.53858/arocnpr01021728

F. N. Ujowundu, N. N. Oparaeche, C. Onuoha, M. A. Haruna, Chukwudoruo Sunday Chieme, C. Ujowundu

{"title":"Combretum dolichopentalum extract normalized biochemical and haematological parameters in carbon tetrachloride (CCL4) intoxicated rats","authors":"F. N. Ujowundu, N. N. Oparaeche, C. Onuoha, M. A. Haruna, Chukwudoruo Sunday Chieme, C. Ujowundu","doi":"10.53858/arocnpr01021728","DOIUrl":"https://doi.org/10.53858/arocnpr01021728","url":null,"abstract":"Background: The ethanol extract of Combretum dolichopentalum (EECD) is employed in Nigeria to stabilize the uterus after parturition. The ability of EECD to confer protection on rats destabilized by moderate concentrations of carbon tetrachloride (CCl4) was evaluated. Methods: Fifty rats were assigned to 5 groups of 10 rats each. The experimental animals after acclimatization were handled accordingly: Groups 1 and 2 respectively were maintained on food and water only throughout the study. Group 3, 4, and group 5 were pre-treated with 250 mg/kg and 500 mg/kg body weight of EECD and 50 mg/kg of silymarin for 28 respectively. All groups except group 1 were intoxicated to 0.2 ml/kg body weight of CCl4, administered via an intraperitoneal route on day 29. Serum pipetted from the blood of the rats after cardiac puncture was assayed for antioxidant enzymes, lipid peroxidation product and serum iron, zinc and biocarbonate. Haematological analysis was also conducted. Results: Administration of CCl4 at 0.2 ml/kg b.w slightly increased the oxidizing species as indicated in the concentration of malondialdehyde in the rats while reducing the antioxidant enzymes; it increased the Iron and zinc concentrations and also the haematological parameters except for the white blood cells. However, this was corrected by pre-treatment with the EECD dosedependently. Conclusion: These characteristics portends that the crude ethanol extract of C. dolichopentalum could be employed to correct minor oxidative perturbation induced by CCl4 intoxication","PeriodicalId":8396,"journal":{"name":"AROC in Natural Products Research","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83677781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical screening, quantification and correlation matrix of Nigerian medicinal plant: Waltheria americana 尼日利亚药用植物美洲Waltheria americana的植物化学筛选、定量及相关矩阵分析

AROC in Natural Products Research Pub Date : 2021-09-09 DOI: 10.53858/arocnpr01020916

P. Dass, J. J. Deshi, F. P. Andrew, B. M. Wufem

{"title":"Phytochemical screening, quantification and correlation matrix of Nigerian medicinal plant: Waltheria americana","authors":"P. Dass, J. J. Deshi, F. P. Andrew, B. M. Wufem","doi":"10.53858/arocnpr01020916","DOIUrl":"https://doi.org/10.53858/arocnpr01020916","url":null,"abstract":"Background: Plant’s kingdom provides new and important leads against various pharmacological targets due to the current wide spread of belief that green medicine is safe and more dependable than the costly synthetic drugs. The medicinal property of plants step from their ability to synthesize aromatic substances and secondary metabolites that are potent bioactive compounds found in medicinal plant parts that are precursors for the synthesis of useful drugs. In the present study, the leaf, stem, and root extracts of Waltheria americana were evaluated for phytochemical compositions and their correlation matrix. Methods: Quantitative and quantitative standard methods of analysis were used to evaluate the presence, amount, and the correlationships of the different phytochemicals in the leaf, root and stem of W. americana plant. Results: The quantitative phytochemicals percentage composition of W. americana varied with large ranges for alkaloids, tannins, flavonoids, but short ranges occurred of terpenes and cardiac glycosides. Alkaloids had the highest percentage composition and cardiac glycosides showed the lowest for all the plant parts. The stem seems to be the major area of phytochemical production than other parts of the plant, indicating that the stem of W. americana could serve as a major source of phytochemicals in any herbal concoction. “The correlation” of phytochemical constituents, alkaloids and tannins in the leaf were positively and significantly correlated with cardiac glycosides in the stem at 95% confidence respectiely. However, no correlation was observed of any phytochemicals in the other plant. Conclusion: These findings indicated that the production, quantification, and distribution of these phytochemicals were complimentary in nature in Waltheria americana plant, and the shoot may have played a major role in this regard","PeriodicalId":8396,"journal":{"name":"AROC in Natural Products Research","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82978156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative free radical scavenging and hypoglycemic activities of n-hexane, ethyl-acetate, and aqueous fractions of Azanza garckeana pulp Azanza garckeana纸浆中正己烷、乙酸乙酯和水馏分自由基清除和降糖活性的比较

AROC in Natural Products Research Pub Date : 2021-08-18 DOI: 10.53858/arocnpr01020108

A. Yusuf, Toheeb D. Yissa, A. Agboola, Sodiq M Balogun, P. O. Adeboye, Opeyemi N. Hassan, Iliyasu S. Raji

{"title":"Comparative free radical scavenging and hypoglycemic activities of n-hexane, ethyl-acetate, and aqueous fractions of Azanza garckeana pulp","authors":"A. Yusuf, Toheeb D. Yissa, A. Agboola, Sodiq M Balogun, P. O. Adeboye, Opeyemi N. Hassan, Iliyasu S. Raji","doi":"10.53858/arocnpr01020108","DOIUrl":"https://doi.org/10.53858/arocnpr01020108","url":null,"abstract":"Background: The prevalence of diabetes mellitus is increasing on a global trend. The aim of the present study is to identify the most effective antioxidants and hypoglycemic fraction of Azanza garckeana. Methods: The fractions (nhexane or ethyl-acetate or aqueous) of A. garckeana were administered to the alloxan-induced diabetic rats at doses of 100, 200, and 400 mg/kg for 15 days. Antioxidants activities were evaluated at concentrations of 62.5, 125, 250, and 500 µg/mL using the DPPH scavenging assay. Results: Results revealed that both the hexane, ethyl-acetate, and aqueous fractions exhibited hypoglycemic and antioxidants activities in a dose-dependent manner. The n-hexane fraction demonstrated highest percentage DPPH scavenging effect of 26.34±3.43, 38.44±4.35, 59.34±3.45, and 74.83±5.35 at 62.5, 125, 250, and 500 µg/mL respectively. The ethyl-acetate fraction demonstrated 19.33±2.98, 28.94±3.24, 47.34±2.90, and 57.82±4.54 respectively while the aqueous fraction exhibited the least activities of 12.45±23.45, 18.64±2.94, 27.94±3.89, and 39.43±3.89 at concentrations of 62.5, 125, 250, and 500 µg/mL respectively. In addition, the n-hexane fraction demonstrated the most significant hypoglycemic effect with the highest glucose reduction of 58.97 ±3.45 %, 63.86±5.35 %, and 66.51±4.35 %, ethyl acetate fraction demonstrated glucose reduction of 7.55±0.54%, 21.77±2.35 %, and 29.56±3.46 % while the aqueous fraction demonstrated the least hypoglycemic effect of 9.89±2.67 %, 18.09±3.45 %, and 18.87±3.24 at 100, 200 and 400 mg/kg bw respectively. Conclusion: The n-hexane fraction of Azanza garckeana extract could serve as a reservoir of bioactive agents that could be useful for the development of a new anti-diabetic agent","PeriodicalId":8396,"journal":{"name":"AROC in Natural Products Research","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77656360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Phytochemical compositions, antimicrobial activities, and thin layer chromatography analysis of aqueous, and methanol extracts of Tectona grandis leaf 大地构造草叶水、甲醇提取物的植物化学成分、抗菌活性及薄层色谱分析

AROC in Natural Products Research Pub Date : 2021-07-24 DOI: 10.53858/arocnpr01014451

H. Muhammed, Lare H. Abdullahi, F. G. Mayaki, U. H. Boko

{"title":"Phytochemical compositions, antimicrobial activities, and thin layer chromatography analysis of aqueous, and methanol extracts of Tectona grandis leaf","authors":"H. Muhammed, Lare H. Abdullahi, F. G. Mayaki, U. H. Boko","doi":"10.53858/arocnpr01014451","DOIUrl":"https://doi.org/10.53858/arocnpr01014451","url":null,"abstract":"Background: Teak (Tectona grandis) from the family Verbenaceae/Lamiaceae is indigenous to India, other tropical countries, and one of the naturally discovered plants to be known by scientists due to its high potential and effectiveness in disease preventive and curative action. The present study evaluated the phytochemical composition, anti-microbial activity of methanol and aqueous extract of Tectona grandis leaf, and characterized the extracts using thin-layer chromatography (TLC). Methods: The phytochemical, anti-microbial activity thin layer chromatography (TLC) analysis was conducted using established protocols. Results: The results revealed that the methanol extract of teak plant leaves contains steroids, tannins, saponin, coumarin, protein, carbohydrates, alkaloids, diterpenes, phytosterol, phlobatannin while the aqueous extract contains tannins, saponin, coumarin, protein, carbohydrate, alkaloid, diterpenes, phytosterol, and phlobatannins. The methanol extract of Tectona grandis showed the highest activity on S. epidermasis (14mm) and against S.aureus (10mm) at a concentration of 40mg/ml followed by the activities of aqueous extract of teak plant leaf against Candida Albicans (8mm) at a concentration of 40mg/ml. The extract had no inhibitory effect at all other concentrations. Conclusion: The result confirmed that Tectona grandis contain several bioactive phytochemicals that can be explored for the treatment of pathogenic microorganism.","PeriodicalId":8396,"journal":{"name":"AROC in Natural Products Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76381010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical compositions, and hypoglycemic effect of methanol leaf extract of Telfairia Occidentalis in alloxan-induced diabetic rats 西洋参叶甲醇提取物对四氧嘧啶诱导的糖尿病大鼠的植物化学成分及降糖作用

AROC in Natural Products Research Pub Date : 2021-07-24 DOI: 10.53858/arocnpr01015260

A. Abubakar, Fatimah O. Badmos, A. Saidu, I. Yunus, B. Lawal

{"title":"Phytochemical compositions, and hypoglycemic effect of methanol leaf extract of Telfairia Occidentalis in alloxan-induced diabetic rats","authors":"A. Abubakar, Fatimah O. Badmos, A. Saidu, I. Yunus, B. Lawal","doi":"10.53858/arocnpr01015260","DOIUrl":"https://doi.org/10.53858/arocnpr01015260","url":null,"abstract":"Background: The use of medicinal plants for the treatment of diabetes is increasing due to several reasons such as safety, affordability and efficacy. In the present study, the phytochemical compositions and hypoglycemic effect of the methanol leaf extract of Telfairia occidentalis (ML-TO) were investigated. Methods: Phytochemical screening was conducted using standard methods. Fifteen rats were divided into 5 groups (n=3). Diabetes was induced in rats allocated to groups A-D using alloxan monohydrate (120 mg/kg BW) and was treated with 200 and 400 mg/kg BW ML-TO, 5 mg/kg BW glibenclamide and 5 ml/kg BW normal saline respectively. All treatments were administered orally, once daily for 29 days. Results: The results revealed that the ML-TO contains phenols, alkaloids, tannins, steroids, glycosides while flavonoids and saponins were not detected. Quantitatively, total phenols (9570±13.24 µg/mg) was the most abundant phytochemicals identified while tannins (3000.56±23.45 µg/mg) and alkaloids (0.2378±0.013µg/mg) were also present in appreciable amount in ML-TO. The extract produced a significant (p <0.05) and dose-dependent hypoglycemic effect with maximum activities occurring at 400 mg/kg BW having suppressed the fasting blood glucose levels from 334±33.62 to 137±37.31 mg/dL while the rats treated with 200 mg/kg BW lowered blood glucose level from 386±171 to 174±108.55mg/dL. The standard antidiabetic drug (Glibenclamide) produced a comparable hypoglycemic effect and suppressed the FBS from 350±169.74 to125±76.35 mg/dL. Conclusion: ML-To had a significant hypoglycemic effect and was able to ameliorate the weight loss in the diabetic rats, hence it could serve as a source of potential hypoglycemic agent","PeriodicalId":8396,"journal":{"name":"AROC in Natural Products Research","volume":"156 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78850253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Anti-Trypanosomal Activities of Crude and Alkaloidal Fraction of Diospyros mespiliformis (African Ebony) Leaf on Trypanosoma Evansi Infected Rats. 非洲乌木叶粗提取物和生物碱提取物对伊文氏锥虫感染大鼠的抗锥虫活性研究

AROC in Natural Products Research Pub Date : 2021-07-24 DOI: 10.53858/arocnpr01016169

S. Abolarinwa, P. C. Agbadoronye, V. Oigbochie, Z.M Ubabu, E. Ifeanyichukwu, S. Ngamdu

{"title":"Anti-Trypanosomal Activities of Crude and Alkaloidal Fraction of Diospyros mespiliformis (African Ebony) Leaf on Trypanosoma Evansi Infected Rats.","authors":"S. Abolarinwa, P. C. Agbadoronye, V. Oigbochie, Z.M Ubabu, E. Ifeanyichukwu, S. Ngamdu","doi":"10.53858/arocnpr01016169","DOIUrl":"https://doi.org/10.53858/arocnpr01016169","url":null,"abstract":"African trypanosomiasis is a parasitic disease that affects both humans and animals. This study investigated the antitrypanosomal activities of crude and an alkaloidal fraction of Diospyros mespiliformis in Trypanosoma evansi – infected rats. A total of twenty-one (21) albino rats were infected with Trypanosoma evansi and grouped into seven (A-G) of 3 rats each. Group A serve as normal control, groups B and C were given 0.2 ml normal saline/kg BW and 3.5 mg/kg BW diminazene aceturate respectively, groups D and E were treated with 100 and 200 mg/kg BW alkaloidal while groups E and F received crude extract at 200 and 400 mg/kg respectively for twelve days. Results revealed that both crude and an alkaloidal fraction of D. mespiliformis exhibited significant (p<0.05) dose-dependent antitrypanosomal activities. The crude extract exhibited 54.55±3.04 % (200 mg/kg BW) and 66.02±5.03 (200 mg/kg BW) curative effect while the alkaloidal fraction exhibited better antitrypanosomal activities with 68.68±2.34 % and 70.87±2.93 curative effect at 100 and 200 mg/kg respectively. Furthermore, the crude extract prolonged the survival of the animals to 19.02±2.06 (200 mg/kg BW) and 22.90±3.78 (400 mg/kg BW) while the alkaloidal fraction at 100 and 200 mg/kg prolonged the survival of the mice to 23.45±1.24 and 29.34±3.45 days respectively and improved the body weight gain of the animals when compared with the non-treated control (13.24±1.33 days). In conclusion, the leaves of Diospyros mespiliformis could be employed for the treatment of T. evansi infection as an alternative to conventional medicines that are besieged with undesirable properties","PeriodicalId":8396,"journal":{"name":"AROC in Natural Products Research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87612285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phyto-pharmacological and safety reports of Khaya senegalensis (Desr) A Juss (Meliaceae), an important multifunctional tropical forest plant 热带森林重要的多功能植物senegalensis (Desr) A Juss (Meliaceae)的植物药理和安全性报告

AROC in Natural Products Research Pub Date : 2021-07-24 DOI: 10.53858/arocnpr01012843

Dauda Muhammed, Ovaiyoza Blessing Adaaja, Iyaji Godwin Otiwa, Yuyu Ezekiel Zaman, Olayinka Ezekiel Oloyede

{"title":"Phyto-pharmacological and safety reports of Khaya senegalensis (Desr) A Juss (Meliaceae), an important multifunctional tropical forest plant","authors":"Dauda Muhammed, Ovaiyoza Blessing Adaaja, Iyaji Godwin Otiwa, Yuyu Ezekiel Zaman, Olayinka Ezekiel Oloyede","doi":"10.53858/arocnpr01012843","DOIUrl":"https://doi.org/10.53858/arocnpr01012843","url":null,"abstract":"Medicinal plants have curative properties due to the presence of various complex chemical substances of different compositions, which are found as secondary plant metabolites in one or more parts of these plants. Khaya senegalensis (Desr) A Juss is a popular medicinal plant among the Nupes and Yorubas in Nigeria. It belongs to the family Meliaceae (mahogany) and has been reported by several works for its usefulness in the treatment of various diseases. The plant has been studied for its various pharmacological activities like antioxidant, antibacterial, antifungal, antiprotozoal, anticancer, hypoglycemic, and antiparasitic properties. A scrutiny of the literature reveals some notable pharmacological activities of the plant. The phytochemistry and pharmacology of this plant necessitate a comprehensive review of its prospects as an important therapeutic agent for the management of numerous diseases commonly affecting humans. The present review provides a detailed report of the phytochemical, pharmacological, and toxicological properties carried out on this plant and also throws light on its therapeutic prospects","PeriodicalId":8396,"journal":{"name":"AROC in Natural Products Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82726823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional Management of Diabetes Mellitus: An appraisal of the role of Medicinal plants 糖尿病的营养管理:药用植物作用的评价

AROC in Natural Products Research Pub Date : 2021-07-24 DOI: 10.53858/arocnpr01010127

Dauda Muhammed, Yetunde H. Adebiyi, B. O. Odey, J. Ibrahim, Opeyemi N. Hassan, Peter I Ugwunnaji, E. Berinyuy

{"title":"Nutritional Management of Diabetes Mellitus: An appraisal of the role of Medicinal plants","authors":"Dauda Muhammed, Yetunde H. Adebiyi, B. O. Odey, J. Ibrahim, Opeyemi N. Hassan, Peter I Ugwunnaji, E. Berinyuy","doi":"10.53858/arocnpr01010127","DOIUrl":"https://doi.org/10.53858/arocnpr01010127","url":null,"abstract":"Diabetes mellitus is a heterogeneous metabolic syndrome characterized by chronic hyperglycemia with partial or total lack of insulin secretion and insulin resistance. The most common symptoms are polydipsia, polyuria, blurred vision, slow healing sore, nerve damage. Diabetes, being a metabolic, endocrine disorder is directly connected to carbohydrates, lipid, and protein metabolism. As a result, nutrition therapy forms an integral part of diabetes management. Daily caloric intake of 50% - 55% carbohydrates is recommended. Carbohydrate with low glycaemic index is preferred to those with high glycaemic index. Nonnutritive sweeteners are also encouraged for people with diabetes to add increased variety to their food choices. The protein requirement for persons with diabetes is not different from the general population, 15-20 % of total caloric intake. Both soluble and insoluble fibers are encouraged in amounts similar to the recommendations for the general population (20–35 g). Fibers are useful as they prolong gastric emptying, prevent constipation, lower serum cholesterol level, and reduce nutrients diffusion rates, thus reducing blood glucose response. A low-fat diet is advisable for diabetics in order to reach and maintain good weight and health. As part of a healthy diet, 30% of daily calories should come from fats, and of these less than 10% should be saturated fat, less than 10% polyunsaturated fat and 10- 15% monounsaturated fat. As the general population, people with diabetes have no need for vitamin and mineral supplementation when the dietary intake is adequate. Despite much research on nutritional factors in the etiology and management of diabetes, the risk associated with several individual nutrients is not entirely clear. In order to achieve maximum benefit from nutritional interventions in the management of diabetes changes in government policies and legislation will be needed in addition to individual and community-based programs.","PeriodicalId":8396,"journal":{"name":"AROC in Natural Products Research","volume":"252 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75815121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1