Arquivos brasileiros de endocrinologia e metabologia最新文献_第3页

Evaluation of percutaneous ethanol injections in benign thyroid nodules. 经皮乙醇注射治疗良性甲状腺结节的疗效评价。

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-12-01 DOI: 10.1590/0004-2730000003444

Camila Luhm Silva Perez, Tayane Muniz Fighera, Fabiola Miasaki, Cleo Otaviano Mesa Junior, Gilberto Jorge da Paz Filho, Hans Graf, Gisah Amaral de Carvalho

{"title":"Evaluation of percutaneous ethanol injections in benign thyroid nodules.","authors":"Camila Luhm Silva Perez, Tayane Muniz Fighera, Fabiola Miasaki, Cleo Otaviano Mesa Junior, Gilberto Jorge da Paz Filho, Hans Graf, Gisah Amaral de Carvalho","doi":"10.1590/0004-2730000003444","DOIUrl":"https://doi.org/10.1590/0004-2730000003444","url":null,"abstract":"Objective: The objective of this study was to evaluate the efficacy and safety of percutaneous ethanol injection (PEI) in the treatment of benign thyroid nodules.Subjects and methods: We evaluated 120 patients with benign thyroid nodules. Patients underwent evaluation of serum TSH and free T4, cervical ultrasound, and thyroid scintigraphy (in those with suppressed TSH levels). The application of sterile ethanol 99% was guided by ultrasound, with the injected volume amounting to one-third of the nodule volume. Response was considered complete (reduction of 90%); partial (reduction between 50 and 90%); or none (reduction of < 50%). Autonomous nodules were evaluated for normalization of TSH levels.Results: Among the nodules studied, 30.8% were solid, 56.7% were mixed, 12.5% were cystic, and 21.6% were hyperfunctioning. The initial volume of the treated nodules ranged from 0.9 to 74.8 mL (mean 13.1 ± 12.4 mL). We performed 1-8 sessions of PEI, applying an average of 6.2 mL of ethanol for patient. After 2 years of follow-up, 17% of patients achieved a complete response (94% reduction); 53%, a partial response (70% reduction); and 30%, no response. A reduction in the volume of autonomous nodules was noted in 70% of cases, and 54% had a normalized value of TSH. The main side effect is local pain, lasting less than 24 hours in most cases.Conclusion: This study showed that PEI is a safe and effective procedure for treatment of benign, solid or mixed thyroid nodules. Most cases resulted in significant reduction in nodule volume, with normalization of thyroid function.","PeriodicalId":8395,"journal":{"name":"Arquivos brasileiros de endocrinologia e metabologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/0004-2730000003444","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33337739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

[Study of polymorphism G54D of MBL2 gene in gestational diabetes mellitus]. 妊娠期糖尿病患者MBL2基因G54D多态性研究

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-12-01 DOI: 10.1590/0004-2730000002819

Rejane Baggenstoss, Silvia Vanderléia Petzhold, Izabela K Michels Willemann, Francisco Simões Pabis, Paulo Gimenes, Barbara Vicente de Souza, Paulo Henrique Condeixa de França, Jean Carl Silva

{"title":"[Study of polymorphism G54D of MBL2 gene in gestational diabetes mellitus].","authors":"Rejane Baggenstoss, Silvia Vanderléia Petzhold, Izabela K Michels Willemann, Francisco Simões Pabis, Paulo Gimenes, Barbara Vicente de Souza, Paulo Henrique Condeixa de França, Jean Carl Silva","doi":"10.1590/0004-2730000002819","DOIUrl":"https://doi.org/10.1590/0004-2730000002819","url":null,"abstract":"Objective: To assess the association of the G54D (rs1800450) polymorphism of the gene MBL2 in the gestational diabetes mellitus with the need for additional treatment and the occurrence of large newborns for the gestational age.Subjects and methods: One hundred and five patients recruited in Joinville--Brazil were evaluated between November 2010 and October 2012. Pregnant women were divided in two groups correspondents to the presence (n = 37) or absence (n = 68) of the mutant allele. The variants of the polymorphism G54D were identified by restriction fragment lengths polymorphisms (RFLP). Anthropometric and biochemical parameters of the mother and the newborn, and the necessity of additional therapy associated with diet were assessed as the primary outcomes.Results: Thirty-five point two percent of the evaluated patients carried at least one mutated allele of G54D polymorphism. There were no significant differences in weight gain, parity, age, body mass index and gestational age of arrival at maternity between the two groups. The groups of patients with or without the mutated allele did not differ in the need for additional treatment associated with diet (16.2% vs. 26.7%) respectively and with the occurrence of large newborns for gestational age (24.3% vs. 13.2%).Conclusion: Our data showed that the polymorphism G54D of the gene MBL2 had no effect in the need for additional treatment associated with the diet-based therapy and in the occurrence of large newborns for gestational age in the studied population.","PeriodicalId":8395,"journal":{"name":"Arquivos brasileiros de endocrinologia e metabologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/0004-2730000002819","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33332416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Should a family history of papillary thyroid carcinoma indicate more aggressive therapy in patients with this tumor? 甲状腺乳头状癌的家族史是否表明对这种肿瘤患者进行更积极的治疗?

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-11-01 DOI: 10.1590/0004-2730000003350

Pedro Weslley Rosario, Maria Regina Calsolari

{"title":"Should a family history of papillary thyroid carcinoma indicate more aggressive therapy in patients with this tumor?","authors":"Pedro Weslley Rosario, Maria Regina Calsolari","doi":"10.1590/0004-2730000003350","DOIUrl":"https://doi.org/10.1590/0004-2730000003350","url":null,"abstract":"Objective: To determine whether the currently recommended therapy for papillary thyroid carcinoma (PTC) that show no classical factors indicating a poor prognosis is also effective in cases with a family history of this tumor.Subjects and methods: Forty-two patients were studied; 10 were submitted to lobectomy and 32 to total thyroidectomy, including 23 without lymph node dissection and 9 with lymph node dissection. None of the patients received radioiodine or was maintained under TSH suppression.Results: No case of recurrence was detected by imaging methods and there was no increase in thyroglobulin or antithyroglobulin antibodies during follow-up (24 to 72 months).Conclusion: The treatment usually recommended for patients with PTC does not need to be modified in the presence of a family history of this tumor if no factors indicating a poor prognosis are present (tumor ≤2 cm, non-aggressive histology, no extensive extrathyroid invasion or important lymph node involvement, complete tumor resection, no evidence of persistent disease after surgery).","PeriodicalId":8395,"journal":{"name":"Arquivos brasileiros de endocrinologia e metabologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/0004-2730000003350","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32872033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Mutation screening of the sodium iodide symporter gene in a cohort of 105 China patients with congenital hypothyroidism. 105例中国先天性甲状腺功能减退症患者碘化钠同转运体基因突变筛查。

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-11-01 DOI: 10.1590/0004-2730000003436

Chunyun Fu, Shaoke Chen, Rongyu Chen, Xin Fan, Jingsi Luo, Chuan Li, Jiale Qian

{"title":"Mutation screening of the sodium iodide symporter gene in a cohort of 105 China patients with congenital hypothyroidism.","authors":"Chunyun Fu, Shaoke Chen, Rongyu Chen, Xin Fan, Jingsi Luo, Chuan Li, Jiale Qian","doi":"10.1590/0004-2730000003436","DOIUrl":"https://doi.org/10.1590/0004-2730000003436","url":null,"abstract":"Objective: Dyshormonogenetic congenital hypothyroidism (CH) was reported to be associated with a mutation in the sodium iodide symporter (NIS) gene. The present study was undertaken in the Guangxi Zhuang Autonomous Region of China, to determine the nature and frequency of NIS gene mutations among patients with CH due to dyshormonogenesis.Subjects and methods: Blood samples were collected from 105 dyshormonogenetic CH patients in Guangxi Zhuang Autonomous Region, China, and genomic DNA was extracted from peripheral blood leukocytes. All exons of the NIS gene together with their exon-intron boundaries were screened by next-generation sequencing.Results: Two silent variations (T221T and T557T) and one missense variation (M435L), as well as two polymorphisms (rs200587561 and rs117626343) were found.Conclusions: Our results indicate that the NIS mutation rate is very low in the Guangxi Zhuang Autonomous Region, China, and it is necessary to study mutations of other genes that have major effects on thyroid dyshormonogenesis and have not as yet been studied in this population.","PeriodicalId":8395,"journal":{"name":"Arquivos brasileiros de endocrinologia e metabologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/0004-2730000003436","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32872036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Breast cancer metastasis to the pituitary gland. 乳腺癌转移到脑垂体。

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-11-01 DOI: 10.1590/0004-2730000002950

Julia Fragoso Magalhães, Renata Prota Bacchin, Priscila Scatena Costa, Gisele Malavazi Alves, Fadlo Fraige Filho, Lenira Cristina Stella

引用次数: 11

Sitting-height measures are related to body mass index and blood pressure levels in children. 坐高测量与儿童的体重指数和血压水平有关。

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-11-01 DOI: 10.1590/0004-2730000003312

Daniele Gasparini Marcato, Jéssica Dutra Sampaio, Eduardo Roberty Badiani Alves, Julyanna Silva Araujo de Jesus, Jeanne Teixeira Bessa Fuly, Nayara Paula Bermudes Giovaninni, Everlayny Fiorot Costalonga

{"title":"Sitting-height measures are related to body mass index and blood pressure levels in children.","authors":"Daniele Gasparini Marcato, Jéssica Dutra Sampaio, Eduardo Roberty Badiani Alves, Julyanna Silva Araujo de Jesus, Jeanne Teixeira Bessa Fuly, Nayara Paula Bermudes Giovaninni, Everlayny Fiorot Costalonga","doi":"10.1590/0004-2730000003312","DOIUrl":"https://doi.org/10.1590/0004-2730000003312","url":null,"abstract":"Objective: Sitting height (SH) is an important parameter in the evaluation of children with growth and pubertal disorders. Besides this, it has been viewed as a biomarker of cardiovascular risk, which is increased in adults with relatively short legs. So, the aim of this study was to evaluate the relationship between body proportions and cardiovascular risk markers in children.Subjects and methods: Eight hundred and seventeen children aged 6-13 years were evaluated. Weight, height, sitting-height (SH), sitting-height/height (SH/H), body mass index (BMI) and blood pressure (BP) were assessed and converted to standard deviation scores (SDS) for age and sex. Statistical analyses were performed.Results: There was a positive association of BMI SDS with SH and SH/H SDS (p<0.001). Overweight children showed SH 0.8 SDS superior to eutrophic children (p<0.001). SH SDS was also directly related to BP SDS, but this association was not independent of the association between obesity and BP when assessed by multiple regression analyzes.Conclusion: Measures of SH are strongly associated with BMI and BP in children, although the association between SH and BP is probably dependent on the association of both those variables with BMI. This is (an) important information for correct interpretation of SH values in children.","PeriodicalId":8395,"journal":{"name":"Arquivos brasileiros de endocrinologia e metabologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/0004-2730000003312","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32872986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-11-01 DOI: 10.1590/0004-2730000003283

Henrique Vara Luiz, Diogo Gonçalves, Tiago Nunes da Silva, Isabel Nascimento, Ana Ribeiro, Manuela Mafra, Isabel Manita, Jorge Portugal

{"title":"IgG4-related Hashimoto's thyroiditis--a new variant of a well known disease.","authors":"Henrique Vara Luiz, Diogo Gonçalves, Tiago Nunes da Silva, Isabel Nascimento, Ana Ribeiro, Manuela Mafra, Isabel Manita, Jorge Portugal","doi":"10.1590/0004-2730000003283","DOIUrl":"https://doi.org/10.1590/0004-2730000003283","url":null,"abstract":"Hashimoto's thyroiditis (HT) has been characterized for many years as a well-defined clinicopathologic entity, but is now considered a heterogeneous disease. IgG4-related HT is a new subtype characterized by thyroid inflammation rich in IgG4-positive plasma cells and marked fibrosis. It may be part of the systemic IgG4-related disease. We report a case of a 56-year-old Portuguese man who presented with a one-month history of progressive neck swelling and dysphagia. Laboratory testing revealed increased inflammatory parameters, subclinical hypothyroidism and very high levels of thyroid autoantibodies. Cervical ultrasound (US) demonstrated an enlarged and heterogeneous thyroid gland and two hypoechoic nodules. US-guided fine needle aspiration cytology was consistent with lymphocytic thyroiditis. The patient was submitted to total thyroidectomy and microscopic examination identified typical findings of HT, marked fibrosis limited within the thyroid capsule and lymphoplasmacytic infiltration, with >50 IgG4-positive plasma cells per high-power field and an IgG4/IgG ratio of >40%. After surgery, serum IgG4 concentration was high-normal. Symptoms relief and reduction in laboratory inflammatory parameters were noticed. Thyroid function is controlled with levothyroxine. To our knowledge we report the first case of IgG4-related HT in a non-Asian patient. We also perform a review of the literature regarding IgG4-related disease and IgG4-related HT. Our case highlights this new variant of the well known HT, and helps physicians in recognizing its main clinical features, allowing for proper diagnosis and treatment. ","PeriodicalId":8395,"journal":{"name":"Arquivos brasileiros de endocrinologia e metabologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/0004-2730000003283","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32872846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Association of leptin levels with pathogenetic risk of coronary heart disease and stroke: a meta-analysis. 瘦素水平与冠心病和中风发病风险的关联:一项荟萃分析

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-11-01 DOI: 10.1590/0004-2730000003390

Rui Zeng, Chun-Hua Xu, Yuan-Ning Xu, Ya-Li Wang, Mian Wang

{"title":"Association of leptin levels with pathogenetic risk of coronary heart disease and stroke: a meta-analysis.","authors":"Rui Zeng, Chun-Hua Xu, Yuan-Ning Xu, Ya-Li Wang, Mian Wang","doi":"10.1590/0004-2730000003390","DOIUrl":"https://doi.org/10.1590/0004-2730000003390","url":null,"abstract":"Objective: This meta-analysis aimed to investigate the association of leptin levels with pathogenetic risk of CHD and stroke.Materials and methods: Studies were identified in the PubMed, Embase, and Springer link database without language restriction. Odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were used as effect indexes. The association of leptin levels with pathogenetic risk of CHD and stroke, as well as the risk variation of CHD with each additional one unit of leptin level were examined via meta-analysis. The publication bias was assessed via Egger's linear regression test.Results: Eight nested case-control studies consisting of 1,980 patients and 11,567 controls were included for current meta-analysis. ORs (95% CIs) of association of leptin levels with CHD and stroke was 1.90 (1.06, 3.43), and 2.14 (1.48, 3.08), respectively. In addition, significant result was obtained regarding the risk variation of CHD with each additional one unit of leptin level (OR =1.04, 95% CI =1.00-1.08, P=0.044). There was no significant publication bias as suggested by Egger test outcomes.Conclusion: There was a significant association of leptin with pathogenetic risk of CHD and stroke, and raised leptin levels could significantly increase the pathogenetic risk of CHD.","PeriodicalId":8395,"journal":{"name":"Arquivos brasileiros de endocrinologia e metabologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/0004-2730000003390","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32872034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

Short-term effects of triiodothyronine on thyroid hormone receptor alpha by PI3K pathway in adipocytes, 3T3-L1. 三碘甲状腺原氨酸对脂肪细胞中PI3K通路中甲状腺激素受体的短期影响。

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-11-01 DOI: 10.1590/0004-2730000003295

Miriane de Oliveira, Regiane Marques Castro Olimpio, Maria Teresa De Sibio, Fernanda Cristina Fontes Moretto, Renata de Azevedo Mello Luvizotto, Célia Regina Nogueira

{"title":"Short-term effects of triiodothyronine on thyroid hormone receptor alpha by PI3K pathway in adipocytes, 3T3-L1.","authors":"Miriane de Oliveira, Regiane Marques Castro Olimpio, Maria Teresa De Sibio, Fernanda Cristina Fontes Moretto, Renata de Azevedo Mello Luvizotto, Célia Regina Nogueira","doi":"10.1590/0004-2730000003295","DOIUrl":"https://doi.org/10.1590/0004-2730000003295","url":null,"abstract":"Objective: The present study aimed to examine the effects of thyroid hormone (TH), more precisely triiodothyronine (T3), on the modulation of TH receptor alpha (TRα) mRNA expression and the involvement of the phosphatidyl inositol 3 kinase (PI3K) signaling pathway in adipocytes, 3T3-L1, cell culture.Materials and methods: It was examined the involvement of PI3K pathway in mediating T3 effects by treating 3T3-L1 adipocytes with physiological (P=10nM) or supraphysiological (SI =100 nM) T3 doses during one hour (short time), in the absence or the presence of PI3K inhibitor (LY294002). The absence of any treatment was considered the control group (C). RT-qPCR was used for mRNA expression analyzes. For data analyzes ANOVA complemented with Tukey's test was used at 5% significance level.Results: T3 increased TRα mRNA expression in P (1.91±0.13, p<0.001), SI (2.14±0.44, p<0.001) compared to C group (1±0.08). This increase was completely abrogated by LY294002 in P (0.53±0.03, p<0.001) and SI (0.31±0.03, p<0.001). To examine whether TRα is directly induced by T3, we used the translation inhibitor cycloheximide (CHX). The presence of CHX completely abrogated levels TRα mRNA in P (1.15±0.05, p>0.001) and SI (0.99±0.15, p>0.001), induced by T3.Conclusion: These results demonstrate that the activation of the PI3K signaling pathway has a role in T3-mediated indirect TRα gene expression in 3T3-L1 adipocytes.","PeriodicalId":8395,"journal":{"name":"Arquivos brasileiros de endocrinologia e metabologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/0004-2730000003295","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32872037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Images in endocrinology: multinodular goitre. 内分泌影像:多结节性甲状腺肿。

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-11-01 DOI: 10.1590/0004-2730000003549

Umberto G Rossi, Maurizio Cariati

引用次数: 0