{"title":"Detection of the vulnerable coronary atheromatous plaque. Where are we now?","authors":"Sophia Vaina, Christodoulos Stefanadis","doi":"10.1080/14628840510011252","DOIUrl":"https://doi.org/10.1080/14628840510011252","url":null,"abstract":"<p><p>Atherosclerosis is a progressive process with potentially devastating consequences and has been identified as the leading cause of morbidity and mortality, especially in the industrial countries. The underlying mechanisms include endothelial dysfunction, lipid accumulation and enhanced inflammatory involvement resulting in plaque disruption or plaque erosion and subsequent thrombosis. However, it has been made evident, that the majority of rupture prone plaques that produce acute coronary syndromes are not severely stenotic. Conversely, lipid-rich plaques with thin fibrous cap, heavily infiltrated by inflammatory cells have been shown to predispose to rupture and thrombosis, independently of the degree of stenosis. Therefore, given the importance of plaque composition, a continuously growing interest in the development and improvement of diagnostic modalities will promptly and most importantly, accurately detect and characterize the high-risk atheromatous plaque. Use of these techniques may help risk stratification and allow the selection of the most appropriate therapeutic approach.</p>","PeriodicalId":83747,"journal":{"name":"International journal of cardiovascular interventions","volume":"7 2","pages":"75-87"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14628840510011252","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25240387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Carotid artery stenting: update.","authors":"Robert S Dieter, John R Laird","doi":"10.1080/14628840510039559","DOIUrl":"https://doi.org/10.1080/14628840510039559","url":null,"abstract":"<p><p>\"Extracranial carotid artery stenosis is responsible for approximately 20-30% of ischemic strokes. Traditionally, carotid artery stenosis has been treated with carotid endarterectomy. However, the low periprocedural complication rate and the mid term durability of carotid artery stenting has made it a competitive alternative treatment strategy. This update reviews the technical aspects of carotid artery stenting, clinical data supporting carotid artery stenting-particularly in high risk patients, and the complications associated with carotid artery stenting.\"</p>","PeriodicalId":83747,"journal":{"name":"International journal of cardiovascular interventions","volume":"7 3","pages":"126-33"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14628840510039559","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25651711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Danny Dvir, Hadar Marom, Victor Guetta, Ran Kornowski
{"title":"Three-dimensional coronary reconstruction from routine single-plane coronary angiograms: in vivo quantitative validation.","authors":"Danny Dvir, Hadar Marom, Victor Guetta, Ran Kornowski","doi":"10.1080/14628840500193398","DOIUrl":"https://doi.org/10.1080/14628840500193398","url":null,"abstract":"<p><strong>Background: </strong>Current X-ray technology displays the complex 3-dimensional (3-D) geometry of the coronary arterial tree as 2-dimensional (2-D) images. To overcome this limitation, an algorithm was developed for the reconstruction of the 3-D pathway of the coronary arterial tree using routine single-plane 2-D angiographic imaging. This method provides information in real-time and is suitable for routine use in the cardiovascular catheterization laboratory.</p><p><strong>Objectives: </strong>The purpose of this study was to evaluate the precision of this algorithm and to compare it with 2-D quantitative coronary angiography (QCA) system.</p><p><strong>Methods: </strong>Thirty-eight angiographic images were acquired from 11 randomly selected patients with coronary artery disease undergoing diagnostic cardiac catheterization. The 2-D images were analyzed using QCA software. For the 3-D reconstruction, an algorithm integrating information from at least two single-plane angiographic images taken from different angles was formulated.</p><p><strong>Results: </strong>3-D acquisition was feasible in all patients and in all selected angiographic frames. Comparison between pairs of values yielded greater precision of the 3-D than the 2-D measurements of the minimal lesion diameter (P<0.005), minimal lesion area (P<0.05) and lesion length (P<0.01).</p><p><strong>Conclusions: </strong>The study validates the 3-D reconstruction algorithm, which may provide new insights into vessel morphology in 3-D space. This method is a promising clinical tool, making it possible for cardiologists to appreciate the complex curvilinear structure of the coronary arterial tree and to quantify atherosclerotic lesions more precisely.</p>","PeriodicalId":83747,"journal":{"name":"International journal of cardiovascular interventions","volume":"7 3","pages":"141-5"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14628840500193398","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25651714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"CT angiography is here--are we expected to see a change of angiography referral pattern?","authors":"Ariel Roguin, Jon R Resar","doi":"10.1080/14628840500280609","DOIUrl":"https://doi.org/10.1080/14628840500280609","url":null,"abstract":"<p><p>A 52-year-old asymptomatic man, with cardiac risk factors of hypertension, Type II diabetes, hypertriglyceridemia, low HDL, obesity, and positive family history for early coronary artery disease (CAD), was referred to nuclear stress test. He exercised for 14 minutes, achieved his target heart rate, without any symptoms or ECG changes. Nuclear images were entirely normal. However, the patient was still concerned and anxious so he underwent CT angiography that revealed coronary narrowings. Next, he underwent coronary angiography with similar findings. The lesions were treated with stents. We present a case report to illustrate how newer technology such as CT angiography alters the way in which we diagnose CAD and decide on whether to pursue further invasive therapy.</p>","PeriodicalId":83747,"journal":{"name":"International journal of cardiovascular interventions","volume":"7 3","pages":"152-4"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14628840500280609","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25651660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bo Han, Moen Aboud, Menahem Nahir, Farid Noem, Yonathan Hasin
{"title":"Cutting balloons versus conventional long balloons for PCI of long coronary lesions.","authors":"Bo Han, Moen Aboud, Menahem Nahir, Farid Noem, Yonathan Hasin","doi":"10.1080/14628840510011171","DOIUrl":"https://doi.org/10.1080/14628840510011171","url":null,"abstract":"<p><strong>Background: </strong>PCI for long coronary lesions remains a challenge because of high incidence of early complications and late restenosis. Cutting balloon angioplasty may result in reduced procedural complications and late restenosis than angioplasty with conventional long balloons (LBA) due to minimized injury to the culprit arteries.</p><p><strong>Objective: </strong>To compare the immediate and one-year outcomes of CBA and LBA for long coronary lesions.</p><p><strong>Methods: </strong>169 consecutive patients were retrospectively identified who underwent CBA or LBA for de novo lesions 20 mm in length and 2.5 mm in diameter. The primary endpoint was immediate procedural outcomes and angiographic restenosis at one year.</p><p><strong>Results: </strong>CBA was performed in 54 patients (56 lesions) and LBA in 115 patients (151 lesions). Baseline characteristics were similar in both groups with a mean lesion length of 34.89+/-11.19 mm, and vessel diameter of 3.03+/-0.54 mm. CBA resulted in reduced incidence of side branch loss (23.2% versus 41.7%, P=0.022) which was associated with less peri-procedural infarction (OR: 11.39 (95% CI: 1.34-96.53), P=0.026). It also caused less dissection (23.2% versus 38.4%, P=0.048) leading to a trend of less provisional focal stenting (32.1% versus 41.1%, P=0.264). The rate of angiographic restenosis and clinically driven target lesion revascularization at one year (follow-up 91.1%) was similar (25% versus 21.2%, and 20.4% versus 20%, for CBA versus LBA, both P=NS). The mean event-free survival was also similar (10.15+/-0.45 months for CBA versus 9.50+/-0.39 months for LBA, P=NS).</p><p><strong>Conclusion: </strong>CBA demonstrated better immediate results and equivalent late results than LBA, and therefore, it may be considered a reasonable firstline approach for PCI of long coronary lesions.</p>","PeriodicalId":83747,"journal":{"name":"International journal of cardiovascular interventions","volume":"7 1","pages":"29-35"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14628840510011171","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25190698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ariel Roguin, Benjamin A Steinberg, Stanley P Watkins, Jon R Resar
{"title":"Safety of bivalirudin during percutaneous coronary interventions in patients with abnormal renal function.","authors":"Ariel Roguin, Benjamin A Steinberg, Stanley P Watkins, Jon R Resar","doi":"10.1080/14628840510011298","DOIUrl":"https://doi.org/10.1080/14628840510011298","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease is associated with an increased risk of ischemic and bleeding complications after percutaneous coronary intervention (PCI). Bivalirudin, a direct thrombin inhibitor, has been shown to reduce adverse bleeding events compared to unfractionated heparin in patients undergoing PCI. However, the effect of diminished renal function on the safety and efficacy of bivalirudin for PCI is unknown. We aimed to test the safety of bivalirudin in routine practice and to assess whether this benefit was influenced by renal function.</p><p><strong>Methods and results: </strong>The interaction between renal impairment and benefit from bivalirudin was assessed in 115 consecutive patients (age 68.5+/-12.1, 45% female) undergoing PCI. Bivalirudin dosing was adjusted based on renal function. Creatinine clearance (CrCl) was calculated using the Cockroft-Gault formula. The composite endpoints of in-hospital death, myocardial infarction or revascularization and bleeding events were assessed. Overall, these events occurred in 10 (8.7%) patients. Patients with a CrCl<60 ml/min had a significantly increased risk for in-hospital complications (18.6 versus 2.78%, P = 0.011). Univariate analysis for MACE and bleeding were significant for CrCl<60 ml/min OR: 2.54 (95% CI: 1.61-39.7, P = 0.011), age OR: 3.29 (95% CI: 1.07-1.39, P<0.001) and female gender OR: 2.1 (95% CI: 0.036-0.89, P = 0.036). Risk of complications increased with decreasing renal function: 2.7, 14.2, and 37.5% for CrCl of >60, 30-60 or <30 ml/min, respectively, P = 0.002).</p><p><strong>Conclusion: </strong>Advanced age, renal dysfunction, and female gender remain important risk factors for ischemic and bleeding complications in patients undergoing PCI with bivalirudin.</p>","PeriodicalId":83747,"journal":{"name":"International journal of cardiovascular interventions","volume":"7 2","pages":"88-92"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14628840510011298","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25240388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joerg Herrmann, Aaron Ciechanover, Lilach O Lerman, Amir Lerman
{"title":"The ubiquitin-proteasome system--micro target for macro intervention?","authors":"Joerg Herrmann, Aaron Ciechanover, Lilach O Lerman, Amir Lerman","doi":"10.1080/14628840510011234","DOIUrl":"https://doi.org/10.1080/14628840510011234","url":null,"abstract":"<p><p>The ubiquitin-proteasome system is the two sequential labeling and degradation system that accounts for the degradation of 80-90% of all intracellular proteins. Based on the diversity of its substrates, it is integrated in many different biological processes, especially inflammation and cell proliferation. Given the significance of these two processes for primary atherosclerosis and restenosis, the ubiquitin-proteasome system may be an amendable target in cardiovascular therapy. This review provides background information on the ubiquitin-proteasome system, currently available data on its involvement in cardiovascular diseases, and a future perspective on the targeted use proteasome inhibitors, including drug-eluting stents.</p>","PeriodicalId":83747,"journal":{"name":"International journal of cardiovascular interventions","volume":"7 1","pages":"5-13"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14628840510011234","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25189276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bo Han, Li Liu, Mouin Aboud, Menahem Nahir, Yonathan Hasin
{"title":"Provisional stenting for multivessel PCI.","authors":"Bo Han, Li Liu, Mouin Aboud, Menahem Nahir, Yonathan Hasin","doi":"10.1080/14628840510011162","DOIUrl":"https://doi.org/10.1080/14628840510011162","url":null,"abstract":"<p><strong>Background: </strong>Bare stents reduce acute complications and repeat revascularization following percutaneous coronary intervention (PCI), but are costly and may lead to in-stent restenosis. It remains unclear whether stents should be universally implanted or whether provisional stenting mainly to suboptimal balloon dilatation results is an acceptable approach for multivessel PCI.</p><p><strong>Objective: </strong>To compare the long-term clinical restenosis and target lesion revascularization (TLR) of stented and non-stented coronary artery lesions in patients who had multivessel PCI.</p><p><strong>Methods: </strong>We performed retrospective analysis of matched data from 129 consecutive patients who underwent multivessel PCI (at least optimal balloon angioplasty to one coronary artery segment and balloon angioplasty plus stenting to another coronary artery in the same patient, all lesions are de novo native coronary artery lesions with vessel diameter >/=2.5 mm). The study endpoint was restenosis and repeat revascularization at one-year follow-up.</p><p><strong>Results: </strong>Baseline characteristics were similar in both groups. Low in-hospital MACE (3.1%). Acute myocardial infarction, emergency revascularization via either PCI or CABG was detected and angiographic success was achieved in 99.3% of lesions in both groups. The rate of clinically driven angiographic restenosis and TLR at one-year (follow-up 100%) was similar (17.1% versus 18.6%, P=0.871, and 13.9% versus 16.3%, P=0.728, for optimal balloon angioplasty versus provisional stenting.</p><p><strong>Conclusions: </strong>The main findings from this study are that long-term angiographic restenosis and TLR was comparable for optimal balloon angioplasty and provisional stenting, suggesting that provisional stenting is an acceptable approach for multivessel PCI.</p>","PeriodicalId":83747,"journal":{"name":"International journal of cardiovascular interventions","volume":"7 1","pages":"46-51"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14628840510011162","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25190701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chiara Pedone, Maniyal Vijayakumar, Jourgen M L Ligthart, Marco Valgimigli, Elena Biagini, Nico De Jong, Patrick W Serruys, Folkert J Ten Cate
{"title":"Intracardiac echocardiography guidance during percutaneous transluminal septal myocardial ablation in patients with obstructive hypertrophic cardiomyopathy.","authors":"Chiara Pedone, Maniyal Vijayakumar, Jourgen M L Ligthart, Marco Valgimigli, Elena Biagini, Nico De Jong, Patrick W Serruys, Folkert J Ten Cate","doi":"10.1080/14628840500280575","DOIUrl":"https://doi.org/10.1080/14628840500280575","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous transluminal septal myocardial ablation (PTSMA) recently emerged as an alternative to myectomy for hypertrophic obstructive cardiomyopathy (HOCM) patients with drug-refractory symptoms. The target septal branch selection is a main point to achieve the therapeutic result.</p><p><strong>Methods and results: </strong>We report about PTSMA performed using intracardiac echocardiography (ICE) to guide the procedure in 9 symptomatic HOCM patients. The target septal branch was chosen on the basis of the risk-area visualized using ICE after injection of a contrast agent. During alcohol administration a backscattered signal enhancement of the infarcted area was detected. The procedures were uncomplicated and effective to reduce the gradient from 78.9+/-20.4 mmHg to 7.8+/-7.9 mmHg (p<0.0001).</p><p><strong>Conclusions: </strong>In this initial experience ICE monitoring during PTSMA was safe and provided high quality and continuous imaging of the treated segment of the septum during the whole procedure.</p>","PeriodicalId":83747,"journal":{"name":"International journal of cardiovascular interventions","volume":"7 3","pages":"134-7"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14628840500280575","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25651712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hatem Hamood, Nabeel Makhoul, Amin Hassan, Arie Shefer, Uri Rosenschein
{"title":"Embolic protection: limitations of current technology and novel concepts.","authors":"Hatem Hamood, Nabeel Makhoul, Amin Hassan, Arie Shefer, Uri Rosenschein","doi":"10.1080/14628840500285038","DOIUrl":"https://doi.org/10.1080/14628840500285038","url":null,"abstract":"<p><p>Distal embolic event is one of the major limitations of coronary and non-coronary vascular interventions. Balloon and filter-based Embolic Protection Devices (EPDs) are a new class of interventional devices, used to prevent consequential morbidity and mortality of the distal embolic events. Data from first generation EPD supply proof of concept and show approximately 40% reduction in mortality and morbidity, when EPDs are used during saphenous vein grafts (SVGs) interventions. Current limitations of all first generation EPD technology taper their penetration. With breakthroughs in embolic protection technology, it is estimated that, in the near future, EPDs will be used with stenting in all high-risk lesions (SVGs, carotid arteries and acute coronary syndromes), become the standard of care and even be used in low risk cases.</p>","PeriodicalId":83747,"journal":{"name":"International journal of cardiovascular interventions","volume":"7 4","pages":"176-82"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14628840500285038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25766042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}