Annals of Colorectal Research最新文献_第5页

Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer 肿瘤内质网应激、未折叠蛋白反应(UPR)和Wnt信号通路之间的串扰

Annals of Colorectal Research Pub Date : 2020-03-01 DOI: 10.30476/ACRR.2020.46538

M. Siri, S. Hosseini, S. Dastghaib, P. Mokarram

{"title":"Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer","authors":"M. Siri, S. Hosseini, S. Dastghaib, P. Mokarram","doi":"10.30476/ACRR.2020.46538","DOIUrl":"https://doi.org/10.30476/ACRR.2020.46538","url":null,"abstract":"Abstract: 1. Context Endoplasmic reticulum stress (ER stess) is associated with endoplasmic reticulum perturbation homeostasis. Prolonged ER stress conditions may induce cell death. Unfolded protein response (UPR) attempts to restore normal cell conditions. 2. Evidence Acquisition There now exists an emergent body of evidence identifying the WNT signaling network as a regulator of cancer cell metabolism. Given that existing findings show that the WNT pathway and ER stress regulates changes in metabolic activities of cancer cells suggesting these signaling pathways represent critical nodes in the regulation of central metabolism in tumors. 3. Results Findings suggest that the molecular cross-talks between hypoxic ER stress, Wnt/βcatenin signaling, may represent an important mechanism that enables some tumor subtypes to survival and grow in hypoxic conditions. 4. Conclusions The present article disuses differential effects of the activation of the three arms of UPR, namely endoplasmic reticulum kinase (PERK), activation transcription factor -6 (ATF-6), and inositol –requiring enzyme (IRE-1) on cancer. This review also highlights regulators and downstream effectors of Wnt cascade and addresses the increasingly apparent crosstalk of Wnt with other tumorigenic signaling pathways.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78267953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cancer bio-repository 癌症bio-repository

Annals of Colorectal Research Pub Date : 2019-12-01 DOI: 10.30476/ACRR.2019.46388

S. Fakher, S. Hosseini, Mozhdeh Zamani, L. Ghahramani, P. Mokaram

{"title":"Cancer bio-repository","authors":"S. Fakher, S. Hosseini, Mozhdeh Zamani, L. Ghahramani, P. Mokaram","doi":"10.30476/ACRR.2019.46388","DOIUrl":"https://doi.org/10.30476/ACRR.2019.46388","url":null,"abstract":"Background: Cancer research is highly dependent of large amount of data and high quality samples which can be provided by networks to enable large-scale multi-center research projects. Biologic materials, such as blood, tissue samples, DNA, body fluids and the related data obtained in cohorts and clinical trials are valuable sources for research which should be managed by policies and standard operating procedures as biorepositories or biobanks. Methods and evidence acquisition: The authors investigated and summarized pubmed database articles using biobanks and describing the policies. Conclusion: biobanking as a young discipline in different countries needs new technologies, standards and harmonization. In this review article, we have an overview on biorepository, cancer biobanking and the emerging registry in Iran. Background: Cancer research is highly dependent of large amount of data and high quality samples which can be provided by networks to enable large-scale multi-center research projects. Biologic materials, such as blood, tissue samples, DNA, body fluids and the related data obtained in cohorts and clinical trials are valuable sources for research which should be managed by policies and standard operating procedures as biorepositories or biobanks. Methods and evidence acquisition: The authors investigated and summarized pubmed database articles using biobanks and describing the policies. Conclusion: biobanking as a young discipline in different countries needs new technologies, standards and harmonization. In this review article, we have an overview on biorepository, cancer biobanking and the emerging registry in Iran.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87525217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining Hyper-Reactivity to Defecation-Related Sensations in Children With Functional Defecation Disorders (FDD) 功能性排便障碍(FDD)患儿对排便相关感觉的高反应性研究

Annals of Colorectal Research Pub Date : 2019-12-01 DOI: 10.5014/ajot.2020.74s1-rp201a

Isabelle Beaudry-Bellefeuille, A. Lane, E. Ramos-Polo, S. Lane

{"title":"Examining Hyper-Reactivity to Defecation-Related Sensations in Children With Functional Defecation Disorders (FDD)","authors":"Isabelle Beaudry-Bellefeuille, A. Lane, E. Ramos-Polo, S. Lane","doi":"10.5014/ajot.2020.74s1-rp201a","DOIUrl":"https://doi.org/10.5014/ajot.2020.74s1-rp201a","url":null,"abstract":"Background: Adequate sensory perception and reactivity to sensory stimuli associated with defecation is key to successful stool toileting. Preliminary reports suggests that some of the difficulties that many children with FDD experience with toileting could be related to sensory hyper-reactivity. Objective: This study investigated the relationship between sensory hyper-reactivity and functional defecation disorders (FDD). Methods: Parents of three to six-year-old children with and without FDD completed two questionnaires; the Toileting Habit Profile Questionnaire-Revised (THPQ-R; tool that measures sensory hyper-reactivity to defecation related sensations) and the Short Sensory Profile (SSP). On both questionnaires, low scores indicate more concerns. Between group comparisons and the relationship between scores on the THPQ-R and on the sensory hyper-reactivity items of the SSP were examined. Results: The sensory hyper-reactivity mean score of the SSP was lower for children with FDD. The difference was statistically significant (p < .0005). There was a positive correlation between THPQ-R and SSP hyper-reactivity scores (r274 = .485, p < .0005). Further, higher levels of sensory hyperreactivity (low SSP score) were associated with a higher frequency of the challenging defecation behaviors described in the THPQ-R (low THPQ-R score). Conclusion: Health practitioners do not usually consider sensory hyper-reactivity as a possible factor contributing to the difficulties of the child with FDD. Our results indicate that routine screening for sensory hyper-reactivity may be an important practice element when working with children with FDD. In addition, the present study adds support to the validity of the THPQ-R in identifying behaviors potentially linked to sensory hyper-reactivity.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78890390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The Results and Outcomes of Rectal Cancer Treatment in the Era of Adjuvant Chemoradiation 辅助放化疗时代直肠癌治疗的结果与结局

Annals of Colorectal Research Pub Date : 2019-12-01 DOI: 10.30476/ACRR.2019.45941

A. Izadpanah, S. Hosseini, M. Al-Qanbar, Mozhdeh Zamani, Behnam Kadkhodaei

{"title":"The Results and Outcomes of Rectal Cancer Treatment in the Era of Adjuvant Chemoradiation","authors":"A. Izadpanah, S. Hosseini, M. Al-Qanbar, Mozhdeh Zamani, Behnam Kadkhodaei","doi":"10.30476/ACRR.2019.45941","DOIUrl":"https://doi.org/10.30476/ACRR.2019.45941","url":null,"abstract":"Abstract Background: Colorectal cancer causes many deaths worldwide and rectal cancer includes one-third of them. Surgical mesorectal excision along with preoperative neoadjuvant chemoradiotherapy is known as the standard treatment for rectal cancer. However, inaccurate preoperative staging is a main concern which leads to large number of patients not being treated with neoadjuvant therapy. Selection of the best treatment approach for these patients is controversial. Although significant better survival was observed is patients who received postoperative adjuvant chemoradiation compared with patients who treated with surgery alone, other studies did not find such results. Due to these contradictory results, this study was designed to further evaluate the survival outcomes in rectal cancer patients who received adjuvant chemoradiotherapy without neoadjuvant therapy. Methods: Totally 197 rectal cancer patients who received adjuvant chemoradiation were included in this study. The demographic and clinico-pathological characteristics of the patients were evaluated by statistical analysis. Results: Based on the univariate cox regression, poor disease free survival (DFS) was significantly associated with male sex and T3 stage. Poor overall survival (OS) was also associated with stage II/III, T3/T4, NI/NII, grade II/III, positive node number (> 3), perineural invasion, lymphovascular invasion, and margin involvement. According to the multivariate cox regression, independent predictive factors for DFS were T3 andT4 stage, and for OS were also T3/ T4 stage, grade II/ III and lymphovascular invasion. Conclusions: Taken together, obtained results indicated that combined adjuvant chemoradiation contributes to improve survival outcomes in the rectal cancer patients who did not received neoadjuvant therapy.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86677148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Desmoid tumor initially unresectable – About two cases 硬纤维瘤最初不可切除-约2例

Annals of Colorectal Research Pub Date : 2019-12-01 DOI: 10.30476/ACRR.2019.45966

Sara Senti Farraraons, A. González, C. Velazquez, Clara Gené Škrabec, I. C. Ausàs

引用次数: 0

Prevalence of Neuroendocrine Tumors in the Gastrointestinal and Hepatobiliary Systems 胃肠道和肝胆系统神经内分泌肿瘤的患病率

Annals of Colorectal Research Pub Date : 2019-06-01 DOI: 10.5812/ACR.88004

M. V. Lorenzo, F. M. Agel, R. A. Belando, E. Mengual

{"title":"Prevalence of Neuroendocrine Tumors in the Gastrointestinal and Hepatobiliary Systems","authors":"M. V. Lorenzo, F. M. Agel, R. A. Belando, E. Mengual","doi":"10.5812/ACR.88004","DOIUrl":"https://doi.org/10.5812/ACR.88004","url":null,"abstract":"Background: Carcinoid tumors are the most common neuroendocrine tumors. In recent years, these tumors have had an increasein incidence, which is probably due to a higher number of them being incidentally found as a result of the rise of preventivemedicine.Objectives: This study aimed to analyze a series of digestive carcinoid tumors detected by conventional endoscopy and/or echoendoscopyto evaluate the prevalence of those located in the colon and rectum, and subsequently make a comparison with data availablein the literature.Methods: In this retrospective, multicenter study (two centers), the clinical records of 100 white patients with more than 100 digestivecarcinoid tumors (some multiple) diagnosed from 1994 to 2018 were reviewed.Results: The mean age of presentation was 52 years and 57% of the patients were men. The mean tumor size was 10 mm. The localizationof the tumors was: stomach 43% (n = 43); duodenum 5% (n = 5); intestine 8% (n = 8); appendix 14% (n = 14); colon 4% (n = 4);rectum 19% (n = 19); pancreas 3% (n = 3); liver 2% (n = 2); gallbladder 1% (n = 1); primary tumor of unknown origin 1% (n = 1). Mostmultifocal tumors were in the stomach (20%; n = 20), followed by the duodenum (1%; n = 1) and intestine (1%; n = 1). Metastases andcarcinoid syndrome were observed in 6% and 5% of the cases, respectively. General survival at the closure of the study was 80%.Conclusions: Age and sex were similar to those described in the literature, while the colon and rectum represented 23% of all carcinoidtumors. There was a predominance of gastroduodenal and rectal carcinoid tumors, probably because the series analyzedwas essentially endoscopic. In comparison with the literature, less cases of metastases or carcinoid syndrome were recorded andsurvival was greater, perhaps due to earlier diagnosis and treatment.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74970658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Insights into the Roles of Yes-Associated Protein (YAP1) in Colorectal Cancer Development and Progression yes相关蛋白(YAP1)在结直肠癌发生和进展中的作用的新见解

Annals of Colorectal Research Pub Date : 2019-06-01 DOI: 10.5812/ACR.96458

F. Dehghanian, Zahra Azhir, Atefe Akbari, Z. Hojati

{"title":"New Insights into the Roles of Yes-Associated Protein (YAP1) in Colorectal Cancer Development and Progression","authors":"F. Dehghanian, Zahra Azhir, Atefe Akbari, Z. Hojati","doi":"10.5812/ACR.96458","DOIUrl":"https://doi.org/10.5812/ACR.96458","url":null,"abstract":"Yes-associated protein (YAP1), the downstream effector of the Hippo pathway, plays important roles in the regulation of tissue reconstruction,stem cell proliferation, and development of different cancers. The regulation of YAP1 phosphorylation, YAP1 expressionlevel, and its cellular localization have been considered in cancer development. There are different experimental evidences thatindicate that YAP1 activation results in tumorigenesis, tumor progression, and metastasis. YAP1 is a transcription co-activator, andits dysregulation has been suggested in various cancers including colorectal cancer (CRC). The localization of YAP1 in the nucleusresults in YAP1 interactions with different transcription factors to promote the expression of genes involved in cell proliferation,metastasis, and stem cell maintenance. However, a number of studies have been reported the tumor suppressor role of YAP1 in CRC.Therefore, a better understanding of the YAP1 regulation could be helpful for prevention, diagnosis, and treatment of CRC. In thisreview, we will discuss different roles of YAP1 in CRC progression through the regulatory roles of long non-coding RNAs (LncRNAs),microRNAs (miRNAs) and circular RNAs (CircRNAs) in YAP1 regulation.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80374174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Carausius morosus (Phasmatodea) Homologues of Human Genes with Elevated Expression in the Colon 人类结肠中表达升高基因的同源性研究

Annals of Colorectal Research Pub Date : 2019-06-01 DOI: 10.5812/ACR.93703

M. Shelomi

{"title":"Carausius morosus (Phasmatodea) Homologues of Human Genes with Elevated Expression in the Colon","authors":"M. Shelomi","doi":"10.5812/ACR.93703","DOIUrl":"https://doi.org/10.5812/ACR.93703","url":null,"abstract":"Background: Preliminary testing of novel drugs for colorectal conditions must be performed on animal models, with invertebratemodels desirable for practical reasons. The insect excretory organs, the Malpighian tubules, have been cited as models for humanrenal disease research because they differentially express several genes homologous to those differentially expressed in humankidneys. Their role in excretion and homeostasis suggests that they could be models for human colorectal disease. The insect Carausiusmorosus (Phasmatodea) has been a model organism for decades. Regarding its potential use as a colorectal disease model,it has an advantage over other insects in that excretion in Phasmatodea is split between two organs: Malpighian tubules and thePhasmatodea-specific “appendices of the midgut”.Objectives: To find homologues of human colon genes expressed in the excretory tissues of C. morosus for potential use in drugtesting and other experiments requiring an animal model.Methods: Pre-existing transcriptomics data for the excretory system of the C. morosus were examined to find genes homologous tothose known to have elevated expression in the human colon. This was done with the goal of possibly determining the excretorytissues in which they are differentially expressed.Results: Exactly sixty transcripts from the excretory system transcriptome of C. morosus showed high sequence homology withhuman colon-specific genes, with a minimum e-value of 1e-50. Examples include solute carriers, myosin, bestrophin, carbonic anhydrase,and nitric oxide synthase. Several genes were identified with prognostic value for renal, pancreatic, endometrial, liver, skin,and urothelial cancers.Conclusions: C. morosus can be used as model insect for human medical research applications, including colorectal drug testing.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81931382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zika Virus Infection and Colorectal Involvement 寨卡病毒感染与结直肠病变

Annals of Colorectal Research Pub Date : 2019-06-01 DOI: 10.5812/ACR.93108

V. Wiwanitkit

{"title":"Zika Virus Infection and Colorectal Involvement","authors":"V. Wiwanitkit","doi":"10.5812/ACR.93108","DOIUrl":"https://doi.org/10.5812/ACR.93108","url":null,"abstract":"Dear Editor, In medicine, the clinical spectrum of vector-borne diseases is an important issue. In particular, the colorectal involvement of these diseases has attracted much interest. In a previous publication, the interrelationship between the dengue virus and colorectal disease was explored (1). In the present article, the author would like to highlight the importance of investigating the relationship between Zika virus infection and colorectal disease. Zika virus disease is an emerging vector-borne disease presently considered as a significant public health problem. As a new disease, further clinical research on this condition is still required. To the best of our knowledge, the colorectal presentation of Zika virus infection is yet to be reported. Nevertheless, it has already been ascertained that the Zika virus can infect the colorectal mucosa (2). In a recent report by Li et al. the Zika virus was reported to be able to infect rectal mucosa, with this pathology being related to the fecal shedding of the virus (2). The Zika virus can also be detected using rectal swabs (3, 4); a recent report demonstrated that rectal swab samples led to positive viral tests in 10% of patients infected with the Zika virus (4). Rectal infection with the Zika virus can explain the disease transmission via homosexual contact, which is an important mode of Zika virus infection (5). It can also imply the necessity for infection control during any medical procedure involving the colorectal area. Finally, it is an interesting research issue to follow up whether any clinical problems are caused by Zika virus infection at the colorectal mucosa.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72713313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Principles of Minimally Invasive Surgery for Colorectal Cancer, A Mini Review Article 结直肠癌微创手术原理综述

Annals of Colorectal Research Pub Date : 2019-06-01 DOI: 10.5812/ACR.90936

J. Ruiz-Tovar

引用次数: 0