Yakushigaku zasshi最新文献

The Heroic and Noble Life of Morizo ISHIDATE Commemorating the 115 years since his birth and 20 years since his death. 石idate的英雄和高贵的一生纪念他诞辰115周年和逝世20周年。

Yakushigaku zasshi Pub Date : 2016-01-01

Kazushige Morimoto

{"title":"The Heroic and Noble Life of Morizo ISHIDATE Commemorating the 115 years since his birth and 20 years since his death.","authors":"Kazushige Morimoto","doi":"","DOIUrl":"","url":null,"abstract":"Morizo Ishidate was born in the city of Aomori on January 24, 1901, the third son in his family. As the 16th Director General of the NIHS, he announced his decision to reform the organization and implemented this action in 1966. In September 1970, as the president of the Central Pharmaceutical Affairs Council, he decided to stop the use of all quinoform preparations. On May 21, 1973, he held a historic talk with Dr. Taro Takemi. After the meeting, the separation of dispensing and prescribing functions opened a new chapter in pharmaceutical history. Such a heroic and noble life may be due to his faith. In April 1922, he entered “Doushikai,” a dormitory belonging to Tokyo Imperial University. Yoshinosuke Konishi was his best friend in the dormitory. They joined a bible class directed by an American missionary, Miss Laura J. Maukʼ. In September 1947, at the age of 49, Yoshinosuke decided to devote the rest of his life to being an evangelist. After that time, Morizo supported him for 33 years. At the age of 70, Morizo confessed his belief of Jesus Christ’s resurrection from the dead based upon following words in the bible, “Therefore, if anyone is in Christ, he is a new creation. The old has passed away; behold, the new has come,” (2 CORINTHIANS 5 : 17). On July 18, 1996, he passed away at the age of 95.","PeriodicalId":83554,"journal":{"name":"Yakushigaku zasshi","volume":"51 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36463719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Change of Reference to Post-Marketing Surveillance Based on the Sequence of Revising the Pharmaceutical Affairs Law. 从《药事法》修改顺序看上市后监管权限的变化。

Yakushigaku zasshi Pub Date : 2016-01-01

Haruo Takahashi

{"title":"The Change of Reference to Post-Marketing Surveillance Based on the Sequence of Revising the Pharmaceutical Affairs Law.","authors":"Haruo Takahashi","doi":"","DOIUrl":"","url":null,"abstract":"The present Pharmaceutical Affairs Law (PAL) was promulgated in October 1960 and enforced in February 1961．Thereafter, PAL has been frequently revised, was renamed the Pharmaceuticals and Medical Devices Act (PMD Act) in November 2013, and the PMD Act was enforced in November 2014. It describes the change of reference to Post-Marketing Surveillance (PMS) based on the sequence of revisions of PAL for approximately 50 years. Although the purpose of PAL in 1960 was “to control and regulate drugs, quasi-drugs, cosmetics and medical devices (drugs, etc.), and to contrive proper use,” it did not include rules regarding PMS. Thereafter, “to assure the quality, efficacy and safety of drugs, etc.,” “to promote research and development of orphan drugs, etc.” and “to regulate designated substances” were added to the purpose of PAL over a period of time. At the time of establishing the PMD Act, “to assure the quality, efficacy and safety of regenerative products, to promote their research and development, and to prevent the onset and spread of hazards to public health and hygiene through the use of drugs, etc. ”was added to the purpose. Simultaneously, the matters of control and regulation using PAL were increased whenever PAL was revised.\u0000Additionally, the PMS systems, such as adverse drug reactions reporting, drug reevaluation and drug reexamination, and the Good Post-Marketing Surveillance Practice (GPMSP) regarding the enforcement standards of PMS, etc. were initiated by regulatory directions and legislated after their establishment. Moreover, an infection reporting system and early-phase pharmcovigilance, etc. were added to the PMS systems. Furthermore, GPMSP was divided into the Good Vigilance Practice (GVP) for marketing license conditions and the Good Post-Marketing Study Practice (GPSP) for enforcement standards regarding post-marketing investigations and clinical trials, and both are regulated.","PeriodicalId":83554,"journal":{"name":"Yakushigaku zasshi","volume":"51 1","pages":"29-39"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36462967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacology in a Cup of Coffee The Virtue of Coffee and Vitamins Learned from the History of Scurvy and Dropsy. 一杯咖啡中的药理学从坏血病和水肿的历史中了解到咖啡和维生素的好处。

Yakushigaku zasshi Pub Date : 2016-01-01

Kitaro Oka

引用次数: 0

"Terumeru," A Patent Medicine of the Late Edo Era-The Packaging, Efficacy Statement, and Dosage Form. 江户时代晚期的一种专利药——“特鲁姆露”的包装、功效说明和剂型。

Yakushigaku zasshi Pub Date : 2016-01-01

Kayoko Nojiri

引用次数: 0

Transition of Psychotropic Drugs in Japanese Pharmacopoeia (JP) (Part 18) The Study for New Knowledge and Decisions regarding Cultivation Method for Japanese Valerian (Kisso). 日本药典中精神药物的变迁(第十八部分)日本缬草栽培方法的新认识与新决策研究

Yakushigaku zasshi Pub Date : 2016-01-01

Kiyohisa Yanagisawa

{"title":"Transition of Psychotropic Drugs in Japanese Pharmacopoeia (JP) (Part 18) The Study for New Knowledge and Decisions regarding Cultivation Method for Japanese Valerian (Kisso).","authors":"Kiyohisa Yanagisawa","doi":"","DOIUrl":"","url":null,"abstract":"In Japanese Pharmacopoeia (JPXVII 2016), there is a description about Kanokoso, “This item is the root and rootstock of Kanokoso Valeriana fauriei Briquet (Valerianaceae). Kanokoso Valeriana fauriei Briquet is referring to Ezokanokoso Valeriana fauriei forma yezoensis Hara, which is the same variety. The Hokkai-kisso currently cultivated in Japan is the Ezokanokoso variety. The author analyzed the history of the variety of Japanese Valerian previously cultivated, but it’s incomplete. To maintain the quality and efficacy of a medicine, it is important to disseminate information regarding the origin of the crude drug. To ensure the quality of Kanokoso and stable efficacy of the medicine, it’s indispensable to maintain the original plant variety when cultivated.The author obtained the following knowledge during research. The variety cultivated in Kanagawa early in the Showa era was Japanese Valerian, sometimes being two kinds, lobule and round leaf. It is presumed that the original variety cultivated in Kanagawa early in the Showa era was Hokkai-kisso.The ingredients of the variety of Japanese Valerian cultivated and that which grows wild vary. The basis of the chemical structure of sesqui terpene kinds of α-Kessyl alcohol (KA) and Kessyl glycol diacetate (KGD), etc. has Kessane skeleton. It’s this consistency and is gathered using the same type of system. The consistency is interesting. Pursuing the relation between the consistency and type of system is regarded as a problem. To obtain the same kind of ingredient and form from Hokkai-kisso in the current state seems difficult. To maintain today’s quality of Hokkai-kisso and medicinal efficacy, it’s important for continue to cultivating the plant by dividing the roots for replanting.","PeriodicalId":83554,"journal":{"name":"Yakushigaku zasshi","volume":"51 2","pages":"96-103"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36462934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Historical and Hygienic Aspects on Roles of Quality Requirements for Antibiotic Products in Japan : Part 3-Introduction of Technologyand Knowledge in the Production Process and Quality Control of Penicillin from the United States of America. 日本抗生素产品质量要求的历史和卫生方面的作用:第3部分:美国青霉素生产过程和质量控制的技术和知识介绍。

Yakushigaku zasshi Pub Date : 2016-01-01

Morimasa Yagisawa, Patrick J Foster, Tatsuo Kurokawa

{"title":"Historical and Hygienic Aspects on Roles of Quality Requirements for Antibiotic Products in Japan : Part 3-Introduction of Technology\u0000and Knowledge in the Production Process and Quality Control of Penicillin from the United States of America.","authors":"Morimasa Yagisawa, Patrick J Foster, Tatsuo Kurokawa","doi":"","DOIUrl":"","url":null,"abstract":"In order to investigate the roles of quality requirements for antibiotic products in Japan, from historical and hygienic aspects, we examined and analyzed how technology and knowledge in the production and quality control of penicillin were introduced from the United States of America, applied, and further developed.\u0000Owing to the strong support of Colonel Crawford Sams, the chief of the Public Health and Welfare Section of the Supreme Commander for Allied Power/General Headquarters, via the Ministry of Welfare in Japan, the technology and knowledge were acquired from an experienced leader, Dr. Jackson W. Foster, and as a result, domestic production of penicillin was successfully achieved in amounts required to meet national demands sufficiently within three years in a devastated post-war-torn Japan.\u0000Based on the consensus that penicillin should be dealt with as “biological products” similar to vaccines and antisera, the quality standards for penicillin were enacted as the “Minimum Requirements for Penicillin (MRP)” on the 1st of May 1947. Due to the development of penicillin production technology, the quality standards of penicillin provided by the MRP were revised often to higher levels ; content of the active element from no less than 60 units/mg (purity 3.8%) to no less than 1,430 units/mg (purity 89.7%). Regarding the penicillin preparations, the content of the active ingredient per vial was changed from 30,000 units at the beginning, to 100,000 units in January 1948, to 3,000,000 units in December 1950, and two preparations containing 200,000 units and 1,000,000 units per vial are currently available, according to clinical convenience.","PeriodicalId":83554,"journal":{"name":"Yakushigaku zasshi","volume":"51 1","pages":"18-28"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36462968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studies on the History of Pharmacy and the Evolution of Word Usage-Japanese Yakumi and Ryouri. 药物史与词的演变研究——日本的“Yakumi”和“Ryouri”。

Yakushigaku zasshi Pub Date : 2016-01-01

Makoto Mayanagi

引用次数: 0

Transition of Psychotropic Drugs in Japanese Pharmacopoeia (JP) (Part 17) Transitions in the Standards and Test Methods of Valproic Acid and Sodium Valproate in Japanese Pharmacopoeia (JP), Pharmacopoeia of the USA (USP), British Pharmacopoeia (BP), and the Knowledge and Judgment aboutJapanese Valeriana, and Valproic Acid from Valeric Acid 日本药典中精神药物的过渡(第十七部分)日本药典(JP)、美国药典(USP)、英国药典(BP)中丙戊酸和丙戊酸钠标准和试验方法的过渡，以及对日本缬草和戊酸中丙戊酸的认识和判断

Yakushigaku zasshi Pub Date : 2016-01-01

Kiyohisa Yanagisawa

{"title":"Transition of Psychotropic Drugs in Japanese Pharmacopoeia (JP) (Part 17) Transitions in the Standards and Test Methods of Valproic Acid and Sodium Valproate in Japanese Pharmacopoeia (JP), Pharmacopoeia of the USA (USP), British Pharmacopoeia (BP), and the Knowledge and Judgment about\u0000Japanese Valeriana, and Valproic Acid from Valeric Acid","authors":"Kiyohisa Yanagisawa","doi":"","DOIUrl":"","url":null,"abstract":"Valproic acid (VPA) and sodium valproate (VPA-Na) are used for the treatment of various things today, such as epilepsy and manic-depressive states. Moreover, use has expanded to a variety of applications, such as the prevention of migraine headaches. As a result, a high demand has been maintained. The chemical structure is a branching low-grade saturated fatty acid, which is simpler than other psychotropic drugs. VPA is called 2-propyl-pentanoic acid and 2-propyl-valeric acid under the IUPAC system, and is derived from Valeric acid. This time, the author researched transitions in the standards and testing methods for VPA and VPA-Na in JP, USP and BP. It was found that each countryʼs pharmacopoeia described a detection test for substances related to VPA. It can be explained that VPA is derived from Valeric acid based on the test contents. Valeric acid is a component of Japanese Valeriana and Valerian root. It is believed that there is a sense of value as the origin of VPA is Japanese Valeriana and Valeriana root.","PeriodicalId":83554,"journal":{"name":"Yakushigaku zasshi","volume":"51 1","pages":"40-57"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36462970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

History of French Pharmaceutical Education from 16th Century up to the Present􁴷Study on Japanese Pharmaceutical Education : Comparison between Japan and France - Pharmaceutical Education System. 16世纪至今法国药学教育史􁴷Study日本药学教育:日法比较——药学教育体系。

Yakushigaku zasshi Pub Date : 2016-01-01

Kumiko Giga, Hirotoshi Echizen

{"title":"History of French Pharmaceutical Education from 16th Century up to the Present􁴷Study on Japanese Pharmaceutical Education : Comparison between Japan and France - Pharmaceutical Education System.","authors":"Kumiko Giga, Hirotoshi Echizen","doi":"","DOIUrl":"","url":null,"abstract":"After the long isolation in the Edo era, the new Meiji government tried to import science and culture from western countries. In the field of medical science, Kanpo, Chinese medicine, was abolished and western medicine was introduced in Japan. A medical system was established in 1874, but the division of prescribing medicines and dispensing them had not been introduced yet, and this situation prevented the increase in newborn pharmacists and solid pharmaceutical education for a long time. However, when the division of prescribing and dispensing medicines started in the late 1980s, the demand for pharmacists increased and a six-year pharmaceutical education system was introduced in 2006. The core curriculum that was established about 10 years ago had many problems, but the system was revised in 2013. The goal of the efforts is to improve the situation regarding the quality, quantity and contents of clinical pharmaceutical education for the new generation of pharmacists to come over the next 10 years. It is important to look at the pharmaceutical education of Japan in light of that of France, where the division of prescribing and dispensing medicine, and the pharmacy itself had been established in medieval times, focusing on the history of the educational system and requirements for pharmacists.","PeriodicalId":83554,"journal":{"name":"Yakushigaku zasshi","volume":"51 1","pages":"58-63"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36462933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

["Holtos," a Patented Medicine of the Late Edo Era--Wrapping Style, Statement of Medicine Efficacy, and Tablet Form]. [“Holtos”，江户时代晚期的专利药物——包装风格、药效陈述和片剂形式]。

Yakushigaku zasshi Pub Date : 2015-01-01

Kayoko Nojiri

引用次数: 0