Archives of Internal Medicine Research最新文献

{"title":"Myelofibrosis with Transient Pancytopenia and CD-68 Marker Positivity: A Case to Review","authors":"M. Asghar, S. Aslam, Durre Naman, Maryam Zafar, Narmin Khan, Haris Alvi, U. Rasheed, Abubakar Tauseef","doi":"10.26502/aimr.0012","DOIUrl":"https://doi.org/10.26502/aimr.0012","url":null,"abstract":"Myelofibrosis is characterized by a group of clonal neoplastic proliferation under the influence of cytokines such as fibroblast growth factor (particularly by megakaryocytes) which leads to the replacement of normal hematopoietic bone marrow with connective tissue via collagen fibrosis. It most commonly affects patients in the fifth and sixth decade of their life. Constitutional symptoms such as fatigue along with massive splenomegaly, easy fatigability, and easy bruising are reported most commonly in such patients. Here we present a case of a 76-year-old male who was diagnosed with myelofibrosis having transient pancytopenia and CD-68 marker positive.","PeriodicalId":8282,"journal":{"name":"Archives of Internal Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75335457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geriatric Patients: Data on Dental Problems at this Age","authors":"A. Heta, Merilda Tarja, Sonila Kapaj, Eduard Kapaj, E. Milo, Ilma Robo","doi":"10.26502/aimr.0014","DOIUrl":"https://doi.org/10.26502/aimr.0014","url":null,"abstract":"Introduction: As the age increases, the frequency of hearing loss, visual impairment, cataract and glaucoma is increased. Most of the geriatric patients suffer from at least one chronic disease. The aim of the study is the evaluation of the presence of dental problems in geriatric age and comparison of the frequency of lesion manifestations of pre-geriatric age. Material and methods: In a sample of 73 ad-hoc presented patients, at the University Clinic, Albanian University, for dental treatments, data on the oral status of geriatric patients were collected over a period of 2 weeks, 7-21 May 2019. The conditions for inclusion in the study were the age of the patient, 50 years and over. The mean age of geriatric age is 65 years, but the age of the study was decided to compare the elements of dental problems before the geriatric age, such as a pre-geriatric specimen or geriatric pathologies. Patients were evaluated for age, degree of education, number of teeth in the oral cavity, number of replaceable teeth, number of teeth with caries in the tooth crown, number of denture teeth in the tooth root, number of teeth with gingival recession 3 or more mm. etc. Results: Regardless of the age distribution, almost 55% of the oral cavities are full of natural tooth, the fixed prosthesis is at the highest level at age 50-65 years. Independently of the gender, the average age of the patients involved  is  almost the same 67 years. Crown caries expresses the highest level of 14% at oral cavity at 66-90 years of age, caries of root amounted to 14% of oral cavity at 50-65 years of age. Xerostomia appears at 13% in the age 50-65 years, and 20% in the age of 66-90. Gingival recession and loss of attachment express the highest values at male patients, with a value over 3mm. Conclusions: At geriatric patients, the aim should be to reduce the number of bacteria in the mouth and the mechanical cleaning of the teeth. At pre-geriatric age, it is more common the appearance of caries of the crown than in the geriatric age, where the most common is the caries of the roots of teeth. This fact is supported by the addition and agitation of xerostomia in the oral cavity, which increases with age. The pre-geriatric age still has naturally occurring oral cavity that can be used for fixed prosthetics. At the age of geriatric patients, the total prosthetic replacement takes the highest weight.","PeriodicalId":8282,"journal":{"name":"Archives of Internal Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84417286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Mortality in Patients with TB/HIV Co-Infection at the General Provincial Reference Hospital of Kinshasa, Democratic Republic of the Congo","authors":"Palambwa Ansot Anzats Ruphine, N. K. Oscar,, G. Bongo, Nsobani Lukelo Désiré, Amuli Jiwe Jean-Pierre","doi":"10.26502/aimr.006","DOIUrl":"https://doi.org/10.26502/aimr.006","url":null,"abstract":"Background: The HIV (human immunodeficiency virus) pandemic has been accompanied by an increase in the incidence of many opportunistic infections like tuberculosis (TB). Despite curative and preventive efforts and free treatment for TB -HIV co-infection, the Democratic Republic of Congo remains the fourth country in Africa where the prevalence of this co-infection remains very high. The aim of this study was to identify the factors that explain mortality in patients with TB/HIV co-infection at the Kinshasa Provincial General Reference Hospital in order to reduce the incidence of complications related to this century's pandemic.Methods: The survey was conducted at the General Provincial Reference Hoisptal of Kinshasa (GPRHK), Kinshasa, DR Congo. This cross-sectional study was conducted between January and November 2018, whereby medical files for patients suffering from TB/HIV co-infection were analyzed. The sample size was determined on the basis of the Fischer formula. Thus, one hundred and forty-four (144) files were selected and consulted. Data were collected based on a pre-established, standardized and anonymous questionnaire. This questionnaire was tested on a sample of 40 files subsequently validated. Descriptive analyses were used to describe the sample profile. The correlational analysis using the Chi-square association test (X2), the confidence interval of the Odds-ratio was performed between different variables. All data were analyzed using SPSS software version 22.0. The p value < 0.05 was considered statistically significant.Results: Multiple regression analysis indicates that the main determinants of mortality in patients with TB/HIV co-infection are as follows: the main predictors of mortality from TB/HIV co-infection were, in order of importance, patients diagnosed with HIV (0.448; p0.05), patients treated with anti-tubercular drugs (0.231; p0.05). The clinical form of tuberculosis ( -0.032; p0.05) and the age of people living with HIV (0.038; p0.05) are not significantly associated with TB-HIV co-infection.Conclusion: The diagnosis of HIV infection in TB patients in the absence of anti-tuberculin prophylaxis, followed by the clinical form of tuberculosis coupled with poor compliance and significant immunosuppression are the major risk factors for mortality.","PeriodicalId":8282,"journal":{"name":"Archives of Internal Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83128408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Vitamin D Deficiency in Pregnant Diabetic Patients in Western Libya","authors":"Ghrew Murad, Ellafi Hanan, M. Abdulghani, Bashein Abdulla, Sultan Mohammed, S. Khaled","doi":"10.26502/aimr.005","DOIUrl":"https://doi.org/10.26502/aimr.005","url":null,"abstract":"Despite the relative abundance of sunny weather, surprisingly, there is increasing evidence that vitamin D deficiency is extremely prevalent in females of reproductive age in Middle East countries. There is also increasing interest in the non-classical roles of vitamin in health and disease including its relation to incidence of gestational diabetes, its impact on glycaemic control in diabetes mellitus, and its association with some complications of pregnancy like preeclampsia. The objective of this study was to estimate the prevalence of Vitamin D deficiency in pregnant diabetic patients in west Libya and analyse potential links to socioeconomic and cultural factors. This is a cross sectional observational study. Random plasma was collected form expected mothers attending the Antenatal Diabetes Clinic at Tripoli’s Main Maternity Hospital. Demographics and socioeconomic and cultural factors were recorded at the same time. Samples were analysed for vitamin D level and biochemical screening panel. Vitamin D level was obtained from 160 patients (mean age 35 years). Over all 95 % of the study population had vitamin D levels below normal (defined as vitamin D level of 30 ng/ml, only 1.3%, 2 patients). All patients were taking daily vitamin D Supplements at a dose of 400 IU as per hospital policy. Vitamin D deficiency is extremely prevalent in pregnant diabetic patients in Libya. There is no clear association with socioeconomic risk factors like employment, type of accommodation or geographic distribution. However, most of the study population had life style characterized by minimal exposure to direct sun light. Routine supplementation of Vitamin D in doses of 400 IU/day does not appear to ameliorate the severity of vitamin D deficiency in this group.","PeriodicalId":8282,"journal":{"name":"Archives of Internal Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78795150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global DNA Methylation in Children with Complicated Urinary Tract Infection","authors":"K. Sekar, S. Krishnamurthy, J. Mandal, M. Rajappa","doi":"10.26502/aimr.0017","DOIUrl":"https://doi.org/10.26502/aimr.0017","url":null,"abstract":"Background and Objectives: The Study suggests that pathogen interceded DNA methylation changes influence the gene expression pattern contributing to disease progression. To study the association between pathogen-induced global DNA methylation variation in children with complicated Urinary tract infection and healthy children. Methods: The study was conducted in the Department of Pediatrics of a referral hospital. For this study, 50 children as cases with complicated UTI and 50 healthy children as controls were enrolled. Whole blood genomic DNA was isolated from the cases as well as controls. Using 5-mC (methylcytosine) DNA ELISA method, the percentage of genomic DNA methylation in these children was established.  Results: Global DNA methylation level was found highly significant between cases and controls and the percentage of DNA methylation level was (Cases: 25.81 ± 6.9; Controls: 15.354 ± 3.17; P<0.001). Receiver operating curve analysis showed that the area under curve 0.92 for the total study population. Interpretation and conclusions: The results of this study show that genomic DNA methylation varies significantly among cases and controls. This study points towards the role of DNA methylation in the pathogenesis of complicated urinary tract infection.","PeriodicalId":8282,"journal":{"name":"Archives of Internal Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79929480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SFRP2 Promoter Methylation Analysis in Tumor Tissue, Stool, and Plasma DNA of Patients with Colorectal Cancer","authors":"Yong-Suk Kim, Song-Hak Kim, Myong-Nam Kim, Un-Rim Sim","doi":"10.26502/aimr.009","DOIUrl":"https://doi.org/10.26502/aimr.009","url":null,"abstract":"Noninvasive method for early detection of human cancers is promising way to provide more quality health service to the population. The serum and stool of colorectal cancer patients often harbor increased free DNA levels, which can potentially be used for cancer detection. Because SFRP2 (secreted frizzled related protein 2) is considered a Wnt inhibitor whose CpGs were frequently hypermethylated in several human cancers, we investigated the frequency of aberrant SFRP2 promoter methylation in primary tumors and serum or stool samples of colorectal cancer patients by MS-PCR. We detected methylation of SFRP2 in 111 of 117 (94.9%) paraffin-embedded colorectal cancer tissues. Fifty-nine of the 68 (86.8%) available serum samples from these cases carried detectable amounts of the methylated SFRP2 promoter. Sixty-one of 68 (89.7%) available stool samples from the same cases carried positive methylation in the promoter region of SFRP2 gene. In contrast, no methylated SFRP2 promoter DNA was detected in serum and stool samples from 60 healthy controls. Only 2 cases of 68 healthy controls showed methylated SFRP2 promoter DNA in their colorectal tissue. But high frequency of methylated SFRP2 gene promoter has no correlation with the clinic-pathologic features. We concluded that SFRP2 methylation analysis appeared to be a noninvasive tumor marker in serum and/or stool DNA","PeriodicalId":8282,"journal":{"name":"Archives of Internal Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74190350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Subdural Haemorrhage Following a Trivial Fall - A Case Report","authors":"Navin Kumar Devaraj","doi":"10.26502/aimr.008","DOIUrl":"https://doi.org/10.26502/aimr.008","url":null,"abstract":"","PeriodicalId":8282,"journal":{"name":"Archives of Internal Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77742490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Review on the Obstinate Childhood Nocturnal Enuresis Treated with Manual Cure","authors":"C. Jang, U. Chon, Chol-Song Ri","doi":"10.26502/aimr.0011","DOIUrl":"https://doi.org/10.26502/aimr.0011","url":null,"abstract":"Childhood nocturnal enuresis is concerned to be related mainly to the dysfunction of the autonomic nervous system with parasympathetic nerve accentuation, feeble-mindedness, the organic disorder of the central nervous system, the organic abnormality of the urethra, diabetes, diabetes insipidus, parasites, tonsillar hypertrophy, dysmature, dyscontrol of urination and the decrease of ADH secretion. We gave a new outlook that childhood nocturnal enuresis may as well be developed when some functions concerned with voluntary constriction of the external urethral sphincter, constriction and relaxation of cystic smooth muscles are out of control of pelvic and public nerve from S2-4 nerves along sacral segment by subluxation of sacroiliac joint resulting in the depression or dysfunction of sacral segment. In below-mentioned cases who suffered from the obstinate childhood nocturnal enuresis that did not respond at all to modern and Koryo medicines, acupuncture, moxibustion, etc., we introduced the remedy of sacroiliac joint subluxation correction and they were all recovered. This is a new suggestion that childhood nocturnal enuresis might he cause by subluxation of sacroiliac joint and it can be cured with correction remedy.","PeriodicalId":8282,"journal":{"name":"Archives of Internal Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76620128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unscarred Uterine Rupture (UUR) - Not A Rarity In Developing Countries","authors":"Fizzah Arif","doi":"10.26502/aimr.004","DOIUrl":"https://doi.org/10.26502/aimr.004","url":null,"abstract":"Uterine rupture during pregnancy is a life threatening obstetric complication. It is defined as a nonsurgical disruption in the wall of the uterus along with visceral peritoneum. It is far more common in developing countries due to the numerous direct and indirect factors like lack of family planning, poor maternal health, poor management of labor, home deliveries by untrained professionals and others. It commonly manifests as acute abdomen and hemodynamic instability due to hemoperitoneum. Letter To The Editor Dear Editor, Worldwide incidence of uterine rupture during pregnancy is 1 per 1,416 pregnancies (0.07%). Single most important factor leading to this consequence is a scarred uterus due to previous uterine surgery. Rupture of an unscarred uterus occurs rarely in developed countries its rate is 1 per 8,434 pregnancies (0.012%) whereas the incidence is eight times higher in developing countries that is 1 in 920 (0.11%) [1]. It has been found that uterine rupture can occur in previously normal uterus in early pregnancies and beforehand preparations in such cases prevent from the lethal complications of this dreadful event. Uterine Rupture is a potentially fatal sequalae of late pregnancy and labor in a uterus with scarring. Rupture of unscarred uterus most commonly involves the lower segment of uterus which is the weakest part [2]. In Pakistan, incidence of uterine rupture is reported in 1 out of 64 deliveries [3]. Only 0.012% of normal uteri are at risk of rupture and chances of rupture increases with the number of previous scars. It is 0.5% after one caesarean section and 2% after two or more than two scars [1]. 29.5 % of the diagnosed Pakistani women had unscarred uteri previously [4]. Arch Intern Med Res 2019;2(1): 001-003 DOI: 10.26502/aimr.004 Archives of Internal Medicine Research 2 Factors associated with unscarred uterine rupture (UUR) in developing countries are high parity [5,2], abnormal placenta implantation, uterine anomalies, malpresentations, injudicious use of uterotonics [2] breech extraction, uterine instrumentation, myomectomy and macrosomia [1]. Other factors are low socioeconomic status, unbooked patients, prolonged and mismanaged labor and delay in receiving care during obstructed labor [5]. Clinical presentation of uterine rupture varies at different gestational ages and on the site of rupture. Signs and symptoms include abdominal pain, hemorrhage (revealed or concealed), fetal bradycardia, recession of fetal presenting part, gut prolapse in vagina, presence of placenta at vulva [3], hypotension and hypovolemic shock. Maternal consequences arising from this event include hemorrhage, anemia, bladder injury, need for hysterectomy, hypovolemic shock and death whereas fetal hypoxia, acidosis, admission to NICU and fetal death can occur [1]. In a study conducted to determine the risk factors of uterine rupture in developing countries, it has been reported that the frequency of uterine rupture is twice among the females who ","PeriodicalId":8282,"journal":{"name":"Archives of Internal Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87792827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Unusual Case of Child Tantrum - A Case Report","authors":"N. Devaraj","doi":"10.26502/aimr.007","DOIUrl":"https://doi.org/10.26502/aimr.007","url":null,"abstract":"This is an amazing case report about an eight years old child that displayed child tantrum more synonym of the younger age group. This case also entails how the author managed to uncover the true reasons for his tantrum that left his guardian truly amazed at the ability of physicians to solve a seemingly difficult behavioural problem.","PeriodicalId":8282,"journal":{"name":"Archives of Internal Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80818869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}