Archives of Internal Medicine Research最新文献

{"title":"Knowledge, Attitude, and Practice of Diabetic Patients Following Up In King Khalid University Hospital about Insulin Use; a Cross-Sectional Study","authors":"Faisal Alshuwair, Abdulaziz Alalwan, Ibrahim Alshayea, Nasser AbuDujain, Eman Alhammad, Ibtisam Alkhlassi, Yousef Alluhaymid","doi":"10.26502/aimr.0153","DOIUrl":"https://doi.org/10.26502/aimr.0153","url":null,"abstract":"Objectives: There are not many studies evaluating the knowledge, attitudes, and practices of insulin self-administration in Saudi Arabia; therefore, we conducted this study aiming to determine the level of knowledge diabetic patients have on insulin use. amd also to establish the most common mistakes, most patients do.","PeriodicalId":8282,"journal":{"name":"Archives of Internal Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135506851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of mortality and aspirin use for COVID-19 residents at VA Community Living Center Nursing Homes","authors":"Y. Abul, F. Devone, Thomas A Bayer, C. Halladay, K. McConeghy, Nadia Mujahid, Mriganka Singh, C. Leeder, S. Gravenstein, James L. Rudolph","doi":"10.1101/2022.08.03.22278392","DOIUrl":"https://doi.org/10.1101/2022.08.03.22278392","url":null,"abstract":"Background/Objectives: Coronavirus disease 2019 (COVID-19) is associated with a hypercoagulable state and increased thrombotic risk in infected individuals. Several complex and varied coagulation abnormalities were proposed for this association1 .Acetylsalicylic acid(ASA, aspirin) is known to have inflammatory, antithrombotic properties and its use was reported as having potency to reduce RNA synthesis and replication of some types of coronaviruses including human coronavirus-299E (CoV-229E) and Middle East Respiratory Syndrome (MERS)-CoV 2,3. We hypothesized that chronic low dose aspirin use may decrease COVID-19 mortality relative to ASA non-users. Methods: This is a retrospective, observational cohort analysis of residents residing at Veterans Affairs Community Living Centers from December 13, 2020, to September 18, 2021, with a positive SARS-CoV-2 PCR test. Low dose aspirin users had low dose (81mg) therapy (10 of 14 days) prior to the positive COVID date and were compared to aspirin non-users (no ASA in prior 14 days). The primary outcome was mortality at 30 and 56 days post positive test and hospitalization within 14 days of positive test result. Results: We identified 1.823 residents who had SARS-CoV-2 infection and 1,687 residents were eligible as a final analytic sample after excluding high dose and intermittent/partial dose aspirin users. Overall mean age was 72.28+/-11.66 years and 3.3% (n=67) female in the final analytic sample. Among the 511 (30.3%) residents taking chronic low dose aspirin, 30-day mortality after an initial SARS-CoV-2 test establishing infection was 6.46% (n=33) compared to 10.29% (n=121) of non-users (SMD >0.1). 56-day mortality after initial SARS-CoV-2 test establishing infection was 9.0% (n=46) compared to 13.18% (n=155) not taking low dose aspirin (SMD >0.1). Cox proportional hazards model showed that aspirin use was independently associated with a reduced risk of 30 days of mortality (adjusted HR, 0.60, 95% CI, 0.40-0.90) and 56 days of mortality (adjusted HR, 0.67, 95% CI, 0.47-0.95) Conclusion: In this retrospective observational study of VA Community Living Center residents infected with SARS-CoV-2, low dose aspirin use for primary or secondary prevention of cardiovascular events is associated with lower COVID-19 mortality and fewer breakthrough cases. Although additional randomized controlled trials are required to understand these associations and the potential implications more fully for improving care, aspirin remains a medication with known side effects and clinical practice should not change based on these findings.","PeriodicalId":8282,"journal":{"name":"Archives of Internal Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84494923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telemedicine and Use of Remote Monitoring in Cardiovascular Disease: A Systematic Review","authors":"Umna Safdar Khan, Babivigasan Gunasegaran, Ann Mary Behanan, Suganya Giri Ravindran, Obianuju Efobi, N. Sultana, Iffat Iqbal, Srija Chowdary Vanka, Deepkumar Patel, Abiodun O. Aboaba, Olubukola Oloniyo, Esosa Daniel Omoregie, Stephen Dada, Mayowa Stephen Apata, Osahon David Omoregie","doi":"10.26502/aimr.0085","DOIUrl":"https://doi.org/10.26502/aimr.0085","url":null,"abstract":"Dow International Medical College (DIMC), Dow University of Health Sciences (DUHS), Pakistan Caribbean Medical University, Willemstad Curacao Kanyakumari Government Medical College, India Danylo Halytsky Lviv National Medical University, Ukraine Shaheed Suhrawardy Medical College, Bangladesh Dow University of Health Sciences (DUHS), Pakistan Dr. Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, India Smt. B. K. Shah Medical Institute & Research Centre (SBKS), India Avalon University School of Medicine, Willemstad Curacao Windsor University School of Medicine, St. Kitts University of Benin, School of Medicine, Nigeria","PeriodicalId":8282,"journal":{"name":"Archives of Internal Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84936968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron Deficiency Anemia Predisposing to Acute Ischemic Stroke – Is there a Need for more Aggressive Approach?","authors":"Rida Mansoor, Mohammad Waseem Lodhi, Hania Zafar, Shahbaz Haider, Rukhsana Abdul Sattar","doi":"10.26502/aimr.0135","DOIUrl":"https://doi.org/10.26502/aimr.0135","url":null,"abstract":"anemia results in decreased iron causing microcytic hypochromic erythropoiesis with decreased serum iron and Abstract Background: An increase or","PeriodicalId":8282,"journal":{"name":"Archives of Internal Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87886574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives of Hospitalists in an Academic Health System.","authors":"T R Clarke,&nbsp;Josh Laban,&nbsp;Ahmed Luqman","doi":"10.26502/aimr.0139","DOIUrl":"https://doi.org/10.26502/aimr.0139","url":null,"abstract":"<p><strong>Objectives: </strong>The primary outcome of this study is to assess the perspectives of Hospitalists on their workload and their perceived effects on patient care. The secondary outcomes are to evaluate the satisfaction of the Hospitalists with their compensation, quality of life, scholarship activity and promotion in their department and the support received to achieve this.</p><p><strong>Methodology: </strong>We developed a 49-question questionnaire. The questionnaire was based on (a) Oldenburg Burnout Inventory and (b) topics specific to census, compensation, academic support with desire for promotion, and the effects of workload on patient care and teaching. All questions were formatted with a 4-point Likert-type response scale. The questionnaires were distributed electronically using an online survey platform to all 32 of the Hospitalists at our institution.</p><p><strong>Conclusion: </strong>Each institution needs to do a self-assessment based on clinician feedback: Hospitalists workload, burn-out and satisfaction to reduce the high turnover rates and brevity of this role. From this study in this academic institution, the perspectives of Hospitalists revealed a high level of burn out (exhaustion and disengagement) and high assigned patient censuses that negatively impact their ability to deliver optimal patient care. Most Hospitalists reported lack of mentorship and inadequate time allocated for scholarly activity. The majority reported not having their input on decisions made by the administration that directly affect them. Most were unsatisfied with their compensation and the lack of PTO (paid time off). The majority would like to be promoted in this academic institution but feel unsupported to achieve this goal.</p>","PeriodicalId":8282,"journal":{"name":"Archives of Internal Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10366312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Learning Objectives, What’s to Gain in Bedside Teaching?","authors":"Verkleij S P C, de Graaf I M","doi":"10.26502/aimr.0118","DOIUrl":"https://doi.org/10.26502/aimr.0118","url":null,"abstract":"","PeriodicalId":8282,"journal":{"name":"Archives of Internal Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78375720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the COVID-19 Pandemic on Florida Medical Students’ Wellbeing and Academic Experience During “Lockdown”","authors":"Shadi A. Baajour, W. Wahood, Kate J F Carnevale","doi":"10.26502/aimr.0136","DOIUrl":"https://doi.org/10.26502/aimr.0136","url":null,"abstract":"record-Abstract Introduction: The global pandemic of coronavirus disease 2019 (COVID-19) has continued to demonstrate considerable impacts on all aspects of life, as well as mental health across populations. Medical students may be considered a particularly vulnerable population during the COVID-19 pandemic due to the compounding mental stress of a demanding medical education. Methods: A cross-sectional online","PeriodicalId":8282,"journal":{"name":"Archives of Internal Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83307835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial Genome Screening Identified 26 Novel Variants in Children with Nonsyndromic Congenital Hearing Impairment","authors":"Hema Bindu L, Shehnaz Sultana, P. Pardhanandana Reddy","doi":"10.26502/aimr.0095","DOIUrl":"https://doi.org/10.26502/aimr.0095","url":null,"abstract":"Mitochondrial Genome Screening Identified 26 Novel Variants in Children with Nonsyndromic Congenital Hearing Impairment. Abstract Background: Mitochondrial DNA (mtDNA) mutations may be responsible for the pathogenesis of maternally inherited hearing loss in both nonsyndromic and syndromic condition. Several mitochondrial genes, including genes coding for rRNA, tRNA, and respiratory chain complex subunits and protein coding genes play significant role in nonsyndromic deafness. Materials and Methods: 175 children with congenital hearing impairment and 92 normal subjects were screened for 13 mitochondrial genes comprising of two small ribosomal genes (12S rRNA and 16S rRNA), 7 tRNA genes (tRNA Val, tRNA Leu (UUR), tRNA Ile, tRNA Gln, tRNA Met, tRNA Ser (UCN) and tRNA Asp) and 4 protein coding genes (NADH dehydrogenase 1, NADH dehydrogenase 2, Cytochrome Oxidase I and Cytochrome Oxidase II) genes using specific sets of overlapping oligonucleotide primers for amplification. Results: A total of 26 novel variations were observed in the present study. 8 of COI genes. Three variants, each belonging to ND1 (3456T/G), COI (6140C/A) and COII (8115G/A) genes were found to be heteroplasmic. Out of 26, 8 variants were observed to be transversions and 11 as transitions. Out of 19 novel variants of protein coding genes, 3 missense (A3652G, G7830A, 8115G/A) mutations and 16 silent mutations were observed. Conclusion: This study demonstrated that various mitochondrial genes including protein-coding genes might be responsible for nonsyndromic deafness, providing new insights on the molecular bases of this pathology.","PeriodicalId":8282,"journal":{"name":"Archives of Internal Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88458639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why the HPV Vaccine is Essential to Preventing a Rising Threat","authors":"Krishna Vedala MD MPH, Gopika Gopakumar, Raghuveer Vedala MD","doi":"10.26502/aimr.0086","DOIUrl":"https://doi.org/10.26502/aimr.0086","url":null,"abstract":"Over the past few decades, the prevalence of HPVassociated oral cancers has steadily risen. Such a trend can be attributed to changing sexual behaviors, specifically oral sexual activity among adolescents. The HPV vaccine has been a key component in the battle against cervical cancer. It is therefore imperative we similarly emphasize adherence to the HPV vaccine among adolescents for greater prevention of HPV-associated oral cancers.","PeriodicalId":8282,"journal":{"name":"Archives of Internal Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73466400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital Gangrene Accelerated by Diabetic Ketoacidosis in the Setting of Polycythemia Vera","authors":"Goonja Patel, S. Singhal, P. Khandwala, Oladimeji Lanade, Robert Kleyman","doi":"10.26502/aimr.0094","DOIUrl":"https://doi.org/10.26502/aimr.0094","url":null,"abstract":"","PeriodicalId":8282,"journal":{"name":"Archives of Internal Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89792481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}