Annual review of biophysics and biomolecular structure最新文献_第9页

Conformational spread: the propagation of allosteric states in large multiprotein complexes. 构象扩散:大型多蛋白复合物中变构状态的传播。

Annual review of biophysics and biomolecular structure Pub Date : 2004-01-01 DOI: 10.1146/annurev.biophys.33.110502.132703

Dennis Bray, Thomas Duke

引用次数: 193

Computer simulations of enzyme catalysis: methods, progress, and insights. 酶催化的计算机模拟:方法、进展和见解。

Annual review of biophysics and biomolecular structure Pub Date : 2003-01-01 Epub Date: 2003-02-05 DOI: 10.1146/annurev.biophys.32.110601.141807

Arieh Warshel

{"title":"Computer simulations of enzyme catalysis: methods, progress, and insights.","authors":"Arieh Warshel","doi":"10.1146/annurev.biophys.32.110601.141807","DOIUrl":"https://doi.org/10.1146/annurev.biophys.32.110601.141807","url":null,"abstract":"Understanding the action of enzymes on an atomistic level is one of the important aims of modern biophysics. This review describes the state of the art in addressing this challenge by simulating enzymatic reactions. It considers different modeling methods including the empirical valence bond (EVB) and more standard molecular orbital quantum mechanics/molecular mechanics (QM/MM) methods. The importance of proper configurational averaging of QM/MM energies is emphasized, pointing out that at present such averages are performed most effectively by the EVB method. It is clarified that all properly conducted simulation studies have identified electrostatic preorganization effects as the source of enzyme catalysis. It is argued that the ability to simulate enzymatic reactions also provides the chance to examine the importance of nonelectrostatic contributions and the validity of the corresponding proposals. In fact, simulation studies have indicated that prominent proposals such as desolvation, steric strain, near attack conformation, entropy traps, and coherent dynamics do not account for a major part of the catalytic power of enzymes. Finally, it is pointed out that although some of the issues are likely to remain controversial for some time, computer modeling approaches can provide a powerful tool for understanding enzyme catalysis.","PeriodicalId":8270,"journal":{"name":"Annual review of biophysics and biomolecular structure","volume":"32 ","pages":"425-43"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev.biophys.32.110601.141807","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22234810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 393

Structure and function of natural killer cell surface receptors. 自然杀伤细胞表面受体的结构与功能。

Annual review of biophysics and biomolecular structure Pub Date : 2003-01-01 Epub Date: 2002-12-02 DOI: 10.1146/annurev.biophys.32.110601.142347

Sergei Radaev, Peter D Sun

{"title":"Structure and function of natural killer cell surface receptors.","authors":"Sergei Radaev, Peter D Sun","doi":"10.1146/annurev.biophys.32.110601.142347","DOIUrl":"https://doi.org/10.1146/annurev.biophys.32.110601.142347","url":null,"abstract":"Since mid-1990, with cloning and identification of several families of natural killer (NK) receptors, research on NK cells began to receive appreciable attention. Determination of structures of NK cell surface receptors and their ligand complexes led to a fast growth in our understanding of the activation and ligand recognition by these receptors as well as their function in innate immunity. Functionally, NK cell surface receptors are divided into two groups, the inhibitory and the activating receptors. Structurally, they belong to either the immunoglobulin (Ig)-like receptor superfamily or the C-type lectin-like receptor (CTLR) superfamily. Their ligands are either members of class I major histocompatibility complexes (MHC) or homologs of class I MHC molecules. The inhibitory form of NK receptors provides the protective immunity through recognizing class I MHC molecules with self-peptides on healthy host cells. The activating, or the noninhibitory, NK receptors mediate the killing of tumor or virally infected cells through their specific ligand recognition. The structures of activating and inhibitory NK cell surface receptors and their complexes with the ligands determined to date, including killer immunoglobulin-like receptors (KIRs) and their complexes with HLA molecules, CD94, Ly49A, and its complex with H-2Dd, and NKG2D receptors and their complexes with class I MHC homologs, are reviewed here.","PeriodicalId":8270,"journal":{"name":"Annual review of biophysics and biomolecular structure","volume":"32 ","pages":"93-114"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev.biophys.32.110601.142347","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22144598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 95

Liquid-liquid immiscibility in membranes. 膜中的液-液不混相。

Annual review of biophysics and biomolecular structure Pub Date : 2003-01-01 Epub Date: 2003-01-31 DOI: 10.1146/annurev.biophys.32.110601.141704

Harden M McConnell, Marija Vrljic

引用次数: 241

The structure of mammalian cyclooxygenases. 哺乳动物环氧合酶的结构。

Annual review of biophysics and biomolecular structure Pub Date : 2003-01-01 Epub Date: 2003-02-05 DOI: 10.1146/annurev.biophys.32.110601.141906

R Michael Garavito, Anne M Mulichak

引用次数: 136

Optical single transporter recording: transport kinetics in microarrays of membrane patches. 光学单转运体记录:膜贴片微阵列中的转运动力学。

Annual review of biophysics and biomolecular structure Pub Date : 2003-01-01 Epub Date: 2003-02-06 DOI: 10.1146/annurev.biophys.32.110601.142429

Reiner Peters

引用次数: 39

The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors. 视紫红质的晶体学模型及其在其他G蛋白偶联受体研究中的应用。

Annual review of biophysics and biomolecular structure Pub Date : 2003-01-01 Epub Date: 2003-02-05 DOI: 10.1146/annurev.biophys.32.110601.142520

Slawomir Filipek, David C Teller, Krzysztof Palczewski, Ronald Stenkamp

引用次数: 129

The state of lipid rafts: from model membranes to cells. 脂筏的状态:从模型膜到细胞。

Annual review of biophysics and biomolecular structure Pub Date : 2003-01-01 Epub Date: 2003-01-16 DOI: 10.1146/annurev.biophys.32.110601.142439

Michael Edidin

引用次数: 1288

Structure and function of the calcium pump. 钙泵的结构和功能。

Annual review of biophysics and biomolecular structure Pub Date : 2003-01-01 Epub Date: 2003-02-19 DOI: 10.1146/annurev.biophys.32.110601.142433

David L Stokes, N Michael Green

引用次数: 87

Acetylcholine binding protein (AChBP): a secreted glial protein that provides a high-resolution model for the extracellular domain of pentameric ligand-gated ion channels. 乙酰胆碱结合蛋白(Acetylcholine binding protein, AChBP):一种分泌性胶质蛋白，为五聚体配体门控离子通道的胞外结构域提供了高分辨率模型。

Annual review of biophysics and biomolecular structure Pub Date : 2003-01-01 Epub Date: 2003-02-21 DOI: 10.1146/annurev.biophys.32.110601.142536

Titia K Sixma, August B Smit

引用次数: 144