Annals of Dermatology最新文献

{"title":"A Randomized, Prospective, Split-Face Pilot Study to Evaluate the Safety and Efficacy of 532-nm and 1,064-nm Picosecond-Domain Neodymium:Yttrium-Aluminum-Garnet Lasers Using a Diffractive Optical Element for Non-Ablative Skin Rejuvenation: Clinical and Histological Evaluation.","authors":"Hye Sung Han,&nbsp;Jun Ki Hong,&nbsp;Su Jung Park,&nbsp;Byung Cheol Park,&nbsp;Kui Young Park","doi":"10.5021/ad.22.070","DOIUrl":"https://doi.org/10.5021/ad.22.070","url":null,"abstract":"<p><strong>Background: </strong>The advent of fractionated picosecond (ps) lasers has provided an opportunity to explore new ways of creating microinjuries in the skin to induce skin rejuvenation.</p><p><strong>Objective: </strong>To compare the efficacy and safety of diffractive optical element (DOE)-assisted ps neodymium: yttrium-aluminum-garnet (Nd:YAG) lasers with 532-nm and 1,064-nm wavelengths (532-nm and 1,064-nm Nd:YAG P-DOE) using a novel fractional handpiece for the treatment of photoaged skin.</p><p><strong>Methods: </strong>An <i>ex vivo</i> guinea pig skin experiment was performed by evaluating the histology of the skin after 532-nm Nd:YAG P-DOE irradiation. A randomized, prospective, split-face study was performed on eight subjects with 532-nm and 1,064-nm Nd:YAG P-DOE.</p><p><strong>Results: </strong>Based on the histological evaluation using <i>ex vivo</i> guinea pig skin, a reasonable safety profile and the potential to generate effective skin rejuvenation was observed using the 532-nm Nd:YAG P-DOE. Results demonstrated that both 532- and 1,064-nm Nd:YAG P-DOE were similarly effective in improving skin texture and skin pores; however, 532-nm Nd:YAG P-DOE was more effective in treating dyspigmentation.</p><p><strong>Conclusion: </strong>At a preliminary level, this study revealed that 532-nm and 1,064-nm ps Nd:YAG lasers using DOE fractional technology may improve photoaged skin. In conclusion, 532-nm Nd:YAG P-DOE may be especially beneficial for skin with epidermal pigmentary lesions.</p>","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 1","pages":"23-31"},"PeriodicalIF":1.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1b/4b/ad-35-23.PMC9905855.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10738012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report of a Novel Association between Anti-p200 Pemphigoid and Acquired Haemophilia A.","authors":"Xuan Qi Koh,&nbsp;Kong Bing Tan,&nbsp;Enno Schmidt,&nbsp;Detlef Zillikens,&nbsp;Nisha Suyien Chandran","doi":"10.5021/ad.20.301","DOIUrl":"https://doi.org/10.5021/ad.20.301","url":null,"abstract":"<p><p>Anti-p200 pemphigoid is an uncommon subepidermal autoimmune bullous disease that, unlike many other autoimmune bullous diseases, has not previously been associated with hematological diseases. The diagnosis of anti-p200 pemphigoid in a patient with congruent clinical features requires the demonstration of subepidermal blistering, with linear deposition of immunoglobulin (Ig) G and/or C3 at the dermoepidermal junction on direct immunofluorescence, and a floor-binding pattern on indirect immunofluorescence. In addition, the detection of antibodies against p200 antigen via immunoblotting is ideal but not readily accessible in many facilities, leading to a potential under-recognition and under-diagnosis of this condition. In this case report, we describe a 53-year-old gentleman with recently diagnosed acquired hemophilia A who developed a concurrent vesiculobullous eruption and was evaluated to have anti-p200 pemphigoid. Both of his conditions were controlled with immunosuppression via prednisolone and cyclophosphamide. While we acknowledge the contemporaneous occurrence of both diseases in this patient may be a mere coincidence, it is important to recognize the possibility of this association given the potential clinical significance. Whether the activity of one disease parallels the other will require further evaluation.</p>","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 1","pages":"61-65"},"PeriodicalIF":1.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/38/ad-35-61.PMC9905869.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10738013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal Maternal Risk Factors Contributing to Atopic Dermatitis: A Systematic Review and Meta-Analysis of Cohort Studies.","authors":"Hong Cui,&nbsp;Zhijuan Mu","doi":"10.5021/ad.21.268","DOIUrl":"https://doi.org/10.5021/ad.21.268","url":null,"abstract":"<p><strong>Background: </strong>The gestational risk factors predispose to the manifestation of early childhood atopic dermatitis (AD).</p><p><strong>Objective: </strong>We evaluated the association between modifiable and non-modifiable gestational and prenatal risk factors that affect the AD prevalence in children.</p><p><strong>Methods: </strong>We performed the systematic review and meta-analysis of cohort studies (n=27) in PubMed and EMBASE (2000~2021). A meta-analysis was performed using random-effects models to estimate pooled odds ratios (OR) or hazard ratio (HR). We performed a systematic review according to Preferred Reporting Item for Systematic Review and Meta-Analyses (PRISMA) guidelines and summarized cohort studies investigating gestational and prenatal risk factor those predispose to AD in off spring. Leading modifiable and non-modifiable were identified through ORs. Meta-analysis using the random effect model was also conducted to provide an overall estimate for several significant factors.</p><p><strong>Results: </strong>Among the non-modifiable risk factors gestational diabetes (7.2, 95% confidence interval [CI]: 1.4~34.5), maternal history of allergy (2.14, 95% CI: 1.54~2.97) and prenatal history of eczema (2.46, 95% CI: 1.0~5.8) were found as major determining risk factors in early manifestation of AD in children. Further, maternal exposure to industrial products (1.89, 95% CI: 1.10~3.16), exposure to antibiotics during pregnancy (3.59, 95% CI: 1.19~10.85) and passive smoking during pregnancy (2.60, 95% CI: 1.11~6.1) are leading causes of early AD manifestation.</p><p><strong>Conclusion: </strong>Conclusively, both genetic and environmental factors play a pivotal role in early manifestation of AD. The better managing the environmental factors during gestational phase to the least can help curtail the prevalence of AD in children.</p>","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 1","pages":"11-22"},"PeriodicalIF":1.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a5/0c/ad-35-11.PMC9905861.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10738011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Hybrid Epidermoid and Apocrine Cysts of Scalp.","authors":"Hyun-Min Seo,&nbsp;Ju Wang Jang,&nbsp;Se Kwang Park,&nbsp;Se Uk Oh,&nbsp;Hyung Kwon Park,&nbsp;Joung Soo Kim","doi":"10.5021/ad.20.331","DOIUrl":"https://doi.org/10.5021/ad.20.331","url":null,"abstract":"Corresponding Author Joung Soo Kim Department of Dermatology, Hanyang University Guri Hospital, 153 Gyeongchun-ro, Guri 11923, Korea Tel: +82-31-560-2284, Fax: +82-31-557-4872, E-mail: tuentuen@hanyang.ac.kr https://orcid.org/0000-0002-3014-9645 A B Fig. 1. (A) The patient presented with solitary hyperkeratotic nodule on scalp. (B) Multiple dermal cysts filled with keratinous material (H&E, ×1.2). We received the patient’s consent form about publishing all photographic materials. Brief Report Annals of Dermatology 2023;35(1) • https://doi.org/10.5021/ad.20.331","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 1","pages":"84-85"},"PeriodicalIF":1.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0a/26/ad-35-84.PMC9905857.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9302257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celebrating the 30th Annual Meeting of the Korean Society for Investigative Dermatology (KSID).","authors":"Soyun Cho,&nbsp;Won Ji Song,&nbsp;Eung Ho Choi,&nbsp;Jin Ho Chung","doi":"10.5021/ad.35.001","DOIUrl":"https://doi.org/10.5021/ad.35.001","url":null,"abstract":"","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 1","pages":"1-5"},"PeriodicalIF":1.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/25/ab/ad-35-1.PMC9905858.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10725500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA-1246 Inhibits NFATc1 Phosphorylation and Regulates T Helper 17 Cell Activation in the Pathogenesis of Severe Alopecia Areata.","authors":"Si-Si Qi,&nbsp;Ying Miao,&nbsp;You-Yu Sheng,&nbsp;Rui-Ming Hu,&nbsp;Jun Zhao,&nbsp;Qin-Ping Yang","doi":"10.5021/ad.22.126","DOIUrl":"https://doi.org/10.5021/ad.22.126","url":null,"abstract":"<p><strong>Background: </strong>We found microRNA (miR)-1246 to be significantly differentially expressed between severe active alopecia areata (AA) patients and healthy individuals.</p><p><strong>Objective: </strong>To explore the role and mechanism of miR-1246 in severe AA.</p><p><strong>Methods: </strong>Expression of miR-1246, dual-specific tyrosine phosphorylation-regulated kinase 1A (DYRK1A), and nuclear factor of activated T cells 1c (NFATc1) in peripheral CD4⁺ T cells and in scalp tissues of patients were detected using RT-qPCR, Western blot, and immunohistochemistry assays. Peripheral CD4⁺ T cells from the AA patients were transfected with lentiviral vectors overexpressing miR-1246. RT-qPCR and Western blot analysis were used to measure mRNA or protein expression of retinoic-acid-receptor-related orphan nuclear receptor gamma (ROR-γt), interleukin (IL)-17, DYRK1A, NFATc1, and phosphorylated NFATc1. Flow cytometry was used to assay the CD4⁺IL-17⁺ cells proportion. ELISA was used to measure cytokine levels.</p><p><strong>Results: </strong>miR-1246 levels decreased and DYRK1A and NFATc1 mRNA levels significantly increased in the peripheral CD4⁺ T cells and scalp tissues of severe active AA samples. NFATc1 protein expression was also significantly increased in the peripheral CD4⁺ T cells but not in the scalp tissues. NFATc1 positive cells were mainly distributed among infiltrating inflammatory cells around hair follicles. In peripheral CD4⁺ T cells of severe active AA, overexpression of miR-1246 resulted in significant downregulation of DYRK1A, NFATc1, ROR-γt, and IL-17 mRNA and phosphorylated NFATc1 protein, as well as a decrease in the CD4⁺IL-17⁺ cells proportion and the IL-17F level.</p><p><strong>Conclusion: </strong>miR-1246 can inhibit NFAT signaling and Th17 cell activation, which may be beneficial in the severe AA treatment.</p>","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 1","pages":"46-55"},"PeriodicalIF":1.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/62/94/ad-35-46.PMC9905862.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10725501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Risk Allele Frequencies of Psoriasis-Associated Single-Nucleotide Polymorphisms in Different Population Groups.","authors":"Donghoon Lee,&nbsp;Taehan Koo,&nbsp;Jiho Park,&nbsp;Hyun-Tae Shin","doi":"10.5021/ad.22.110","DOIUrl":"https://doi.org/10.5021/ad.22.110","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of psoriasis differs by population, and it appears to be more common among Europeans than in East Asians. Recent genome-wide association studies (GWAS) have identified alleles that increase the risk of psoriasis, and these alleles may present different frequencies in different geographic regions.</p><p><strong>Objective: </strong>We aimed to gain insights into the causes of differences in disease frequencies according to populations and the factors affecting prevalence and pattern differences.</p><p><strong>Methods: </strong>We collected a total of 147 psoriasis-associated single-nucleotide polymorphisms (SNPs) from the GWAS catalog and compared the allele frequency differences in 27 populations using public population frequency in the 1000 Genomes Project phase 3 (n=2,504) and the Korean Reference Genome Database (n=1,722). Additionally, we calculated the composited genetic risk scores across the population groups.</p><p><strong>Results: </strong>There were distinct patterns of allele frequencies in different population groups. In many cases, East Asians exhibited allele frequencies opposite to that of Europeans. The genetic risk score was higher in Europeans (average: 0.487) and Americans (average: 0.492) than in East Asians (average: 0.471). The prevalence of psoriasis correlated with the average genetic risk score of the population.</p><p><strong>Conclusion: </strong>We observed a difference in the allele frequencies of psoriasis-associated SNPs between the studied populations. This result suggests that the difference in the prevalence of psoriasis between population groups can be interpreted to some extent by the genotype.</p>","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 1","pages":"32-37"},"PeriodicalIF":1.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/52/86/ad-35-32.PMC9905865.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10738009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual Complex Apocrine Tumor Consisting of Syringocystadenoma Papilliferum and Apocrine Hidrocystoma within a Single Lesion: A Case Report.","authors":"Joong Ho Kim,&nbsp;Ji An Uh,&nbsp;Jae Ho Lee,&nbsp;Ho Young Kim,&nbsp;Soo Kyung Lee,&nbsp;Myoung Shin Kim,&nbsp;Un Ha Lee","doi":"10.5021/ad.21.023","DOIUrl":"https://doi.org/10.5021/ad.21.023","url":null,"abstract":"<p><p>Syringocystadenoma papilliferum (SCAP) and apocrine hidrocystoma (AH) are benign apocrine neoplasms that usually occur separately. SCAP arises predominantly in head and neck, while AH typically develop in periorbital area. We report a case of a 68-year-old male with an asymptomatic erythematous papulonodule that occurred on his back 3 years ago. Histologic examination showed cystic invagination extending from the epidermis into the dermis with some papillary projections. The invaginated portion was lined by epithelial bilayer composed of cuboidal and columnar cells, and decapitation secretion was observed in the inner epithelial layer. In the deep dermis, multiple cystic spaces with variable sizes were observed, and these cysts also presented double layers of the epithelium and decapitation secretion. According to such histologic features, the coexistence of SCAP and AH within a single lesion was demonstrated. The patient was recommended to completely remove the remaining lesion after punch biopsy, but he refused further surgical management. Herein, we report an unusual case of complex apocrine tumor with a rare composition in an atypical site.</p>","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 1","pages":"66-70"},"PeriodicalIF":1.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2a/52/ad-35-66.PMC9905859.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10738015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphangiectatic Variant of Low-Grade Malignant Eccrine Spiradenoma.","authors":"Gizem Akkas Akgun,&nbsp;Anvar Ahmedov,&nbsp;Ali Xc Xb Hsan Parlar,&nbsp;Mehmet Hüseyin Metineren,&nbsp;Ayse Nur Deger","doi":"10.5021/ad.20.226","DOIUrl":"https://doi.org/10.5021/ad.20.226","url":null,"abstract":"<p><p>Low-grade malignant eccrine spiradenoma (spiradenocarcinoma) is a rare sweat gland tumor, which usually arises from a pre-existing benign eccrine spiradenoma. This paper presents the case of a 55-year-old male who had a lesion in his right elbow for 10 years. The microscopic examination revealed a well-demarcated, multilobulated tumor in the dermis and subcutis, which presented with many blood-filled vessels and extensive hemorrhage. The tumor was composed of hyperchromatic, round to oval cells with nucleolar prominence, mild to moderate atypia, and increased mitotic index. Additionally, lymphangiectatic appearance was observed in areas with prominent stromal lymphedema. P53 and Ki-67 had high positivity. Surgical excision of the lesion was performed with adequate surgical margins, and the dissected lymph nodes in the axilla were tumor-negative. After 15 months of follow-up, there was no recurrence or distant metastasis.</p>","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 1","pages":"71-74"},"PeriodicalIF":1.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/28/2a/ad-35-71.PMC9905852.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9302255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kaposi Sarcoma in a Patient with Bullous Pemphigoid Treated with Low-Dose Corticosteroids.","authors":"Sang Gyun Lee,&nbsp;Dae San Yoo,&nbsp;Soo-Chan Kim,&nbsp;Jong Hoon Kim","doi":"10.5021/ad.20.196","DOIUrl":"https://doi.org/10.5021/ad.20.196","url":null,"abstract":"Dear Editor: Kaposi’s sarcoma (KS) is a lymphatic and vascular neoplasm, that develops in patients with human herpesvirus-8 (HHV-8) infection and presents as multiple purplish papules or nodules. KS is classified into four clinical types: classic, endemic, iatrogenic immunosuppression-related, and acquired immune deficiency syndrome-associated KS. The risk of KS is increased in immunosuppressed patients owing to their lack of immunity to HHV-8. Bullous pemphigoid (BP) is an autoimmune blistering disorder characterized by subepidermal bullae on pruritic and urticarial plaques. BP occurs when autoantibodies develop against BP180 and BP230 and systemic corticosteroids and/or immunosuppressive agents are required. Some case reports have discussed the coexistence of KS in terms of BP; however, no case reports from Korea have been published. Herein, we describe a case of KS in a patient with BP who had received low-dose systemic corticosteroids for 25 months. An 84-year-old female patient presented with a 4-month history of purpuric patches and nodules on the right lower leg. She had a history of hypertension and atrial fibrillation. She presented with multiple bullae and erosions on the chest for 30 months. She was diagnosed with BP based on the findings of a subepidermal blister with granulocytes in histology, C3 deposition along the basement membrane in direct immunofluo-","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 1","pages":"79-81"},"PeriodicalIF":1.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/63/1b/ad-35-79.PMC9905866.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9302256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}