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Pediatric pathology & molecular medicine最新文献

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Pathological case of the month: sudden death in a child as a result of pancreatitis during valproic acid therapy. 本月病理病例:丙戊酸治疗期间胰腺炎导致一名儿童猝死。
Pediatric pathology & molecular medicine Pub Date : 2002-09-01 DOI: 10.1080/15227950290104805
Darinka Mileusnic, Edmund R Donoghue, Barry D Lifschultz
{"title":"Pathological case of the month: sudden death in a child as a result of pancreatitis during valproic acid therapy.","authors":"Darinka Mileusnic,&nbsp;Edmund R Donoghue,&nbsp;Barry D Lifschultz","doi":"10.1080/15227950290104805","DOIUrl":"https://doi.org/10.1080/15227950290104805","url":null,"abstract":"<p><p>Valproic acid is a widely used drug in the treatment of epilepsy and, compared to other anticonvulsant drugs, is considered safe. The most common side effects of valproic acid ingestion or therapy are transient nausea, vomiting, abdominal cramps, and diarrhea. Most of these complaints are mild. However, more serious adverse reactions can occur such as hepatotoxicity and pancreatitis. It has been proposed that, whenever possible, valproic acid not be used in the younger child, the child with a severe seizure disorder or other neurological disorders, mental retardation, developmental delay, organic brain disease, congenital abnormalities, or the child who is taking multiple anticonvulsant drugs, as these factors may increase the likelihood of hepatotoxicity and/or pancreatitis. In the present report, we describe a fatal case of acute hemorrhagic pancreatitis in a four and a half-year-old Hispanic female child who was receiving valproic acid in combination with another anticonvulsant drug for control of focal seizures. The patient also received the macrolide antibiotic azithromycin. For pediatricians and forensic pathologists valproic acid-induced pancreatitis can be a challenging diagnosis which must not be mistaken for abdominal trauma. We discuss the workup of the patient and differential diagnosis.</p>","PeriodicalId":82276,"journal":{"name":"Pediatric pathology & molecular medicine","volume":"21 5","pages":"477-84"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15227950290104805","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22080653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
An unusual cause of breast enlargement in a 5-year-old boy. 一个五岁男孩乳房增大的不寻常原因。
Pediatric pathology & molecular medicine Pub Date : 2002-09-01 DOI: 10.1080/15227950290104788
Ahmed H Al Salem, Mona Al Nazer
{"title":"An unusual cause of breast enlargement in a 5-year-old boy.","authors":"Ahmed H Al Salem,&nbsp;Mona Al Nazer","doi":"10.1080/15227950290104788","DOIUrl":"https://doi.org/10.1080/15227950290104788","url":null,"abstract":"<p><p>A 5-year-old male developed painless enlargement of the left breast and was found to have a soft, mobile, and nontender swelling that was excised. Histological examination revealed a galactocele, which is a very rare cause of breast enlargement in male infants and children.</p>","PeriodicalId":82276,"journal":{"name":"Pediatric pathology & molecular medicine","volume":"21 5","pages":"485-9"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15227950290104788","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22080654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Pathology teach and tell: congenital paratesticular rhabdomyosarcoma. 病理教学:先天性睾丸旁横纹肌肉瘤。
Pediatric pathology & molecular medicine Pub Date : 2002-09-01 DOI: 10.1080/02770930290056587
Sanjay Jogai, Bishan D Radotra, Kusum Joshi
{"title":"Pathology teach and tell: congenital paratesticular rhabdomyosarcoma.","authors":"Sanjay Jogai,&nbsp;Bishan D Radotra,&nbsp;Kusum Joshi","doi":"10.1080/02770930290056587","DOIUrl":"https://doi.org/10.1080/02770930290056587","url":null,"abstract":"","PeriodicalId":82276,"journal":{"name":"Pediatric pathology & molecular medicine","volume":"21 5","pages":"513-6"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/02770930290056587","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22080657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Clinico-pathologic conference: 18-month old boy with fever and severe respiratory infection. 临床病理会议:18个月男童，发热伴严重呼吸道感染。
Pediatric pathology & molecular medicine Pub Date : 2002-09-01 DOI: 10.1080/pdp.21.5.491.506
William F Pomputius, Atilano Lacson, Herbert H Pomerance
{"title":"Clinico-pathologic conference: 18-month old boy with fever and severe respiratory infection.","authors":"William F Pomputius,&nbsp;Atilano Lacson,&nbsp;Herbert H Pomerance","doi":"10.1080/pdp.21.5.491.506","DOIUrl":"https://doi.org/10.1080/pdp.21.5.491.506","url":null,"abstract":"<p><p>An 18-month-old boy with severe combined immunodeficiency (SCID) due to an IL2-y-receptor defect had a successful engraftment following a related mismatched allogenic bone transplant. He subsequently developed post-transplantation lymphoproliferative disorder, with severe respiratory infection which resulted in death. The case presentation is followed by a discussion with differential diagnosis of the clinical findings, and then by a discussion of the pathology found and the implications of this diagnosis.</p>","PeriodicalId":82276,"journal":{"name":"Pediatric pathology & molecular medicine","volume":"21 5","pages":"491-506"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/pdp.21.5.491.506","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22104852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sequence of right laterality with spleen: widening the spectrum of heterotaxy. 右外侧带脾序列:扩大异位谱。
Pediatric pathology & molecular medicine Pub Date : 2002-09-01 DOI: 10.1080/15227950290104779
Marco A Durán, Avril Guereña
{"title":"Sequence of right laterality with spleen: widening the spectrum of heterotaxy.","authors":"Marco A Durán,&nbsp;Avril Guereña","doi":"10.1080/15227950290104779","DOIUrl":"https://doi.org/10.1080/15227950290104779","url":null,"abstract":"<p><p>This is a report of two postmortem cases with sequence of right laterality and spleen. The presence of visceral right laterality and spleen is discordant with that indicated for the asplenia syndrome. The unusual presence of spleen, as in these two cases and previously reported cases, does not faithfully indicate the laterality sequence. Its recommended laterality should be defined as either right or left or considered heterotaxia instead of naming the anomaly based on asplenia or polysplenia syndrome.</p>","PeriodicalId":82276,"journal":{"name":"Pediatric pathology & molecular medicine","volume":"21 5","pages":"461-5"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15227950290104779","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22080650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
An autopsy case of Pena-Shokeir syndrome: severe retardation of skeletal muscle development compared with neuronal abnormalities. Pena-Shokeir综合征尸检一例:骨骼肌发育严重迟缓与神经元异常比较。
Pediatric pathology & molecular medicine Pub Date : 2002-09-01 DOI: 10.1080/15227950290104797
Ikuko Torii, Shigeru Morikawa, Junichi Tanaka, Junko Takahashi
{"title":"An autopsy case of Pena-Shokeir syndrome: severe retardation of skeletal muscle development compared with neuronal abnormalities.","authors":"Ikuko Torii,&nbsp;Shigeru Morikawa,&nbsp;Junichi Tanaka,&nbsp;Junko Takahashi","doi":"10.1080/15227950290104797","DOIUrl":"https://doi.org/10.1080/15227950290104797","url":null,"abstract":"<p><p>An infant with multiple joint ankyloses, facial anomalies, and pulmonary hypoplasia, features similar to the phenotype of Pena-Shokeir syndrome, was examined at autopsy. Histological examination of the skeletal muscles revealed many small muscle fibers in a mixed, not group, distribution, although the structure of them was normally arranged. Histochemical assessment of adenosine triphosphatase (ATPase) activity of the iliopsoas muscle demonstrated the failure of the differentiation into type I fibers and the retardation of the skeletal muscle. At the same time, severe pulmonary hypoplasia, which was the likely cause for the retardation of the respiratory system, was found. In contrast to these numerous pathologic changes in the skeletal muscles, no significant abnormalities were observed in the central nervous system except for a somewhat immature external appearance; however, an examination of the spinal cord could not be carried out. Overall, this pattern of pathology suggests the possibility that developmental disorders of the mesenchyme are the primary contributors to the pathogenesis of Pena-Shokeir syndrome, while the immaturity of the central nervous system is involved to a lesser degree.</p>","PeriodicalId":82276,"journal":{"name":"Pediatric pathology & molecular medicine","volume":"21 5","pages":"467-76"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15227950290104797","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22080651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Pathology teach and tell: surfactant protein B deficiency. 病理教诉:表面活性剂蛋白B缺乏。
Pediatric pathology & molecular medicine Pub Date : 2002-09-01 DOI: 10.1080/02770930290056578
Barbara K Fulton, Mary M Davis
{"title":"Pathology teach and tell: surfactant protein B deficiency.","authors":"Barbara K Fulton,&nbsp;Mary M Davis","doi":"10.1080/02770930290056578","DOIUrl":"https://doi.org/10.1080/02770930290056578","url":null,"abstract":"","PeriodicalId":82276,"journal":{"name":"Pediatric pathology & molecular medicine","volume":"21 5","pages":"507-11"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/02770930290056578","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22080655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The placenta in hematogenous infections. 血液感染中的胎盘。
Pediatric pathology & molecular medicine Pub Date : 2002-07-01 DOI: 10.1080/152279502760157768
A. Bittencourt, A. P. Garcia
{"title":"The placenta in hematogenous infections.","authors":"A. Bittencourt, A. P. Garcia","doi":"10.1080/152279502760157768","DOIUrl":"https://doi.org/10.1080/152279502760157768","url":null,"abstract":"Although congenital infections have been known since ancient times, at present they constitute an evolution due to the broadening of diagnostic methods. Also, the histopathological examination of selected placentas has increased in perinatal pathology. All placentas should be examined grossly by the obstetrician or the neonatologist who must select the specimens to be sent for pathologic examination. The indications for selection at delivery to detect hematogenous infection are listed in Table 1. The placentas that do not meet guidelines for pathologic examination must be kept stored at 40 degrees C for at least 72 h. This routine ensures that the placentas of asymptomatic newborns who might present early manifestations suggestive of infection would be submittedfor pathologic examination.","PeriodicalId":82276,"journal":{"name":"Pediatric pathology & molecular medicine","volume":"21 4 1","pages":"401-32"},"PeriodicalIF":0.0,"publicationDate":"2002-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/152279502760157768","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59824395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Pathogenesis and pathology of hematogenous infections of the fetus and newborn. 胎儿和新生儿血液感染的发病机制和病理。
Pediatric pathology & molecular medicine Pub Date : 2002-07-01 DOI: 10.1080/152279502760157759
A. Bittencourt, A. P. Garcia
{"title":"Pathogenesis and pathology of hematogenous infections of the fetus and newborn.","authors":"A. Bittencourt, A. P. Garcia","doi":"10.1080/152279502760157759","DOIUrl":"https://doi.org/10.1080/152279502760157759","url":null,"abstract":"The earlier infections occur in intrauterine life the more severe are they. When the infection develops during embryogenesis, the lesions are much more serious, sometimes causing disruptions (malformations). At this time the organs are not completely formed and microorganisms may interfere with organogenesis to such an extent that the development of the functions necessary for viability become impaired. Infection acquired in utero may result in resorption of the embryo, abortion, stillbirth, neonatal death, intrauterine growth retardation (IUGR), or prematurity. The infected newborns commonly are apparently normal at birth but they may develop a late onset disease. Otherwise, neonates presenting symptomatology may derelop untoward sequelae.","PeriodicalId":82276,"journal":{"name":"Pediatric pathology & molecular medicine","volume":"21 4 1","pages":"353-99"},"PeriodicalIF":0.0,"publicationDate":"2002-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/152279502760157759","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59824385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Relevance of hypercholesterolemia to fetal and pediatric atherosclerosis. 高胆固醇血症与胎儿和儿童动脉粥样硬化的相关性。
Pediatric pathology & molecular medicine Pub Date : 2002-05-01 DOI: 10.1080/02770930290056505
W. Stehbens
{"title":"Relevance of hypercholesterolemia to fetal and pediatric atherosclerosis.","authors":"W. Stehbens","doi":"10.1080/02770930290056505","DOIUrl":"https://doi.org/10.1080/02770930290056505","url":null,"abstract":"Ubiquitous atherosclerotic changes in fetal and pediatric subjects demonstrate the fundamental importance of repetitive hemodynamic stresses and cannot be explained on the basis of the hypercholesterolemic/lipid hypothesis because serum cholesterol levels at this age lie within allegedly \"desirable blood levels.\" This fact, inconsistent with the lipid hypothesis, renders absurd the widespread dietary restriction of cholesterol and animal fats as prevention of atherosclerosis. Iatrogenic effects of atherosclerosis in humans and its experimental production in herbivores at serum cholesterol levels below infant levels strongly support the \"vascular fatige\" concept and negate the lipid hypothesis. Neither is atherosclerosis a manifestation of senescence because age is merely a time factor indicating the duration of exposure to hemodynamic stresses that are variable with time and location.","PeriodicalId":82276,"journal":{"name":"Pediatric pathology & molecular medicine","volume":"21 3 1","pages":"259-78"},"PeriodicalIF":0.0,"publicationDate":"2002-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/02770930290056505","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59430435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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