Archives internationales de pharmacodynamie et de therapie最新文献_第7页

Physiological doses of [Ile5]- and [Val5]-Angiotensin II fail to increase plasma catecholamines at the peak pressor response in rats. 生理剂量的[Ile5]-和[Val5]-血管紧张素II不能增加大鼠血压反应峰值时的血浆儿茶酚胺。

Archives internationales de pharmacodynamie et de therapie Pub Date : 1995-03-01

D G Butler, D A Butt

引用次数: 0

Enhancement of defecation and distal colonic motor activity by KW-5092, a novel gastroprokinetic agent, in rats. 一种新型胃促动力剂KW-5092对大鼠排便和远端结肠运动活动的增强作用。

Archives internationales de pharmacodynamie et de therapie Pub Date : 1995-03-01

N Kishibayashi, T Yokoyama, A Karasawa

引用次数: 0

Prevention of organophosphate-induced toxicity in mice. 有机磷致小鼠毒性的预防。

Archives internationales de pharmacodynamie et de therapie Pub Date : 1995-03-01

U Ozkutlu, J P Long, J G Cannon, M F Sahin, C Liang

引用次数: 0

Protective effects of pergolide on dopamine levels in the 6-hydroxydopamine-lesioned mouse brain. 培高利特对6-羟多巴胺损伤小鼠脑内多巴胺水平的保护作用。

Archives internationales de pharmacodynamie et de therapie Pub Date : 1995-03-01

M Asanuma, N Ogawa, S Nishibayashi, M Kawai, Y Kondo, E Iwata

{"title":"Protective effects of pergolide on dopamine levels in the 6-hydroxydopamine-lesioned mouse brain.","authors":"M Asanuma, N Ogawa, S Nishibayashi, M Kawai, Y Kondo, E Iwata","doi":"","DOIUrl":"","url":null,"abstract":"Pergolide, along with bromocriptine and lisuride, is one of the most active dopamine receptor agonists. To determine whether or not pergolide protects against dopaminergic neuronal damage, via its activity on monoamine metabolism, we studied the effects of pergolide pretreatment on changes in monomaines and their metabolites in the mouse striatum after intracerebroventricular injection of 6-hydroxydopamine with pretreatment of desipramine. After intracerebroventricular administration of 6-hydroxydopamine (40 micrograms) in mice, the levels of dopamine and its metabolites (DOPAC, HVA) in the striatum rapidly decreased to 49%, 29% and 68%, respectively, of the naive controls at week 1 but then gradually recovered to control levels at weeks 2 and 4. Repeated pretreatment with pergolide (0.5 mg/kg, i.p.) for 7 days before administration of 6-hydroxydopamine, almost completely protected against reduction in striatal dopamine and its metabolites 1 week after injection of 6-hydroxydopamine. Therefore, pergolide could normalize the decreased dopamine synthesis or storage, and has a neuroprotective effect against dopaminergic dysfunction induced by the neurotoxin, 6-hydroxydopamine. Although we found that pergolide did not show radical scavenging activity in an in vitro system that generated hydroxyl radicals, it has been reported in vivo that pergolide treatment may induce Cu/Zn superoxide dismutase in the rat striatum. Considering these findings, pergolide may well be protective to dopaminergic neurons, largely because of its effects on presynaptic autoreceptors and on its induction of Cu/Zn superoxide dismutase. Further research on the neuroprotective effects of pergolide in Parkinson disease models, by injection of 6-hydroxydopamine, is needed to clarify its mechanism of action on dopaminergic indices.","PeriodicalId":8166,"journal":{"name":"Archives internationales de pharmacodynamie et de therapie","volume":"329 2","pages":"221-30"},"PeriodicalIF":0.0,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19520789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of ambrein, a major constituent of ambergris, on masculine sexual behavior in rats. 龙涎香主要成分琥珀素对大鼠雄性性行为的影响。

Archives internationales de pharmacodynamie et de therapie Pub Date : 1995-03-01

S A Taha, M W Islam, A M Ageel

引用次数: 0

Central cardiovascular effects of CPU-23, a substituted tetrahydroisoquinoline, in rats. 取代的四氢异喹啉CPU-23对大鼠中枢心血管的影响。

Archives internationales de pharmacodynamie et de therapie Pub Date : 1995-03-01

H Dong, C M Lee, K W Ng, T M Wong

引用次数: 0

Furosemide-sensitive K+ transport in transformed and nontransformed rat liver epithelial cells: regulation by protein kinase C and involvement in cell growth. 转化和非转化大鼠肝上皮细胞中速尿敏感的K+转运:蛋白激酶C的调控和参与细胞生长

Archives internationales de pharmacodynamie et de therapie Pub Date : 1995-03-01

J P Anger, L Vernhet, A Hichami, A Corlu, E Lepalabe, A Troussard, A Legrand

{"title":"Furosemide-sensitive K+ transport in transformed and nontransformed rat liver epithelial cells: regulation by protein kinase C and involvement in cell growth.","authors":"J P Anger, L Vernhet, A Hichami, A Corlu, E Lepalabe, A Troussard, A Legrand","doi":"","DOIUrl":"","url":null,"abstract":"Using Rb+ as a K+ tracer and atomic absorption spectrophotometry for measuring the Rb+ stable isotope, we studied K+ transport systems and their regulation by protein kinase C in nontransformed and spontaneously transformed rat liver epithelial cells. Ouabain-sensitive Na+/K(+)-ATPase and the furosemide-sensitive Na+/K+/Cl- cotransport had comparable activity ratios in both cell types (0.92 and 1 in nontransformed and transformed rat liver epithelial cells, respectively). The protein kinase C activators, dioctanoylglycerol and phorbol myristate acetate, partly inhibited the Na+/K+/Cl- cotransport in both cell types but their effect was stronger in nontransformed cells, suggesting that, in transformed cells, the Na+/K+/Cl- cotransport had partly lost the ability to be inhibited by protein kinase C. In both cell types, phorbol myristate acetate had little and dioctanoylglycerol had no inhibitory effect on Na+/K(+)-ATPase. Furosemide (1 mM) partly inhibited the [3H]thymidine incorporation in both cell types, suggesting an involvement of the Na+/K+/Cl- cotransport in rat liver epithelial cell growth.","PeriodicalId":8166,"journal":{"name":"Archives internationales de pharmacodynamie et de therapie","volume":"329 2","pages":"307-18"},"PeriodicalIF":0.0,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19522108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of serotoninergic agents on downregulation of beta-adrenoceptors by the selective serotonin reuptake inhibitor sertraline. 血清素能药物对选择性血清素再摄取抑制剂舍曲林下调β -肾上腺素受体的影响。

Archives internationales de pharmacodynamie et de therapie Pub Date : 1995-03-01

B K Koe, L A Lebel

{"title":"Effects of serotoninergic agents on downregulation of beta-adrenoceptors by the selective serotonin reuptake inhibitor sertraline.","authors":"B K Koe, L A Lebel","doi":"","DOIUrl":"","url":null,"abstract":"The results of the present study show that the down-regulation of beta-adrenoceptors of rat brain, induced by subacute administration of sertraline, is facilitated when this selective serotonin reuptake inhibitor was co-administered with the serotonin releaser, norfenfluramine, or the serotonin terminal autoreceptor antagonist, methiothepin. The respective drug combination produced a reduction in Bmax of [3H]dihydroalprenolol binding to cortical membranes of treated rats at a dose of the releaser, release enhancer, or sertraline, which was ineffective when administered alone. In a similar manner, the 5-HT1A agonists, gepirone and 8-OH-DPAT, were found to facilitate the downregulation of beta-adrenoceptors induced by sertraline. The 5-HT1B agonist, 3-trifluoromethylphenylpiperazine, and the 5-HT2 antagonist, ritanserin, showed neither facilitation nor antagonism of sertraline, but the 5-HT3 antagonist, ondansetron, attenuated the decrease of Bmax of [3H]dihydroalprenolol binding elicited by sertraline. Agents that putatively increase the serotoninergic activity facilitated the down-regulation of beta-adrenoceptors induced by sertraline, suggesting that the enhancement of serotonin transmission, expected of the selective serotonin reuptake inhibitor itself, may play a role in this effect of sertraline. Whether the downregulation of brain beta-adrenoceptors by sertraline plays any role in its antidepressant activity cannot be deduced from these experiments.","PeriodicalId":8166,"journal":{"name":"Archives internationales de pharmacodynamie et de therapie","volume":"329 2","pages":"231-44"},"PeriodicalIF":0.0,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19520788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatoprotective effect of SY-640, a novel acetamide derivative, on Propionibacterium acnes and lipopolysaccharide-induced liver injury in mice. 新型乙酰胺衍生物SY-640对痤疮丙酸杆菌和脂多糖所致小鼠肝损伤的保护作用。

Archives internationales de pharmacodynamie et de therapie Pub Date : 1995-03-01

Y Tanaka, A Takahashi, K Kobayashi, I Arai, S Higuchi, S Otomo, H L Wei, G T Liu

{"title":"Hepatoprotective effect of SY-640, a novel acetamide derivative, on Propionibacterium acnes and lipopolysaccharide-induced liver injury in mice.","authors":"Y Tanaka, A Takahashi, K Kobayashi, I Arai, S Higuchi, S Otomo, H L Wei, G T Liu","doi":"","DOIUrl":"","url":null,"abstract":"The hepatoprotective effect of SY-640 on Propionibacterium acnes and lipopolysaccharide-induced liver injury in mice and its protective mechanism were examined. Oral administration of SY-640, 150 mg/kg once daily for 7 days, significantly inhibited Propionibacterium acnes and lipopolysaccharide-induced liver injury, but a single administration was without effect. Liver-infiltrating cells (T-lymphocytes and macrophages) play an important role in Propionibacterium and lipopolysaccharide-induced liver injury and express a higher level of leukocyte function-associated antigen-1. SY-640 inhibited the number of liver-infiltrating cells and attenuated the increased expression of leukocyte function-associated antigen-1 on these cells. Tumor necrosis factor-alpha mediated Propionibacterium acnes and lipopolysaccharide-induced liver injury, and SY-640 inhibited the elevation of the serum tumor necrosis factor-alpha concentration after injection of lipopolysaccharide in Propionibacterium acnes-primed mice. The putative effects of SY-640 are inhibitory effects on infiltration into the liver and on activation of T-lymphocytes and macrophages after Propionibacterium acnes-priming, and attenuation of expression of cell adhesion molecules such as leukocyte function-associated antigen-1. The immunological effect of SY-640 is likely to be closely related to the inhibition of Propionibacterium and lipopolysaccharide-induced liver injury.","PeriodicalId":8166,"journal":{"name":"Archives internationales de pharmacodynamie et de therapie","volume":"329 2","pages":"319-30"},"PeriodicalIF":0.0,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19521416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of the neurogenic plasma extravasation in the airways. 气道内神经源性血浆外渗的特点。

Archives internationales de pharmacodynamie et de therapie Pub Date : 1995-01-01

P R Germonpré, G F Joos, R A Pauwels

{"title":"Characterization of the neurogenic plasma extravasation in the airways.","authors":"P R Germonpré, G F Joos, R A Pauwels","doi":"","DOIUrl":"","url":null,"abstract":"Release of neuropeptides from sensory nerves causes an increase in vascular permeability, plasma extravasation and edema. The sensory nerves in the airways can be activated by electrical stimulation of the vagus nerve or by application of chemical and mechanical irritants, such as capsaicin, hypertonic saline, isocapnic hyperpnea and cigarette smoke. In rodent airways, the neurogenic plasma extravasation is mediated by tachykinins released from the capsaicin-afferent nerve fibres, and involves activation of neurokinin-1 tachykinin receptors. In peripheral guinea-pig airways, neurokinin-2 tachykinin receptors have also been implicated in the neurogenic plasma exudation. The tachykinins can increase vascular permeability by both a direct effect on venular endothelium, and indirect mechanisms involving mast cell activation and serotonin release. Tachykinins and their receptors are present in the human airways. Release of tachykinins, following antigen challenge, has been demonstrated in the nose and lower airways. In humans, tachykinins have been shown to increase plasma exudation in the nasal mucosa, but whether neurogenic inflammation also occurs in the lower airways still remains to be proven.","PeriodicalId":8166,"journal":{"name":"Archives internationales de pharmacodynamie et de therapie","volume":"329 1","pages":"185-203"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18549709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0