Current opinion in orthopaedics最新文献_第2页

Mechanism of cell-mediated mineralization 细胞介导的矿化机制

Current opinion in orthopaedics Pub Date : 2007-09-01 DOI: 10.1097/BCO.0B013E3282742022

C. H. A. Lest, A. Vaandrager

引用次数: 14

Mother was right 母亲是对的

Current opinion in orthopaedics Pub Date : 2007-09-01 DOI: 10.1097/BCO.0B013E3282BE8F35

L. Tosi

引用次数: 5

Physiological and pathological mineralization: a complex multifactorial process 生理和病理矿化:一个复杂的多因素过程

Current opinion in orthopaedics Pub Date : 2007-09-01 DOI: 10.1097/BCO.0B013E3282E6F3DE

T. Kirsch

引用次数: 17

Rickets: new insights into a re-emerging problem 佝偻病:对一个重新出现的问题的新见解

Current opinion in orthopaedics Pub Date : 2007-09-01 DOI: 10.1097/BCO.0B013E3282B97118

P. Dimitri, N. Bishop

{"title":"Rickets: new insights into a re-emerging problem","authors":"P. Dimitri, N. Bishop","doi":"10.1097/BCO.0B013E3282B97118","DOIUrl":"https://doi.org/10.1097/BCO.0B013E3282B97118","url":null,"abstract":"Rickets is a disease that has plagued communities for centuries. Once thought of as a disease that was left behind in the industrial revolution of the nineteenth century, nutritional rickets is re-emerging as a problem in Western Europe and the US. Reduction in vitamin D and calcium intake in children's diets along with migration of culturally vulnerable groups to more temperate climates have increased, predisposing large populations to vitamin D deficiency and rickets. \u0000Recent evidence suggests that vitamin D deficiency during pregnancy may have both an immediate and longer-term deleterious effect on children. Focus on hypophosphataemic rickets has identified FGF23 as the phosphaturic factor central to renal phosphate loss. Mutations in the dentin matrix protein-1 gene have been implicated in autosomal recessive hypophosphataemic rickets. \u0000Rickets is the most common form of metabolic bone disease worldwide. Measures such as adequate sunlight exposure and dietary supplementation are simple but effective in reducing rickets. It is important to target culturally vulnerable groups and pregnant women. Preterm babies form a specific population that is particularly vulnerable to the metabolic consequences of calcium and phosphate deficiency, requiring early intervention.","PeriodicalId":81061,"journal":{"name":"Current opinion in orthopaedics","volume":"18 1","pages":"486-493"},"PeriodicalIF":0.0,"publicationDate":"2007-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/BCO.0B013E3282B97118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62100534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The inorganic phosphate/inorganic pyrophosphate axis in the mineralization of cartilage and bone 软骨和骨矿化中的无机磷酸盐/无机焦磷酸盐轴

Current opinion in orthopaedics Pub Date : 2007-09-01 DOI: 10.1097/BCO.0B013E328285DFFC

R. Zaka, C. Williams

引用次数: 5

Bone??s material and structural strength 骨?S材质和结构强度

Current opinion in orthopaedics Pub Date : 2007-09-01 DOI: 10.1097/BCO.0B013E3282A9C162

E. Seeman

引用次数: 34

The impact of bariatric surgery on bone metabolism 减肥手术对骨代谢的影响

Current opinion in orthopaedics Pub Date : 2007-09-01 DOI: 10.1097/BCO.0B013E3282BA54C4

Naina Sinha, R. Bockman

引用次数: 2

Extracellular ATP and its effects on physiological and pathological mineralization 细胞外ATP及其在生理和病理矿化中的作用

Current opinion in orthopaedics Pub Date : 2007-09-01 DOI: 10.1097/BCO.0B013E328285DFE8

C. Thouverey, F. Bleicher, J. Bandorowicz-Pikula

引用次数: 7

Transglutaminase modification of the matrix through promotion of calcification 转谷氨酰胺酶通过促进钙化修饰基质

Current opinion in orthopaedics Pub Date : 2007-09-01 DOI: 10.1097/BCO.0B013E3282748EBD

Kristen A. Johnson

{"title":"Transglutaminase modification of the matrix through promotion of calcification","authors":"Kristen A. Johnson","doi":"10.1097/BCO.0B013E3282748EBD","DOIUrl":"https://doi.org/10.1097/BCO.0B013E3282748EBD","url":null,"abstract":"Transglutaminases have been identified for more than 60 years, but it was not until recently that the functions of these enzymes began to be understood. Currently, transglutaminases are accepted to be modulators of both osteoblastic and chondrocytic mineralization. This review details recent findings regarding this action of transglutaminases, primarily transglutaminase-2 and factor XIIIA, in both physiologic and pathologic mineralization of bone and cartilage. \u0000Osteoblast and chondrocyte mineralization is stimulated by the presence of extracellular factor XIIIA or transglutaminase-2. Specifically, the binding of transglutaminase-2 to GTP is critical for maximal induction of type X collagen expression and matrix calcification in articular chondrocytes. Furthermore, these enzymes can modulate collagen expression and therefore the related terminal cell differentiation events. Finally recent work suggests that transglutaminases are responsible for modifying other proteins to promote mineral deposition. \u0000The mechanism of transglutaminase-induced mineralization is critical to our understanding and potential modulation of pathologic mineralization events. Elucidation of these events could promote new disease-modifying therapies for the hypertrophic differentiation and mineralization found in osteoarthritic cartilage as well as other soft tissue calcification disorders.","PeriodicalId":81061,"journal":{"name":"Current opinion in orthopaedics","volume":"18 1","pages":"467-471"},"PeriodicalIF":0.0,"publicationDate":"2007-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/BCO.0B013E3282748EBD","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62100695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The role of noncollagenous proteins in mineralization 非胶原蛋白在矿化中的作用

Current opinion in orthopaedics Pub Date : 2007-09-01 DOI: 10.1097/BCO.0B013E32825E1D84

A. Rosenthal

引用次数: 8