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Instructions for Authors 作者须知
Computers and the humanities Pub Date : 2019-07-01 DOI: 10.1023/B:CHUM.0000009353.57404.05
G. Pal
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引用次数: 0
Effects of interleukin-1ß on cortical spreading depolarization and cerebral vasculature. 白细胞介素-1ß对皮层扩散去极化和脑血管的影响
Computers and the humanities Pub Date : 2017-05-01 Epub Date: 2016-01-01 DOI: 10.1177/0271678X16641127
Frank Richter, Annett Eitner, Johannes Leuchtweis, Reinhard Bauer, Alfred Lehmenkühler, Hans-Georg Schaible
{"title":"Effects of interleukin-1ß on cortical spreading depolarization and cerebral vasculature.","authors":"Frank Richter, Annett Eitner, Johannes Leuchtweis, Reinhard Bauer, Alfred Lehmenkühler, Hans-Georg Schaible","doi":"10.1177/0271678X16641127","DOIUrl":"10.1177/0271678X16641127","url":null,"abstract":"<p><p>During brain damage and ischemia, the cytokine interleukin-1ß is rapidly upregulated due to activation of inflammasomes. We studied whether interleukin-1ß influences cortical spreading depolarization, and whether lipopolysaccharide, often used for microglial stimulation, influences cortical spreading depolarizations. In anaesthetized rats, cortical spreading depolarizations were elicited by microinjection of KCl. Interleukin-1ß, the IL-1 receptor 1 antagonist, the GABA<sub>A</sub> receptor blocker bicuculline, and lipopolysaccharide were administered either alone or combined (interleukin-1ß + IL-1 receptor 1 antagonist; interleukin-1ß + bicuculline; lipopolysaccharide + IL-1 receptor 1 antagonist) into a local cortical treatment area. Using microelectrodes, cortical spreading depolarizations were recorded in a non-treatment and in the treatment area. Plasma extravasation in cortical grey matter was assessed with Evans blue. Local application of interleukin-1ß reduced cortical spreading depolarization amplitudes in the treatment area, but not at a high dose. This reduction was prevented by IL-1 receptor 1 antagonist and by bicuculline. However, interleukin-1ß induced pronounced plasma extravasation independently on cortical spreading depolarizations. Application of lipopolysaccharide reduced cortical spreading depolarization amplitudes but prolonged their duration; EEG activity was still present. These effects were also blocked by IL-1 receptor 1 antagonist. Interleukin-1ß evokes changes of neuronal activity and of vascular functions. Thus, although the reduction of cortical spreading depolarization amplitudes at lower doses of interleukin-1ß may reduce deleterious effects of cortical spreading depolarizations, the sum of interleukin-1ß effects on excitability and on the vasculature rather promote brain damaging mechanisms.</p>","PeriodicalId":80983,"journal":{"name":"Computers and the humanities","volume":"6 1","pages":"1791-1802"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73887511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent publications 最近的出版物
Computers and the humanities Pub Date : 2016-11-06 DOI: 10.1007/BF02402635
Ziyanah Ladak, Sarah Taylor, Emilie Whitman
{"title":"Recent publications","authors":"Ziyanah Ladak, Sarah Taylor, Emilie Whitman","doi":"10.1007/BF02402635","DOIUrl":"https://doi.org/10.1007/BF02402635","url":null,"abstract":"","PeriodicalId":80983,"journal":{"name":"Computers and the humanities","volume":"6 1","pages":"160"},"PeriodicalIF":0.0,"publicationDate":"2016-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02402635","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52265720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging Technologies and their Applications in Lipid Compartment Measurement. 脂质区室测量中的新兴技术及其应用。
Computers and the humanities Pub Date : 2015-12-01 Epub Date: 2015-11-17 DOI: 10.1016/j.tem.2015.10.003
Steven B Heymsfield, Houchun Harry Hu, Wei Shen, Owen Carmichael
{"title":"Emerging Technologies and their Applications in Lipid Compartment Measurement.","authors":"Steven B Heymsfield, Houchun Harry Hu, Wei Shen, Owen Carmichael","doi":"10.1016/j.tem.2015.10.003","DOIUrl":"10.1016/j.tem.2015.10.003","url":null,"abstract":"<p><p>Non-Communicable diseases (NCDs), including obesity, are emerging as the major health concern of the 21st century. Excess adiposity and related NCD metabolic disturbances have stimulated development of new lipid compartment measurement technologies to help us to understand cellular energy exchange, to refine phenotypes, and to develop predictive markers of adverse clinical outcomes. Recent advances now allow quantification of multiple intracellular lipid and adipose tissue compartments that can be evaluated across the human lifespan. With magnetic resonance methods leading the way, newer approaches will give molecular structural and metabolic information beyond the laboratory in real-world settings. The union between these new technologies and the growing NCD population is creating an exciting interface in advancing our understanding of chronic disease mechanisms. </p>","PeriodicalId":80983,"journal":{"name":"Computers and the humanities","volume":"35 1","pages":"688-698"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80106742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent publications 最近的出版物
Computers and the humanities Pub Date : 2015-04-25 DOI: 10.1007/BF02402497
Sarah Gilkes, Daniel Jandréus, Elani Owen, D. Runde
{"title":"Recent publications","authors":"Sarah Gilkes, Daniel Jandréus, Elani Owen, D. Runde","doi":"10.1007/BF02402497","DOIUrl":"https://doi.org/10.1007/BF02402497","url":null,"abstract":"","PeriodicalId":80983,"journal":{"name":"Computers and the humanities","volume":"2 1","pages":"222"},"PeriodicalIF":0.0,"publicationDate":"2015-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02402497","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52264636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editor's note 编者按
Computers and the humanities Pub Date : 2014-04-30 DOI: 10.1007/BF02400127
Arien Mack, J. Béja
{"title":"Editor's note","authors":"Arien Mack, J. Béja","doi":"10.1007/BF02400127","DOIUrl":"https://doi.org/10.1007/BF02400127","url":null,"abstract":"","PeriodicalId":80983,"journal":{"name":"Computers and the humanities","volume":"20 1","pages":"323-324"},"PeriodicalIF":0.0,"publicationDate":"2014-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02400127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52214149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stochastic Models for Automatic Diacritics Generation of Arabic Names 阿拉伯名字自动变音符号生成的随机模型
Computers and the humanities Pub Date : 2004-11-01 DOI: 10.1007/S10579-004-2323-6
Fawaz S. Al-Anzi
{"title":"Stochastic Models for Automatic Diacritics Generation of Arabic Names","authors":"Fawaz S. Al-Anzi","doi":"10.1007/S10579-004-2323-6","DOIUrl":"https://doi.org/10.1007/S10579-004-2323-6","url":null,"abstract":"","PeriodicalId":80983,"journal":{"name":"Computers and the humanities","volume":"14 1","pages":"469-481"},"PeriodicalIF":0.0,"publicationDate":"2004-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S10579-004-2323-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52068958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Experimenting with a Question Answering System for the Arabic Language 阿拉伯语问答系统的实验
Computers and the humanities Pub Date : 2004-11-01 DOI: 10.1007/s10579-004-1917-3
B. Hammo, S. Abuleil, S. Lytinen, M. Evens
{"title":"Experimenting with a Question Answering System for the Arabic Language","authors":"B. Hammo, S. Abuleil, S. Lytinen, M. Evens","doi":"10.1007/s10579-004-1917-3","DOIUrl":"https://doi.org/10.1007/s10579-004-1917-3","url":null,"abstract":"","PeriodicalId":80983,"journal":{"name":"Computers and the humanities","volume":"38 1","pages":"397-415"},"PeriodicalIF":0.0,"publicationDate":"2004-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10579-004-1917-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52068903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 47
Evaluation of Linguistic Features for Word Sense Disambiguation with Self-Organized Document Maps 自组织文档地图词义消歧的语言特征评价
Computers and the humanities Pub Date : 2004-11-01 DOI: 10.1007/s10579-004-1948-9
Krister Lindén
{"title":"Evaluation of Linguistic Features for Word Sense Disambiguation with Self-Organized Document Maps","authors":"Krister Lindén","doi":"10.1007/s10579-004-1948-9","DOIUrl":"https://doi.org/10.1007/s10579-004-1948-9","url":null,"abstract":"","PeriodicalId":80983,"journal":{"name":"Computers and the humanities","volume":"38 1","pages":"417-435"},"PeriodicalIF":0.0,"publicationDate":"2004-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10579-004-1948-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52068942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Automatic Acquisition and Expansion of Hypernym Links 超词链接的自动获取和扩展
Computers and the humanities Pub Date : 2004-11-01 DOI: 10.1007/s10579-004-1926-2
E. Morin, C. Jacquemin
{"title":"Automatic Acquisition and Expansion of Hypernym Links","authors":"E. Morin, C. Jacquemin","doi":"10.1007/s10579-004-1926-2","DOIUrl":"https://doi.org/10.1007/s10579-004-1926-2","url":null,"abstract":"","PeriodicalId":80983,"journal":{"name":"Computers and the humanities","volume":"38 1","pages":"363-396"},"PeriodicalIF":0.0,"publicationDate":"2004-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10579-004-1926-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52068930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 84
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