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Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes最新文献

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Development and evaluation of recombinant biomolecules for the immunological diagnosis of hepatitis C 重组生物分子在丙型肝炎免疫诊断中的应用进展及评价
Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes Pub Date : 2022-01-01 DOI: 10.35259/isi.2022_52157
R. Deodato, E. Ferreira, Mayara Silva, J. Mendonça, D. Santos
{"title":"Development and evaluation of recombinant biomolecules for the immunological diagnosis of hepatitis C","authors":"R. Deodato, E. Ferreira, Mayara Silva, J. Mendonça, D. Santos","doi":"10.35259/isi.2022_52157","DOIUrl":"https://doi.org/10.35259/isi.2022_52157","url":null,"abstract":"","PeriodicalId":8089,"journal":{"name":"Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76860240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Construction and standardization of a self- updatable graph antibody database for the training neural networks to optimization of potential antiviral immunobiologicals 自更新图抗体数据库的构建与标准化，用于训练神经网络优化潜在抗病毒免疫生物制剂
Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes Pub Date : 2022-01-01 DOI: 10.35259/isi.2022_52296
D. Almeida, G. Sartori, João Silva
{"title":"Construction and standardization of a self- updatable graph antibody database for the training neural networks to optimization of potential antiviral immunobiologicals","authors":"D. Almeida, G. Sartori, João Silva","doi":"10.35259/isi.2022_52296","DOIUrl":"https://doi.org/10.35259/isi.2022_52296","url":null,"abstract":"on Methodology: Three-dimensional of their respective retrieved from database standardized in and numbering. The converted to representation. characterization of the fundamental units that form the from specific molecular such the surface area and of between for respectively. for Results: Conclusion: for development of","PeriodicalId":8089,"journal":{"name":"Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79252895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination of neutralizing antibodies to sars-cov-2 by recombinant pseudovirus methodology in a cohort of patients with mild to moderate infection and/or vaccinated 用重组假病毒方法测定轻至中度感染和/或接种疫苗患者的sars-cov-2中和抗体
Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes Pub Date : 2022-01-01 DOI: 10.35259/isi.2022_52170
Sarah A R Sérgio, K. Lourenço, L. Andrade, Flávia Bagno, R. Gazzinelli
{"title":"Determination of neutralizing antibodies to sars-cov-2 by recombinant pseudovirus methodology in a cohort of patients with mild to moderate infection and/or vaccinated","authors":"Sarah A R Sérgio, K. Lourenço, L. Andrade, Flávia Bagno, R. Gazzinelli","doi":"10.35259/isi.2022_52170","DOIUrl":"https://doi.org/10.35259/isi.2022_52170","url":null,"abstract":"","PeriodicalId":8089,"journal":{"name":"Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82619081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determining identity, purity and activity of Benzonase® endonuclease applied on the Recombinant Covid-19 Vaccine active pharmaceutical ingredient production 应用于重组Covid-19疫苗活性药物成分生产的苯并酶®内切酶的鉴定、纯度和活性测定
Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes Pub Date : 2022-01-01 DOI: 10.35259/isi.2022_52256
Débora Oliveira, Weslley Santos, I. Santos, Karolyne Ruibal, Lucas Silva
{"title":"Determining identity, purity and activity of Benzonase® endonuclease applied on the Recombinant Covid-19 Vaccine active pharmaceutical ingredient production","authors":"Débora Oliveira, Weslley Santos, I. Santos, Karolyne Ruibal, Lucas Silva","doi":"10.35259/isi.2022_52256","DOIUrl":"https://doi.org/10.35259/isi.2022_52256","url":null,"abstract":"gel was able to detect the presence of putative contaminant proteins in amounts as low as 0.6 μg. The enzymatic activity by UV-Visible method proved to be precise and robust for variations in the incubation time on ice and wavelength of reading. The validation of ICP-OES method for the elemental impurities complied with selectivity acceptance criteria and showed an acceptable sensibility degree. Conclusion: Our results providing sufficient evidences to demonstrate that all assays are suitable for its intended purpose. This multidisciplinary work is now part of the routine of analysis required before Benzonase® utilization in the production of the Recombinant Covid-19 Vaccine API by Bio-Manguinhos/Fiocruz.","PeriodicalId":8089,"journal":{"name":"Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88022157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recombinant influenza virus encoding a Streptococcus pneumoniae conserved antigen: a bivalent intranasal and intramuscular broad-spectrum vaccine against pneumonia and Flu 编码肺炎链球菌保守抗原的重组流感病毒:一种抗肺炎和流感的鼻内和肌内双价广谱疫苗
Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes Pub Date : 2022-01-01 DOI: 10.35259/isi.2022_52198
K. Cardoso, B. Santos, Ketyllen Carvalho, F. Kano, Marco Campos
{"title":"Recombinant influenza virus encoding a Streptococcus pneumoniae conserved antigen: a bivalent intranasal and intramuscular broad-spectrum vaccine against pneumonia and Flu","authors":"K. Cardoso, B. Santos, Ketyllen Carvalho, F. Kano, Marco Campos","doi":"10.35259/isi.2022_52198","DOIUrl":"https://doi.org/10.35259/isi.2022_52198","url":null,"abstract":"IgG antibodies by both routes. In pneumococcal lethal challenges, were observed in vaccine group 65% and 100% protection rates with IN and IM immunization, respectively. The control groups didn’t present relevant protection rates. Since specific antibodies are essential against these pathogens, it’s possible that the high titers of anti-SP IgG antibodies may have contributed to the challenge protection, and that the anti-influenza IgG induced by the intramuscular immunization result in protection against influenza, as already previously observed with intranasal immunization. Conclusion: Thus, these results demonstrate the effectiveness of this vaccine protocol both in intranasal and intramuscular immunization, being, therefore, a promising bivalent broad-spectrum vaccine candidate against pneumonia and Flu.","PeriodicalId":8089,"journal":{"name":"Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89561809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biosimilars 生物仿制药
Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes Pub Date : 2020-12-07 DOI: 10.1201/9781351013154-6
B. Behera
{"title":"Biosimilars","authors":"B. Behera","doi":"10.1201/9781351013154-6","DOIUrl":"https://doi.org/10.1201/9781351013154-6","url":null,"abstract":"","PeriodicalId":8089,"journal":{"name":"Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84423106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biopharmaceutical Production 生物制药生产
Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes Pub Date : 2020-12-07 DOI: 10.1201/9781351013154-2
B. Behera
{"title":"Biopharmaceutical Production","authors":"B. Behera","doi":"10.1201/9781351013154-2","DOIUrl":"https://doi.org/10.1201/9781351013154-2","url":null,"abstract":"","PeriodicalId":8089,"journal":{"name":"Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes","volume":"189 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78026434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introductory Chapter: Biopharmaceuticals 导论:生物制药
Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes Pub Date : 2018-09-19 DOI: 10.5772/INTECHOPEN.79194
Yuan-Chuan Chen, M. Yeh
{"title":"Introductory Chapter: Biopharmaceuticals","authors":"Yuan-Chuan Chen, M. Yeh","doi":"10.5772/INTECHOPEN.79194","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.79194","url":null,"abstract":"","PeriodicalId":8089,"journal":{"name":"Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89413281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Impact of Immunotherapy in the Treatment of Glioblastoma 免疫疗法对胶质母细胞瘤治疗的影响
Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes Pub Date : 2018-09-19 DOI: 10.5772/INTECHOPEN.78603
J. Silva, Ana Miranda, João Sousa, A. Pais, C. Vitorino
{"title":"Impact of Immunotherapy in the Treatment of Glioblastoma","authors":"J. Silva, Ana Miranda, João Sousa, A. Pais, C. Vitorino","doi":"10.5772/INTECHOPEN.78603","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.78603","url":null,"abstract":"Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor. Despite the efforts developed in the respective treatment, consisting of maximal surgical resection followed by adjuvant radiotherapy and chemotherapy, the prognosis remains very poor. This may be partly related to the resistance of GBM cells and their infiltrative and invasive nature into the surrounding brain tissue. Therefore, newer and challenging alternative approaches for the treatment have emerged, including immunotherapy. This anticancer therapy, based on the stimulation of the host’s immune system, has been currently investigated and several advances in the clinical trial stage have already been reached. Immunotherapeutic strategies comprise a set of modalities, including vaccines (cell-free and cell-based), chimeric antigen receptor (CAR) T-cell therapy, immune checkpoint inhibitors, monoclonal antibodies (mAbs), and oncolytic viruses (OVs). In this chapter, we will review the principal concepts and the recent prog ress in immunotherapy for GBM.","PeriodicalId":8089,"journal":{"name":"Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82619793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scientific and Regulatory Perspective on Monoclonal Antibody Biosimilars 单克隆抗体生物类似药的科学与监管展望
Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes Pub Date : 2018-09-19 DOI: 10.5772/INTECHOPEN.78583
Po-Chih Wu, Yi-Chen Yang, Der-Yuan Wang, Hwei-Fang Cheng
{"title":"Scientific and Regulatory Perspective on Monoclonal Antibody Biosimilars","authors":"Po-Chih Wu, Yi-Chen Yang, Der-Yuan Wang, Hwei-Fang Cheng","doi":"10.5772/INTECHOPEN.78583","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.78583","url":null,"abstract":"Similar biotherapeutic products (SBPs), also called biosimilars, exhibit similar biological and clinical properties to authorized reference products. Biosimilars, including small molecules like erythropoietin and complex macromolecules like monoclonal antibodies (mAbs), have been used extensively in disease treatment. Monoclonal antibody biosimilars have gradu-ally become a dominant development in the global pharmaceutical industry since their patents or data protection have been expired or nearing expiration. Since the mAb biosimilars are complex biological macromolecules with various post-translation modifications, it is important to evaluate whether these tiny differences significantly affect the quality. From a regulatory perspective, the comparability study needs to be performed to demonstrate that the quality, safety, and efficacy are similar to the biological reference. Based on these comprehensive comparative results, the indicated extrapolation might be acceptable. Post- market surveillance is also required because of unexpected biological variation caused by slightly different manufacturing processes. This chapter presents the scientific and regula - tory considerations for monoclonal antibody biosimilar products for manufactures and for the regulatory authorities to administrate wisely and comprehensively.","PeriodicalId":8089,"journal":{"name":"Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73212707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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