Annals of the Rheumatic Diseases最新文献

{"title":"Correspondence on 'Real-life use of the PEXIVAS reduced-dose glucocorticoid regimen in granulomatosis with polyangiitis and microscopic polyangiitis' by Nagle et al.","authors":"Yusuf Yazici","doi":"10.1016/j.ard.2025.01.040","DOIUrl":"https://doi.org/10.1016/j.ard.2025.01.040","url":null,"abstract":"","PeriodicalId":8087,"journal":{"name":"Annals of the Rheumatic Diseases","volume":" ","pages":""},"PeriodicalIF":20.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-myxovirus resistance protein 1: a novel biomarker for autoimmune myositis and interstitial lung disease in systemic lupus erythematosus.","authors":"Eugene Krustev, Marvin J Fritzler, Sasha Bernatsky, Yvan St Pierre, Paul J Sciore, Evelyne Vinet, Christian A Pineau, Arielle Mendel, Fares Kalache, Louis-Pierre Grenier, Thaisa Cotton, Omid Zahedi Niaki, May Y Choi","doi":"10.1016/j.ard.2025.01.031","DOIUrl":"https://doi.org/10.1016/j.ard.2025.01.031","url":null,"abstract":"","PeriodicalId":8087,"journal":{"name":"Annals of the Rheumatic Diseases","volume":" ","pages":""},"PeriodicalIF":20.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning-based clustering for endotyping and post-arthroplasty response classification using knee osteoarthritis multiomic data.","authors":"Jason S Rockel, Divya Sharma, Osvaldo Espin-Garcia, Katrina Hueniken, Amit Sandhu, Chiara Pastrello, Kala Sundararajan, Pratibha Potla, Noah Fine, Starlee S Lively, Kim Perry, Nizar N Mahomed, Khalid Syed, Igor Jurisica, Anthony V Perruccio, Y Raja Rampersaud, Rajiv Gandhi, Mohit Kapoor","doi":"10.1016/j.ard.2025.01.012","DOIUrl":"https://doi.org/10.1016/j.ard.2025.01.012","url":null,"abstract":"<p><strong>Objectives: </strong>Primary knee osteoarthritis (KOA) is a heterogeneous disease with clinical and molecular contributors. Biofluids contain microRNAs and metabolites that can be measured by omic technologies. Multimodal deep learning is adept at uncovering complex relationships within multidomain data. We developed a novel multimodal deep learning framework for clustering of multiomic data from 3 subject-matched biofluids to identify distinct KOA endotypes and classify 1-year post-total knee arthroplasty (TKA) pain/function responses.</p><p><strong>Methods: </strong>In 414 patients with KOA, subject-matched plasma, synovial fluid, and urine were analysed using microRNA sequencing or metabolomics. Integrating 4 high-dimensional datasets comprising metabolites from plasma and microRNAs from plasma, synovial fluid, or urine, a multimodal deep learning variational autoencoder architecture with K-means clustering was employed. Features influencing cluster assignment were identified and pathway analyses conducted. An integrative machine learning framework combining 4 molecular domains and a clinical domain was then used to classify Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain/function responses after TKA within each cluster.</p><p><strong>Results: </strong>Multimodal deep learning-based clustering of subjects across 4 domains yielded 3 distinct patient clusters. Feature signatures comprising microRNAs and metabolites across biofluids included 30, 16, and 24 features associated with clusters 1 to 3, respectively. Pathway analyses revealed distinct pathways associated with each cluster. Integration of 4 multiomic domains along with clinical data improved response classification performance, surpassing individual domain classifications alone.</p><p><strong>Conclusions: </strong>We developed a multimodal deep learning-based clustering model capable of integrating complex multifluid, multiomic data to assist in uncovering biologically distinct patient endotypes and enhance outcome classifications to TKA surgery, which may aid in future precision medicine approaches.</p>","PeriodicalId":8087,"journal":{"name":"Annals of the Rheumatic Diseases","volume":" ","pages":""},"PeriodicalIF":20.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Correspondence on 'Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integration' by Fan et al.","authors":"Yue Fan, Xuzhao Bian, Di Zhang, Shiquan Sun","doi":"10.1016/j.ard.2024.11.002","DOIUrl":"https://doi.org/10.1016/j.ard.2024.11.002","url":null,"abstract":"","PeriodicalId":8087,"journal":{"name":"Annals of the Rheumatic Diseases","volume":" ","pages":""},"PeriodicalIF":20.3,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Annals of the Rheumatic Diseases Collection on juvenile idiopathic arthritis (JIA) 2019-2024.","authors":"Lianne Kearsley-Fleet, Samantha L Smith, Athimalaipet V Ramanan, Kimme L Hyrich","doi":"10.1016/j.ard.2024.11.004","DOIUrl":"https://doi.org/10.1016/j.ard.2024.11.004","url":null,"abstract":"","PeriodicalId":8087,"journal":{"name":"Annals of the Rheumatic Diseases","volume":" ","pages":""},"PeriodicalIF":20.3,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why the term nr-axSpA should not be used for diagnosis.","authors":"Juergen Braun","doi":"10.1016/j.ard.2024.11.003","DOIUrl":"https://doi.org/10.1016/j.ard.2024.11.003","url":null,"abstract":"","PeriodicalId":8087,"journal":{"name":"Annals of the Rheumatic Diseases","volume":" ","pages":""},"PeriodicalIF":20.3,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic literature review informing the EULAR points to consider for patient education in physical activity and self-management of pain during transitional care.","authors":"Javier Courel-Ibáñez, Rafael Prieto-Moreno, Erica Briones-Vozmediano, Patrocinio Ariza-Vega, Saskya Angevare, Jordi Anton, Ilaria Bini, Daniel Clemente, Matilde Correia, Wendy Costello, Diederik De Cock, Andrea Domjan, Leticia Leon, Andrea Marques, Kirsten Minden, Ana Filipa Mourão, Aurelie Najm, Seza Özen, Georgina Pimentel, Zainab Saleem, Tomas Vetrovsky, Nico Wulffraat, Andrea Zacarias, Yeliz Prior, Loreto Carmona, Fernando Estévez-López","doi":"10.1016/j.ard.2025.01.017","DOIUrl":"https://doi.org/10.1016/j.ard.2025.01.017","url":null,"abstract":"<p><strong>Objectives: </strong>To synthesise existing evidence on transitional care programmes for young people with juvenile-onset rheumatic and musculoskeletal diseases (jRMDs), focusing on their structure and implementation, the qualitative experiences and perceptions of those involved, and the quantitative outcomes associated with these programmes. Together with additional information, these insights have informed the European Alliance of Associations for Rheumatology (EULAR) Points to Consider for patient education in physical activity and self-management of pain in jRMDs during transitional care.</p><p><strong>Methods: </strong>A systematic literature review was conducted with a broadened scope beyond patient education in physical activity and self-management of pain to provide a comprehensive overview of transitional care in rheumatology, aiming to optimise current strategies, support evidence-based approaches, and identify areas for clinical improvement. The search was conducted in PubMed and the Cochrane Library from inception until November 1, 2023. Descriptive, qualitative, and quantitative studies were included. Two researchers independently conducted the search, screening, data extraction, and quality assessment.</p><p><strong>Results: </strong>From 31 studies, we identified 18 transitional care programmes with key approaches, including individualised and developmentally appropriate plans that often integrate educational strategies. These programmes, which generally aim to increase readiness to transfer, health-related quality of life, and continuity of care, frequently involved multidisciplinary teams and early intervention strategies. Young people with jRMDs and their families reported satisfaction with these transitional care experiences, particularly valuing early self-management support. While these programmes showed potential in promoting positive health outcomes and clinical practices, quantitative evidence supporting their effectiveness is limited, with few experimental studies confirming consistent benefits.</p><p><strong>Conclusions: </strong>This systematic review highlights the diverse yet fragmented approaches in transitional care for jRMDs, emphasising the need for stronger quantitative evidence. Thus, it is important to conduct further experimental research to optimise existing programmes or develop new ones, ultimately contributing to a smoother transition to adult care and improved long-term outcomes.</p>","PeriodicalId":8087,"journal":{"name":"Annals of the Rheumatic Diseases","volume":" ","pages":""},"PeriodicalIF":20.3,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukin-18 and interleukin-1β blockade to control inflammation in PAMI syndrome before and after HSCT.","authors":"Benjamin Fournier, Laurye-Anne Eveillard, Agathe Escudier, Guilaine Boursier, Anne Welfringer, Bénédicte Neven, Brigitte Bader-Meunier","doi":"10.1016/j.ard.2024.12.002","DOIUrl":"https://doi.org/10.1016/j.ard.2024.12.002","url":null,"abstract":"","PeriodicalId":8087,"journal":{"name":"Annals of the Rheumatic Diseases","volume":" ","pages":""},"PeriodicalIF":20.3,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarifying responsibility in AI-assisted healthcare: a closer look at ChatGPT's role.","authors":"Yuanbin Huang, Hongjin Wang, Xinmiao Ma","doi":"10.1016/j.ard.2024.12.001","DOIUrl":"https://doi.org/10.1016/j.ard.2024.12.001","url":null,"abstract":"","PeriodicalId":8087,"journal":{"name":"Annals of the Rheumatic Diseases","volume":" ","pages":""},"PeriodicalIF":20.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of Janus kinase inhibitors in immune-mediated inflammatory diseases-a systematic literature review informing the 2024 update of an international expert consensus statement.","authors":"Victoria Konzett, Josef S Smolen, Peter Nash, Kevin Winthrop, Daniel Aletaha, Thomas Dörner, Roy Fleischmann, Yoshiya Tanaka, Jette Primdahl, Xenofon Baraliakos, Iain B McInnes, Michael Trauner, Naveed Sattar, Maarten de Wit, Jan W Schoones, Andreas Kerschbaumer","doi":"10.1016/j.ard.2025.01.024","DOIUrl":"10.1016/j.ard.2025.01.024","url":null,"abstract":"<p><strong>Objectives: </strong>This systematic literature review (SLR) on safety outcomes was performed to inform the 2024 update of the expert consensus statement on the treatment of immune-mediated inflammatory diseases (IMIDs) with Janus kinase inhibitors (JAKi).</p><p><strong>Methods: </strong>An update of the 2019 SLR was performed in MEDLINE, Embase, and the Cochrane Library. For safety, randomised, placebo-controlled or active-controlled trials on all JAKi investigated in IMIDs, long-term extension (LTE) studies, pooled trial data analyses, and cohort and claims studies were included.</p><p><strong>Results: </strong>We screened 13,905 records, of which 209 were finally included. Three safety trials and 13 post hoc analyses, 83 efficacy randomised controlled trials (RCTs) with adequate safety reporting, 56 integrated safety analyses and LTE of RCTs, 20 additional conference abstracts on RCT data, as well as 37 real-world cohort studies were presented to the task force. Safety profiles of JAKi were overall consistent across compounds and indications, but impacts of patient profiles, treatment dosing, and other cofactors like background medications on drug safety could be observed. Furthermore, differential effects of variously selective JAKi on distinct adverse events of special interest (AESI) and laboratory outcomes were discerned.</p><p><strong>Conclusion: </strong>A substantial amount of literature was published on JAKi safety since 2019. A comprehensive overview of these data supports the optimal use of JAKi in patients with IMIDs, by consideration and balance of their benefits as well as risks in every patient.</p>","PeriodicalId":8087,"journal":{"name":"Annals of the Rheumatic Diseases","volume":" ","pages":""},"PeriodicalIF":20.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}