BMC nuclear medicine最新文献_第3页

Comparison of Technetium-99m-MIBI imaging with MRI for detection of spine involvement in patients with multiple myeloma. 锝-99m- mibi成像与MRI检测多发性骨髓瘤患者脊柱受累的比较。

BMC nuclear medicine Pub Date : 2003-12-11 DOI: 10.1186/1471-2385-3-2

Siroos Mirzaei, Martin Filipits, Andrea Keck, Walter Bergmayer, Peter Knoll, Horst Koehn, Heinz Ludwig, Martin Pecherstorfer

{"title":"Comparison of Technetium-99m-MIBI imaging with MRI for detection of spine involvement in patients with multiple myeloma.","authors":"Siroos Mirzaei, Martin Filipits, Andrea Keck, Walter Bergmayer, Peter Knoll, Horst Koehn, Heinz Ludwig, Martin Pecherstorfer","doi":"10.1186/1471-2385-3-2","DOIUrl":"https://doi.org/10.1186/1471-2385-3-2","url":null,"abstract":"BACKGROUND: Recently, radiopharmaceutical scanning with Tc-99m-MIBI was reported to depict areas with active bone disease in multiple myeloma (MM) with both high sensitivity and specificity. This observation was explained by the uptake of Tc-99m-MIBI by neoplastic cells. The present investigation evaluates whether Tc-99m-MIBI imaging and magnetic resonance imaging (MRI) perform equally well in detecting myelomatous bone marrow lesions. METHODS: In 21 patients with MM, MRIs of the vertebral region TH12 to S1 and whole body scans with Tc-99m-MIBI were done. RESULTS: Tc-99m-MIBI scanning missed bone marrow infiltration in 43 of 87 vertebrae (50.5%) in which MRI showed neoplastic bone marrow involvement. In patients with disease stage I+II, Tc-99m-MIBI scanning was negative in all of 24 vertebrae infiltrated according to MRI. In patients with disease stage III, Tc-99m-MIBI scanning detected 44 of 63 (70%) vertebrae involved by neoplastic disease. CONCLUSION: Tc-99m-MIBI scanning underestimated the extent of myelomatous bone marrow infiltration in the spine, especially in patients with low disease stage.","PeriodicalId":80684,"journal":{"name":"BMC nuclear medicine","volume":"3 1","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2003-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1471-2385-3-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24121349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Assessment of diffuse Lewy body disease by 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET). 2-[18F]氟-2-脱氧-d -葡萄糖正电子发射断层扫描(FDG PET)评估弥漫性路易体病。

BMC nuclear medicine Pub Date : 2003-02-20 DOI: 10.1186/1471-2385-3-1

Siroos Mirzaei, Peter Knoll, Horst Koehn, Thomas Bruecke

{"title":"Assessment of diffuse Lewy body disease by 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET).","authors":"Siroos Mirzaei, Peter Knoll, Horst Koehn, Thomas Bruecke","doi":"10.1186/1471-2385-3-1","DOIUrl":"https://doi.org/10.1186/1471-2385-3-1","url":null,"abstract":"BACKGROUND: Lewy body disease is, after Alzheimer's disease, the second most common cause of senile degenerative dementia with progressive cognitive deterioration, fluctuation of cognitive and motoric functions and psychotic symptoms. It is characterized histologically by the occurrence of Lewy bodies in allocortical, neocortical and subcortical structures. The aim of this study was to measure the cortical glucose metabolism using FDG PET (2-[18F]fluoro-2-deoxy-D-glucose position emission tomography) compared to normal subjects. PATIENTS AND METHODS: Five patients (5 m, mean age 75 y) with clinically suspected diffuse Lewy body disease (DLB) were studied with FDG PET. PET studies of the head were performed with a Siemens ECAT-ART PET-scanner with attenuation correction using 137-Cs point sources. RESULTS: We found the same distribution pattern of diffuse glucose hypometabolism in the entire cortical region with relative sparing of the primary sensory-motor cortex in all the patients. The few cases reported in the literature so far describe findings similar to ours. CONCLUSION: The pattern of diffuse glucose hypometabolism in the entire cortex including the occipital region seems to be a typical feature of DLB that is distinctive from dementia of Alzheimer's disease.","PeriodicalId":80684,"journal":{"name":"BMC nuclear medicine","volume":"3 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2003-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1471-2385-3-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22278997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Physico-chemical characterisation and biological evaluation of 188-Rhenium colloids for radiosynovectomy. 放射性滑膜切除术中188-铼胶体的物理化学特征和生物学评价。

BMC nuclear medicine Pub Date : 2002-10-14 DOI: 10.1186/1471-2385-2-1

Ma Ures, Eduardo Savio, Antonio Malanga, Marcelo Fernández, Andrea Paolino, Javier Gaudiano

{"title":"Physico-chemical characterisation and biological evaluation of 188-Rhenium colloids for radiosynovectomy.","authors":"Ma Ures, Eduardo Savio, Antonio Malanga, Marcelo Fernández, Andrea Paolino, Javier Gaudiano","doi":"10.1186/1471-2385-2-1","DOIUrl":"https://doi.org/10.1186/1471-2385-2-1","url":null,"abstract":"BACKGROUND: Radiosynovectomy is a type of radiotherapy used to relieve pain and inflammation from rheumatoid arthritis. In this study, 188-Rhenium (188Re) colloids were characterized by physical and biological methodologies. This was used to assess which parameters of the kit formulation would be the basis in the development of a more effective radiopharmaceutical for synovectomy. Intraarticular injection in knees of rabbits assessed cavity leakage of activity. METHODS: The physical characteristics of tin (Sn) and sulphur (S) colloids were determined to assess the formulation with suitable properties. Particles were grouped in three ranges for analyzing their distribution according to their number, volume and surface. The ideal particle size range was considered to be from 2 to 10 microns. Membrane filtration and laser diffraction characterization methodologies were used. RESULTS: While membrane filtration could give misleading data, laser diffraction proportions more reliable results. The Sn colloid showed a better distribution of particle volume and surface than S colloid, in the 2 to 10 microns range. The 188Re-Sn colloid was obtained with a radiochemical purity higher than 95% after 30 minutes of autoclaving. While Sn colloid kit stability was verified for 60 days, the 188Re-Sn preparation was stable in the first 24 hrs. No significant intrabatch variability (n = 3) was detected. Biodistribution and scintigraphic studies in rabbits after intraarticular injection showed relevant activity only in knee, being 90% at 48 hours. CONCLUSION: The 188Re-Sn colloid is easy to prepare, is stable for 24 hours and shows minimal cavity leakage after intraarticular injection into rabbit knees, suggesting this radiotherapeutical agent has suitable physical properties for evaluation for joint treatment in humans.","PeriodicalId":80684,"journal":{"name":"BMC nuclear medicine","volume":"2 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2002-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1471-2385-2-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22065717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

A mathematical model of optimized radioiodine-131 therapy of Graves' hyperthyroidism 放射性碘-131优化治疗Graves甲亢的数学模型

BMC nuclear medicine Pub Date : 2001-08-28 DOI: 10.1186/1471-2385-1-1

S. Doi, I. Loutfi, K. A. Al-Shoumer

引用次数: 29

Re-HEDP : pharmacokinetic characterization, clinical and dosimetric evaluation in osseous metastatic patients with two levels of radiopharmaceutical dose. Re-HEDP：两种放射性药物剂量水平下骨转移患者的药代动力学特征、临床和剂量评估。

BMC nuclear medicine Pub Date : 2001-01-01 DOI: 10.1186/1471-2385-1-2

Eduardo Savio, Javier Gaudiano, Ana M Robles, Henia Balter, Andrea Paolino, Andrea López, Juan C Hermida, Eugenia De Marco, Graciela Martinez, Eduardo Osinaga, Furn F Knapp

{"title":"Re-HEDP : pharmacokinetic characterization, clinical and dosimetric evaluation in osseous metastatic patients with two levels of radiopharmaceutical dose.","authors":"Eduardo Savio, Javier Gaudiano, Ana M Robles, Henia Balter, Andrea Paolino, Andrea López, Juan C Hermida, Eugenia De Marco, Graciela Martinez, Eduardo Osinaga, Furn F Knapp","doi":"10.1186/1471-2385-1-2","DOIUrl":"10.1186/1471-2385-1-2","url":null,"abstract":"BACKGROUND: A study for pain relief therapy with 188Re-HEDP was done in patients with bone metastases secondary to breast and prostate cancer. MATERIALS AND METHODS: Patients received 1.3 or 2.2 GBq, in single or multiple doses. Platelets, white and red cells were evaluated during 11 weeks. Pharmacokinetic characterization was done from blood and urine samples for 5 patients along 24 hours. Urinary excretion was evaluated in other 16 patients during 6 hours. Bone uptake was estimated as remaining activity in whole body. Scintigraphic images were acquired at 2 and 24 hs post-administration. Absorbed dose in bone marrow was estimated with Mirdose3. Analgesics intake and pain score were daily recorded. Tumour markers (PSA, and Tn-structure) were monitored in 9 patients during 4 to 6 months. Single doses of low activity (1.3 GBq) were given to twelve patients. Nine patients received multiple doses. RESULTS: All except one patient had normal levels of platelets, white and red cells. Remaining dose in blood at 2 hours was 9%. Urinary elimination was 58%. Bone uptake at 24 hours was 43% (mean value; n = 5). No changes of the haematological parameters were detected along follow-up period. Pain relief was evidenced by decrease or supression of opioid analgesic and by subjective index. PSA showed a decrease in prostate cancer patients (n = 4). Tn-structure showed a significant increase after 4 to 8 months. CONCLUSION: Single or multiple dose scheme could be safely used, with administered activity of 188Re-HEDP up to 60 mCi, with low bone marrow absorbed doses.","PeriodicalId":80684,"journal":{"name":"BMC nuclear medicine","volume":"1 1","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1471-2385-1-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65647447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36