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Hypothalamic hormone deficiency enables physiological anorexia. 下丘脑激素缺乏会导致生理性厌食。
Behaviorists for Social Action journal Pub Date : 2024-03-11 DOI: 10.1101/2023.03.15.532843
Sarah M Mohr, Rafael Dai Pra, Maryann P Platt, Viktor V Feketa, Marya Shanabrough, Luis Varela, Ashley Kristant, Haoran Cao, Dana K Merriman, Tamas L Horvath, Sviatoslav N Bagriantsev, Elena O Gracheva
{"title":"Hypothalamic hormone deficiency enables physiological anorexia.","authors":"Sarah M Mohr, Rafael Dai Pra, Maryann P Platt, Viktor V Feketa, Marya Shanabrough, Luis Varela, Ashley Kristant, Haoran Cao, Dana K Merriman, Tamas L Horvath, Sviatoslav N Bagriantsev, Elena O Gracheva","doi":"10.1101/2023.03.15.532843","DOIUrl":"10.1101/2023.03.15.532843","url":null,"abstract":"<p><p>Mammalian hibernators survive prolonged periods of cold and resource scarcity by temporarily modulating normal physiological functions, but the mechanisms underlying these adaptations are poorly understood. The hibernation cycle of thirteen-lined ground squirrels <i>(Ictidomys tridecemlineatus)</i> lasts for 5-7 months and comprises weeks of hypometabolic, hypothermic torpor interspersed with 24-48-hour periods of an active-like interbout arousal (IBA) state. We show that ground squirrels, who endure the entire hibernation season without food, have negligible hunger during IBAs. These squirrels exhibit reversible inhibition of the hypothalamic feeding center, such that hypothalamic arcuate nucleus neurons exhibit reduced sensitivity to the orexigenic and anorexigenic effects of ghrelin and leptin, respectively. However, hypothalamic infusion of thyroid hormone during an IBA is sufficient to rescue hibernation anorexia. Our results reveal that thyroid hormone deficiency underlies hibernation anorexia and demonstrate the functional flexibility of the hypothalamic feeding center.</p>","PeriodicalId":80628,"journal":{"name":"Behaviorists for Social Action journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10979886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73960092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Role for Universities in Creating and Disseminating Tools for Community Development 大学在创造和传播社区发展工具方面的作用
Behaviorists for Social Action journal Pub Date : 1984-10-01 DOI: 10.1007/BF03449109
S. Fawcett, T. Seekins, P. L. Whang, Y. Suarez de Balcazar, Charles Muiu, M. Johnson
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引用次数: 2
Using Each Other: An Analysis of Leadership as Operant Conditioning 相互利用:领导力作为操作性条件反射的分析
Behaviorists for Social Action journal Pub Date : 1984-10-01 DOI: 10.1007/BF03449113
J. A. Barlow
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引用次数: 0
The Dandelion Community 蒲公英群落
Behaviorists for Social Action journal Pub Date : 1984-10-01 DOI: 10.1007/BF03449111
Richard Graham
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引用次数: 3
Erratum to: Toward a United Front: a Class Analysis of Social and Political Action 《走向统一战线:对社会和政治行动的阶级分析》的勘误
Behaviorists for Social Action journal Pub Date : 1984-10-01 DOI: 10.1007/BF03449115
J. Ulman
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引用次数: 0
Old Dogs and New Tricks: Disarmament and Alternatives to War 老狗和新把戏:裁军和替代战争
Behaviorists for Social Action journal Pub Date : 1984-10-01 DOI: 10.1007/BF03449110
J. Nevin
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引用次数: 2
BFSA Statement of Purpose BFSA宗旨声明
Behaviorists for Social Action journal Pub Date : 1984-01-01 DOI: 10.1007/BF03449118
{"title":"BFSA Statement of Purpose","authors":"","doi":"10.1007/BF03449118","DOIUrl":"https://doi.org/10.1007/BF03449118","url":null,"abstract":"","PeriodicalId":80628,"journal":{"name":"Behaviorists for Social Action journal","volume":"4 1","pages":"27"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03449118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52337573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1984 BFSA Symposium at ABA: “Animal Rights and Behavior Analysis: Constraints on Learning About Behavior” 1984年美国动物协会研讨会:“动物权利和行为分析:对行为学习的约束”
Behaviorists for Social Action journal Pub Date : 1984-01-01 DOI: 10.1007/BF03449116
R. Rakos
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引用次数: 0
Addendum: Dandelion Community Behavior Code 附录:蒲公英社区行为规范
Behaviorists for Social Action journal Pub Date : 1984-01-01 DOI: 10.1007/BF03449112
{"title":"Addendum: Dandelion Community Behavior Code","authors":"","doi":"10.1007/BF03449112","DOIUrl":"https://doi.org/10.1007/BF03449112","url":null,"abstract":"","PeriodicalId":80628,"journal":{"name":"Behaviorists for Social Action journal","volume":"4 1","pages":"15-19"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03449112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52337254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toward a United Front: a Class Analysis of Social and Political Action 走向统一战线:对社会政治行动的阶级分析
Behaviorists for Social Action journal Pub Date : 1983-05-01 DOI: 10.1007/BF03406169
J. Ulman
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引用次数: 5
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