{"title":"Cytochrome P450 Enzyme Metabolites in Lead Discovery and Development.","authors":"Sylvie E Kandel, Larry C Wienkers, Jed N Lampe","doi":"10.1016/B978-0-12-800167-7.00022-5","DOIUrl":"https://doi.org/10.1016/B978-0-12-800167-7.00022-5","url":null,"abstract":"<p><p>The cytochrome P450 (CYP) enzymes are a versatile superfamily of heme-containing monooxygenases, perhaps best known for their role in the oxidation of xenobiotic compounds. However, due to their unique oxidative chemistry, CYPs are also important in natural product drug discovery and in the generation of active metabolites with unique therapeutic properties. New tools for the analysis and production of CYP metabolites, including microscale analytical technologies and combinatorial biosynthesis, are providing medicinal chemists with the opportunity to use CYPs as a novel platform for lead discovery and development. In this review, we will highlight some of the recent examples of drug leads identified from CYP metabolites and the exciting possibilities of using CYPs as catalysts for future drug discovery.</p>","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"49 ","pages":"347-359"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-800167-7.00022-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33152120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chapter Six - Small-Molecule Modulators of GPR40 (FFA1)","authors":"Sean P. Brown, Joshua P. Taygerly","doi":"10.1016/B978-0-12-800167-7.00006-7","DOIUrl":"https://doi.org/10.1016/B978-0-12-800167-7.00006-7","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"49 1","pages":"77-86"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-800167-7.00006-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54159043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chapter Thirteen - Modulators of Atypical Protein Kinase C as Anticancer Agents","authors":"J. Roffey, G. R. Ott","doi":"10.1016/B978-0-12-800167-7.00013-4","DOIUrl":"https://doi.org/10.1016/B978-0-12-800167-7.00013-4","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"49 1","pages":"189-206"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-800167-7.00013-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54159074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chapter Twenty - Disease-Modifying Agents for the Treatment of Cystic Fibrosis","authors":"B. Tait, J. Miller","doi":"10.1016/B978-0-12-800167-7.00020-1","DOIUrl":"https://doi.org/10.1016/B978-0-12-800167-7.00020-1","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"49 1","pages":"317-330"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-800167-7.00020-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54159101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chapter Twenty-One – Advancements in Stapled Peptide Drug Discovery & Development","authors":"V. Guerlavais, T. Sawyer","doi":"10.1016/B978-0-12-800167-7.00021-3","DOIUrl":"https://doi.org/10.1016/B978-0-12-800167-7.00021-3","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"49 1","pages":"331-345"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-800167-7.00021-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54159106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chapter Nine - Advances in the Discovery of Small-Molecule IRAK4 Inhibitors","authors":"J. Hynes, S. Nair","doi":"10.1016/B978-0-12-800167-7.00009-2","DOIUrl":"https://doi.org/10.1016/B978-0-12-800167-7.00009-2","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"49 1","pages":"117-133"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-800167-7.00009-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54159055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chapter Seven - Recent Advances in the Development of P2Y12 Receptor Antagonists as Antiplatelet Agents","authors":"Allorie T. Caldwell, E. B. Watkins","doi":"10.1016/B978-0-12-800167-7.00007-9","DOIUrl":"https://doi.org/10.1016/B978-0-12-800167-7.00007-9","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"49 1","pages":"87-99"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-800167-7.00007-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54159047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chapter Eight - Current Approaches to the Treatment of Atrial Fibrillation","authors":"Heather J. Finlay","doi":"10.1016/B978-0-12-800167-7.00008-0","DOIUrl":"https://doi.org/10.1016/B978-0-12-800167-7.00008-0","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"49 1","pages":"101-113"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-800167-7.00008-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54159052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}