Clinical cornerstonePub Date : 2008-01-01Epub Date: 2008-11-29DOI: 10.1016/S1098-3597(08)60032-0
{"title":"CME Test Answer Sheet and Evaluation Form for Abdominal Adiposity: An Emerging Marker of Cardiometabolic Risk Volume 9, Number 1","authors":"","doi":"10.1016/S1098-3597(08)60032-0","DOIUrl":"https://doi.org/10.1016/S1098-3597(08)60032-0","url":null,"abstract":"","PeriodicalId":80265,"journal":{"name":"Clinical cornerstone","volume":"9 1","pages":"Pages 73-79"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1098-3597(08)60032-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137353056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical cornerstonePub Date : 2008-01-01Epub Date: 2008-11-29DOI: 10.1016/S1098-3597(08)60029-0
Richard A. Johnson MD
{"title":"Commentary on Current Literature","authors":"Richard A. Johnson MD","doi":"10.1016/S1098-3597(08)60029-0","DOIUrl":"10.1016/S1098-3597(08)60029-0","url":null,"abstract":"","PeriodicalId":80265,"journal":{"name":"Clinical cornerstone","volume":"9 1","pages":"Pages 67-68"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1098-3597(08)60029-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56553755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical cornerstonePub Date : 2008-01-01Epub Date: 2009-05-02DOI: 10.1016/S1098-3597(09)60021-1
Derek LeRoith MD, PhD
{"title":"Hyperglycemia, Hypertension, and Dyslipidemia in Type 2 Diabetes Mellitus: Goals for Diabetes Management","authors":"Derek LeRoith MD, PhD","doi":"10.1016/S1098-3597(09)60021-1","DOIUrl":"10.1016/S1098-3597(09)60021-1","url":null,"abstract":"<div><p>Type 2 diabetes mellitus (DM) is frequently associated with other major cardiovascular risk factors, namely, hypertension and hypertriglyceridemia<span><span>; low levels of high-density lipoprotein cholesterol and elevated levels of low-density lipoprotein cholesterol; the likely presence of metabolic syndrome<span>; and the spectrum of nontraditional risk factors, including inflammation, hypercoagulability<span><span>, and vascular endothelial abnormalities, that often accompany insulin resistance. Patients with type 2 DM, therefore, are at an increased risk for cardiovascular disease (CVD) and mortality. Along with the prevention of microvascular complications, the prevention of CVD events and mortality are major goals of diabetes therapy. Research has helped to establish targets for the </span>treatment of the 3 major risk factors for type 2 DM–hypertension, </span></span></span>hyperglycemia, and dyslipidemia—and clinical guidelines agree about the need to monitor and treat these risk factors. Lifestyle modification is recommended as a first-line approach to risk reduction; however, many patients will also require pharmacotherapy to achieve their treatment goals.</span></p></div>","PeriodicalId":80265,"journal":{"name":"Clinical cornerstone","volume":"9 ","pages":"Pages S8-S16"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1098-3597(09)60021-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56553781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical cornerstonePub Date : 2008-01-01Epub Date: 2008-11-29DOI: 10.1016/S1098-3597(08)60024-1
Christopher P. Cannon MD
{"title":"Obesity-Related Cardiometabolic Complications","authors":"Christopher P. Cannon MD","doi":"10.1016/S1098-3597(08)60024-1","DOIUrl":"10.1016/S1098-3597(08)60024-1","url":null,"abstract":"<div><p><span>Obese patients are at increased risk for developing numerous cardiometabolic complications, including hypertension, insulin resistance, diabetes mellitus, dyslipidemia<span>, and cardiovascular disease (CVD). These complications are associated with an increase in mortality and appear to be related to the changes in adipocytcs that occur with obesity. The enlarged adipocytes<span> found in obese individuals release more glycerol, free fatty acids, and proinflammatory factors and less adiponectin. Some of these changes result in insulin resistance, which appears to be integral to the development of the obesity-associated cardiometabolic complications. Weight loss and increased physical activity are key to reducing the risk for obese individuals to develop cardiovascular complications. However, many patients also require drug therapy. Because many obese patients have multiple cardiometabolic complications, ideally, drug therapy that has positive effects on multiple </span></span></span>CVD risk factors<span> should be used. Therapies directed at obesity, such as sibutramine<span><span> and endocannabinoid </span>receptor blockers (eg, rimonabant), have shown improvements in weight, blood pressure, the lipid profile, and glucose levels.</span></span></p></div>","PeriodicalId":80265,"journal":{"name":"Clinical cornerstone","volume":"9 1","pages":"Pages 11-22"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1098-3597(08)60024-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27871248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}