Transfusion science最新文献

{"title":"Systematic analysis of global health research funding in Canada, 2000-2016.","authors":"Steven J Hoffman, Elliot Gunn, Susan Rogers Van Katwyk, Stephanie Nixon","doi":"10.17269/s41997-019-00247-8","DOIUrl":"10.17269/s41997-019-00247-8","url":null,"abstract":"<p><strong>Objectives: </strong>Considering recent shifts in global funding landscapes, this study analyzes Canada's long-term global health research funding trends in the hope of informing a new Canadian global health research strategy. Examining past investments can help prioritize limited future resources to either build on Canada's existing strengths or fill gaps where needed, while simultaneously informing the investments of research funders in other countries.</p><p><strong>Methods: </strong>Administrative data were analyzed covering all 1584 global health research grants awarded by the Canadian Institutes of Health Research (CIHR) to 927 unique principal investigators from 2000 to 2016, totalling C$341 million. Existing metadata associated with each grant was supplemented by additional qualitative coding. Descriptive time-series analyses of global health research grant data were conducted using various measures related to each grant's recipient (e.g., province, university, sex, distribution) and subject matter (e.g., research theme, area, focus).</p><p><strong>Results: </strong>CIHR's total annual global health research funding increased sharply from $3.6 million in FY2000/2001 to $30.3 million in FY2015/2016, with the largest share of research funding now focused on health equity-representing nearly 50% of CIHR's global health research funding. Past grants have concentrated on infectious disease and public health research. One third of CIHR's global health grant funding went to 20 principal investigators. Only 42.2% of global health research funding came from CIHR's open investigator-driven competitions, with the rest coming from strategic priority-driven competitions.</p><p><strong>Conclusion: </strong>Global health research has seen steady increases in funding from CIHR's open competitions when preceded by investment in strategic competitions, which suggests the level of a national research funding agency's strategic investments in global health research may determine the size of the field in their country. The greatest concentration of past investment lies in health equity research, followed by infectious disease research. Future analyses of research funding would benefit from an internationally accepted keyword classification scheme and more granular administrative data.</p>","PeriodicalId":80242,"journal":{"name":"Transfusion science","volume":"13 1","pages":"80-95"},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75846918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical aspects of hemochromatosis","authors":"Pierre Brissot,&nbsp;Dominique Guyader,&nbsp;Olivier Loréal,&nbsp;Fabrice Lainé,&nbsp;Anne Guillygomarc'h,&nbsp;Romain Moirand,&nbsp;Yves Deugnier","doi":"10.1016/S0955-3886(00)00088-6","DOIUrl":"10.1016/S0955-3886(00)00088-6","url":null,"abstract":"<div><p>Hemochromatosis is one of the most frequent genetic diseases among the white populations, affecting one in three hundred persons. Its diagnosis has been radically transformed by the discovery of the HFE gene. In a given individual, the diagnosis can, from now on, be ascertained on the sole association of a plasma transferrin saturation (TS) over 45% and homozygosity for the C282Y mutation. Liver biopsy is only required to search for cirrhosis whenever there is hepatomegaly and/or serum ferritin &gt;1000 ng/ml and/or elevated serum AST. Family screening is mandatory, primarily centered on the siblings. The treatment remains based on venesection therapy which improves many features of the disease (one of the most refractory, however, being the joint signs) and permits normal life expectancy provided the diagnosis is established prior to the development of cirrhosis or of insulin-dependent diabetes. In view of the prevalence, the non-invasive diagnosis, the spontaneous severity and the efficacy of a very simple therapy, hemochromatosis should benefit from population screening. This screening could be based, first, on the assessment of transferrin saturation, followed – when elevated – by the search for the C282Y mutation. The discovery of the HFE gene has also paved the road for the individualization of other types of iron overload syndromes which are not HFE-related.</p></div>","PeriodicalId":80242,"journal":{"name":"Transfusion science","volume":"23 3","pages":"Pages 193-200"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0955-3886(00)00088-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21923990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of intracellular iron levels in iron-acceptor and iron-donor cells","authors":"Manuela Santos ,&nbsp;Maria de Sousa ,&nbsp;J.J.M. Marx","doi":"10.1016/S0955-3886(00)00109-0","DOIUrl":"10.1016/S0955-3886(00)00109-0","url":null,"abstract":"<div><p>In recent years many new genes and proteins were identified with crucial functions in iron metabolism. This gave an explosion of our knowledge and understanding of iron related disorders. Mutations have been found that are responsible for disturbances in iron transport, leading to either iron overload or iron deficiency. For experts in the field, these new findings clarify the sky and open new routes for exploring hitherto hidden fields of research. For the physician, however, iron metabolism may become even more complicated. In this review, we have tried to assemble all new iron related genes into the context of pathophysiology. Important results from animal experiments, mainly derived from knockout mouse models, are included in this review as they often explain the phenotype of human disease.</p></div>","PeriodicalId":80242,"journal":{"name":"Transfusion science","volume":"23 3","pages":"Pages 225-235"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0955-3886(00)00109-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21923993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free radical formation and oxyhemoglobin oxidation in β-thalassemic red blood cells in the presence of prooxidants: effects of the free radical scavenger rutin and oral chelator L1","authors":"Igor B Afanas'ev ,&nbsp;Ilya I Afanas'ev ,&nbsp;Irina B Deeva ,&nbsp;Ludmila G Korkina","doi":"10.1016/S0955-3886(00)00091-6","DOIUrl":"10.1016/S0955-3886(00)00091-6","url":null,"abstract":"","PeriodicalId":80242,"journal":{"name":"Transfusion science","volume":"23 3","pages":"Pages 237-238"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0955-3886(00)00091-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21923994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single automated donor plateletpheresis increases the plasma level of proinflammatory cytokine tumor necrosis factor-α which does not associate with endothelial release markers von Willebrand factor and fibronectin","authors":"İhsan Karadoğan,&nbsp;Mustafa Özdoğan,&nbsp;Levent Ündar","doi":"10.1016/S0955-3886(00)00084-9","DOIUrl":"10.1016/S0955-3886(00)00084-9","url":null,"abstract":"<div><p>The effect of plateletpheresis on endothelium, which has strong effects on blood coagulation, fibrinolysis and platelet function, is not known. Activation of leukocytes and subsequent generation of proinflammatory cytokines during the extracorporeal circulation may activate the endothelium. To test this hypothesis we measured plasma levels of tumor necrosis factor (TNF)-α as a prototype of the proinflammatory cytokines, and von Willebrand factor (vWF) and fibronectin as endothelial release/damage markers before and after a single plateletpheresis procedure on an intermittent-flow machine Haemonetics MCS 3p in 17 healthy donors. We found a significant increase in median plasma level of TNF-α following plateletpheresis (3.5 vs 26.5 pg/ml, <em>P</em>=0.02). Such increases in vWF and fibronectin were not observed. The increase in plasma TNF-α indicates that a single plateletpheresis procedure causes leukocyte activation which does not seemingly impair endothelial cell function. The relation of plateletpheresis-induced proinflammatory cytokine release to some adverse effects observed in both donors and recipients, and the effect of repeated plateletpheresis on endothelium deserve further studies.</p></div>","PeriodicalId":80242,"journal":{"name":"Transfusion science","volume":"23 3","pages":"Pages 171-175"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0955-3886(00)00084-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patent report","authors":"","doi":"10.1016/S0955-3886(00)00068-0","DOIUrl":"https://doi.org/10.1016/S0955-3886(00)00068-0","url":null,"abstract":"","PeriodicalId":80242,"journal":{"name":"Transfusion science","volume":"23 3","pages":"Pages II-VIII"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0955-3886(00)00068-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134651111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-transfusion thrombocytopenia in recipients with anti-HLA antibody","authors":"Hitoshi Ohto ,&nbsp;Hiroyasu Yasuda ,&nbsp;Hiroo Maeda ,&nbsp;Shoichi Inaba","doi":"10.1016/S0955-3886(00)00108-9","DOIUrl":"10.1016/S0955-3886(00)00108-9","url":null,"abstract":"<div><p>Allogeneic red cell transfusion produced a significant decrease in the platelet counts of recipients who possessed anti-HLA antibodies.</p></div>","PeriodicalId":80242,"journal":{"name":"Transfusion science","volume":"23 3","pages":"Pages 271-273"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0955-3886(00)00108-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21923847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of non-transferrin bound iron in disorders of iron metabolism","authors":"W Breuer ,&nbsp;C Hershko ,&nbsp;Z.I Cabantchik","doi":"10.1016/S0955-3886(00)00087-4","DOIUrl":"10.1016/S0955-3886(00)00087-4","url":null,"abstract":"<div><p>The concept of non-transferrin bound iron (NTBI) was introduced 22 years ago by Hershko et al. (Brit. J. Haematol. 40 (1978) 255). It stemmed from a suspicion that, in iron overloaded patients, the large amounts of excess iron released into the circulation are likely to exceed the serum transferrin (Tf) iron-binding capacity (TIBC), leading to the appearance of various forms of iron not bound to Tf. In accordance with this assumption, NTBI was initially looked for and detected in patients with ⩾100% Tf-saturation. As techniques for its detection became more sophisticated and sensitive, NTBI was also found in conditions where Tf was not fully saturated, leading to a revision of the original view of NTBI as a simple spillover phenomenon. In this review, we will discuss some of the properties of NTBI, methods for its detection, its significance and potential value as an indicator for therapeutic regimens of iron chelation and supplementation.</p></div>","PeriodicalId":80242,"journal":{"name":"Transfusion science","volume":"23 3","pages":"Pages 185-192"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0955-3886(00)00087-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21923989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L1 effects on reactive oxygen (ROS) and nitrogen species (RNS) release, hemoglobin oxidation, low molecular weight antioxidants, and antioxidant enzyme activities in red and white blood cells of thalassemic patients","authors":"L Korkina ,&nbsp;C De Luca ,&nbsp;I Deeva ,&nbsp;S Perrotta ,&nbsp;B Nobili ,&nbsp;S Passi ,&nbsp;P Puddu","doi":"10.1016/S0955-3886(00)00099-0","DOIUrl":"10.1016/S0955-3886(00)00099-0","url":null,"abstract":"","PeriodicalId":80242,"journal":{"name":"Transfusion science","volume":"23 3","pages":"Pages 253-254"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0955-3886(00)00099-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21924002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using SQUID biomagnetic liver susceptometry in the treatment of thalassemia and other iron loading diseases","authors":"P Nielsen ,&nbsp;R Engelhardt ,&nbsp;M Duerken ,&nbsp;G.E Janka ,&nbsp;R Fischer","doi":"10.1016/S0955-3886(00)00101-6","DOIUrl":"10.1016/S0955-3886(00)00101-6","url":null,"abstract":"","PeriodicalId":80242,"journal":{"name":"Transfusion science","volume":"23 3","pages":"Pages 257-258"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0955-3886(00)00101-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21924004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}