Medicolegal news最新文献

{"title":"Electrical Stimulation to Enhance Axon Regeneration After Peripheral Nerve Injuries in Animal Models and Humans.","authors":"Tessa Gordon","doi":"10.1007/s13311-015-0415-1","DOIUrl":"10.1007/s13311-015-0415-1","url":null,"abstract":"<p><p>Injured peripheral nerves regenerate their lost axons but functional recovery in humans is frequently disappointing. This is so particularly when injuries require regeneration over long distances and/or over long time periods. Fat replacement of chronically denervated muscles, a commonly accepted explanation, does not account for poor functional recovery. Rather, the basis for the poor nerve regeneration is the transient expression of growth-associated genes that accounts for declining regenerative capacity of neurons and the regenerative support of Schwann cells over time. Brief low-frequency electrical stimulation accelerates motor and sensory axon outgrowth across injury sites that, even after delayed surgical repair of injured nerves in animal models and patients, enhances nerve regeneration and target reinnervation. The stimulation elevates neuronal cyclic adenosine monophosphate and, in turn, the expression of neurotrophic factors and other growth-associated genes, including cytoskeletal proteins. Electrical stimulation of denervated muscles immediately after nerve transection and surgical repair also accelerates muscle reinnervation but, at this time, how the daily requirement of long-duration electrical pulses can be delivered to muscles remains a practical issue prior to translation to patients. Finally, the technique of inserting autologous nerve grafts that bridge between a donor nerve and an adjacent recipient denervated nerve stump significantly improves nerve regeneration after delayed nerve repair, the donor nerves sustaining the capacity of the denervated Schwann cells to support nerve regeneration. These reviewed methods to promote nerve regeneration and, in turn, to enhance functional recovery after nerve injury and surgical repair are sufficiently promising for early translation to the clinic. </p>","PeriodicalId":80081,"journal":{"name":"Medicolegal news","volume":"8 1","pages":"295-310"},"PeriodicalIF":5.7,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85307778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicolegal Meeting Registry","authors":"","doi":"10.1111/j.1748-720X.1980.tb00623.x","DOIUrl":"https://doi.org/10.1111/j.1748-720X.1980.tb00623.x","url":null,"abstract":"","PeriodicalId":80081,"journal":{"name":"Medicolegal news","volume":"8 1","pages":"14 - 14"},"PeriodicalIF":0.0,"publicationDate":"1980-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1748-720X.1980.tb00623.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63268333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on Terminally Ill Patient Conference","authors":"C. W. Liebert","doi":"10.1111/J.1748-720X.1980.TB00617.X","DOIUrl":"https://doi.org/10.1111/J.1748-720X.1980.TB00617.X","url":null,"abstract":"","PeriodicalId":80081,"journal":{"name":"Medicolegal news","volume":"8 1","pages":"18 - 19"},"PeriodicalIF":0.0,"publicationDate":"1980-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/J.1748-720X.1980.TB00617.X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63268203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Book Reviews: The Politics of Regulation, The Great Billion Dollar Medical Swindle, American Law of Medical Malpractice, Hidden Victims: The Sexual Abuse of Children","authors":"G. Annas, M. Kapp, D. Provost","doi":"10.1111/j.1748-720x.1980.tb00609.x","DOIUrl":"https://doi.org/10.1111/j.1748-720x.1980.tb00609.x","url":null,"abstract":"","PeriodicalId":80081,"journal":{"name":"Medicolegal news","volume":"8 1","pages":"22 - 26"},"PeriodicalIF":0.0,"publicationDate":"1980-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1748-720x.1980.tb00609.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63267993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Book Reviews: The Cradle Will Fall, The Verdict, Cases and Materials on Pharmacy Law, The Lunar Effect: Biological Tides and Human Emotions, Child Psychiatry and the Law, Patients: The Experience of Illness","authors":"G. Annas, W. Wilbanks, A. E. Doudera","doi":"10.1111/j.1748-720X.1980.tb00592.x","DOIUrl":"https://doi.org/10.1111/j.1748-720X.1980.tb00592.x","url":null,"abstract":"The primary reason most professionals get involved in the health law field is because the subject matter is intrinsically fascinating. The general practice of law or medicine can easily become routinized and boring; but health law issues are in a constant state of flux, and the controversies involve issues that are vital both to the individuals involved, and to society as a whole. Therefore, it should come as no surprise that in an era that is witnessing the breakdown of the barrier between fiction and non-fiction, more and more novels use health law issues for their major themes. The two works under review both fall into this category.","PeriodicalId":80081,"journal":{"name":"Medicolegal news","volume":"8 1","pages":"16 - 29"},"PeriodicalIF":0.0,"publicationDate":"1980-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1748-720X.1980.tb00592.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63267677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicolegal Meeting Calendar","authors":"","doi":"10.1111/j.1748-720X.1980.tb00597.x","DOIUrl":"https://doi.org/10.1111/j.1748-720X.1980.tb00597.x","url":null,"abstract":"","PeriodicalId":80081,"journal":{"name":"Medicolegal news","volume":"8 1","pages":"33 - 33"},"PeriodicalIF":0.0,"publicationDate":"1980-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1748-720X.1980.tb00597.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63267745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Book Reviews: Heartsounds, before the Best Interests of the Child, Physicians' Licensure and Discipline, Rounds","authors":"G. Annas, Jonathan Brant","doi":"10.1111/j.1748-720x.1980.tb00574.x","DOIUrl":"https://doi.org/10.1111/j.1748-720x.1980.tb00574.x","url":null,"abstract":"There is a new literary genre: the survivor describing the last years of the life of a desperately ill spouse and his or her interactions with the medical care system. Previous members of this genre reviewed here includeJean’s Way andA Private Battle. Both of those books dealt with death by cancer; this one, like the movieAl1 That Jazz, takes us into the realm of heart disease. The story is gripping and exceptionally told by a loving wife who is a professional journalist. It is her story and that of her husband, Dr. Harold Lear. Lear suffers a heart attack","PeriodicalId":80081,"journal":{"name":"Medicolegal news","volume":"8 1","pages":"14 - 20"},"PeriodicalIF":0.0,"publicationDate":"1980-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1748-720x.1980.tb00574.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63267706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Book Reviews: Aborting America, Violent Death in the City: Suicide, Accident, and Murder in Nineteenth-Century Philadelphia","authors":"G. Annas, K. Scharf, W. Wilbanks","doi":"10.1111/j.1748-720X.1980.tb00561.x","DOIUrl":"https://doi.org/10.1111/j.1748-720X.1980.tb00561.x","url":null,"abstract":"ABOF~TINC AMERICA. By Bernard N. Nathanson, M.D., with Richard N. Ostling. (Doubleday and Company, Garden City, N.Y.) (1979) 303 pp., $10.00. Prochoice activists were outraged in 1974 when New York obstetrician Bernard Nathanson published an article in the NEW ENGLAND JOURNAL OF MEDICINE substantially recanting the prochoice stance which led him to be a founder of the National Association for Repeal of Abortion Laws in 1969, and director of a large New York abortion clinic in 1971 and 1972. Now Nathanson has written a b w k which leads off with more autobiographical material than we want and follows with an account of the early years of the New York prochoice movement which is an arrogant and self-indulgent exercise in gratuitous hostility, ultimately raising more questions about Nathanson’s own psyche than about the moral and historical meaning of the movement he describes. After an embarrassingly narcissistic account of his grandparents, his education, and the illegal abortion of his college lover, Nathanson writes a n m tive familiar to students of the prochoice Literature from Margaret Sanger on: the rime of the ancient medical student, medical resident, or nurse struggling heroically against the hypocrisy and septicemia of the pre-Roe v. Wade era. Nathanson began his practice in a time when wealthy women bought the collusion of physicians and hospital abortion committees and poor women sought illegal abortionists or self-aborted, sometimes with serious or fatal effects. He became disgusted with the system at a time when a group of New York liberals led by Lawrence Lader needed a respectable obstetrician to grace their rolls. From this point on Nathanson’s story becomes a curious psychological document. His descriptions of his allies are couched in terms of such distaste it is difficult to remember that Nathanson was a willing participant, travelling, speaking and writing energetically. Nathanson seems to have two problems with his political bedfellows: he is mortally offended by feminists of any stripe, and he doesn’t like anybody very much. His reaction to the lobbying style of his (ultimately crucial) feminist political allies in Albany in 1970 is characteristic: There were knots of wild-eyed, straggly-haired women chasing panicked legislators through the Capitol halls. One breathless solon dove into a broom closet just behind me, and just ahead of a hunting","PeriodicalId":80081,"journal":{"name":"Medicolegal news","volume":"8 1","pages":"14 - 15"},"PeriodicalIF":0.0,"publicationDate":"1980-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1748-720X.1980.tb00561.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63267475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doctors and the Death Penalty","authors":"G. Annas","doi":"10.1111/J.1748-720X.1980.TB00564.X","DOIUrl":"https://doi.org/10.1111/J.1748-720X.1980.TB00564.X","url":null,"abstract":"","PeriodicalId":80081,"journal":{"name":"Medicolegal news","volume":"8 1","pages":"17 - 17"},"PeriodicalIF":0.0,"publicationDate":"1980-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/J.1748-720X.1980.TB00564.X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63267531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forensic medicine: the medicolegal history.","authors":"E L Sagall","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":80081,"journal":{"name":"Medicolegal news","volume":"8 2","pages":"10-3"},"PeriodicalIF":0.0,"publicationDate":"1980-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21115659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}