{"title":"Prediction of Functional Outcomes at Discharge Using Plasma Concentration of von Willebrand Factor Antigen at Admission in Hospitalized Patients with COVID-19.","authors":"Masayuki Oki, Daisuke Yamasawa, Shinichi Goto, Hidetaka Yanagi, Saki Manabe, Takako Kobayashi, Ayumi Tsuda, Shota Sato, Seiji Morita, Yoshihide Nakagawa, Tsuyoshi Oguma, Koichiro Asano, Norio Yamamoto, Hideki Ozawa, Shinya Goto","doi":"10.3400/avd.oa.25-00153","DOIUrl":"10.3400/avd.oa.25-00153","url":null,"abstract":"<p><strong>Objectives: </strong>Coronavirus disease 2019 (COVID-19) causes endothelial injury through inflammatory and hypoxic stress, leading to vascular dysfunction and immunothrombosis. The plasma level of von Willebrand factor (VWF) could serve as a biomarker of vascular injury. While elevated VWF predicts mortality in severe COVID-19, its relationship with post-discharge functional outcomes remains unclear. This study aimed to determine whether plasma VWF antigen (VWF:Ag) levels at admission predict functional status at discharge in patients hospitalized for COVID-19.</p><p><strong>Methods: </strong>This was a single-center prospective cohort study conducted at Tokai University Hospital from July to September 2021. We evaluated the relationship between plasma VWF:Ag levels at admission and a Clinical Frailty Scale (CFS) score ≥4 at discharge using univariable and multivariable logistic regression analyses.</p><p><strong>Results: </strong>A total of 97 patients were enrolled in the study. The median VWF:Ag level at admission was 330.0% (95% confidence interval [CI]: 273.0-391.8). Univariable analysis showed a significant association between elevated VWF:Ag levels and CFS score ≥4 at discharge. This association remained significant after adjusting for age and sex (odds ratio 1.010, 95% CI: 1.000-1.010, p = 0.005).</p><p><strong>Conclusion: </strong>Elevated VWF:Ag levels at admission predict poor functional outcomes at discharge in COVID-19 patients, independent of age and sex.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12885762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146155872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative Analysis of Adhesive Strength and Flexibility in Surgical Sealants for Cardiovascular Surgery.","authors":"Akiyoshi Yamamoto, Shinichiro Shimura, Kenji Kuwaki, Hidekazu Furuya, Sohsyu Kotani, Kimiaki Okada, Keisuke Ozawa, Goro Kishinami, Shigeyuki Ozaki, Yasunori Cho","doi":"10.3400/avd.oa.25-00100","DOIUrl":"10.3400/avd.oa.25-00100","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this study was to compare the adhesive strength and flexibility of 3 surgical sealants-synthetic (Hydrofit; Sanyo Chemical Industries, Kyoto, Japan), albumin-based (BioGlue; Artivion, Kennesaw, GA, USA), and fibrin-based (Beriplast; CSL Behring, Tokyo, Japan)-which are commonly used in cardiovascular surgery but unexplored under identical experimental conditions.</p><p><strong>Methods: </strong>Adhesive strength was evaluated using a tensile adhesion test on collagen, polyester, and polytetrafluoroethylene substrates. Flexibility was assessed by measuring the maximum stress and elongation at failure in Hydrofit and BioGlue film samples. Beriplast was excluded as it failed to form films.</p><p><strong>Results: </strong>Hydrofit and BioGlue showed similar collagen-collagen adhesion strengths (p = 0.11), while Beriplast was significantly weaker (p <0.01). Hydrofit outperformed both BioGlue and Beriplast (p <0.01) in collagen-polyester and collagen-expanded polytetrafluoroethylene (ePTFE) adhesions. Hydrofit also demonstrated a significantly higher elongation rate, strength, and maximum stress before rupture than BioGlue.</p><p><strong>Conclusions: </strong>These surgical sealants possess distinct adhesive and mechanical characteristics. Hydrofit showed stable adhesion across various substrates, with notable flexibility. BioGlue displayed adequate adhesion on collagen surfaces but had restricted flexibility. Beriplast demonstrated reduced adhesion. Although only adhesive strength and flexibility were evaluated, such properties may offer valuable insights into sealant traits contextually. These potentially aid in the selection of appropriate sealants for cardiovascular procedures that require both durable adhesion and tissue compliance. Further <i>in vivo</i> validation is warranted.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12795642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Keishi Miyazawa, Eriya Imai, Yasunori Iida, Tomomi Ueda, Tomoyuki Sato
{"title":"Intraoperative Cardiac Arrest during Zone 0 Thoracic Endovascular Aortic Repair in a Post-Coronary Artery Bypass Grafting Patient with Bilateral Internal Thoracic Artery Grafts.","authors":"Keishi Miyazawa, Eriya Imai, Yasunori Iida, Tomomi Ueda, Tomoyuki Sato","doi":"10.3400/avd.cr.26-00067","DOIUrl":"10.3400/avd.cr.26-00067","url":null,"abstract":"<p><p>An 85-year-old man, with a history of coronary artery bypass grafting (CABG) using bilateral internal thoracic artery (ITA) grafts, underwent zone 0 thoracic endovascular aortic repair (TEVAR) for an aortic arch aneurysm. The procedure involved axillary debranching and the combined use of conventional and fenestrated stent grafts. During deployment of the fenestrated graft, ventricular fibrillation occurred, temporally associated with a transient reduction in brachiocephalic artery blood flow that compromised ITA graft flow. He was discharged without neurological deficits. This case highlights the potentially critical risk of myocardial ischemia during zone 0 TEVAR in post-CABG patients, emphasizing the need for meticulous multidisciplinary planning.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Complete Modular Disconnection between AFX2 and VELA Leading to a Type IIIa Endoleak Two Years after Endovascular Aneurysm Repair.","authors":"Kotaro Mukasa, Yasunori Yakita, Ryosuke Marushima, Musashi Tsuda, Shinichiro Abe, Soichi Asano","doi":"10.3400/avd.cr.25-00129","DOIUrl":"10.3400/avd.cr.25-00129","url":null,"abstract":"<p><p>The AFX endograft (Endologix, Irvine, CA, USA) is known to have a high incidence of late type III endoleaks. We report a 76-year-old male who developed a type IIIa endoleak due to complete modular separation 2 years after endovascular aneurysm repair with an AFX2 main body and a VELA extension. Open surgical graft replacement was performed, and the postoperative course was uneventful. This case demonstrates that in the presence of a large aneurysm diameter or significant neck angulation, even Instructions for Use-compliant and recommended overlap may be insufficient. It suggests the necessity of securing greater overlap and implementing stricter follow-up.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thoracic Endovascular Aortic Repair.","authors":"Kiyomitsu Yasuhara","doi":"10.3400/avd.ra.26-00056","DOIUrl":"10.3400/avd.ra.26-00056","url":null,"abstract":"<p><p>Thoracic endovascular aortic repair has revolutionized the treatment of thoracic aortic diseases. It is now indicated not only for descending aortic aneurysms but also for acute and chronic type B dissections and blunt thoracic aortic injuries. In addition, the scope of treatment is expanding. The thoracic aortic stent graft has been on the market in Japan for 15 years with good results, and the number of operations continues to increase. However, although stent grafts are highly recommended in Japanese and international guidelines for many aortic diseases, re-intervention increases over time in all disease groups. Careful follow-up is important because of morphologic changes and new complications after treatment. (This is a translation of Jpn J Vasc Surg 2024; 33: 73-77.).</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13193956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148012706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Strategic Surgical Management of Idiopathic Iliac Vein Rupture: A Case Report Emphasizing Preoperative IVC Filter and Distal Venous Control.","authors":"Keita Miyaishi, Moriyasu Nakaema, Masahiro Toyama, Shogo Niizaki, Shotaro Higa, Kojiro Furukawa","doi":"10.3400/avd.cr.26-00011","DOIUrl":"https://doi.org/10.3400/avd.cr.26-00011","url":null,"abstract":"<p><p>Idiopathic iliac vein rupture (IIVR) is a rare, life-threatening condition. We report a successful case of a 66-year-old woman with hemorrhagic shock and disseminated intravascular coagulation managed with a strategic surgical approach. To prevent intraoperative pulmonary embolism from extensive deep vein thrombosis, a temporary inferior vena cava filter was placed. Distal venous control was achieved via a femoral vein clamp through a separate inguinal incision prior to pelvic exploration. Primary suture repair combined with thrombectomy successfully preserved venous outflow. This multistep strategy is effective for managing IIVR, ensuring hemodynamic stability and preventing fatal embolic complications.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13485485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preoperative Mural Thrombus Volume Ratio Predicts Aneurysm Enlargement in Type 2 Endoleak after Endovascular Aortic Repair.","authors":"Yuki Oga, Tomoaki Kudo, Yasuka Nakanishi, Mitsuru Yuzaki, Tomohiko Sakamoto, Yusuke Ki, Toru Kuratani","doi":"10.3400/avd.oa.26-00001","DOIUrl":"10.3400/avd.oa.26-00001","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to identify anatomical predictors of aneurysm enlargement in patients with lumbar artery (LA)-related type 2 endoleak (T2EL) after endovascular aortic repair (EVAR).</p><p><strong>Methods: </strong>This retrospective observational cohort study included 59 patients with infrarenal abdominal aortic aneurysms who developed T2EL caused exclusively by LAs after EVAR between January 2019 and July 2024. Computed tomography-based anatomical parameters, including mural thrombus volume ratio, calcified volume ratio, aneurysm diameter, and LA anatomy, were analyzed.</p><p><strong>Results: </strong>During a median follow-up of 33 months, aneurysm enlargement occurred in 9 patients (15.3%). Patients with aneurysm enlargement had a significantly lower mural thrombus volume ratio (<i>p</i> <0.001). Female sex (hazard ratio [HR], 0.23; 95% confidence interval [CI], 0.06-0.84; <i>p</i> = 0.026) and mural thrombus volume ratio (HR, 0.88 per 1% increase; 95% CI, 0.80-0.96; <i>p</i> = 0.003) were significantly associated with aneurysm enlargement, whereas LA anatomy was not. Receiver operating characteristic analysis identified an optimal cutoff value of 29.2% (area under the curve, 0.82).</p><p><strong>Conclusions: </strong>A low preoperative mural thrombus volume ratio was associated with aneurysm enlargement in patients with LA-related T2EL after EVAR. This parameter may serve as a practical imaging biomarker to support selective consideration of preemptive embolization.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13051297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recurrent Type A Aortic Dissection and New Entry after Endovascular Repair.","authors":"Akihito Matsushita, Takashi Hattori, Wahei Mihara","doi":"10.3400/avd.cr.26-00098","DOIUrl":"https://doi.org/10.3400/avd.cr.26-00098","url":null,"abstract":"<p><p>Thoracic endovascular aortic repair (TEVAR) for acute type B aortic dissection can be complicated by retrograde type A aortic dissection (RTAD) and stent graft-induced new entry (SINE). A 77-year-old man developed acute type A aortic dissection after TEVAR and subsequently experienced recurrent RTAD and 3 episodes of distal SINE despite multiple surgical and endovascular interventions, eventually dying of postoperative bleeding. This case highlights the potential for repeated RTAD and SINE in the same patient and underscores the importance of careful surgical planning and endovascular device selection in patients with fragile, tortuous dissected aortas.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13626744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Compression Therapy in Patients Aged 65 and Older with Late Stage II Secondary Lower Limb Lymphedema.","authors":"Midori Tsukagoshi, Jiro Maegawa","doi":"10.3400/avd.oa.26-00030","DOIUrl":"https://doi.org/10.3400/avd.oa.26-00030","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to clarify the relationship between selection of compression stockings and grip strength in older outpatients with secondary lower limb lymphedema following gynecologic cancer surgery.</p><p><strong>Methods: </strong>This retrospective observational study involved 71 outpatients aged ≥65 years with late-stage II (International Society of Lymphology) secondary lower limb lymphedema requiring compression therapy after gynecologic cancer surgery. We investigated the patient's profile, grip strength, and the status of compression therapy. Patients were divided into early-older (65-74 years; n = 41) and late-older (75-86 years; n = 30) groups, and outcomes were compared. Additionally, patients were divided by compression stocking types: a flat-knit stocking group (n = 51) and a circular-knit stocking group (n = 20).</p><p><strong>Results: </strong>All patients continued compression therapy during the observation period between September 2022 and April 2025. Grip strength was comparable between the early-older and late-older patient groups. However, the flat-knit stocking group had significantly greater grip strength (21.1 kg) than the circular-knit stocking group (19.1 kg) (<i>p</i> = 0.004).</p><p><strong>Conclusions: </strong>Even late-older patients could continue to use flat-knit stockings as long as their grip strength was maintained.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13478886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}