{"title":"Metagenomic Analysis of Gut Microbiota for Abdominal Aortic Aneurysm.","authors":"Eisaku Ito, Takao Ohki, Naoki Toya, Takuo Emoto, Tomoya Yamashita, Tomomi Sugiyama, Takuji Yamada, Hiroshi Mori, Atsushi Toyoda, Ken-Ichi Hirata","doi":"10.3400/avd.oa.24-00105","DOIUrl":"10.3400/avd.oa.24-00105","url":null,"abstract":"<p><p><b>Objectives:</b> The pathophysiological mechanism of abdominal aortic aneurysm (AAA) remains unclear. We previously reported that <i>Bifidobacterium adolescentis</i> levels were reduced in the feces of patients with AAA by 16S ribosomal ribonucleic acid (RNA) gene sequencing. In this study, we increased the number of cases and conducted metagenomic analyses to examine bacterial genes associated with the pathophysiology of AAA. <b>Methods:</b> For gut microbiota data, feces from 55 patients with AAA and 52 patients with no history of AAA, lower extremity artery disease, or coronary artery disease (control group) were collected. Metagenomic analysis was performed by collecting raw stool samples from patients. For intestinal microbiota analysis, metagenomic analysis of the fecal samples was performed. <b>Results:</b> Oral bacteria, including <i>Actinomyces oris</i> (<i>p</i> <0.0001), <i>Streptococcus salivarius</i> (<i>p</i> <0.001), <i>Lactobacillus salivarius</i> (<i>p</i> <0.001), and <i>Streptococcus</i> sp. (<i>p</i> <0.001), were increased in the feces of patients with AAA. In addition, bacterial genes related to alpha lipoic acid (ALA) biosynthesis (M00882, M00883, and M00884, <i>p</i> <0.0001) were decreased in patients with AAA. <b>Conclusions:</b> In the feces of patients with AAA, there was an increase in oral bacteria, and the expression of bacterial genes related to ALA biosynthesis was reduced. The results suggest the possibility of developing gut microbial drug treatments for AAA.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"18 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Surgical Outcomes of the Boat-Form Vein Cuff Technique in Peripheral Artery Bypass Grafting.","authors":"Shun-Ichiro Sakamoto, Anna Tsuji, Motohiro Maeda, Atsushi Hiromoto, Kenji Suzuki, Jiro Honda, Yosuke Ishii","doi":"10.3400/avd.oa.24-00134","DOIUrl":"10.3400/avd.oa.24-00134","url":null,"abstract":"<p><p><b>Objectives:</b> The venous cuff technique has been used primarily for arterial bypass using artificial grafts to the lower extremities. The boat-form vein cuff was designed to allow adjustment of the size and angle of the anastomosis at any anatomic site. We report our experience and outcomes of the original vein cuff technique in various peripheral artery bypass grafting procedures. <b>Methods:</b> A total of 10 patients underwent arterial bypass grafting using a polytetrafluoroethylene (PTFE) graft with a boat-form venous cuff. The indications for the surgery consisted of peripheral artery disease (n = 4), acute limb ischemia (n = 4), chronic mesenteric ischemia (n = 1), and traumatic upper limb ischemia (n = 1). Five patients required emergency surgery. Surgical outcomes, such as mortality and morbidity, limb salvage rate, and graft patency, were examined using perioperative and postoperative follow-up data. <b>Results:</b> There were no operative deaths or serious complications, including amputation of the lower extremity. During the follow-up period (44 ± 36.9 months), the PTFE graft remained patent in 9 patients (90%). In 1 patient, occlusion of the femoropopliteal bypass graft was observed 3 months after surgery. <b>Conclusions:</b> The simple design and creation of the boat-form vein cuff are useful at any anatomical site in peripheral artery bypass grafting with a PTFE graft.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"18 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12129623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"One-Stage Hybrid Surgery for Complicated Acute Type B Aortic Dissection Involving Distal Arch Aneurysm: A Case Report.","authors":"Kenji Kishita, Naoki Washiyama, Yuki Takeuchi, Masahiro Hirano, Ken Yamanaka, Yuko Ohashi, Kazumasa Tsuda, Kazuma Okamoto","doi":"10.3400/avd.cr.25-00039","DOIUrl":"10.3400/avd.cr.25-00039","url":null,"abstract":"<p><p>An 84-year-old woman with an acute type B aortic dissection (ATBAD), an entry tear in a distal arch aneurysm, and lower-body malperfusion underwent a hybrid approach combining total arch replacement with an elephant trunk (TAR+ET), thoracic endovascular aortic repair (TEVAR), and left renal artery stenting. This strategy avoided direct resection of the aneurysm or primary entry, yet stabilized hemodynamics and restored organ perfusion. Postoperative CT was favorable, and the patient was discharged without complications. In this elderly case of complicated ATBAD involving a distal aortic arch aneurysm, we performed TAR+ET, TEVAR, and renal artery stenting, and achieved a favorable outcome.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"18 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Successful Hybrid Endovascular and Open Approach for Exclusion of a Left Subclavian Artery Aneurysm.","authors":"Kotaro Mukasa, Yasunori Yakita, Ryosuke Marushima, Shinichiro Abe, Soichi Asano","doi":"10.3400/avd.cr.24-00139","DOIUrl":"10.3400/avd.cr.24-00139","url":null,"abstract":"<p><p>Subclavian artery aneurysms are rare and challenging to treat owing to their anatomical location and proximity to critical branches, including the vertebral artery. We report the case of a 78-year-old man with a left subclavian artery aneurysm. The aneurysm was located in the mediastinum and measured 31 mm in diameter. The proximal side of the aneurysm was sealed with a stent graft, while the distal side was accessed through a supraclavicular incision and directly ligated. Postoperative imaging confirmed complete exclusion. This hybrid approach avoided invasive open surgery and provided a favorable outcome.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"18 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Supplement of Clinical Practice Guidelines for Endovenous Thermal Ablation for Varicose Veins 2019: Laser Ablation of Varicose Tributaries.","authors":"Masayuki Hirokawa, Junichi Utoh, Satoru Sugiyama, Osamu Suzuki, Takashi Yamamoto, Tomohiro Ogawa, Makoto Mo","doi":"10.3400/avd.gl.25-00053","DOIUrl":"10.3400/avd.gl.25-00053","url":null,"abstract":"<p><p>In the treatment of saphenous varicose veins with endovenous laser ablation, simultaneous treatment of varicose tributaries using stab avulsion or sclerotherapy is commonly performed. To address the limitations of these conventional treatments, laser ablation for varicose tributaries has recently gained widespread acceptance. This guideline, developed by the Japanese Society of Phlebology, outlines appropriate treatment protocols for laser ablation of varicose tributaries. Indications include primary varicose veins requiring concurrent treatment of the saphenous trunk and varicose tributaries. The procedure utilizes slim radial fibers, with puncture and ablation performed using either short- or long-axis approaches. Although rare, adverse events such as skin burns, nerve injury, and fiber breakage have been reported. A learning curve is necessary to ensure the safe execution of the procedure. Further clinical studies are essential to enhance the safety and efficacy of laser ablation for varicose tributaries. (This is a secondary publication from Jpn J Phlebol 2025; 36: 51-58.).</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"18 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12148710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Two-Stage Hybrid Treatment of Residual Inferior Pancreaticoduodenal Artery Aneurysm Following Treatment of Ruptured Superior Pancreaticoduodenal Artery Aneurysm: A Case Report.","authors":"Hodaka Wakisaka, Taiki Kakiuchi, Kohei Hachiro, Noriyuki Takashima, Tetsuya Katsumori, Tomoaki Suzuki","doi":"10.3400/avd.cr.25-00018","DOIUrl":"10.3400/avd.cr.25-00018","url":null,"abstract":"<p><p>Herein, we describe the case of a 72-year-old man who presented with a residual inferior pancreaticoduodenal artery aneurysm following the rupture and treatment of a superior pancreaticoduodenal artery aneurysm. Open surgery for pancreaticoduodenal artery aneurysms requires carefully planned vascular reconstruction to prevent organ ischemia and minimize pressure changes caused by fluctuations in mechanical stress. Additionally, in cases of rupture, factors such as the patient's condition, presence of hematoma and adhesions, and pressure changes resulting from prior transarterial embolization must be considered. This case report outlines the surgical strategy employed for managing the residual inferior pancreaticoduodenal artery aneurysm.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"18 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of Gut Microbes in Hypertension: A Systematic Review of Literature.","authors":"Swapnil S Garde, Somesh Garde","doi":"10.3400/avd.ra.24-00121","DOIUrl":"10.3400/avd.ra.24-00121","url":null,"abstract":"<p><strong>Objectives: </strong>Hypertension is a metabolic disorder affecting a significant proportion of the global population. Growing evidence suggests the contribution of gut microbiota to blood pressure homeostasis and the effectiveness of antihypertensive interventions. This systematic review evaluates the role of gut microbiota in hypertension and identifies microbial taxa contributing to or alleviating the condition.</p><p><strong>Methods: </strong>A systematic search was conducted in PubMed and Cochrane databases for non-randomized studies, randomized controlled trials, and registry studies published in English. Studies were classified according to microbial taxa involved in the improvement or worsening of hypertension.</p><p><strong>Results: </strong>According to the inclusion criteria, 19 studies were included. Some bacterial genera, such as <i>Lactobacillus paracasei</i>, <i>Akkermansia</i>, and <i>Veillonella</i>, had potential protective effects against hypertension by regulating blood pressure through dietary interactions and microbial metabolites. On the other hand, <i>Klebsiella</i> sp., <i>Streptococcus</i> sp., and <i>Parabacteroides merdae</i> were more abundant in hypertensive patients and were involved in dysbiosis and inflammation. The fungal taxa <i>Malassezia</i> and <i>Mortierella</i> were also involved in the pathogenesis of hypertension.</p><p><strong>Conclusions: </strong>Gut microbiota composition may play crucial roles in hypertension, with certain taxa potentially contributing to or alleviating the condition. Modulating gut microbes through probiotics and diet may offer new therapeutic approaches.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"18 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12592320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145480705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of Dementia on the Outcome of Surgical Revascularization for Chronic Limb-Threatening Ischemia.","authors":"Atsushi Guntani, Shinsuke Mii, Kimihiro Komori","doi":"10.3400/avd.oa.25-00040","DOIUrl":"10.3400/avd.oa.25-00040","url":null,"abstract":"<p><p><b>Objectives:</b> Dementia and chronic limb-threatening ischemia (CLTI) are independent risk factors for a poor life prognosis. We investigated the long-term results of surgical revascularization for CLTI complicated by dementia. <b>Methods:</b> The clinical records of 174 consecutive patients with CLTI and 205 revascularized limbs were prospectively collected from a database. According to the criteria for dementia, the patients were divided into a low-grade dementia group (L group, n = 152) and a high-grade dementia group (H group, n = 22), and the long-term results after surgery were retrospectively analyzed. <b>Results:</b> The 2-year amputation-free survival (AFS) after surgery was significantly lower in the H group than in the L group (L group, 82.3%; H group, 39.3%; p <0.001). However, no marked differences were observed between the dementia groups regarding the freedom from major adverse limb event (MALE) (L group, 86.6%; H group, 83.1%; p = 0.103), freedom from major adverse cardiovascular event (MACE) (L group, 75.6%; H group, 71.3%; p = 0.685), and limb salvage (L group, 75.6%; H, group 71.3%; p = 0.685) after surgery. <b>Conclusions:</b> Dementia may be a predictor of a poor prognosis after surgery for CLTI. However, surgical revascularization may lead to limb salvage without serious postoperative complications. Therefore, surgical revascularization may be a useful treatment option if the patient or family requires such treatment.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"18 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"True Digital Artery Aneurysm: A Case Report.","authors":"Hiroki Nakabori, Hideyasu Ueda, Kenji Iino","doi":"10.3400/avd.cr.25-00096","DOIUrl":"10.3400/avd.cr.25-00096","url":null,"abstract":"<p><p>True aneurysms of the digital artery are extremely rare, and only several dozen cases have been reported worldwide. A 29-year-old man presented with a pulsatile, tender nodule in his left index finger. Angiography revealed a 7-mm saccular aneurysm of the proper palmar digital artery with well-developed distal collaterals. Under local anesthesia, the aneurysm was excised following proximal and distal ligation. It was histopathologically confirmed as a true aneurysm. Postoperatively, symptoms resolved without ischemic or neurological complications and without recurrence after 1 year. Thus, simple ligation and excision are effective when collateral circulation is sufficient.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"18 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12626734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145556181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endovascular Therapy as an Emerging Paradigm for the Treatment of Popliteal Artery Thrombosis Following Total Knee Arthroplasty: A New Approach to Acute Limb Ischemia Management.","authors":"Tammiraju Iragavarapu, Gurrala Kartheek Krishna, Subhendra Nath Sobhanadri, Aditya Kota, V Venkata Sushma","doi":"10.3400/avd.oa.24-00068","DOIUrl":"10.3400/avd.oa.24-00068","url":null,"abstract":"<p><p><b>Objectives:</b> The objective of this research was to examine the occurrence, clinical features, treatment approaches, and results associated with a rare complication of thrombosis of the popliteal artery after total knee arthroplasty (TKA), leading to acute limb ischemia (ALI). <b>Methods:</b> A retrospective study on 1020 TKA procedures spanning 5 years. Cases of ALI were identified through clinical evaluation and arterial Doppler studies. Peripheral angioplasty was done to recanalize the popliteal artery. Manifestations, complications, and management strategies were evaluated. <b>Results:</b> Among the 1020 TKA cases, 5 cases of ALI were identified which accounts for 0.49% of all TKA cases. Female predominance and left-sided presentations are notable observations. Most patients presented within 8 hours of symptom onset with diverse complications ranging from foot drop to compartment syndrome. Except for 1 case, all patients recovered with thrombosuction and balloon dilatation. <b>Conclusions:</b> A rare but potentially fatal complication of TKA is popliteal artery thrombosis leading to ALI so it becomes important for early recognition and intervention to mitigate the adverse outcomes. In our study, endovascular treatment has emerged as the preferred modality in terms of effective management and reducing complications and morbidity from surgical procedures.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"18 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}