P. Kosev, Cvetan Sokolov, Y. Andonov, B. Valentinov
{"title":"Minimally invasive total knee arthroplasty.","authors":"P. Kosev, Cvetan Sokolov, Y. Andonov, B. Valentinov","doi":"10.5272/JIMAB.2015211.732","DOIUrl":"https://doi.org/10.5272/JIMAB.2015211.732","url":null,"abstract":"We present our experience with the MIS TKA through a mid-vastus approach. The indications and contraindications of the technique are discussed. Our series include 104 patients. The Knee Society Score is used to rate the results. The average KSS score on 6-th month is 89 points. Eleven patients had skin necrosis. Eight had transient stiffness. One developed late infection. The MIS-TKA is recommended for selected patients and must be performed by an experienced surgeon and prepared team.","PeriodicalId":79832,"journal":{"name":"Clinical privilege white paper","volume":"44 1","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2015-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84767512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Surgical first assistant.","authors":"S. Hall","doi":"10.1002/9781119548935.ch56","DOIUrl":"https://doi.org/10.1002/9781119548935.ch56","url":null,"abstract":"","PeriodicalId":79832,"journal":{"name":"Clinical privilege white paper","volume":"23 1","pages":"1-21"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78174013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Infectious disease.","authors":"R. A. KtJNKLE, J. A. Riciit","doi":"10.1097/00000446-199708000-00003","DOIUrl":"https://doi.org/10.1097/00000446-199708000-00003","url":null,"abstract":"Serapie is a naturally occurring fatal neurodegencrative disease of sheep and goats. Susceptibility to the disease is partly dependent upon the genetic makeup of the host. In a recent study. it was shown that sheep intracercbrally inoculated with a US scrapie agent (No. 13-7) developed scrapie and survived for an average of 19 months post inoculation. In the present study, when this serapie inoculum was further passaged for 3 successive generations, the survival time was reduced by approximately 8 months in scrapie-susceptible (QQ on prion protein gene [PRNP] at codon 171) Suffolk sheep. It is concluded that inoculum No. 13-7 appears to have been stabilized in susceptible (171 QQ) Suffolk sheep and may be considered a specific isolate of sheep serapic agent in the USA and therefore that it can he used to evaluate other isolates of sheep scrapie in this country. Key n'ords: I rnmunohistochemistry PrP genetic susceptibility, sheep scrapic strains transmissible spongilorm encephalopathies (TSEs): Western blot. Scrapie is a naturally occurring fatal neurodegenerative disease of sheep and goats. The susceptibility of' sheep to scrapie is dependent on genetic variation of the host prion protein (PRNP) gene) 410 PRNP genotypes are defined by variations in the amino acids located at codons 136, 154, and 171. At least 5 variant alleles have been found, and they are depicted as ARQ, ARR, VRQ, AHQ, and ARH. The codes represent amino acids at codons 136, 154. and 171, that is, A-136, R-154. and Q-171 (ARQ). where A = alanine, R = arginine. Q = glutamine. H = histidine. and V valine. The level of risk to contract scrapie varies depending on breed and the genotypes found within the fioek ARR are the most resistant, and VRQ are the most Susceptible. 1-4. A study of Suffolk sheep in the United States found 61 of orally inoculated animals developed scrapie. ' All were homozygous for glutanline (QQ) at allele 171 on PRNP gene* In a recent study. it was shown that sheep intracerebrally inoculated with US scrapie agent (inoculum No. 13-7) developed disease within an average of 19 months post inoculation (MPI)) This inoculurn was made with brain tissue of 13 sheep from 7 different source flocks)' This study documents incubation times, pathologic findings, and distribution of abnormal prion Present address: Department of Diagnostic Medicine and Pathobiology. Kansas State University, Manhattan. KS. protein (p1.pSe) by immunohistochemical (IHC) and Western blot (WB) techniques in tissues of genetically susceptible Suffolk sheep (QQ or QH at codon 171 of PRNP gene) that were intracerebrally inoculated with 3 consecutive passages of inoculum No. 13-7 (Table I). The objectives of the study were to reduce the incubation (post inoculation) time of the scrapie inoculum and to stabilize the inoculum so that it can be used to evaluate other isolates of sheep scrapie in this country. Materials and Methods A total of 18 Suffolk lambs (females and castrated males) from National An","PeriodicalId":79832,"journal":{"name":"Clinical privilege white paper","volume":"19 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85900651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Physician assistants in the emergency department.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79832,"journal":{"name":"Clinical privilege white paper","volume":" 409","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33232464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Allergy and immunology.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79832,"journal":{"name":"Clinical privilege white paper","volume":" 124","pages":"1-16"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33232461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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