Annals of Movement Disorders最新文献_第8页

Infection-associated dystonia: A narrative review 感染相关性肌张力障碍:叙述性回顾

Annals of Movement Disorders Pub Date : 2021-09-01 DOI: 10.4103/AOMD.AOMD_13_21

R. Yadav, V. Shankar, S. Desai

{"title":"Infection-associated dystonia: A narrative review","authors":"R. Yadav, V. Shankar, S. Desai","doi":"10.4103/AOMD.AOMD_13_21","DOIUrl":"https://doi.org/10.4103/AOMD.AOMD_13_21","url":null,"abstract":"Infectious diseases are common in tropical countries, and varied complications associated with such diseases are frequently encountered. Movement disorders are a complication of infectious diseases, and the spectrum of movement disorders differs between tropical countries and other countries. We screened three electronic databases for cases of dystonia presenting as a manifestation of infections diseases and selected cases and series describing chorea associated with infections. The studies were identified and data regarding the study design, sample size, neurological assessment, and diagnostic workup, including brain imaging and cerebrospinal fluid analysis were extracted. After a detailed review of 139 selected articles, 39 articles were referred to in the final manuscript of this narrative review. Dystonia is most commonly associated with Japanese encephalitis than other central nervous system infections. The hypothesized mechanisms of infection-related dystonia are vasculopathy, space-occupying lesions, autoimmune reactions, inflammation, or via anti-dopaminergic drug therapy. The infections presenting with dystonia include tuberculosis, Japanese encephalitis, streptococcal infections, varicella-zoster virus, subacute sclerosing panencephalitis, dengue, and neurocysticercosis. In this narrative review, we discuss the different types of central nervous system infections that present with dystonia.","PeriodicalId":7973,"journal":{"name":"Annals of Movement Disorders","volume":"4 1","pages":"111 - 120"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45850690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional movement disorders during the COVID-19 pandemic 新冠肺炎大流行期间的功能性运动障碍

Annals of Movement Disorders Pub Date : 2021-09-01 DOI: 10.4103/AOMD.AOMD_26_21

S. Kamath, N. Kamble, Sindhu D M, K. Sakhardande, C. Basavarajappa, P. Pal

引用次数: 0

Huntington’s disease presenting as adult-onset tourettism: a case report 亨廷顿舞蹈症表现为成人抽动秽语：一例报告

Annals of Movement Disorders Pub Date : 2021-09-01 DOI: 10.4103/AOMD.AOMD_1_21

Mitesh Chandarana, U. Saraf, K. Divya, Syam Krishnan

引用次数: 0

Spectrum of childhood dystonia evaluated at a tertiary care center from south India 印度南部一家三级护理中心评估的儿童肌张力障碍谱系

Annals of Movement Disorders Pub Date : 2021-09-01 DOI: 10.4103/AOMD.AOMD_8_21

Ganaraja V H, N. M, N. Kamble, V. Holla, Dwarakanath Srinivas, R. Yadav, P. Pal

{"title":"Spectrum of childhood dystonia evaluated at a tertiary care center from south India","authors":"Ganaraja V H, N. M, N. Kamble, V. Holla, Dwarakanath Srinivas, R. Yadav, P. Pal","doi":"10.4103/AOMD.AOMD_8_21","DOIUrl":"https://doi.org/10.4103/AOMD.AOMD_8_21","url":null,"abstract":"INTRODUCTION: Dystonia is one of the most common hyperkinetic movement disorders observed in children with neurological disorders. The objective of this study was to evaluate the demographic, etiological, and radiological profile of childhood dystonia. METHODS: This study is a retrospective chart review of children with dystonia (onset ≤18 years) who were admitted to our hospital from 2013 to 2017. All the relevant demographic data including the ethnicity, socioeconomic and cultural background, examination findings, electrophysiological, and other investigations were retrieved from the medical records. RESULTS: A total of 814 children were admitted and evaluated in the pediatric ward, of which 85 (38 girls) children had dystonia. Mean age at onset was 6.21 ± 5.21 years. Mean duration of illness was 3.51 ± 4.23 years. Generalized dystonia was noticed in 83.5% followed by focal dystonia in 8.2%. Hemidystonia and segmental dystonia were less commonly seen with 4.7% and 3.5% of cases, respectively. Brain magnetic resonance imaging (MRI) was available in 82 patients; and diagnostic in 56.1% in the form of Wilson’s disease (14.1%) neurodegeneration with brain iron accumulation (14.1%), perinatal insult (8.2%), encephalitis (7.1%), mitochondrial cytopathy (3.5%), glutaric aciduria (2.4%), isovaleric acidemia (1.2%), metachromatic leukodystrophy (1.2%), acute disseminated encephalomyelitis (1.2%), and neuronal ceroid lipofuscinosis (1.2%). Two patients underwent surgical therapy in the form of deep brain stimulation and bilateral pallidotomy. CONCLUSION: Dystonia constitutes 10.4% of pediatric neurological admissions in our study cohort. Generalized dystonia is the commonest subtype. Brain MRI is useful in identifying etiology and it was diagnostic in nearly half of the patients (56.1%).","PeriodicalId":7973,"journal":{"name":"Annals of Movement Disorders","volume":"4 1","pages":"136 - 142"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49584784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pattern reversal and flash visual evoked potentials in essential tremor 原发性震颤的模式反转和闪光视觉诱发电位

Annals of Movement Disorders Pub Date : 2021-09-01 DOI: 10.4103/AOMD.AOMD_59_20

�encan Buturak, H. Fi̇danci

{"title":"Pattern reversal and flash visual evoked potentials in essential tremor","authors":"�encan Buturak, H. Fi̇danci","doi":"10.4103/AOMD.AOMD_59_20","DOIUrl":"https://doi.org/10.4103/AOMD.AOMD_59_20","url":null,"abstract":"BACKGROUND: There is evidence that nonmotor clinical findings may occur in essential tremor (ET). The aim of the study was to determine whether there is a subclinical impairment of visual pathways in ET by conducting visual evoked potential (VEP) studies on patients with ET. METHODS: Healthy individuals and patients with ET were included in the study. Individuals with visual impairment, eye disease, neurodegenerative diseases, or migraine were not included in the study. Pattern reversal VEP (PrVEP) and flash VEP (FVEP) were applied to all individuals. N75, P100, and N135 waves were obtained by PrVEP, whereas N1, P2, N2, P2, N3, and P3 waves were obtained by FVEP. The latencies and amplitudes of these waves were analyzed. RESULTS: Thirty-five healthy individuals (12 male, 23 female) and 29 patients with ET (16 male, 13 female) were included in the study. The mean age of the patients in the control group and the patients with ET was 33.9 ± 8.5 and 35.9 ± 16.8 years, respectively. Age and gender were not statistically significantly different between the two groups. The mean right/left P100 wave latencies of the control group and ET group were 90.3 ± 7.3/91.5 ± 6.1 ms and 99.4 ± 9.1/101.1 ± 7.8 ms, respectively (P = 0.009/P < 0.001). The mean right/left P2 wave latencies of the control group and ET group were 104.9 ± 15.1/104.8 ± 13.8 ms and 117.6 ± 15.4/118.3 ± 15.6 ms, respectively (P = 0.001/P = 0.001). CONCLUSION: This study showed that subclinical involvement of visual pathways may occur in ET.","PeriodicalId":7973,"journal":{"name":"Annals of Movement Disorders","volume":"4 1","pages":"131 - 135"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43282703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PIGG gene mutation associated with Uner Tan syndrome: A first case report PIGG基因突变与Uner-Tan综合征相关性的第一例报告

Annals of Movement Disorders Pub Date : 2021-09-01 DOI: 10.4103/AOMD.AOMD_28_21

G. Wali, G. Wali, C. Sue

引用次数: 0

Autosomal recessive spastic ataxia of Charlevoix Saguenay (ARSACS) in three brothers of a family from Kerala 喀拉拉邦一家三兄弟的常染色体隐性沙格内痉挛性共济失调（ARSACS）

Annals of Movement Disorders Pub Date : 2021-09-01 DOI: 10.4103/AOMD.AOMD_60_20

S. Sheetal, Amith Sasikumar, L. Tomy

引用次数: 1

Neuroprotective strategies in Parkinson’s disease: A long road ahead 帕金森病的神经保护策略:前面的路很长

Annals of Movement Disorders Pub Date : 2021-09-01 DOI: 10.4103/AOMD.AOMD_38_21

D. Garg, S. Desai

{"title":"Neuroprotective strategies in Parkinson’s disease: A long road ahead","authors":"D. Garg, S. Desai","doi":"10.4103/AOMD.AOMD_38_21","DOIUrl":"https://doi.org/10.4103/AOMD.AOMD_38_21","url":null,"abstract":"Neuroprotection has been a fascinating area of research in Parkinson’s disease (PD). It offers the promise of disease modification, in turn, slowing the disease progression. A vast array of agents has been assessed for its neuroprotective properties. Although many of these agents have achieved varying degrees of efficacy in preclinical models of PD, definitive success has not been observed in clinical trials. The reasons underlying the lack of success lie within the intrinsic heterogeneity of PD. Instead of using a single agent for all patients in a “one-size-fits-all” approach, it is increasingly apparent that a specific study population with a well-defined predominant pathogenic mechanism should be selected for trials, assessing the role of each agent targeting a specific mechanism. Coenzyme Q10 may find use in an enriched cohort of PD patients with PARKIN mutations. The glucagon-like peptide 1 (GLP-1) analogue, exenatide, is currently being assessed in a phase III trial. Other GLP-1 agonists, such as liraglutide, lixisenatide, and semaglutide, are undergoing phase II trials. In addition, coffee has been shown to have a nonlinear relationship with PD risk. With increasing genetic and molecular understanding of PD, the dream of neuroprotection in PD may be realized in the near future. In this review, we summarize the current evidence on neuroprotection in PD.","PeriodicalId":7973,"journal":{"name":"Annals of Movement Disorders","volume":"4 1","pages":"99 - 110"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43860063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Burden of nonmotor symptoms in Parkinson’s disease patients from eastern India 印度东部帕金森病患者的非运动症状负担

Annals of Movement Disorders Pub Date : 2021-09-01 DOI: 10.4103/AOMD.AOMD_5_21

Sulagna Sahu, Adreesh Mukherjee, S. Biswas, V. Leta, K. Rukavina, Shyamal Das, A. Biswas

{"title":"Burden of nonmotor symptoms in Parkinson’s disease patients from eastern India","authors":"Sulagna Sahu, Adreesh Mukherjee, S. Biswas, V. Leta, K. Rukavina, Shyamal Das, A. Biswas","doi":"10.4103/AOMD.AOMD_5_21","DOIUrl":"https://doi.org/10.4103/AOMD.AOMD_5_21","url":null,"abstract":"BACKGROUND: Parkinson’s disease (PD) is classically characterized by motor features. However, nonmotor symptoms (NMSs) represent an important aspect of the disease with a significant impact on quality of life (QoL). OBJECTIVES: The aim of this study was to evaluate NMS in patients with PD, to determine their various correlates, and to assess the impact on QoL. METHODS: This cross-sectional study included 150 consecutive patients with PD and 150 age- and sex-matched healthy controls. NMSs were assessed using the NMS Questionnaire (NMSQuest) and NMS Scale (NMSS). QoL was evaluated by the 8-item Parkinson’s Disease Questionnaire scored as summary index (PDQ-8-SI). RESULTS: Every patient experienced NMS and 90% had more than five NMSs. Patients with PD had a significantly higher prevalence of NMS compared to healthy controls. The most common NMSs in patients with PD were unexplained pain, anxiety, constipation, insomnia, and memory impairment. Miscellaneous was the most prevalent domain of NMSS, followed by sleep/fatigue, gastrointestinal tract, and mood/cognition. Attention/memory impairment and pain were greater in females. Cardiovascular/falls and perceptual/hallucination showed a positive correlation with duration of disease. Sexual dysfunction decreased with increasing age. In the young-onset group (YOPD), mood/cognition involvement was higher. PDQ-8-SI showed a significant correlation with total NMSS score and most of the individual domain scores. Contrary to other Indian studies, our patients reported restless legs more frequently, whereas urinary symptoms were less common. Our observations showed a greater prevalence of pain and constipation compared to the Western studies. CONCLUSIONS: All of our patients experienced NMS. The prevalence of various NMS in our study showed differences with previous reports. NMS had a significant impact on QoL.","PeriodicalId":7973,"journal":{"name":"Annals of Movement Disorders","volume":"4 1","pages":"121 - 130"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46016001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Analysis of dysgraphia in advanced Parkinson’s disease patients following bilateral STN-DBS: a prospective study 双侧STN-DBS后晚期帕金森病患者书写障碍分析:一项前瞻性研究

Annals of Movement Disorders Pub Date : 2021-09-01 DOI: 10.4103/AOMD.AOMD_4_21

Swapnil Kolpakwar, R. Alugolu, Vijayasaradhi Mudumba, R. Kandadai, R. Borgohain

{"title":"Analysis of dysgraphia in advanced Parkinson’s disease patients following bilateral STN-DBS: a prospective study","authors":"Swapnil Kolpakwar, R. Alugolu, Vijayasaradhi Mudumba, R. Kandadai, R. Borgohain","doi":"10.4103/AOMD.AOMD_4_21","DOIUrl":"https://doi.org/10.4103/AOMD.AOMD_4_21","url":null,"abstract":"BACKGROUND: Parkinson’s disease (PD) is characterized by varying intensities of bradykinesia, rigidity, and tremor leading to disturbances in writing skills of the patient. We undertook this study to evaluate dysgraphia features in advanced PD cases and changes in these features after bilateral subthalamic nucleus deep brain stimulation (DBS). METHODS: All idiopathic PD cases who underwent DBS at our center were included in this study. Patients were assessed preoperatively for dysgraphia by analysis of handwriting in “off” phase by a single investigator on bedside testing. For quantification of micrographia, vertical length of first letter and width of the word written were calculated. An analysis of legibility of handwriting was also done for all patients using Fahn-Tolosa-Marin Tremor Rating Scale (FTMTRS). Patients were analyzed for dysgraphia at 6 months post-surgery in drug ‘off’ phase, and outcomes were correlated with baseline parameters. RESULTS: There were a total of 51 patients who were included in our study. Significant reduction was noted in postoperative Unified Parkinson’s Disease Rating Scale part III (UPDRS III) scores (P = 0.0001). Age more than 65 years was associated with less improvement in FTMTRS grades. Prevalence of micrographia reduced in the postoperative period, but the difference was not statistically significant. Median FTMTRS grade in preoperative and postoperative “off” phase was 3 and 2, respectively. Difference in pre- and postsurgery FTMTRS grades was found to be statistically significant (P = 0.00001). CONCLUSION: Subthalamic nucleus DBS results in substantial improvement in legibility of handwriting of patients, particularly in cases with age less than 65 years.","PeriodicalId":7973,"journal":{"name":"Annals of Movement Disorders","volume":"4 1","pages":"143 - 148"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45400855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0