Skin pharmacology and applied skin physiology最新文献_第10页

EEMCO guidance for the in vivo assessment of skin greasiness. The EEMCO Group. EEMCO体内皮肤油腻性评估指南。EEMCO集团。

Skin pharmacology and applied skin physiology Pub Date : 2000-11-01 DOI: 10.1159/000029945

G E Piérard, C Piérard-Franchimont, R Marks, M Paye, V Rogiers

{"title":"EEMCO guidance for the in vivo assessment of skin greasiness. The EEMCO Group.","authors":"G E Piérard, C Piérard-Franchimont, R Marks, M Paye, V Rogiers","doi":"10.1159/000029945","DOIUrl":"https://doi.org/10.1159/000029945","url":null,"abstract":"Sebaceous gland activity has four distinct components which are sebum production (a secretion rate function), storage (a volume function), surface output (a delivery rate function) and stratum corneum permeation (an influx rate function). The oily appearance of skin results from an excess of sebum excretion and spreading over the body surface and its interaction with the skin surface. A multi-pronged approach is often useful to assess skin greasiness with precision. The clinical evaluation of skin greasiness and its shiny appearance should be further complemented by quantifying the large pores, follicular plugs and comedones. The sebum amount present at the skin surface can be measured non-invasively using one of several methods based on solvent extraction, cigarette paper pads, photometric assessment, bentonite clay and lipid-sensitive tapes. Quantitative parameters include the sebum casual level, the sebum excretion rate, the sebum replacement time, the instant sebum delivery, the follicular excretion rate, the density in sebum-enriched reservoirs and the sustainable rate of sebum excretion. A series of environmental and biological features influence the data. Hence rigorous methodological designs are mandatory to support claims. As a rule, accuracy of the methods is adversely affected by skin temperature, degree of hydration and surface roughness. An additional confounding factor is the inherent difficulty of collecting the surface lipids without a contribution from the follicular reservoir. A better understanding of factors that alter the sebum amount at the skin surface may well assist in the development of sebosuppressive agents to help the reduction of the skin greasiness and improve acne.","PeriodicalId":79724,"journal":{"name":"Skin pharmacology and applied skin physiology","volume":"13 6","pages":"372-89"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000029945","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21921040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 136

New insights into the pathomechanisms of contact dermatitis by the use of transgenic mouse models. 利用转基因小鼠模型对接触性皮炎的病理机制有了新的认识。

Skin pharmacology and applied skin physiology Pub Date : 2000-11-01 DOI: 10.1159/000029938

C Traidl, H F Merk, A Cavani, N Hunzelmann

引用次数: 16

Antipruritic and thermal sensation effects of hydrocortisone creams in human skin. 氢化可的松乳膏对人体皮肤的止痒和热感觉作用。

Skin pharmacology and applied skin physiology Pub Date : 2000-11-01 DOI: 10.1159/000029943

H Zhai, S Frisch, A Pelosi, S Neibart, H I Maibach

{"title":"Antipruritic and thermal sensation effects of hydrocortisone creams in human skin.","authors":"H Zhai, S Frisch, A Pelosi, S Neibart, H I Maibach","doi":"10.1159/000029943","DOIUrl":"https://doi.org/10.1159/000029943","url":null,"abstract":"Few studies evaluate the effect of topical corticosteroids on thermal sensation and in alleviation of itch produced by intradermal injection of histamine. We evaluated the antipruritic effect of hydrocortisone (1% and 2.5%) on histamine-induced itch and sensory effects by measuring itch magnitude, itch duration and thermal thresholds using a computerized thermal sensory analyzer (TSA). This was a double-blind, random, comparative, controlled, single-dose and single-center study. Itch was experimentally induced in both forearms by intracutaneous injection of histamine in 18 subjects. Hydrocortisone 1%, 2.5% and placebo were applied to test sites on both forearms. The thermal threshold for warmth sensation, cold sensation, cold and heat pain was measured with the TSA. Itch magnitude was measured each minute after histamine injection for 10 min with a visual analogue scale (VAS). Itch duration was also recorded. In comparison to placebo, 2.5% hydrocortisone significantly (p = 0.03) reduced itch duration from 12.6 +/- 11.0 min (mean +/- SD) to 8.6 +/- 8.2 min (the reducing rate was 32%) as well as itch magnitude (at minutes 3, 6, 7 and overall). Placebo, 1% and 2.5% hydrocortisone significantly altered (p <0.05) the cold sensation threshold. No treatment altered cold or heat pain thresholds. These data suggest that topical application of 2.5% hydrocortisone may be significantly beneficial for the treatment of histamine-induced itch. The correlation between thermal measurements and antipruritic effects warrants further study.","PeriodicalId":79724,"journal":{"name":"Skin pharmacology and applied skin physiology","volume":"13 6","pages":"352-7"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000029943","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21921037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Detection of skin irritation potential of cosmetics by non-invasive measurements. 化妆品皮肤刺激电位的非侵入性检测。

Skin pharmacology and applied skin physiology Pub Date : 2000-11-01 DOI: 10.1159/000029944

V Zuang, C Rona, G Archer, E Berardesca

{"title":"Detection of skin irritation potential of cosmetics by non-invasive measurements.","authors":"V Zuang, C Rona, G Archer, E Berardesca","doi":"10.1159/000029944","DOIUrl":"https://doi.org/10.1159/000029944","url":null,"abstract":"This study analyses the ability of four non-invasive techniques (laser Doppler velocimetry, evaporimetry, chromametry and corneometry) to discriminate between irritant and non-irritant products, when compared to appropriate controls, and to detect subliminal changes in barrier function and erythema. These changes, which remain undetectable in the traditional visual and palpable clinical assessment, can be used as early reactions that are followed by the development of overt skin irritation. Laser Doppler velocimetry and evaporimetry were good discriminators between irritant and non-irritant substances, whereas corneometry and chromametry did not clearly distinguish between them. Laser Doppler velocimetry and evaporimetry detected early stages in the development of an irritant reaction before it became visible, but chromametry was not able to detect an early irritant response. It was concluded that non-invasive measurements could improve the quality and relevance of data obtained from human irritation testing, since the data they provide are objective, quantitative and sometimes subclinical, which also allows the concentration of a positive control to be reduced, resulting in the induction of less skin damage in human volunteers and reducing the ethical concerns related to the deliberate induction of an irritant response in a 'healthy' volunteer.","PeriodicalId":79724,"journal":{"name":"Skin pharmacology and applied skin physiology","volume":"13 6","pages":"358-71"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000029944","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21921039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Histamine receptors on lymphocytes: distribution and functional significance. 淋巴细胞上组胺受体的分布及其功能意义。

Skin pharmacology and applied skin physiology Pub Date : 2000-11-01 DOI: 10.1159/000029939

B Sachs, M Hertl, H F Merk

引用次数: 14

Penetration enhancers assessed by corneoxenometry. 用角膜测厚法评估穿透增强剂。

Skin pharmacology and applied skin physiology Pub Date : 2000-09-01 DOI: 10.1159/000029934

V Goffin, F Henry, C Piérard-Franchimont, G E Piérard

引用次数: 27

Tazarotene induces epidermal cell differentiation in the mouse tail test used as an animal model for psoriasis. 他沙罗汀诱导表皮细胞分化的小鼠尾巴试验作为牛皮癣动物模型。

Skin pharmacology and applied skin physiology Pub Date : 2000-09-01 DOI: 10.1159/000029935

B Sebök, B Bonnekoh, M Kerényi, H Gollnick

{"title":"Tazarotene induces epidermal cell differentiation in the mouse tail test used as an animal model for psoriasis.","authors":"B Sebök, B Bonnekoh, M Kerényi, H Gollnick","doi":"10.1159/000029935","DOIUrl":"https://doi.org/10.1159/000029935","url":null,"abstract":"Disturbed epidermal proliferation and keratinization are major features of psoriatic skin lesions. The so-called mouse tail test is known as an animal model to evaluate the antipsoriatic efficacy of topical drugs with regard to the induction of orthokeratosis. The purpose of the present study was to investigate the effect of tazarotene, a novel, receptor-specific retinoid, by the mouse tail test in a direct comparison to dithranol representing a classical topical antipsoriatic compound. The tails of CFLP mice were treated with tazarotene gel (0.1%, 0.05%), dithranol ointment (1.0%), tretinoin cream (0.05%) and methylcellulose (5%) hydrogel (vehicle control) for 2 weeks. Longitudinal histological sections were prepared from the tail skin, and the degree of orthokeratosis was determined by measuring the horizontal length of the fully developed granular layer within an individual scale in relation to its total length according to a method originally described by Bosman and co-authors. The degree of orthokeratosis was significantly (p < or = 0.05) increased by 0.1% tazarotene (87+/-20%), 1.0% dithranol (75+/-26%), 0.05% tazarotene (59+/-27%), and 0.05% tretinoin (23+/-13%) as compared to untreated (11+/-6%) and methylcellulose hydrogel-treated (13+/-6%) controls. Under the conditions of the mouse tail test, tazarotene showed a strong potency to induce orthokeratosis. With regard to clinically relevant concentrations this effect was even more pronounced than that observed for dithranol.","PeriodicalId":79724,"journal":{"name":"Skin pharmacology and applied skin physiology","volume":"13 5","pages":"285-91"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000029935","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21778971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Synergistic activity of benzoyl peroxide and erythromycin. 过氧化苯甲酰与红霉素的协同作用。

Skin pharmacology and applied skin physiology Pub Date : 2000-09-01 DOI: 10.1159/000029936

C N Burkhart, K Specht, D Neckers

{"title":"Synergistic activity of benzoyl peroxide and erythromycin.","authors":"C N Burkhart, K Specht, D Neckers","doi":"10.1159/000029936","DOIUrl":"https://doi.org/10.1159/000029936","url":null,"abstract":"Background: Benzoyl peroxide (BP) is the most widely used topical agent for acne since its introduction in the 1960s. Concomitant topical treatment of BP and erythromycin is stated to be superior to BP alone. However, no synergistic activity has been found with this combination. Instead, such combination therapies are hypothesized to gain their efficacy by the coupled action of two effective treatments. The antibiotic kills all susceptible bacteria and the BP eliminates the resistant strains.Objective: The purpose was to compare radical production by BP alone and with various antibiotics to determine whether certain antibiotics increase radical formation by BP, as the antibacterial activity of BP may correlate with the amount of radicals it forms.Methods: Polymerization of tetraethylene glycol dimethacrylate was used as a test of BP radical activity.Results: The results suggest that radical activity increases upon addition of certain antibiotics, such as erythromycin, to a solution of BP.Conclusion: Radical activity of BP in tetraethylene glycol dimethacrylate is increased when tested in consort with several antibiotics, such as the macrolides. We propose that the tertiary amines contained on certain antibiotics are responsible for catalysis of BP radical formation. If increased radical formation correlates with enhanced biological effect, then these data reveal the possibility of a biological synergism in mixtures of BP and antibiotics. An understanding of the mechanism of catalysis of BP radical formation by antibiotics may lead to the discovery of improved treatments for acne.","PeriodicalId":79724,"journal":{"name":"Skin pharmacology and applied skin physiology","volume":"13 5","pages":"292-6"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000029936","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21778973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 43

The pig as an experimental animal model of percutaneous permeation in man: qualitative and quantitative observations--an overview. 猪作为人类经皮渗透的实验动物模型:定性和定量观察综述。

Skin pharmacology and applied skin physiology Pub Date : 2000-09-01 DOI: 10.1159/000029928

G A Simon, H I Maibach

引用次数: 364

Preview of potential therapeutic applications of leukotriene B4 inhibitors in dermatology. 白三烯B4抑制剂在皮肤病学中的潜在治疗应用展望。

Skin pharmacology and applied skin physiology Pub Date : 2000-09-01 DOI: 10.1159/000029929

Y I Zhu, M J Stiller

引用次数: 13