Scandinavian cardiovascular journal. Supplement最新文献

Abstracts of the XV Swedish Cardiovascular Spring Meeting. Göteborg, Sweden. April 17–19, 2013. 第十五届瑞典心血管春季会议摘要。Goteborg,瑞典。2013年4月17日至19日。

Scandinavian cardiovascular journal. Supplement Pub Date : 2013-04-01 DOI: 10.3109/14017431.2013.783674

引用次数: 0

Milrinone and levosimendan administered after reperfusion improve myocardial stunning in swine. 再灌注后给予米力农和左西孟旦可改善猪心肌昏迷。

Scandinavian cardiovascular journal. Supplement Pub Date : 2013-02-01 Epub Date: 2012-10-10 DOI: 10.3109/14017431.2012.732236

Itsuko Shibata, Sungsam Cho, Osamu Yoshitomi, Hiroyuki Ureshino, Takuji Maekawa, Tetsuya Hara, Koji Sumikawa

{"title":"Milrinone and levosimendan administered after reperfusion improve myocardial stunning in swine.","authors":"Itsuko Shibata, Sungsam Cho, Osamu Yoshitomi, Hiroyuki Ureshino, Takuji Maekawa, Tetsuya Hara, Koji Sumikawa","doi":"10.3109/14017431.2012.732236","DOIUrl":"https://doi.org/10.3109/14017431.2012.732236","url":null,"abstract":"Objectives: We assessed the effect of milrinone application timing after reperfusion against myocardial stunning as compared with levosimendan in swine. Furthermore, we examined the role of p38 mitogen-activated protein kinase (p38 MAPK) in the milrinone-induced cardioprotection.Design: All swine were subjected to 12-minutes ischemia followed by 90-minutes reperfusion to generate stunned myocardium. Milrinone or levosimendan was administered intravenously either for 20 minutes starting just after reperfusion or for 70 minutes starting 20 minutes after reperfusion. In another group, SB203580, a selective p38 MAPK inhibitor, was administered with and without milrinone. Regional myocardial contractility was assessed by percent segment shortening (%SS).Results: Milrinone starting just after reperfusion, but not starting 20 minutes after reperfusion, improved %SS at 30, 60, and 90 minutes after reperfusion compared with that in the control group. SB203580 abolished the beneficial effect of milrinone. On the other hand, levosimendan starting 20 minutes after reperfusion, but not for 20 minutes starting just after reperfusion, improved %SS at 60 and 90 minutes after reperfusion.Conclusions: Milrinone should be administered just after reperfusion to protect myocardial stunning through p38 MAPK, whereas levosimendan improvement of contractile function could be mainly dependent on its positive inotropic effect.","PeriodicalId":79533,"journal":{"name":"Scandinavian cardiovascular journal. Supplement","volume":"47 1","pages":"50-7"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/14017431.2012.732236","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30922669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Preoperative NT-proBNP independently predicts outcome in patients with acute coronary syndrome undergoing CABG. 术前NT-proBNP独立预测急性冠脉综合征行冠脉搭桥患者的预后。

Scandinavian cardiovascular journal. Supplement Pub Date : 2013-02-01 Epub Date: 2012-10-10 DOI: 10.3109/14017431.2012.731518

Jonas Holm, Mårten Vidlund, Farkas Vanky, Orjan Friberg, Erik Håkanson, Rolf Svedjeholm

{"title":"Preoperative NT-proBNP independently predicts outcome in patients with acute coronary syndrome undergoing CABG.","authors":"Jonas Holm, Mårten Vidlund, Farkas Vanky, Orjan Friberg, Erik Håkanson, Rolf Svedjeholm","doi":"10.3109/14017431.2012.731518","DOIUrl":"https://doi.org/10.3109/14017431.2012.731518","url":null,"abstract":"Objectives: The predictive value of preoperative N-terminal pro-B-type natriuretic peptide (NT-proBNP) was evaluated in patients with acute coronary syndrome undergoing coronary artery bypass grafting (CABG).Design: As a substudy to a clinical trial 383 patients with acute coronary syndrome undergoing CABG were studied. 17 patients had a concomitant procedure. NT-proBNP was measured immediately preoperatively and evaluated with regard to in-hospital mortality, and severe circulatory failure postoperatively according to prespecified criteria. Follow-up was 3.2 ± 0.9 years.Results: In patients with isolated CABG, receiver operating characteristics (ROC) analysis showed an area under the curve (AUC) of 0.82 for in-hospital mortality and 0.87 for severe circulatory failure respectively with a best cut-off for preoperative NT-proBNP of 1028 ng/L. This cut-off level independently predicted severe circulatory failure. Patients with NT-proBNP < 1028 ng/L had significantly better long-term survival (p = 0.004). Preoperative NT-proBNP was higher in patients with concomitant procedure than isolated CABG (2146 ± 1858 v 887 ± 1635 ng/L; p = 0.0005). In patients with concomitant procedure ROC analysis showed an AUC of 0.93 for severe circulatory failure with a best cut-off for preoperative NT-proBNP of 3145 ng/L.Conclusions: Preoperative NT-proBNP predicted in-hospital mortality, severe circulatory failure postoperatively and long-term survival in patients undergoing surgery for acute coronary syndrome but a higher threshold was found in patients having concomitant procedures.","PeriodicalId":79533,"journal":{"name":"Scandinavian cardiovascular journal. Supplement","volume":"47 1","pages":"28-35"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/14017431.2012.731518","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30915418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Effects of simvastatin and ezetimibe on interleukin-6 and high-sensitivity C-reactive protein. 辛伐他汀和依折替米布对白细胞介素-6和高敏c反应蛋白的影响。

Scandinavian cardiovascular journal. Supplement Pub Date : 2013-02-01 Epub Date: 2012-10-18 DOI: 10.3109/14017431.2012.734635

Heiner K Berthold, Kaspar Berneis, Christos S Mantzoros, Wilhelm Krone, Ioanna Gouni-Berthold

{"title":"Effects of simvastatin and ezetimibe on interleukin-6 and high-sensitivity C-reactive protein.","authors":"Heiner K Berthold, Kaspar Berneis, Christos S Mantzoros, Wilhelm Krone, Ioanna Gouni-Berthold","doi":"10.3109/14017431.2012.734635","DOIUrl":"https://doi.org/10.3109/14017431.2012.734635","url":null,"abstract":"Objectives: Statins decrease cardiovascular events mainly by lowering cholesterol but anti-inflammatory effects also play a role. The effects of the cholesterol absorption inhibitor ezetimibe on markers of inflammation remain unclear. We performed an exploratory post-hoc analysis whether these drugs influence the pro-inflammatory markers interleukin-6 and high-sensitivity C-reactive protein in subjects with very-low cardiovascular risk.Design: Single center, randomized, parallel 3-group study in 72 healthy men without apparent cardiovascular disease (age 32 ± 9 years, BMI 25.7 ± 3.2 kg/m(2)). Each group of 24 subjects received a 14-day treatment with either simvastatin 40 mg, ezetimibe 10 mg, or their combination.Results: Baseline IL-6 and hsCRP concentrations in the total cohort were 0.72 ± 0.57 ng/l and 0.40 ± 0.65 mg/l, respectively, with no differences between the 3 groups. Median changes (interquartile range) in IL-6 and hsCRP concentrations were -22% (-43 to 0%) and -30% (-44 to +19%) after simvastatin, -5% (-36 to +30%) and +9% (-22 to +107%) after ezetimibe, and +15% (-15 to +86%) and +1 (-30 to +49%) after the combination. Using a generalized linear model, the multivariable adjusted overall P-values for these changes were 0.008 (IL-6) and 0.1 (hsCRP).Conclusions: Simvastatin decreases the pro-inflammatory markers IL-6 and almost significantly hsCRP while ezetimibe monotherapy or the combination with simvastatin has no effect.","PeriodicalId":79533,"journal":{"name":"Scandinavian cardiovascular journal. Supplement","volume":"47 1","pages":"20-7"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/14017431.2012.734635","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30936216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Pharmacological conversion of recent-onset atrial fibrillation: a systematic review. 最近发作的房颤的药理学转换:一个系统的回顾。

Scandinavian cardiovascular journal. Supplement Pub Date : 2013-02-01 Epub Date: 2012-11-13 DOI: 10.3109/14017431.2012.740572

Magnus Heldal, Dan Atar

{"title":"Pharmacological conversion of recent-onset atrial fibrillation: a systematic review.","authors":"Magnus Heldal, Dan Atar","doi":"10.3109/14017431.2012.740572","DOIUrl":"https://doi.org/10.3109/14017431.2012.740572","url":null,"abstract":"Objectives: Recent-onset (duration ≤ 1 week) atrial fibrillation (AF) has a high rate of spontaneous conversion to sinus rhythm (SR); still anti-arrhythmic drugs (AAD) are given for conversion purposes. We assessed the effect of AADs by reviewing the literature regarding conversion rates of available drugs in a systematic manner.Design: PubMed searches were performed using the terms \"drug name\", \"atrial fibrillation\", and \"clinical study/RCT\", and a list of 1302 titles was generated. These titles, including abstracts or complete papers when needed, were reviewed for recent-onset of AF, the use of a control group, and the endpoint of SR within 24 hours. Postoperative and intensive care settings were excluded.Results: Five AADs were demonstrated to have an effect, and these were Amiodarone, Ibutilide (only one study and risk of torsade de pointes), Flecainide and Propafenone (only to be used in patients without structural heart disease) and Vernakalant. The time taken for conversion differed markedly; Vernakalant converted after 10 minutes, while Amiodarone converted only after 24 hours; Propafenone and Flecainide had conversion times in-between.Conclusions: For a rapid response in a broad group of patients, Vernakalant appears to be a reasonable first choice, while Flecainide and Propafenone can be used in patients without structural heart disease.","PeriodicalId":79533,"journal":{"name":"Scandinavian cardiovascular journal. Supplement","volume":"47 1","pages":"2-10"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/14017431.2012.740572","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30979238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

Aortic regurgitation after transcatheter aortic valve implantation of the Edwards SAPIEN ™ valve. 经导管主动脉瓣植入Edwards SAPIEN™瓣膜后主动脉瓣反流。

Scandinavian cardiovascular journal. Supplement Pub Date : 2013-02-01 Epub Date: 2012-10-15 DOI: 10.3109/14017431.2012.731519

Hans Henrik Møller Nielsen, Henrik Egeblad, Henning Rud Andersen, Leif Thuesen, Steen Hvitfeldt Poulsen, Kaj-Erik Klaaborg, Carl-Johan Jakobsen, Vibeke Elisabeth Hjortdal

{"title":"Aortic regurgitation after transcatheter aortic valve implantation of the Edwards SAPIEN ™ valve.","authors":"Hans Henrik Møller Nielsen, Henrik Egeblad, Henning Rud Andersen, Leif Thuesen, Steen Hvitfeldt Poulsen, Kaj-Erik Klaaborg, Carl-Johan Jakobsen, Vibeke Elisabeth Hjortdal","doi":"10.3109/14017431.2012.731519","DOIUrl":"https://doi.org/10.3109/14017431.2012.731519","url":null,"abstract":"Introduction: Transcatheter aortic valve implantation (TAVI) is established as an attractive treatment option for high-risk patients with aortic valve stenosis. One concern is the high risk of prosthetic valve regurgitation. This study aimed to examine for potential preoperative risk factors for postprocedural transcatheter heart valve regurgitation and to quantify the risk, degree, and consequences of postprocedural regurgitation.Materials and methods: 100 consecutive patients who underwent femoral (n = 22) or transapical (n = 78) TAVI were retrospectively reviewed. Echocardiographic valve regurgitation and clinical parameters were analyzed over the first year after TAVI.Results: Seventy-five percent of all patients had prosthetic valve regurgitation. It was, however, only mild or absent in 64% of patients and did not require re-intervention in any of the patients in the series. The severity of the regurgitation appeared unchanged over the one-year follow-up period. Moderate to severe regurgitation was associated with significant yet stable dilatation of the left ventricle over one year and lesser NYHA class improvement three months after TAVI. Asymmetrical native valve calcification increased the risk of paravalvular regurgitation non-significantly.Conclusion: Transcatheter heart valve regurgitation seems to be mild in the majority of cases and unchanged over a 12 months follow-up period. While affecting left ventricular dimensions in moderate or severe cases, we observed no obvious undesirable consequences of the prosthetic valve regurgitation within the first year.","PeriodicalId":79533,"journal":{"name":"Scandinavian cardiovascular journal. Supplement","volume":"47 1","pages":"36-41"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/14017431.2012.731519","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30915249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Sildenafil after cardiac arrest and infarction; an experimental rat model. 心脏骤停和梗死后的西地那非;实验性大鼠模型。

Scandinavian cardiovascular journal. Supplement Pub Date : 2013-02-01 Epub Date: 2012-10-10 DOI: 10.3109/14017431.2012.732235

Ari A Mennander, Vilma Vuohelainen, Riikka S Aanismaa, Susanna Narkilahti, Timo Paavonen, Matti Tarkka

{"title":"Sildenafil after cardiac arrest and infarction; an experimental rat model.","authors":"Ari A Mennander, Vilma Vuohelainen, Riikka S Aanismaa, Susanna Narkilahti, Timo Paavonen, Matti Tarkka","doi":"10.3109/14017431.2012.732235","DOIUrl":"https://doi.org/10.3109/14017431.2012.732235","url":null,"abstract":"Objectives: Resuscitation after cardiac arrest may lead to ischemia-reperfusion injury and infarction. We evaluated whether sildenafil, a phosphodiesterase-5 inhibitor, has an impact on recovery after cardiac arrest in a rat cardiac transplantation model.Design: Sixty-one Fischer344 rats underwent syngeneic heterotopic cardiac transplantation after ischemia and ligation of the left anterior coronary artery of the heart to yield myocardial infarction (IRI + MI). Of these, 22 rats received subcutaneously injected sildenafil (1 mg/kg/day) (IRI +MI + S). Twenty-three additional grafted animals with transplantation only served as controls with ischemia reperfusion injury (IRI). After 2 days, immunohistochemistry for eNOS, and RT-PCR for iNOS and Aquaporin-7 were performed after graft harvesting and histology.Results: Two days after transplantation, remote intramyocardial arteries were more preserved in IRI + MI + S as compared with IRI +MI and IRI (0.74 ± 0.14, 0.56 ± 0.23 and 0.55 ± 0.22, PSU, p < 0.05, respectively). Decreased eNOS staining confirmed the presence of developing infarction in IRI + MI and IRI + MI + S. The expression of iNOS was significantly lower during IRI + MI +S as compared with IRI + MI (0.02 ± 0.01 and 1.02 ± 0.02, FC, p < 0.05).Conclusions: Administered at the onset of reperfusion and developing infarction, sildenafil has an impact on myocardial recovery after cardiac arrest and ischemia.","PeriodicalId":79533,"journal":{"name":"Scandinavian cardiovascular journal. Supplement","volume":"47 1","pages":"58-64"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/14017431.2012.732235","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30919846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Scandinavian cardiovascular journal. Supplement Pub Date : 2013-02-01 Epub Date: 2012-10-10 DOI: 10.3109/14017431.2012.732237

Torbjörn Ivert, Bengt Brorsson

{"title":"Similar survival 15 years after coronary artery surgery irrespective of left main stem stenosis.","authors":"Torbjörn Ivert, Bengt Brorsson","doi":"10.3109/14017431.2012.732237","DOIUrl":"https://doi.org/10.3109/14017431.2012.732237","url":null,"abstract":"Objectives: To evaluate 15-year survival after coronary artery bypass grafting (CABG) in relation to grade left main stenosis (LMS) and right coronary artery (RCA) obstruction.Design: Coronary angiographic findings were prospectively collected in 977 patients who had CABG for stable angina during 1994-1995 and were included in the Swedish Coronary Revascularization - Swedish Council of Technology Assessment study.Results: Significant LMS was present in one fifth of the patients and significant RCA obstruction was found in 61% of those with LMS and in 68% of patients without LMS. The patients were categorized as no LMS (Group I), LMS without RCA obstruction (Group II) or significant LMS with significant right coronary artery (RCA) obstruction (Group III). Early mortality did not differ in the three groups and was 1.2, 1.2% and 0.8% in group I, II and III, respectively. Corresponding survival at 15 years was similar 51%, 47% and 47%, respectively. In multivariable analysis older age, smoking, severe angina, positive stress test, hypertension, diabetes mellitus and ejection fraction < 50% were risk factors for death at 15 years.Conclusions: Death 15 years after CABG correlated to clinical variables but was not predicted from presence of LMS with or without significant associated RCA obstruction.","PeriodicalId":79533,"journal":{"name":"Scandinavian cardiovascular journal. Supplement","volume":"47 1","pages":"42-9"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/14017431.2012.732237","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30921021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Left ventricular systolic dyssynchrony in patients with isolated symptomatic myocardial bridge. 孤立症状性心肌桥患者左室收缩不同步。

Scandinavian cardiovascular journal. Supplement Pub Date : 2013-02-01 Epub Date: 2012-11-01 DOI: 10.3109/14017431.2012.736635

Wei Cai, Yan Dong, Xin Zhou, Shao-Bo Chen, Ji-Hong Zhao, Tie-Min Jiang, Yu-Ming Li

{"title":"Left ventricular systolic dyssynchrony in patients with isolated symptomatic myocardial bridge.","authors":"Wei Cai, Yan Dong, Xin Zhou, Shao-Bo Chen, Ji-Hong Zhao, Tie-Min Jiang, Yu-Ming Li","doi":"10.3109/14017431.2012.736635","DOIUrl":"https://doi.org/10.3109/14017431.2012.736635","url":null,"abstract":"Objectives: The impact of myocardial bridge (MB) on left ventricular (LV) systolic synchrony is insufficiently understood.Design: Thirty-five subjects with isolated mid-left, anterior, descending artery (LAD) MB, preserved LV ejection fraction (LVEF > 50%), and otherwise, normal coronary angiogram were identified from 3607 patients who underwent diagnostic coronary angiography and were evaluated by tissue Doppler imaging and real-time three-dimensional echocardiography (RT3DE). Control subjects consisted of 26 age and sex-matched coronary angiographically \"normal\" subjects.Results: MB patients were characterized by reduced, early, diastolic strain rate in LAD-supplied apical segments (lateral and anterior), with prevalence of LV systolic dyssynchrony of 25.7% (9/35). MB patients were further classified by the medians of MB stenosis and length. For MB stenosis < 52.5%, Class I: length < 17 mm (n = 7), Class II: length ≥ 17 mm (n = 10); for stenosis ≥ 52.5%, Class III: length < 17 mm (n = 10), Class IV: length ≥ 17 mm (n = 8). Binary Logistic regression model revealed that higher MB lesion classification (odds ratio: 4.944, 95%CI 1.174-20.82, P < 0.05) and hypertension (odds ratio: 15.32, 95%CI: 1.252-187.6, P < 0.05) are statistically associated with LV systolic dyssynchrony, which was independent of LV mass.Conclusions: MB in the mid LAD is associated with myocardial dyssynchrony. Hypertensive individuals and those with more severe bridging (determined by length and stenosis) tend to have an increased incidence of dyssynchrony.","PeriodicalId":79533,"journal":{"name":"Scandinavian cardiovascular journal. Supplement","volume":"47 1","pages":"11-9"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/14017431.2012.736635","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30951528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Abstracts from the XII Meeting of the Swedish Heart Association, April 21-23 2010, Gothenburg, Sweden. 2010年4月21日至23日，瑞典哥德堡，瑞典心脏协会第十二届会议。

Scandinavian cardiovascular journal. Supplement Pub Date : 2010-04-01 DOI: 10.3109/14017431003771148

引用次数: 1