Anatomic pathology (Chicago, Ill. : annual)最新文献

{"title":"A symposium on controversies in the pathology of transitional cell carcinomas of the urinary bladder, Part II.","authors":"M B Amin, W M Murphy, V E Reuter, J Y Ro, A G Ayala, M A Weiss, J N Eble, R H Young","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79472,"journal":{"name":"Anatomic pathology (Chicago, Ill. : annual)","volume":"2 ","pages":"71-110"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20497166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-induced vascular lesions of the liver.","authors":"E S Zafrani","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79472,"journal":{"name":"Anatomic pathology (Chicago, Ill. : annual)","volume":"2 ","pages":"135-45"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20497168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of fine-needle aspiration cytology and core biopsy in the diagnosis of proliferative and atypical breast lesions.","authors":"S J Maygarden","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79472,"journal":{"name":"Anatomic pathology (Chicago, Ill. : annual)","volume":"2 ","pages":"165-96"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20497170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic indicators in breast cancer and who needs them.","authors":"D L Page","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the prognosis of breast cancer, pathologists are facing a time of consolidation. Widely accepted guidelines have been gained only recently, with expectations that further developments are soon to come. Prognostic data influence systemic treatment decisions that are largely dependent on stage criteria of lymph nodes and tumor size as well as menopausal status. Some researchers propose that lymph node removal has no therapeutic consequences and may not be necessary if the majority of women are to be treated by chemotherapy. Some pathologists take this information as gospel for simplifying the management of a complex disease, whereas others take information available at different levels of certainty and set treatment threshold probabilities on an individual patient basis. With regard to invasive carcinoma and systemic therapy, I believe that combined histologic grade, including an emphasis on mitotic counts and other proliferation indicators, provides information at either end of the staging spectrum. Thus, high-grade, small tumors are likely to recur and low-grade, large tumors are unlikely to recur, at least within a 2- to 5-year period. Whether use of this information can be extended and verified for use in therapeutic decision making for neoadjuvant chemotherapy or various escalated chemotherapy regimens remains to be established. However, this use of prognostic indicators or predictors to indicate therapeutic responsiveness represents the field's immediate future. There are separate and important indicators of local treatment failure in the breast following conservation. It is likely that the extensiveness of DCIS is the major determinant of local recurrence and that its interaction with extensiveness, type of carcinoma in situ, and the branching ductal anatomy of the breast are of primary importance. Finally, the groups of conditions recognized as DCIS continue to provide a fertile field of questioning and discovery. Unassailable at the present time is the evidence that small, low-grade lesions may be treated effectively by planned wide local excision. Precise guidelines and further information are necessary from planned trials stratified by size and histologic criteria. Prognostic considerations have only become important in guiding treatment decisions in the past few decades. The escalating importance of prognostic categories derives from the availability of more varied treatment options, which have applications in the different clinical settings discussed in this chapter.</p>","PeriodicalId":79472,"journal":{"name":"Anatomic pathology (Chicago, Ill. : annual)","volume":"2 ","pages":"35-52"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20495964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uterine pathology in tamoxifen-treated patients with breast cancer.","authors":"M L Carcangiu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the last 20 years, tamoxifen has become the drug of choice in the treatment of breast carcinoma in both advanced and early stages. Furthermore, the ability of tamoxifen to prevent mammary carcinoma in the contralateral breast has prompted the creation of trials that include healthy patients with an increased risk of developing breast cancer with the purpose of verifying the drug's prophylactic action. As a consequence, a large number of healthy women or women with a long life expectancy are being treated with tamoxifen for long periods, making it crucial to study the possible long-term effects associated with this therapy. A weak estrogen-like effect of tamoxifen on the endometrium has been documented. This is supported by the increased incidence of glandular hyperplasia, polyps, carcinoma, and sarcoma in tamoxifen-treated patients. Some studies have shown that not all endometrial carcinomas arising in tamoxifen-treated patients have the favorable histologic and prognostic features typical of estrogen-associated endometrial cancers. This, in conjunction with the demonstrated carcinogenicity of tamoxifen in some animal models, indicates the need for caution in the use of this drug and makes strict gynecologic surveillance of tamoxifen-treated patients imperative.</p>","PeriodicalId":79472,"journal":{"name":"Anatomic pathology (Chicago, Ill. : annual)","volume":"2 ","pages":"53-70"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20495965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benign mimics of prostatic adenocarcinoma on needle biopsy.","authors":"P B Gaudin,&nbsp;V E Reuter","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Various benign processes can mimic prostatic adenocarcinoma on needle biopsy. These processes include glandular lesions such as adenosis, atrophy, VMGH, and BCH; inflammatory conditions such as acute and chronic or granulomatous prostatitis; and the effects of therapy such as external beam radiation or androgen deprivation. Normal benign prostate tissues including seminal vesicles, paraganglia, and ganglion cells may also be confused histologically with prostatic adenocarcinoma in needle biopsy specimens. With careful attention to architectural and cytologic features, these lesions can be readily distinguished from prostatic adenocarcinoma in most cases. In difficult cases, immunohistochemical studies using antibodies to PSA and high molecular weight cytokeratin (34 beta E12) have proved to be an invaluable adjunct in the differential diagnosis of prostatic adenocarcinoma on needle biopsy.</p>","PeriodicalId":79472,"journal":{"name":"Anatomic pathology (Chicago, Ill. : annual)","volume":"2 ","pages":"111-34"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20497167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction to molecular oncology.","authors":"T S Frank","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79472,"journal":{"name":"Anatomic pathology (Chicago, Ill. : annual)","volume":"2 ","pages":"227-38"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20497172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomenclature of chronic hepatitis: the new look.","authors":"L Ferrell","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The new recommendations for nomenclature, grading, and staging of chronic hepatitis and related biliary and other disorders are attempts to standardize the criteria and simplify the terminology used in making these diagnoses. It is hoped that an emphasis on the etiology as part of the diagnosis will eliminate the previous association with poor prognosis that was implied with a diagnosis of CAH. The inclusion of a system of grading and staging, whether it is numerical or descriptive, simple or complex, matters less than the need for it to communicate important information about the degree of necroinflammatory activity (grade) and the extent of the disease (stage of fibrosis) that are likely factors of prognostic and therapeutic significance.</p>","PeriodicalId":79472,"journal":{"name":"Anatomic pathology (Chicago, Ill. : annual)","volume":"2 ","pages":"21-33"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20495963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary thymic epithelial neoplasms: current concepts and controversies.","authors":"S Suster,&nbsp;C A Moran","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79472,"journal":{"name":"Anatomic pathology (Chicago, Ill. : annual)","volume":"2 ","pages":"1-19"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20495962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malignant mesothelioma in women.","authors":"V L Roggli,&nbsp;T D Oury,&nbsp;E J Moffatt","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>About 8% of our cases of mesothelioma occur in women, with a median age of 59 years. Our percentage is lower than other series reported in the literature because of the large number of occupationally exposed men referred to our laboratory. Tumor arose in the pleura in 86% of the women in our study, and the majority were epithelial. Pleural plaques were found in half of the women for which this information was available, and asbestosis was found in only 16%. A history of exposure to asbestos was identified in three quarters of the women, more than half of whom were household contacts of asbestos workers. Occupational exposure to asbestos was identified in only 19% of patients. An elevated tissue asbestos burden was noted in 70% of women from whom lung tissue was available for analysis. The main fiber type identified was amosite, followed by tremolite and chrysotile. These findings and those from other countries suggest a need for reassessment of the background rate of mesothelioma in industrialized nations.</p>","PeriodicalId":79472,"journal":{"name":"Anatomic pathology (Chicago, Ill. : annual)","volume":"2 ","pages":"147-63"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20497169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}