{"title":"Molecular Characterization of Postoperative Adhesions: The Adhesion Phenotype","authors":"Ghassan M. Saed Ph.D. , Michael P. Diamond M.D.","doi":"10.1016/S1074-3804(05)60041-2","DOIUrl":"10.1016/S1074-3804(05)60041-2","url":null,"abstract":"<div><p>Postoperative adhesion development remains a very frequent occurrence, which is often unrecognized by surgeons because of limited ability to conduct early second-look laparoscopies. The consequences include infertility, pelvic pain, bowel obstruction, and difficult reoperative procedures. To date, approaches to limit adhesions primarily have involved barriers to separate tissue during reepithelization. Future progress in regulating adhesion development and tissue fibrosis likely will require an improved understanding of the molecular processes involved in normal peritoneal repair and its aberrations leading to adhesion development. We hypothesize that tissue hypoxia (in part resulting from tissue incision, fulguration, suture ligation, etc.) is the major inciting event, which leads to a coordinated series of molecular events that promote an inflammatory response leading to enhanced tissue fibrosis. These events are reduced plasminogen activator activity, extracellular matrix deposition, increased cytokine production, increased angiogenesis, and reduced apoptosis (programmed cell death). Improved understanding of these events and their regulation will provide the opportunity to regulate better postoperative adhesion development and tissue fibrosis, thereby reducing the morbidity and mortality they cause.</p></div>","PeriodicalId":79466,"journal":{"name":"The Journal of the American Association of Gynecologic Laparoscopists","volume":"11 3","pages":"Pages 307-314"},"PeriodicalIF":0.0,"publicationDate":"2004-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1074-3804(05)60041-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24825494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Outpatient microwave endometrial ablation experience in bath","authors":"S. Tawfeek","doi":"10.1016/S1074-3804(04)80499-7","DOIUrl":"https://doi.org/10.1016/S1074-3804(04)80499-7","url":null,"abstract":"","PeriodicalId":79466,"journal":{"name":"The Journal of the American Association of Gynecologic Laparoscopists","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2004-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88764678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Total laparoscopic hysterectomy and sexual functioning","authors":"S Patel, P Ahluwalia","doi":"10.1016/S1074-3804(04)80319-0","DOIUrl":"10.1016/S1074-3804(04)80319-0","url":null,"abstract":"","PeriodicalId":79466,"journal":{"name":"The Journal of the American Association of Gynecologic Laparoscopists","volume":"11 3","pages":"Page S22"},"PeriodicalIF":0.0,"publicationDate":"2004-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1074-3804(04)80319-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86147927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cost comparison of two methods of tubal occlusion for female sterilization","authors":"N. Ahmed-Ebbiary","doi":"10.1016/S1074-3804(04)80381-5","DOIUrl":"https://doi.org/10.1016/S1074-3804(04)80381-5","url":null,"abstract":"","PeriodicalId":79466,"journal":{"name":"The Journal of the American Association of Gynecologic Laparoscopists","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2004-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90751540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
FR Nezhat, GJ Gardner, J Yadav, H Gretz, L Chuang, J Rahaman, CJ Cohen
{"title":"Laparoscopic radical hysterectomy: Evolution of technique in a fellowship training program","authors":"FR Nezhat, GJ Gardner, J Yadav, H Gretz, L Chuang, J Rahaman, CJ Cohen","doi":"10.1016/S1074-3804(04)80282-2","DOIUrl":"10.1016/S1074-3804(04)80282-2","url":null,"abstract":"","PeriodicalId":79466,"journal":{"name":"The Journal of the American Association of Gynecologic Laparoscopists","volume":"11 3","pages":"Page S9"},"PeriodicalIF":0.0,"publicationDate":"2004-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1074-3804(04)80282-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89653095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"What is a complication in total laparoscopic hysterectomy?","authors":"IK Orbuch, H Reich","doi":"10.1016/S1074-3804(04)80357-8","DOIUrl":"10.1016/S1074-3804(04)80357-8","url":null,"abstract":"","PeriodicalId":79466,"journal":{"name":"The Journal of the American Association of Gynecologic Laparoscopists","volume":"11 3","pages":"Page S35"},"PeriodicalIF":0.0,"publicationDate":"2004-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1074-3804(04)80357-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85338888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Laparoscopic removal of pelvic cystic tumors resembling ovarian cysts","authors":"A. Mortakis, K. Mavrelos, D. Mavrelos","doi":"10.1016/S1074-3804(04)80480-8","DOIUrl":"https://doi.org/10.1016/S1074-3804(04)80480-8","url":null,"abstract":"","PeriodicalId":79466,"journal":{"name":"The Journal of the American Association of Gynecologic Laparoscopists","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2004-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86310972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Roy, S. Levy, D. Whiteside, G. Malnar, R. Neighbor
{"title":"Office-based endometrial cryoablation with HER Option for menorrhagia: patient tolerance and comparison of oral analgesic and paracervical block regimens","authors":"K. Roy, S. Levy, D. Whiteside, G. Malnar, R. Neighbor","doi":"10.1016/S1074-3804(04)80492-4","DOIUrl":"https://doi.org/10.1016/S1074-3804(04)80492-4","url":null,"abstract":"","PeriodicalId":79466,"journal":{"name":"The Journal of the American Association of Gynecologic Laparoscopists","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2004-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87686597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S Bettocchi, L Nappi, O Ceci, A Santoro, L Selvaggi, G Cormio, A Vimercati
{"title":"Treatment of submucosal and partially intramural myomas using the bipolar Versapoint system","authors":"S Bettocchi, L Nappi, O Ceci, A Santoro, L Selvaggi, G Cormio, A Vimercati","doi":"10.1016/S1074-3804(04)80306-2","DOIUrl":"10.1016/S1074-3804(04)80306-2","url":null,"abstract":"","PeriodicalId":79466,"journal":{"name":"The Journal of the American Association of Gynecologic Laparoscopists","volume":"11 3","pages":"Pages S17-S18"},"PeriodicalIF":0.0,"publicationDate":"2004-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1074-3804(04)80306-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89616432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mapping the thermal gradient of a new radiofrequency bipolar vessel sealing device, EnSeal, using real-time thermography","authors":"Al Brill","doi":"10.1016/S1074-3804(04)80277-9","DOIUrl":"10.1016/S1074-3804(04)80277-9","url":null,"abstract":"","PeriodicalId":79466,"journal":{"name":"The Journal of the American Association of Gynecologic Laparoscopists","volume":"11 3","pages":"Page S7"},"PeriodicalIF":0.0,"publicationDate":"2004-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1074-3804(04)80277-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89817097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}